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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:acute kidney tubular necrosis
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Accession:DOID:12556 term browser browse the term
Definition:An acute kidney failure that is characterized by necrosis of epithelial tubule cells. (DO)
Synonyms:exact_synonym: ATN - acute tubular necrosis;   Lower Nephron Nephroses;   Lower Nephron Nephrosis;   acute renal failure with lesion of tubular necrosis;   acute renal failure with tubular necrosis;   acute tubular necrosis;   acute tubule necrosis
 primary_id: MESH:D007683
 xref: EFO:1000794;   ICD10CM:N17.0;   NCI:C34749
For additional species annotation, visit the Alliance of Genome Resources.



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acute kidney tubular necrosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP7 bone morphogenetic protein 7 ISO associated with Kidney Reperfusion Injury;protein:increased expression:kidney RGD PMID:16284088 RGD:1601494 NCBI chr24:42,203,183...42,294,105
Ensembl chr24:42,204,823...42,294,653
JBrowse link
G CIITA class II major histocompatibility complex transactivator ISO mRNA:increased expression:kidney RGD PMID:9422398 RGD:7242901 NCBI chr 6:31,774,486...31,837,025
Ensembl chr 6:31,774,609...31,836,820
JBrowse link
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 ISO protein:decreased expression:kidney (rat) RGD PMID:21152904 RGD:5134352 NCBI chr 5:45,055,294...45,119,595
Ensembl chr 5:44,884,283...45,120,203
JBrowse link
G FABP1 fatty acid binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18368030 NCBI chr17:38,242,119...38,247,969
Ensembl chr17:38,242,119...38,247,962
JBrowse link
G GSR glutathione-disulfide reductase ISO protein:decreased activity:renal cortex: RGD PMID:12885594 PMID:17078987 RGD:7257555 RGD:7257573 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G HAVCR1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:kidney tubule, urine: RGD PMID:12081583 RGD:7245970 NCBI chr 4:53,012,223...53,066,611
Ensembl chr 4:53,046,970...53,128,952
Ensembl chr 4:53,046,970...53,128,952
JBrowse link
G LOC100856782 T-complex protein 1 subunit eta ISO CTD Direct Evidence: marker/mechanism CTD PMID:31825490 NCBI chr34:37,026,053...37,027,839 JBrowse link
G NOG noggin ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr 9:31,453,604...31,456,060 JBrowse link
G POMC proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism CTD PMID:4358912 PMID:6254450 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:19834340 NCBI chr10:19,934,020...20,006,096
Ensembl chr10:19,934,165...20,006,146
JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:19917352 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G TEK TEK receptor tyrosine kinase ISO associated with Kidney Reperfusion Injury RGD PMID:16284088 RGD:1601494 NCBI chr11:45,278,375...45,377,300
Ensembl chr11:45,278,891...45,409,093
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14860
    disease of anatomical entity 14527
      Urogenital Diseases 4259
        urinary system disease 1996
          kidney disease 1777
            kidney failure 477
              acute kidney failure 281
                acute kidney tubular necrosis 12
paths to the root