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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:malaria
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Accession:DOID:12365 term browser browse the term
Definition:A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (DO)
Synonyms:exact_synonym: MALS;   Marsh Fever;   Paludism;   Plasmodium Infection;   Plasmodium Infections;   induced malaria;   remittent fever
 related_synonym: DUFFY BLOOD GROUP SYSTEM, FY(a-b-) PHENOTYPE;   Glycophorin C, Gerbich Variant;   MALARIA, CEREBRAL, RESISTANCE TO;   MALARIA, CEREBRAL, SUSCEPTIBILITY TO;   MALARIA, MILD, SUSCEPTIBILITY TO;   MALARIA, RESISTANCE TO;   MALARIA, SEVERE, RESISTANCE TO;   MALARIA, SEVERE, SUSCEPTIBILITY TO;   plasmodium vivax, resistance to;   susceptibility to malaria
 primary_id: MESH:D008288
 alt_id: OMIM:609148;   OMIM:611162
 xref: EFO:0001068;   EFO:0009157;   GARD:6961;   ICD10CM:B54;   ICD9CM:084;   NCI:C34797
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A treatment
susceptibility		 ISO DNA:SNP: :c3435C>T(human)
DNA:hypermethylation:promoter
DNA:SNPs,haplotype: :rs2032582, rs1128503 (human)
DNA:haplotype: :1236C>T, 2677G>T,3435C>T (human) 		RGD PMID:28934955 PMID:19331170 PMID:28422980 PMID:17015054 RGD:39456120, RGD:39457680, RGD:39457679, RGD:39456123 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 severity IMP RGD PMID:31234939 RGD:39939120 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ackr1 atypical chemokine receptor 1 (Duffy blood group) ISO ClinVar Annotator: match by term: Plasmodium vivax, resistance to ClinVar
OMIM		 PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More... NCBI chr 1:173,159,457...173,161,079
Ensembl chr 1:173,159,453...173,161,317 		JBrowse link
G Aicda activation-induced cytidine deaminase IEP protein:increased expression: B cell RGD PMID:27980783 RGD:30310233 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139 		JBrowse link
G Ank1 ankyrin 1, erythroid IAGP OMIM:609148 | OMIM:611162 MouseDO NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513 		JBrowse link
G Apoe apolipoprotein E ISO DNA:missense mutations:cds:p.C112R, p.C158R (human) RGD PMID:24116184 RGD:11039486 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Aqp4 aquaporin 4 IAGP OMIM:609148 | OMIM:611162 MouseDO NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Cbs cystathionine beta-synthase susceptibility ISO DNA:insertion:cds: (844ins68) (human) RGD PMID:27198213 RGD:40903062 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Cd163 CD163 antigen exacerbates
severity		 ISO protein:increased expression:blood plasma (human)
protein:altered expression:blood plasma (human)		 RGD PMID:22290142 PMID:18632918 RGD:127285797, RGD:149735529 NCBI chr 6:124,281,596...124,307,488
Ensembl chr 6:124,281,615...124,307,486 		JBrowse link
G Cd1d1 CD1d1 antigen ameliorates
exacerbates		 IMP RGD PMID:12938235 PMID:24703850 RGD:127345117, RGD:127345121 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Cd36 CD36 molecule ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to		 CTD
OMIM
ClinVar		 PMID:10890433 PMID:18305138 PMID:19403559 PMID:25741868 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40 CD40 antigen severity IMP RGD PMID:11485931 RGD:11352239 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand severity IMP RGD PMID:11485931 RGD:11352239 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cish cytokine inducible SH2-containing protein susceptibility ISO ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:20484391 NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:8730300 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 treatment
disease_progression		 IMP
ISO		 RGD PMID:28892065 PMID:28892065 RGD:38455986, RGD:38455986 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Ephb2 Eph receptor B2 IEP mRNA:increased expression:liver RGD PMID:25784101 RGD:127285023 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299 		JBrowse link
G Ephb3 Eph receptor B3 ISO RGD PMID:25784101 RGD:127285023 NCBI chr16:21,023,530...21,042,054
Ensembl chr16:21,023,505...21,042,055 		JBrowse link
G Ephb6 Eph receptor B6 IEP RGD PMID:25784101 RGD:127285023 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443 		JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb susceptibility IAGP
ISO		 OMIM:609148 | OMIM:611162
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, resistance to		 MouseDO
CTD
ClinVar
OMIM		 PMID:12115230 PMID:15459183 PMID:16115811 PMID:16170323 PMID:17435165 More... NCBI chr 1:170,786,186...170,804,141
Ensembl chr 1:170,786,186...170,804,116 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO DNA:missense mutation:cds:p.H131R (human) RGD PMID:19965803 RGD:5147921 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G Foxp3 forkhead box P3 disease_progression ISO RGD PMID:19338000 PMID:16169501 RGD:38455985, RGD:38455992 NCBI chr  X:7,445,915...7,461,482
Ensembl chr  X:7,439,883...7,461,484 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked susceptibility
severity		 ISO DNA:SNPs: :multiple
ClinVar Annotator: match by term: Malaria, susceptibility to
DNA:point mutation:cds:c.968T>C (human)		 OMIM
ClinVar
RGD		 PMID:5448 PMID:16832 PMID:1303173 PMID:1459579 PMID:1551674 More... RGD:10449111, RGD:10449115 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gypa glycophorin A ISO OMIM NCBI chr 8:81,220,674...81,237,414
Ensembl chr 8:81,220,410...81,237,171 		JBrowse link
G Gypc glycophorin C ISO ClinVar Annotator: match by term: Malaria, resistance to ClinVar
OMIM		 PMID:1991173 PMID:5011657 PMID:8157284 PMID:11719395 PMID:12469115 More... NCBI chr18:32,661,373...32,693,087
Ensembl chr18:32,661,375...32,693,087 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain resistance ISO Hemoglobin C; DNA:polymorphism:CDS:69G>A, amino acid E6K
ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to		 RGD
ClinVar
OMIM		 PMID:14973 PMID:49057 PMID:81926 PMID:88735 PMID:700140 More... RGD:1600894
G Hbb-b2 hemoglobin, beta adult minor chain resistance ISO RGD PMID:11001883 RGD:1600894
G Hmox1 heme oxygenase 1 IAGP OMIM:609148 | OMIM:611162 MouseDO NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hp haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:8730300 PMID:16597321 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Icam1 intercellular adhesion molecule 1 susceptibility IAGP
ISO		 OMIM:609148 | OMIM:611162
ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to | ClinVar Annotator: match by term: Malaria, susceptibility to
CTD Direct Evidence: marker/mechanism		 MouseDO
ClinVar
CTD
OMIM		 PMID:9259284 PMID:9861406 PMID:10417733 PMID:10699175 PMID:23609612 More... NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma IAGP OMIM:609148 | OMIM:611162 MouseDO NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:1945893 PMID:3198117 PMID:7803800 PMID:8244337 PMID:8471773 More... NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 IMP RGD PMID:28359899 RGD:39938859 NCBI chr 1:40,444,025...40,504,578
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il21 interleukin 21 exacerbates IMP RGD PMID:25763578 RGD:127285358 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il27 interleukin 27 ameliorates IMP RGD PMID:24522137 PMID:26968425 RGD:126790512, RGD:11530371 NCBI chr 7:126,188,181...126,194,197
Ensembl chr 7:126,188,182...126,194,113 		JBrowse link
G Il33 interleukin 33 IEP protein:increased expression:serum: RGD PMID:28359899 RGD:39938859 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Kir3dl1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 severity ISO DNA:deletion:cds RGD PMID:21889618 RGD:38676475 NCBI chr  X:135,418,748...135,435,055
Ensembl chr  X:135,418,748...135,435,058 		JBrowse link
G LOC111365144 Nos2 promoter region ISO ClinVar Annotator: match by term: Malaria, resistance to ClinVar PMID:12433515 NCBI chr11:78,810,061...78,811,815 JBrowse link
G Ltbr lymphotoxin B receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15788153 NCBI chr 6:125,283,534...125,291,026
Ensembl chr 6:125,283,534...125,290,848 		JBrowse link
G Mapkapk3 mitogen-activated protein kinase-activated protein kinase 3 ISO ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar PMID:20484391 NCBI chr 9:107,132,125...107,167,082
Ensembl chr 9:107,132,126...107,167,076 		JBrowse link
G Mir122 microRNA 122 treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr18:65,381,932...65,381,997
Ensembl chr18:65,381,932...65,381,997 		JBrowse link
G Mir142 microRNA 142 treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr11:87,647,690...87,647,753
Ensembl chr11:87,647,690...87,647,753 		JBrowse link
G Mir669n microRNA 669n treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr 3:115,773,551...115,773,604
Ensembl chr 3:115,773,551...115,773,604 		JBrowse link
G Mir709 microRNA 709 treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr 8:84,812,728...84,812,815
Ensembl chr 8:84,812,728...84,812,815 		JBrowse link
G Mirlet7a-1 microRNA let7a-1 treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr13:48,691,655...48,691,748
Ensembl chr13:48,691,655...48,691,748 		JBrowse link
G Mirlet7c-1 microRNA let7c-1 treatment IEP RGD PMID:28123381 RGD:35673288 NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 IDA associated with Lung Neoplasms RGD PMID:21931708 RGD:6483517 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Ncr3-ps natural cytotoxicity triggering receptor 3, pseudogene susceptibility ISO ClinVar Annotator: match by term: Malaria, severe, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:17208487 NCBI chr17:35,399,512...35,403,785
Ensembl chr17:35,399,511...35,403,638 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO ClinVar Annotator: match by term: Malaria, resistance to | ClinVar Annotator: match by term: Malaria, severe, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to ClinVar
OMIM		 PMID:9457101 PMID:12433515 PMID:31995689 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell susceptibility ISO
IAGP		 DNA:mutations, haplotype:multiple (human)
OMIM:609148 | OMIM:611162
DNA:missense mutation:cds:p.I90N (mouse)		 MouseDO
RGD		 PMID:20377593 PMID:14595440 RGD:11535999, RGD:11537407 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Prf1 perforin 1 (pore forming protein) IMP RGD PMID:21525386 RGD:6482803 NCBI chr10:61,133,530...61,140,463
Ensembl chr10:61,133,612...61,140,459 		JBrowse link
G Procr protein C receptor, endothelial disease_progression ISO RGD PMID:27671831 RGD:126848795 NCBI chr 2:155,592,159...155,597,398
Ensembl chr 2:155,593,037...155,597,391 		JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 ISO DNA:SNP::g.80G>A (human) RGD PMID:27198213 RGD:40903062 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836 		JBrowse link
G Slc4a1 solute carrier family 4 (anion exchanger), member 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, cerebral, resistance to | ClinVar Annotator: match by term: Malaria, susceptibility to		 CTD
ClinVar		 PMID:1378323 PMID:1722314 PMID:1737855 PMID:2146504 PMID:6338046 More... NCBI chr11:102,239,646...102,256,107
Ensembl chr11:102,239,650...102,257,029 		JBrowse link
G Spp1 secreted phosphoprotein 1 IDA RGD PMID:16552072 RGD:1581333 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Tbx21 T-box 21 ISO RGD PMID:19338000 RGD:38455985 NCBI chr11:96,988,833...97,006,157
Ensembl chr11:96,988,897...97,006,157 		JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Malaria, resistance to		 CTD
OMIM
ClinVar		 PMID:16991088 PMID:17322885 PMID:18305471 PMID:25741868 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO DNA:polymorphism:promoter:-376G>A
ClinVar Annotator: match by term: Malaria, cerebral, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM
RGD		 PMID:8056188 PMID:9818939 PMID:10369255 PMID:10450718 PMID:11261930 More... RGD:1624967 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trem1 triggering receptor expressed on myeloid cells 1 severity ISO DNA:SNP: :rs2234237A>T (human) RGD PMID:27671831 RGD:126848795 NCBI chr17:48,539,763...48,553,955
Ensembl chr17:48,539,796...48,553,952 		JBrowse link
G Tslp thymic stromal lymphopoietin IEP mRNA:altered expression:multiple (mouse) RGD PMID:28955823 RGD:38596344 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
cerebral malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 susceptibility ISO DNA:SNP:intron 1: C>T RGD PMID:20117248 RGD:40818420 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Aqp4 aquaporin 4 disease_progression IEP protein:increased expression:astrocyte: RGD PMID:21904632 RGD:8698661 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Cast calpastatin IEP protein:increased express:brain RGD PMID:16236382 RGD:5509817 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cd36 CD36 molecule IMP RGD PMID:17367535 RGD:6893527 NCBI chr 5:17,986,688...18,093,957
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Clec12a C-type lectin domain family 12, member a ameliorates IMP RGD PMID:31269448 RGD:41412201 NCBI chr 6:129,327,207...129,342,266
Ensembl chr 6:129,319,654...129,342,266 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 treatment IMP RGD PMID:25682948 RGD:40400741 NCBI chr 1:40,444,025...40,504,578
Ensembl chr 1:40,468,730...40,504,575 		JBrowse link
G Il33 interleukin 33 treatment IDA
IEP		 protein:increased expression:brain RGD PMID:25659095 PMID:25682948 RGD:39938955, RGD:40400741 NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Jak3 Janus kinase 3 IMP RGD PMID:22363534 RGD:11531103 NCBI chr 8:72,129,027...72,143,221
Ensembl chr 8:72,128,940...72,143,219 		JBrowse link
G Lta lymphotoxin A IMP RGD PMID:12021316 RGD:10449455 NCBI chr17:35,422,141...35,424,568
Ensembl chr17:35,422,141...35,424,327 		JBrowse link
G Nrg1 neuregulin 1 treatment IEP
ISO		 mRNA, protein:increased expression:cerebral cortex (mouse)
human protein in a mouse model		 RGD PMID:29636063 PMID:24433482 RGD:39456084, RGD:39456102 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP RGD PMID:25775137 RGD:38599200 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit IEP mRNA:decreased expression:brain (mouse) RGD PMID:29107705 RGD:39456137 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b IMP RGD PMID:12228317 RGD:5131158 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
Malarial Anemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcgr4 Fc receptor, IgG, low affinity IV severity
susceptibility		 ISO DNA:polymorphism: :p.F176V (human) RGD PMID:20231419 PMID:23045477 RGD:11040771, RGD:11344971 NCBI chr 1:170,846,495...170,857,330
Ensembl chr 1:170,846,489...170,857,330 		JBrowse link
G Slc4a1 solute carrier family 4 (anion exchanger), member 1 severity ISO DNA:snp:promoter:g.-5699T>C (human) RGD PMID:16960783 RGD:10450507 NCBI chr11:102,239,646...102,256,107
Ensembl chr11:102,239,650...102,257,029 		JBrowse link
G Tlr9 toll-like receptor 9 susceptibility ISO DNA:SNP:promoter:g.-1237T>C (rs5743836) (human) RGD PMID:23045477 RGD:11344971 NCBI chr 9:106,099,797...106,104,075
Ensembl chr 9:106,099,797...106,104,082 		JBrowse link
Plasmodium falciparum malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abo ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase) susceptibility ISO DNA:SNPs,haplotype:multiple RGD PMID:18003641 RGD:39938831 NCBI chr 2:26,732,508...26,754,973
Ensembl chr 2:26,732,515...26,754,991 		JBrowse link
G Adamts13 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 ISO protein:decreased activity:plasma (human) RGD PMID:20062916 RGD:10449041 NCBI chr 2:26,863,363...26,899,638
Ensembl chr 2:26,863,428...26,899,640 		JBrowse link
G Bsg basigin ISO CTD Direct Evidence: therapeutic CTD PMID:22080952 PMID:26195724 NCBI chr10:79,540,192...79,547,813
Ensembl chr10:79,540,325...79,547,803 		JBrowse link
G Cast calpastatin ISO protein:alter localization:erythrocyte RGD PMID:17359359 RGD:5509812 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Ccl4 chemokine (C-C motif) ligand 4 ISO mRNA, protein:increased expression:blood, RGD PMID:15972509 RGD:5683898 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Clec11a C-type lectin domain family 11, member a ISO CTD Direct Evidence: marker/mechanism CTD PMID:19884328 NCBI chr 7:43,953,190...43,956,383
Ensembl chr 7:43,952,111...43,956,326 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 treatment ISO DNA:polymorphisms:: RGD PMID:10471063 RGD:124713538 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Fas Fas (TNF receptor superfamily member 6) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21625619 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III severity ISO DNA:missense mutation:cds:p.R131H (rs1801274) (human) RGD PMID:18194515 RGD:5147927 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked severity ISO DNA:missense mutation:cds:202G>A (p.V68M) (human) RGD PMID:24943486 RGD:10449113 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 severity ISO RGD PMID:19635899 RGD:10450848 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*0501 (human) RGD PMID:11076705 RGD:11041780 NCBI chr17:34,482,201...34,488,392
Ensembl chr17:34,476,663...34,488,393 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20305663
G Hp haptoglobin severity ISO DNA:missense mutation:cds:p.K54E (human) RGD PMID:24478401 RGD:11041793 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:plasma RGD PMID:21985368 RGD:5684362 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility ISO DNA:haplotype:exon: RGD PMID:18396436 RGD:11530064 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Tnf tumor necrosis factor severity ISO protein:increased expression:plasma RGD PMID:1984482 RGD:10450571 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Plasmodium vivax malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr1 atypical chemokine receptor 1 (Duffy blood group) ISO ClinVar Annotator: match by term: Resistance to Plasmodium vivax infection OMIM
ClinVar		 PMID:7663520 PMID:8547665 PMID:8651934 PMID:10570183 PMID:10791881 More... NCBI chr 1:173,159,457...173,161,079
Ensembl chr 1:173,159,453...173,161,317 		JBrowse link
Pregnancy-associated Malaria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il10 interleukin 10 ISO RGD PMID:24717969 RGD:11041890 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Mir146 microRNA 146 susceptibility ISO miRNA:SNP: (rs2910164) (human) RGD PMID:30642347 RGD:126925184 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18246
    disease by infectious agent 2181
      parasitic infectious disease 318
        parasitic protozoa infectious disease 167
          malaria 84
            Acute Malaria 0
            Avian Malaria 0
            Malarial Anemia 3
            Plasmodium Falciparum Blood Infection Level 0
            Plasmodium falciparum malaria + 19
            Plasmodium malariae malaria 0
            Plasmodium ovale malaria 0
            Plasmodium vivax malaria 1
            blackwater fever 0
            cerebral malaria 13
            mixed malaria 0
Path 2
Term Annotations click to browse term
  disease 18246
    disease of anatomical entity 15557
      Immune & Inflammatory Diseases 5123
        Inflammation 2504
          Systemic Inflammatory Response Syndrome 398
            Sepsis 396
              Parasitemia 84
                malaria 84
                  Acute Malaria 0
                  Avian Malaria 0
                  Malarial Anemia 3
                  Plasmodium Falciparum Blood Infection Level 0
                  Plasmodium falciparum malaria + 19
                  Plasmodium malariae malaria 0
                  Plasmodium ovale malaria 0
                  Plasmodium vivax malaria 1
                  blackwater fever 0
                  cerebral malaria 13
                  mixed malaria 0
paths to the root