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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:acute kidney tubular necrosis
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Accession:DOID:12556 term browser browse the term
Definition:An acute kidney failure that is characterized by necrosis of epithelial tubule cells. (DO)
Synonyms:exact_synonym: ATN - acute tubular necrosis;   Lower Nephron Nephroses;   Lower Nephron Nephrosis;   acute renal failure with lesion of tubular necrosis;   acute renal failure with tubular necrosis;   acute tubular necrosis;   acute tubule necrosis
 primary_id: MESH:D007683
 xref: EFO:1000794;   ICD10CM:N17.0;   NCI:C34749
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acute kidney tubular necrosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ak4 adenylate kinase 4 ISO protein:decreased expression:kidney (rat) RGD PMID:21152904 RGD:5134352 NCBI chrNW_004936692:2,593,409...2,654,583 JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO associated with Kidney Reperfusion Injury;protein:increased expression:kidney RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936530:71,965...143,940
Ensembl chrNW_004936530:71,920...143,940
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chrNW_004936491:17,017,687...17,033,526
Ensembl chrNW_004936491:17,017,687...17,033,855
JBrowse link
G Ciita class II major histocompatibility complex transactivator ISO mRNA:increased expression:kidney RGD PMID:9422398 RGD:7242901 NCBI chrNW_004936530:9,033,510...9,073,341 JBrowse link
G Fabp1 fatty acid binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18368030 NCBI chrNW_004936712:738,361...743,073
Ensembl chrNW_004936712:738,348...743,955
JBrowse link
G Gsr glutathione-disulfide reductase ISO protein:decreased activity:renal cortex: RGD PMID:12885594 PMID:17078987 RGD:7257555 RGD:7257573 NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:kidney tubule, urine: RGD PMID:12081583 RGD:7245970 NCBI chrNW_004936515:6,030,402...6,051,161 JBrowse link
G Nog noggin ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936490:6,262,651...6,264,069
Ensembl chrNW_004936490:6,262,785...6,263,483
JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4358912 PMID:6254450 NCBI chrNW_004936493:7,060,747...7,065,276
Ensembl chrNW_004936493:7,061,587...7,065,109
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19834340 NCBI chrNW_004936629:3,672,445...3,725,645
Ensembl chrNW_004936629:3,672,460...3,725,626
JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19917352 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781
JBrowse link
G Tek TEK receptor tyrosine kinase ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chrNW_004936611:2,420,176...2,531,726
Ensembl chrNW_004936611:2,420,172...2,531,722
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13815
    disease of anatomical entity 13535
      Urogenital Diseases 4058
        urinary system disease 1893
          kidney disease 1688
            kidney failure 439
              acute kidney failure 247
                acute kidney tubular necrosis 12
paths to the root