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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:vulva cancer
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Accession:DOID:1245 term browser browse the term
Definition:A female reproductive organ cancer that is located_in the vulva. (DO)
Synonyms:exact_synonym: Ca vulva;   cancer of the vulva;   cancer of vulva;   malignant neoplasm of vulva;   malignant tumor of vulva;   malignant vulvar tumor;   vulva cancers;   vulval cancer;   vulvar cancer;   vulvar cancers
 xref: GARD:9349;   ICD10CM:C51;   ICD9CM:184.4;   NCI:C7502
For additional species annotation, visit the Alliance of Genome Resources.


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vulva cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 severity IEP associated with Papillomavirus Infections RGD PMID:22685591 RGD:38676500 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G HLA-A major histocompatibility complex, class I, A susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphism: :HLA-A2 RGD PMID:12543794 RGD:2314696 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,945,884
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DQB1*03032,DQB1*5(human) RGD PMID:12543794 RGD:2314696 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DRB1*11,DRB1*01,DRB1*13(human) RGD PMID:12543794 RGD:2314696 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G MMP13 matrix metallopeptidase 13 IEP vulvar squamous cell carcinoma (SCC); mRNA:increased expression:tumor:expressed in 9/12 tumors but not in normal vulvar epithelium, cervical SCCs, or endometrial or ovarian adenocarcinomas RGD PMID:10027405 RGD:2293612 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G NOS3 nitric oxide synthase 3 disease_progression IAGP DNA:repeat:intron RGD PMID:15196865 RGD:2292078 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
JBrowse link
vulva squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC25A cell division cycle 25A IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDC25B cell division cycle 25B disease_progression IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr20:3,786,951...3,806,118
Ensembl chr20:3,786,772...3,806,121
JBrowse link
G CDC25C cell division cycle 25C disease_progression IEP protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G SFN stratifin IDA DNA, mRNA:hypermethylation, decreased expression:vulva RGD PMID:11896620 RGD:2299936 NCBI chr 1:26,863,149...26,864,456
Ensembl chr 1:26,863,149...26,864,456
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      reproductive system disease 3394
        reproductive organ cancer 1226
          female reproductive organ cancer 543
            vulva cancer 10
              Bartholin's gland cancer + 0
              clitoris cancer 0
              labia minora cancer + 0
              labium majus cancer + 0
              vulva carcinoma + 4
              vulvar glandular tumor + 0
              vulvar melanoma 0
              vulvar sarcoma + 0
              vulvar squamous tumor + 0
Path 2
Term Annotations click to browse term
  disease 20257
    disease of anatomical entity 18858
      Urogenital Diseases 4839
        Female Urogenital Diseases and Pregnancy Complications 2210
          Female Urogenital Diseases 1889
            female reproductive system disease 1885
              Female Genital Neoplasms 751
                Vulvar Neoplasms 17
                  vulva cancer 10
                    Bartholin's gland cancer + 0
                    clitoris cancer 0
                    labia minora cancer + 0
                    labium majus cancer + 0
                    vulva carcinoma + 4
                    vulvar glandular tumor + 0
                    vulvar melanoma 0
                    vulvar sarcoma + 0
                    vulvar squamous tumor + 0
paths to the root