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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:intracranial arterial disease
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Accession:DOID:13089 term browser browse the term
Definition:Pathological conditions involving ARTERIES in the skull, such as arteries supplying the CEREBRUM, the CEREBELLUM, the BRAIN STEM, and associated structures. They include atherosclerotic, congenital, traumatic, infectious, inflammatory, and other pathological processes.
Synonyms:exact_synonym: Arterial Brain Disease;   Arterial Brain Diseases;   Arterial Brain Disorder;   Arterial Brain Disorders;   Intracranial Arterial Disorder;   Intracranial Arterial Disorders;   intracranial arterial diseases
 primary_id: MESH:D020765;   RDO:0005158
For additional species annotation, visit the Alliance of Genome Resources.

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Amyloid Angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:31939705 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
APP-related cerebral amyloid angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO OMIM NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
arteriovenous malformations of the brain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrv1 adhesion G protein-coupled receptor V1 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936469:8,653,031...9,209,840 JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO ClinVar Annotator: match by term: Arteriovenous malformations of the brain
ClinVar Annotator: match by term: Cerebral arteriovenous malformation		 ClinVar PMID:12068308 PMID:12198537 PMID:12447372 PMID:12460918 PMID:12460919 PMID:12619120 PMID:12644542 PMID:12670889 PMID:12794760 PMID:12960123 PMID:14513361 PMID:14602780 PMID:14679157 PMID:15001635 PMID:15035987 PMID:15126572 PMID:15181070 PMID:15342696 PMID:15356022 PMID:15386408 PMID:15687339 PMID:15998781 PMID:16015629 PMID:16174717 PMID:16187918 PMID:16772349 PMID:17374713 PMID:17488796 PMID:17785355 PMID:18398503 PMID:19001320 PMID:19010912 PMID:19018267 PMID:19238210 PMID:19404918 PMID:19537845 PMID:19561230 PMID:20008640 PMID:20350999 PMID:20413299 PMID:20619739 PMID:20630094 PMID:20818844 PMID:20823850 PMID:20857202 PMID:21107320 PMID:21107323 PMID:21129611 PMID:21156289 PMID:21163703 PMID:21426297 PMID:21483012 PMID:21502544 PMID:21639808 PMID:21641636 PMID:21683865 PMID:21975775 PMID:22038996 PMID:22048237 PMID:22113612 PMID:22180495 PMID:22281684 PMID:22351686 PMID:22356324 PMID:22389471 PMID:22448344 PMID:22536370 PMID:22586120 PMID:22608338 PMID:22649091 PMID:22663011 PMID:22735384 PMID:22743296 PMID:22773810 PMID:22805292 PMID:22972589 PMID:22997239 PMID:23020132 PMID:23031422 PMID:23251002 PMID:23302800 PMID:23325582 PMID:23470635 PMID:23524406 PMID:23549875 PMID:23614898 PMID:23685455 PMID:23812671 PMID:23833300 PMID:23845441 PMID:23918947 PMID:24107445 PMID:24112392 PMID:24163374 PMID:24388723 PMID:24508103 PMID:24512911 PMID:24576830 PMID:24583796 PMID:24586605 PMID:24594804 PMID:24670642 PMID:24717435 PMID:25024077 PMID:25037139 PMID:25079330 PMID:25157968 PMID:25265492 PMID:25265494 PMID:25370471 PMID:25399551 PMID:25950823 PMID:25989278 PMID:26619011 PMID:26678033 PMID:27404270 PMID:27480103 PMID:28854169 PMID:28891408 PMID:29925953 PMID:31779674 PMID:31891627 NCBI chrNW_004936592:4,728,371...4,833,830 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Ccnh cyclin H ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:30311386 NCBI chrNW_004936469:5,933,163...5,952,190 JBrowse link
G Cdh2 cadherin 2 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936550:6,885,484...7,067,001 JBrowse link
G Egfr epidermal growth factor receptor ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936678:365,005...560,546 JBrowse link
G Eng endoglin disease_progression ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation
DNA:polymorphism: : 207G>A(human)		 RGD
ClinVar		 PMID:16179574 PMID:24520391 PMID:24876084 PMID:25741868 RGD:11041171 RGD:11041564 RGD:1580962 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO protein:increased expression:endothelial cell: RGD PMID:11220380 RGD:8551824 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Gli2 GLI family zinc finger 2 ISO ClinVar Annotator: match by term: Arteriovenous malformations of the brain ClinVar PMID:25741868 NCBI chrNW_004936469:49,616,552...49,788,760 JBrowse link
G Il17rd interleukin 17 receptor D ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25636053 PMID:25741868 NCBI chrNW_004936473:7,447,292...7,507,819 JBrowse link
G Kdr kinase insert domain receptor ISO protein:increased expression:endothelial cell: RGD PMID:11220380 RGD:8551824 NCBI chrNW_004936482:17,537,697...17,581,320 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO OMIM NCBI chrNW_004936548:2,078,568...2,113,877 JBrowse link
G Lemd3 LEM domain containing 3 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936545:3,385,821...3,453,861 JBrowse link
G LOC101976737 zinc finger FYVE domain-containing protein 16 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936549:8,082,464...8,110,116 JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936713:515,388...616,024 JBrowse link
G Notch4 notch receptor 4 ISO RGD PMID:19546852 RGD:6480671 NCBI chrNW_004936727:1,386,842...1,409,823 JBrowse link
G Pdcd10 programmed cell death 10 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936593:4,650,624...4,693,387 JBrowse link
G Pitpnm3 PITPNM family member 3 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936677:1,451,974...1,528,864 JBrowse link
G Prex2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936496:6,005,410...6,284,332 JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:30311386 NCBI chrNW_004936469:5,839,560...5,933,049 JBrowse link
G Sars1 seryl-tRNA synthetase 1 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936704:747,109...766,981 JBrowse link
G Scube2 signal peptide, CUB domain and EGF like domain containing 2 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936528:8,981,079...9,060,033 JBrowse link
G Syn3 synapsin III ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936492:6,836,441...7,253,867 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 ISO ClinVar Annotator: match by term: Cerebral arteriovenous malformation ClinVar PMID:25741868 NCBI chrNW_004936492:6,996,627...7,046,137 JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:16388189 RGD:1580567 NCBI chrNW_004936476:16,245,134...16,261,180 JBrowse link
CADASIL term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
G Notch3 notch receptor 3 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy		 CTD
ClinVar		 PMID:15229130 PMID:25741868 PMID:26467025 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
CADASIL 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch3 notch receptor 3 ISO OMIM NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
CADASIL 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO OMIM NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
cerebral amyloid angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aoc3 amine oxidase copper containing 3 ISO associated with Alzheimer Disease;protein:increased expression:brain RGD PMID:17393059 RGD:2313919 NCBI chrNW_004936490:17,549,836...17,564,867 JBrowse link
G Apoa1 apolipoprotein A1 ISO RGD PMID:20739292 RGD:5508213 NCBI chrNW_004936542:2,111,055...2,112,626 JBrowse link
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD PMID:11061249 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G App amyloid beta precursor protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21520056 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Aqp4 aquaporin 4 ISO RGD PMID:21107133 RGD:5148012 NCBI chrNW_004936550:5,931,201...5,943,999 JBrowse link
G LOC101964209 C-C chemokine receptor type 1 ISO RGD PMID:14595653 RGD:5688166 NCBI chrNW_004936596:177,774...183,186 JBrowse link
G Mme membrane metalloendopeptidase severity ISO associated with Alzheimer Disease;protein:decreased expression:frontal lobe cortex (human) RGD PMID:17021406 PMID:21382117 RGD:13801026 RGD:1600811 NCBI chrNW_004936519:2,513,896...2,595,896 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 ISO RGD PMID:16328515 RGD:1580993 NCBI chrNW_004936902:405,536...416,393 JBrowse link
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htra1 HtrA serine peptidase 1 ISO OMIM NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
CST3-related cerebral amyloid angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Hereditary cerebral hemorrhage with amyloidosis ClinVar PMID:25741868 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
intracranial aneurysm term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO associated with Diabetes Mellitus, Experimental RGD PMID:23844137 RGD:8547935 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Aoc3 amine oxidase copper containing 3 ISO protein:decreased expression:cerebral artery RGD PMID:18312104 RGD:2313912 NCBI chrNW_004936490:17,549,836...17,564,867 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:25316629 RGD:11522723 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO RGD PMID:14739420 RGD:1581199 NCBI chrNW_004936585:5,650,322...5,686,393 JBrowse link
G Col22a1 collagen type XXII alpha 1 chain susceptibility ISO DNA:SNPs:cds:multiple(human) RGD PMID:30541770 RGD:13831344 NCBI chrNW_004936470:11,762,312...11,994,041 JBrowse link
G Ctsk cathepsin K ISO protein:increased expression:brain, artery
mRNA:increased expression:brain, artery		 RGD PMID:18635848 RGD:2306495 NCBI chrNW_004936580:1,022,762...1,038,020 JBrowse link
G Ctss cathepsin S ISO mRNA:increased expression:brain, artery
protein:increased expression:brain, artery		 RGD PMID:18635848 RGD:2306495 NCBI chrNW_004936580:963,176...991,732 JBrowse link
G Eng endoglin ISO RGD PMID:10223461 RGD:1580964 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Fbn2 fibrillin 2 ISO ClinVar Annotator: match by term: Brain Aneurysm ClinVar PMID:16835936 PMID:19006240 PMID:25525159 PMID:25741868 PMID:26038974 PMID:28492532 NCBI chrNW_004936504:1,535,629...1,757,386 JBrowse link
G Mmp12 matrix metallopeptidase 12 no_association ISO RGD PMID:11546917 RGD:1582365 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:9724118 RGD:1582590 NCBI chrNW_004936722:1,447,189...1,457,632 JBrowse link
G Mmp2 matrix metallopeptidase 2 susceptibility ISO mRNA:increased expression:blood vessel RGD PMID:9724118 PMID:16961137 PMID:17569872 RGD:1582590 RGD:1582646 RGD:2290352 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment
susceptibility		 ISO associated with Diabetes Mellitus, Experimental
mRNA:increased expression:blood vessel
mRNA, protein:increased expression:artery		 RGD PMID:9310982 PMID:16961137 PMID:17122420 PMID:17569872 PMID:21937941 PMID:23844137 RGD:13204853 RGD:13204858 RGD:1582646 RGD:1642055 RGD:2290352 RGD:8547935 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381132 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:21321533 RGD:5131897 NCBI chrNW_004936558:5,162,471...5,302,488 JBrowse link
G Nos3 nitric oxide synthase 3 ISO RGD PMID:21321533 RGD:5131897 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting susceptibility ISO DNA:mutations:multiple (human)
ClinVar Annotator: match by term: Brain aneurysm		 RGD
ClinVar		 PMID:12842373 PMID:25741868 RGD:1580867 NCBI chrNW_004936694:1,923,383...1,958,160 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel susceptibility ISO DNA:mutations:multiple (human) RGD PMID:12842373 RGD:1580867 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:21786025 RGD:6483795 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Smad3 SMAD family member 3 ISO ClinVar Annotator: match by term: Intracranial aneurysm ClinVar PMID:25326637 PMID:25741868 PMID:30311386 NCBI chrNW_004936471:27,080,662...27,185,861 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO RGD PMID:17569872 RGD:2290352 NCBI chrNW_004936502:13,345,936...13,350,170 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO mRNA:increased expression:blood vessel RGD PMID:17569872 RGD:2290352 NCBI chrNW_004936594:3,232,433...3,244,241 JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24628611 RGD:10450592 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vcan versican ISO DNA:SNP: :rs173686 (human) RGD PMID:16917090 RGD:1598495 NCBI chrNW_004936469:2,585,142...2,688,029 JBrowse link
Intracranial Berry Aneurysm 12 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thsd1 thrombospondin type 1 domain containing 1 ISO OMIM NCBI chrNW_004936565:4,925,400...4,952,210 JBrowse link
ITM2B-related cerebral amyloid angiopathy 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2b integral membrane protein 2B ISO OMIM NCBI chrNW_004936565:1,535,570...1,557,667 JBrowse link
ITM2B-related cerebral amyloid angiopathy 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itm2b integral membrane protein 2B ISO OMIM NCBI chrNW_004936565:1,535,570...1,557,667 JBrowse link
middle cerebral artery infarction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 treatment ISO RGD PMID:23149556 PMID:24602692 RGD:12790979 RGD:12791996 NCBI chrNW_004936528:1,608,782...1,682,873 JBrowse link
G Ace2 angiotensin I converting enzyme 2 ISO mRNA, protein:increased expression:brain RGD PMID:24090950 RGD:9685436 NCBI chrNW_004936470:4,964,526...5,011,808 JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chrNW_004936567:1,430,128...1,508,626 JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:24211797 PMID:25446913 RGD:8696008 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Agt angiotensinogen ISO protein:increased expression:brain, serum RGD PMID:24090950 RGD:9685436 NCBI chrNW_004936484:19,713,299...19,721,144 JBrowse link
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO protein:altered localization: : RGD PMID:15181376 RGD:10047403 NCBI chrNW_004936479:1,441,508...1,477,133 JBrowse link
G Ak1 adenylate kinase 1 ISO protein:decreased expression:cerebral cortex (rat) RGD PMID:16468349 RGD:5508760 NCBI chrNW_004936487:15,507,663...15,517,401 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19309543 NCBI chrNW_004936554:7,807,914...7,848,691 JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936490:5,156...127,666 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 treatment ISO RGD PMID:24012531 RGD:13703113 NCBI chrNW_004936492:14,818,561...14,902,231 JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:19623195 RGD:6903926 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G App amyloid beta precursor protein treatment ISO RGD PMID:28963051 RGD:13782054 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Aqp4 aquaporin 4 treatment ISO RGD PMID:20815926 RGD:8695955 NCBI chrNW_004936550:5,931,201...5,943,999 JBrowse link
G Arc activity regulated cytoskeleton associated protein ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936470:9,185,145...9,188,260 JBrowse link
G Atf3 activating transcription factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936557:909,302...922,619 JBrowse link
G Bad BCL2 associated agonist of cell death treatment ISO RGD PMID:21891976 PMID:22200499 RGD:10053665 RGD:10053704 NCBI chrNW_004936599:4,924,349...4,933,683 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcan brevican ISO RGD PMID:15869933 RGD:9590118 NCBI chrNW_004936580:5,816,196...5,828,531 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:23143152 RGD:10054501 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:20417695 RGD:4891138 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G Becn1 beclin 1 treatment ISO RGD PMID:22108007 RGD:11561900 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO protein:increased expression:brain RGD PMID:17379825 RGD:9685412 NCBI chrNW_004936486:18,449,371...18,460,435 JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:15902200 PMID:21029239 RGD:2314138 RGD:9068917 NCBI chrNW_004936757:499,485...523,494 JBrowse link
G C3 complement C3 ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma		 CTD
RGD		 PMID:22103620 PMID:23199288 RGD:7175514 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha ISO RGD PMID:14688616 RGD:1358416 NCBI chrNW_004936504:4,636,863...4,700,887 JBrowse link
G Casp3 caspase 3 treatment ISO RGD PMID:21891976 PMID:23143152 PMID:26868427 RGD:10053704 RGD:10054501 RGD:13782346 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp6 caspase 6 ISO RGD PMID:26868427 RGD:13782346 NCBI chrNW_004936563:912,502...920,025 JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:26868427 RGD:13782346 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Cd36 CD36 molecule treatment ISO RGD PMID:25216018 RGD:11041113 NCBI chrNW_004936810:791,823...838,303 JBrowse link
G Cd86 CD86 molecule ISO protein:increased expression:brain subventricular zone, microglial cell (rat) RGD PMID:19053043 RGD:2313025 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Cdk5 cyclin dependent kinase 5 ISO RGD PMID:24920629 RGD:13782375 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Cldn5 claudin 5 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chrNW_004936619:3,455,508...3,457,053 JBrowse link
G Crh corticotropin releasing hormone ISO protein:decreased expression:median eminence of hypothalamus (rat) RGD PMID:21741032 RGD:5490538 NCBI chrNW_004936496:7,759,656...7,761,555 JBrowse link
G Crp C-reactive protein ISO RGD PMID:15545914 RGD:9585995 NCBI chrNW_004936740:885,855...888,854 JBrowse link
G Crtc1 CREB regulated transcription coactivator 1 treatment ISO RGD PMID:20417695 RGD:4891138 NCBI chrNW_004936596:2,551,621...2,625,327 JBrowse link
G Csf3 colony stimulating factor 3 treatment ISO mRNA, protein:increased expression:brain: RGD PMID:15530654 PMID:19298757 RGD:11039420 RGD:11039425 NCBI chrNW_004936490:15,142,526...15,146,375 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:10825390 RGD:632989 NCBI chrNW_004936676:60,869...63,028 JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO mRNA:increased expression:cerebral cortex RGD PMID:10825390 RGD:632989 NCBI chrNW_004936762:66,636...69,694 JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO RGD PMID:11726790 RGD:9588643 NCBI chrNW_004936659:520,181...565,496 JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO RGD PMID:23516428 RGD:9589049 NCBI chrNW_004936493:6,963,406...7,013,256 JBrowse link
G Dynll1 dynein light chain LC8-type 1 ISO RGD PMID:9522364 RGD:13208524 NCBI chrNW_004936668:451,846...484,841 JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17197033 NCBI chrNW_004936534:885,489...892,292 JBrowse link
G Egr1 early growth response 1 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936531:7,625,956...7,629,041 JBrowse link
G Egr2 early growth response 2 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936753:1,958,250...1,962,640 JBrowse link
G Egr4 early growth response 4 ISO RGD PMID:22645329 RGD:10395314 NCBI chrNW_004936491:17,068,797...17,071,608 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha treatment ISO RGD PMID:19763736 PMID:23669639 RGD:10395346 RGD:10755569 NCBI chrNW_004936495:10,746,687...10,769,304 JBrowse link
G Eng endoglin ISO RGD PMID:24876084 RGD:11041171 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Epcam epithelial cell adhesion molecule ISO RGD PMID:15950761 RGD:11038820 NCBI chrNW_004936508:5,019,513...5,032,610 JBrowse link
G Epn1 epsin 1 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936981:194,176...213,021 JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:20547143 PMID:20833153 RGD:10400898 RGD:10401066 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor ISO RGD PMID:9974119 RGD:10401103 NCBI chrNW_004936728:706,499...843,447 JBrowse link
G F11 coagulation factor XI ISO RGD PMID:16533887 RGD:11041786 NCBI chrNW_004936554:3,205,539...3,223,228 JBrowse link
G F12 coagulation factor XII treatment ISO RGD PMID:16533887 RGD:11041786 NCBI chrNW_004936597:1,687,511...1,694,782 JBrowse link
G F2 coagulation factor II, thrombin ISO CTD Direct Evidence: marker/mechanism CTD PMID:29651748 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Fadd Fas associated via death domain treatment ISO RGD PMID:18950622 PMID:23378241 RGD:11341807 RGD:11344885 NCBI chrNW_004936599:633,501...639,412 JBrowse link
G Fgf21 fibroblast growth factor 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936664:2,826,823...2,828,330 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936488:4,384,710...4,388,118 JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936515:1,982,415...1,997,740 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:25882840 RGD:13792686 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Ghrl ghrelin and obestatin prepropeptide treatment ISO RGD PMID:19352052 RGD:9850083 NCBI chrNW_004936602:3,037,862...3,044,863 JBrowse link
G Ghsr growth hormone secretagogue receptor ISO RGD PMID:19352052 RGD:9850083 NCBI chrNW_004936593:268,736...273,623 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 treatment ISO RGD PMID:26674869 RGD:11068571 NCBI chrNW_004936669:814,330...838,881 JBrowse link
G Grn granulin precursor treatment ISO RGD PMID:23972823 RGD:10401661 NCBI chrNW_004936541:793,548...800,271 JBrowse link
G Grpel1 GrpE like 1, mitochondrial ISO mRNA:increased expression:cerebral cortex RGD PMID:12505684 RGD:632868 NCBI chrNW_004936477:18,883,556...18,891,108 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:28440874 RGD:13792734 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hamp hepcidin antimicrobial peptide ISO mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum RGD PMID:21957487 RGD:11041635 NCBI chrNW_004936570:1,009,344...1,010,654 JBrowse link
G Has2 hyaluronan synthase 2 ISO mRNA:increased expression:brain RGD PMID:11283406 RGD:9588631 NCBI chrNW_004936470:25,418,069...25,443,332 JBrowse link
G Hdac4 histone deacetylase 4 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936745:1,730,743...1,942,071 JBrowse link
G Hdac5 histone deacetylase 5 treatment ISO mRNA,protein:decreased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936541:561,721...598,915 JBrowse link
G Hdac9 histone deacetylase 9 ISO mRNA:increased expression:brain: RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936546:4,398,003...5,247,649 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha treatment ISO RGD PMID:21029239 RGD:9068917 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:23480850 RGD:9681449 NCBI chrNW_004936472:25,236,728...25,246,585 JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:20888632 PMID:23870531 PMID:24252362 RGD:10755587 RGD:10755588 RGD:10755755 NCBI chrNW_004936492:5,042,353...5,049,216 JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO rat gene in mouse model RGD PMID:17473852 PMID:21709150 RGD:5688754 RGD:6218961 NCBI chrNW_004936647:2,087,650...2,133,343 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased expression:brain, cytosol (mouse)
protein:increased expression:brain, cytosol (rat)		 RGD PMID:15306124 PMID:16978742 RGD:2314385 RGD:5688372 NCBI chrNW_004936556:741,718...746,016 JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 ISO RGD PMID:31250553 RGD:14985213 NCBI chrNW_004936558:3,581,409...3,609,714 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936659:616,570...627,172 JBrowse link
G Igf1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment ISO RGD PMID:16286924 RGD:10045955 NCBI chrNW_004936785:358,128...406,751 JBrowse link
G Il11 interleukin 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936886:617,531...620,661 JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,529,933...2,532,503 JBrowse link
G Il1b interleukin 1 beta treatment ISO protein:increased expression:cerebral cortex (rat)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:23028794 PMID:24916922 PMID:25257527 PMID:29498696 RGD:10450594 RGD:13792833 RGD:7204480 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Il1rn interleukin 1 receptor antagonist treatment ISO human gene in a rat model RGD PMID:7790404 RGD:8551708 NCBI chrNW_004936783:1,447,158...1,466,331 JBrowse link
G Il22 interleukin 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936545:6,227,118...6,231,745 JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:cerebral cortex RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,510,457...2,518,576 JBrowse link
G Il5 interleukin 5 ISO RGD PMID:23028794 RGD:7204480 NCBI chrNW_004936647:2,647,982...2,651,477 JBrowse link
G Il6r interleukin 6 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936580:4,055,438...4,081,876 JBrowse link
G Il6st interleukin 6 signal transducer ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936480:11,867,573...11,913,563 JBrowse link
G Ina internexin neuronal intermediate filament protein alpha ISO RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936600:2,747,649...2,760,517 JBrowse link
G Irf4 interferon regulatory factor 4 ISO RGD PMID:25652434 RGD:11530061 NCBI chrNW_004936633:1,565,293...1,580,859 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936659:1,890,786...1,892,619 JBrowse link
G LOC101968921 angiotensin-converting enzyme treatment ISO RGD PMID:24471927 RGD:11039026 NCBI chrNW_004936541:4,157,847...4,178,156 JBrowse link
G LOC101973029 cytochrome P450 2E1 ISO RGD PMID:23002367 RGD:14700877 NCBI chrNW_004936486:19,691,822...19,702,684 JBrowse link
G LOC101976500 haptoglobin ISO RGD PMID:22103620 RGD:7175514 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mag myelin associated glycoprotein treatment ISO RGD PMID:15678116 RGD:9685232 NCBI chrNW_004936570:989,743...1,004,820 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment ISO RGD PMID:27152455 RGD:13800881 NCBI chrNW_004936619:1,889,841...1,932,646 JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment ISO RGD PMID:27152455 RGD:13800881 NCBI chrNW_004936501:12,342,670...12,390,650 JBrowse link
G Mapt microtubule associated protein tau treatment ISO RGD PMID:25903928 PMID:28886009 RGD:13800886 RGD:13800913 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19309543 PMID:24842554 RGD:13204729 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Mt3 metallothionein 3 ISO protein:decreased expression:brain RGD PMID:8869568 RGD:9685807 NCBI chrNW_004936475:8,864,512...8,866,516 JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:21185267 PMID:23777415 PMID:24583056 RGD:10040971 RGD:10040974 RGD:10041016 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:21386696 RGD:13801046 NCBI chrNW_004936475:17,083,175...17,105,098 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase treatment ISO RGD PMID:28495827 RGD:13781880 NCBI chrNW_004936479:17,682,070...17,716,713 JBrowse link
G Nefh neurofilament heavy ISO RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936657:3,443,406...3,453,096 JBrowse link
G Nefl neurofilament light ISO protein:increased expression:brain RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936757:1,642,122...1,646,499 JBrowse link
G Nefm neurofilament medium ISO protein:altered expression:brain RGD PMID:29967576 RGD:27226878 NCBI chrNW_004936757:1,662,905...1,668,707 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 treatment ISO RGD PMID:23880501 PMID:24466583 RGD:10412696 RGD:10412714 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO RGD PMID:21122797 RGD:10413868 NCBI chrNW_004936494:9,537,793...9,541,187 JBrowse link
G Ngf nerve growth factor ISO CTD Direct Evidence: therapeutic CTD PMID:10408807 NCBI chrNW_004936627:635,784...641,290 JBrowse link
G Ngfr nerve growth factor receptor treatment ISO RGD PMID:22678884 RGD:10413900 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 treatment ISO RGD PMID:24842554 RGD:13204729 NCBI chrNW_004936475:3,708,069...3,742,845 JBrowse link
G Nos2 nitric oxide synthase 2 ISO mRNA:increased expression:brain (mouse)
protein:increased expression:brain (rat)		 RGD PMID:21959178 PMID:22020035 RGD:5508751 RGD:5509037 NCBI chrNW_004936538:4,052,277...4,097,051 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment ISO protein:increased expression:brain RGD PMID:21120604 PMID:25069640 RGD:11035212 RGD:5133239 NCBI chrNW_004936475:19,771,384...19,785,034 JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:20691195 RGD:10449015 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase treatment ISO associated with Hypertension RGD PMID:17920569 RGD:8657395 NCBI chrNW_004936602:3,411,106...3,418,826 JBrowse link
G Park7 Parkinsonism associated deglycase treatment ISO RGD PMID:17882163 RGD:13463450 NCBI chrNW_004936623:2,422,780...2,436,817 JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 treatment ISO RGD PMID:21311064 PMID:23143152 PMID:23801245 PMID:25882840 RGD:10054501 RGD:11073732 RGD:13792686 RGD:5683909 NCBI chrNW_004936526:3,102,468...3,147,601 JBrowse link
G Pawr pro-apoptotic WT1 regulator treatment ISO protein:increased expression:brain: RGD PMID:11323519 PMID:16403464 PMID:19352052 RGD:9835380 RGD:9835381 RGD:9850083 NCBI chrNW_004936698:650,225...746,593 JBrowse link
G Pdgfra platelet derived growth factor receptor alpha treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chrNW_004936482:16,804,129...16,853,539 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment ISO RGD PMID:16917016 RGD:11084934 NCBI chrNW_004936504:4,762,251...4,799,789 JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic RGD
CTD		 PMID:12297567 PMID:14512838 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 RGD:1580876 NCBI chrNW_004936785:476,200...503,371 JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:11677890 PMID:15181847 PMID:17702958 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Pld1 phospholipase D1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936593:844,634...1,049,478 JBrowse link
G Prkcg protein kinase C gamma ISO RGD PMID:14688616 RGD:1358416 NCBI chrNW_004936994:87,525...105,125 JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa treatment ISO RGD PMID:24159062 RGD:11100027 NCBI chrNW_004936469:43,841,989...43,850,322 JBrowse link
G Ptprz1 protein tyrosine phosphatase receptor type Z1 ISO mRNA:increased expression:cerebral cortex RGD PMID:15869933 RGD:9590118 NCBI chrNW_004936605:3,195,893...3,368,102 JBrowse link
G Reln reelin severity ISO RGD PMID:16438965 RGD:13207538 NCBI chrNW_004936479:19,628,488...20,088,278 JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a treatment ISO RGD PMID:21840379 PMID:23275173 RGD:9850121 RGD:9850122 NCBI chrNW_004936483:9,753,112...9,792,817 JBrowse link
G Rpl28 ribosomal protein L28 ISO RGD PMID:16805800 RGD:6480229 NCBI chrNW_004936886:633,303...635,888 JBrowse link
G S100a5 S100 calcium binding protein A5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25257527 NCBI chrNW_004936580:3,349,655...3,353,601 JBrowse link
G Serpine1 serpin family E member 1 ISO RGD PMID:14512838 RGD:1580876 NCBI chrNW_004936543:1,032,543...1,040,956 JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO RGD PMID:22714093 RGD:8655545 NCBI chrNW_004936538:7,885,816...7,898,308 JBrowse link
G Serpinh1 serpin family H member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936498:4,341,944...4,351,432 JBrowse link
G Shh sonic hedgehog signaling molecule treatment ISO RGD PMID:22324418 RGD:12879461 NCBI chrNW_004936527:10,033,095...10,042,713 JBrowse link
G Sirt1 sirtuin 1 treatment ISO RGD PMID:23600725 RGD:9585664 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Slc12a2 solute carrier family 12 member 2 treatment ISO protein:increased expression:brain: RGD PMID:12535773 PMID:27798271 RGD:14398833 RGD:1580583 NCBI chrNW_004936504:1,378,812...1,465,463 JBrowse link
G Slc2a1 solute carrier family 2 member 1 treatment ISO RGD PMID:9419067 RGD:12879855 NCBI chrNW_004936474:24,205,878...24,236,611 JBrowse link
G Slc9a1 solute carrier family 9 member A1 treatment ISO RGD PMID:31250553 RGD:14985213 NCBI chrNW_004936474:11,460,266...11,517,420 JBrowse link
G Slpi secretory leukocyte peptidase inhibitor treatment ISO RGD PMID:14500739 RGD:9999390 NCBI chrNW_004936514:7,618,382...7,620,790 JBrowse link
G Smo smoothened, frizzled class receptor treatment ISO RGD PMID:23499832 PMID:23696546 RGD:12832759 RGD:12879404 NCBI chrNW_004936579:5,893,064...5,917,021 JBrowse link
G Smox spermine oxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30576531 NCBI chrNW_004936485:14,566,570...14,603,323 JBrowse link
G Snap91 synaptosome associated protein 91 ISO protein:increased degradation:brain RGD PMID:19240038 RGD:13461853 NCBI chrNW_004936510:7,222,200...7,345,138 JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO mRNA, protein:increased expression:cerebral cortex (rat) RGD PMID:22001340 PMID:22133807 RGD:8657021 RGD:8657023 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Sphk2 sphingosine kinase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:23043544 NCBI chrNW_004936664:2,668,708...2,676,608 JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21940958 NCBI chrNW_004936490:17,119,189...17,178,402 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO RGD PMID:31409163 RGD:14995477 NCBI chrNW_004936661:3,742,080...3,758,266 JBrowse link
G Th tyrosine hydroxylase ISO protein:decreased expression:substantia nigra pars compacta, neuron (rat) RGD PMID:21366664 RGD:5128609 NCBI chrNW_004936794:478,651...486,887 JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:15647744 PMID:24916922 PMID:29498696 RGD:10450594 RGD:13792833 RGD:13825261 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936469:26,129,339...26,145,464 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD PMID:15647744 RGD:13825261 NCBI chrNW_004936709:1,407,327...1,421,448 JBrowse link
G Upp1 uridine phosphorylase 1 ISO mRNA, protein:increased expression:brain (rat) RGD PMID:18457515 RGD:2317094 NCBI chrNW_004936478:22,508,602...22,531,604 JBrowse link
G Xdh xanthine dehydrogenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:12374626 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link
Moyamoya disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle ISO ClinVar Annotator: match by term: Moyamoya disease ClinVar PMID:25741868 PMID:28492532 NCBI chrNW_004936735:266,918...283,858 JBrowse link
G Fas Fas cell surface death receptor ISO ClinVar Annotator: match by term: Moyamoya disease ClinVar NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:16723886 RGD:1580650 NCBI chrNW_004936594:3,232,433...3,244,241 JBrowse link
Moyamoya Disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO ClinVar Annotator: match by term: Moyamoya disease 1 ClinVar PMID:26777256 NCBI chrNW_004936576:2,353,874...2,411,747 JBrowse link
Moyamoya Disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rnf213 ring finger protein 213 susceptibility ISO ClinVar Annotator: match by term: Moyamoya disease 2
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:21048783 PMID:21799892 PMID:22377813 PMID:22931863 PMID:25278557 PMID:25741868 PMID:28492532 PMID:31474762 NCBI chrNW_004936594:4,241,006...4,331,841 JBrowse link
Moyamoya Disease 4 with Short Stature, Hypergonadotropic Hypogonadism, and Facial Dysmorphism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcap31 B cell receptor associated protein 31 ISO ClinVar Annotator: match by term: Chromosome Xq28 deletion syndrome ClinVar PMID:24011989 PMID:25741868 NCBI chrNW_004936809:582,689...614,800 JBrowse link
G Slc6a8 solute carrier family 6 member 8 ISO ClinVar Annotator: match by term: Chromosome Xq28 deletion syndrome ClinVar PMID:24011989 NCBI chrNW_004936809:571,234...578,298 JBrowse link
Moyamoya Disease 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle ISO OMIM NCBI chrNW_004936735:266,918...283,858 JBrowse link
Moyamoya Disease 6 with Achalasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO OMIM NCBI chrNW_004936576:2,353,874...2,411,747 JBrowse link
Multi-Infarct Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO protein:decreased expression:cerebrospinal fluid: RGD PMID:1677459 RGD:10054257 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:18938189 RGD:10054050 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase treatment ISO RGD PMID:21279683 RGD:10449132 NCBI chrNW_004936809:1,269,900...1,285,853 JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8586980 RGD:10047081 NCBI chrNW_004936662:1,594,953...1,599,625 JBrowse link
vascular dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Vascular dementia ClinVar PMID:22312439 PMID:25104557 PMID:25174650 PMID:25604855 PMID:26242991 PMID:26467025 PMID:27312774 PMID:28492532 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha ISO RGD PMID:24448401 RGD:14696801 NCBI chrNW_004936517:743,036...752,836 JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO RGD PMID:24622829 RGD:10059369 NCBI chrNW_004936540:5,530,081...5,582,765 JBrowse link
G C1r complement C1r ISO ClinVar Annotator: match by term: Vascular dementia ClinVar PMID:25741868 NCBI chrNW_004936709:709,001...719,758 JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO ClinVar Annotator: match by term: Vascular dementia ClinVar PMID:25741868 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
G Ccm2 CCM2 scaffold protein ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936478:19,820,092...19,882,358 JBrowse link
G Cdk5 cyclin dependent kinase 5 treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936527:6,478,934...6,483,848 JBrowse link
G Col4a1 collagen type IV alpha 1 chain ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936472:2,416,043...2,543,561 JBrowse link
G Col4a2 collagen type IV alpha 2 chain ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936472:2,270,836...2,416,324 JBrowse link
G Eif4e eukaryotic translation initiation factor 4E ISO protein:decreased expression:hippocampus RGD PMID:23053837 RGD:10401142 NCBI chrNW_004936520:3,922,457...3,964,721 JBrowse link
G Epo erythropoietin ISO RGD PMID:17037738 RGD:10400891 NCBI chrNW_004936543:742,722...745,332 JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 treatment ISO RGD PMID:22500404 RGD:10402076 NCBI chrNW_004936710:1,760,365...1,815,269 JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 treatment ISO RGD PMID:22500404 RGD:10402076 NCBI chrNW_004936472:23,442,946...23,617,523 JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit susceptibility ISO associated with stroke;DNA:polymorphism:promoter:-588C>T(human) RGD PMID:17548779 RGD:10402374 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO RGD PMID:24968700 RGD:11352822 NCBI chrNW_004936529:997,943...999,123 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO associated with Alzheimer's disease RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936669:814,330...838,881 JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A ISO RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936530:8,286,101...8,612,183 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B severity ISO RGD PMID:25261450 RGD:13792687 NCBI chrNW_004936587:3,406,055...3,806,956 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936536:6,730,070...6,893,818 JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO DNA:polymorphism: :-110A>C(human) RGD PMID:15832029 RGD:10402403 NCBI chrNW_004936727:1,732,323...1,735,128 JBrowse link
G Htra1 HtrA serine peptidase 1 ISO ClinVar Annotator: match by term: Vascular dementia ClinVar PMID:24500651 NCBI chrNW_004936486:11,271,130...11,317,271 JBrowse link
G Igf1 insulin like growth factor 1 severity ISO mRNA,protein:decreased expression:hippocampus: RGD PMID:16181175 PMID:22342912 RGD:10045864 RGD:1598446 NCBI chrNW_004936492:11,709,623...11,784,028 JBrowse link
G Igf1r insulin like growth factor 1 receptor ISO RGD PMID:16983186 RGD:10045873 NCBI chrNW_004936483:4,563,995...4,860,231 JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:plasma RGD PMID:16600299 RGD:1626633 NCBI chrNW_004936783:1,251,678...1,256,807 JBrowse link
G Itm2b integral membrane protein 2B ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936565:1,535,570...1,557,667 JBrowse link
G Krit1 KRIT1 ankyrin repeat containing ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936621:2,088,606...2,128,579 JBrowse link
G Mapt microtubule associated protein tau treatment ISO RGD PMID:27118553 RGD:13792766 NCBI chrNW_004936541:2,381,411...2,479,984 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:16385583 RGD:1582624 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO protein:decreased expression:hippocampus RGD PMID:23053837 RGD:10401142 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Notch3 notch receptor 3 ISO ClinVar Annotator: match by term: Vascular dementia ClinVar PMID:26308724 PMID:26467025 PMID:27844030 NCBI chrNW_004936596:5,265,984...5,301,430 JBrowse link
G Nppa natriuretic peptide A ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Pon2 paraoxonase 2 ISO DNA:missense mutation:cds:p.C311S (human) RGD PMID:11803456 RGD:1580219 NCBI chrNW_004936585:4,862,378...4,894,061 JBrowse link
G Psen2 presenilin 2 ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936526:3,584,194...3,611,719 JBrowse link
G Rpgrip1l RPGRIP1 like susceptibility ISO DNA:SNPs:introns:rs16952362,rs17214955,rs17803830(human) RGD PMID:22425971 RGD:13204815 NCBI chrNW_004936475:6,219,187...6,321,612 JBrowse link
G Rps6 ribosomal protein S6 treatment ISO RGD PMID:25767501 RGD:11041644 NCBI chrNW_004936652:1,252,986...1,255,987 JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19465911 NCBI chrNW_004936922:32,655...33,795 JBrowse link
G Snca synuclein alpha ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Sncg synuclein gamma ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chrNW_004936804:16,869...21,684 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO DNA:SNPs, haplotype: :24489C>T, 34995G>T, 68891C>T (human) RGD PMID:16082694 RGD:1581412 NCBI chrNW_004936492:115,923...174,614 JBrowse link
G Sst somatostatin ISO protein:decreased expression:brain RGD PMID:18925713 RGD:2303174 NCBI chrNW_004936578:2,464,310...2,465,673 JBrowse link
G Tmem106b transmembrane protein 106B ISO ClinVar Annotator: match by term: Vascular dementia ClinVar NCBI chrNW_004936761:1,663,099...1,689,580 JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:polymorphism:promoter:-850C>T(human) RGD PMID:11273064 RGD:13825254 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Tp53 tumor protein p53 ISO protein:increased expression:brain RGD PMID:18083315 RGD:2290557 NCBI chrNW_004936595:919,807...935,367 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 11995
    disease of anatomical entity 11563
      cardiovascular system disease 3191
        vascular disease 2293
          cerebrovascular disease 749
            intracranial arterial disease 239
              arteriovenous malformations of the brain + 25
              cerebral arterial disease + 186
              intracranial aneurysm + 25
              intracranial arteriosclerosis + 47
Path 2
Term Annotations click to browse term
  disease 11995
    disease of anatomical entity 11563
      nervous system disease 9501
        central nervous system disease 8051
          brain disease 7460
            cerebrovascular disease 749
              intracranial arterial disease 239
                arteriovenous malformations of the brain + 25
                cerebral arterial disease + 186
                intracranial aneurysm + 25
                intracranial arteriosclerosis + 47
paths to the root