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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:vulva cancer
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Accession:DOID:1245 term browser browse the term
Definition:A female reproductive organ cancer that is located_in the vulva. (DO)
Synonyms:exact_synonym: Ca vulva;   cancer of the vulva;   cancer of vulva;   malignant neoplasm of vulva;   malignant tumor of vulva;   malignant vulvar tumor;   vulva cancers;   vulval cancer;   vulvar cancer;   vulvar cancers
 xref: GARD:9349;   ICD10CM:C51;   ICD9CM:184.4;   NCI:C7502
For additional species annotation, visit the Alliance of Genome Resources.


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vulva cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 severity ISO associated with Papillomavirus Infections RGD PMID:22685591 RGD:38676500 NCBI chr 8:72,317,399...72,335,686
Ensembl chr 8:72,317,869...72,335,193
JBrowse link
G HLA-DRB1 MHC class II DLA DRB1 beta chain susceptibility ISO associated with Papillomavirus Infections;DNA:polymorphisms: :HLA-DRB1*11,DRB1*01,DRB1*13(human) RGD PMID:12543794 RGD:2314696 NCBI chr12:2,151,409...2,164,564 JBrowse link
G MMP13 matrix metallopeptidase 13 ISO vulvar squamous cell carcinoma (SCC); mRNA:increased expression:tumor:expressed in 9/12 tumors but not in normal vulvar epithelium, cervical SCCs, or endometrial or ovarian adenocarcinomas RGD PMID:10027405 RGD:2293612 NCBI chr 5:28,793,568...28,864,832
Ensembl chr 5:28,850,522...28,864,121
JBrowse link
G NOS3 nitric oxide synthase 3 disease_progression ISO DNA:repeat:intron RGD PMID:15196865 RGD:2292078 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
vulva squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC25A cell division cycle 25A ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr20:40,823,683...40,849,113
Ensembl chr20:40,823,459...40,847,608
JBrowse link
G CDC25B cell division cycle 25B disease_progression ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr24:17,552,206...17,561,791
Ensembl chr24:17,553,316...17,561,759
JBrowse link
G CDC25C cell division cycle 25C disease_progression ISO protein:increased expression:vulva RGD PMID:20500813 RGD:2729590 NCBI chr11:25,904,152...25,940,754
Ensembl chr11:25,904,144...25,935,744
JBrowse link
G SFN stratifin ISO DNA, mRNA:hypermethylation, decreased expression:vulva RGD PMID:11896620 RGD:2299936 NCBI chr 2:73,268,289...73,269,663
Ensembl chr 2:73,268,791...73,269,537
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 13805
    disease of anatomical entity 13462
      reproductive system disease 2627
        reproductive organ cancer 1099
          female reproductive organ cancer 496
            vulva cancer 8
              Bartholin's gland cancer + 0
              clitoris cancer 0
              labia minora cancer + 0
              labium majus cancer + 0
              vulva carcinoma + 4
              vulvar glandular tumor + 0
              vulvar melanoma 0
              vulvar sarcoma + 0
              vulvar squamous tumor + 0
Path 2
Term Annotations click to browse term
  disease 13805
    disease of anatomical entity 13462
      Urogenital Diseases 3844
        Female Urogenital Diseases and Pregnancy Complications 1951
          Female Urogenital Diseases 1659
            female reproductive system disease 1655
              Female Genital Neoplasms 679
                Vulvar Neoplasms 14
                  vulva cancer 8
                    Bartholin's gland cancer + 0
                    clitoris cancer 0
                    labia minora cancer + 0
                    labium majus cancer + 0
                    vulva carcinoma + 4
                    vulvar glandular tumor + 0
                    vulvar melanoma 0
                    vulvar sarcoma + 0
                    vulvar squamous tumor + 0
paths to the root