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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thromboangiitis obliterans
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Accession:DOID:12918 term browser browse the term
Definition:A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Synonyms:exact_synonym: Buerger disease;   Buerger's disease;   Buergers disease;   presenile gangrene;   thromboangitis obliterans
 primary_id: MESH:D013919
 alt_id: OMIM:211480
 xref: EFO:1001211;   ICD10CM:I73.1;   ICD9CM:443.1;   NCI:C35070
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
thromboangiitis obliterans term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGER advanced glycosylation end-product specific receptor treatment ISO mRNA, protein:increased expression:femoral artery (rat) RGD PMID:23069071 RGD:7207785 NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162 		JBrowse link
G CRHR1 corticotropin releasing hormone receptor 1 ISO mRNA:increased expression:femoral artery (rat) RGD PMID:19572944 RGD:5508315 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,020...17,306,285 		JBrowse link
G ELN elastin ISO protein:increased expression:blood: RGD PMID:8763587 RGD:9585753 NCBI chr 3:11,214,194...11,245,891
Ensembl chr 3:11,214,205...11,244,897 		JBrowse link
G UCN urocortin ISO mRNA:increased expression:femoral artery (rat) RGD PMID:19572944 RGD:5508315 NCBI chr 3:111,834,082...111,835,932
Ensembl chr 3:111,835,125...111,835,508 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 ISO protein:increased expression:femoral artery: RGD PMID:12086338 PMID:23069071 RGD:1580352 RGD:7207785 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17412
    disease of anatomical entity 14873
      cardiovascular system disease 4328
        vascular disease 3053
          peripheral vascular disease 365
            thromboangiitis obliterans 5
paths to the root