Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:varicocele
go back to main search page
Accession:DOID:12337 term browser browse the term
Definition:A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.
Synonyms:exact_synonym: Varicoceles;   scrotal varices
 primary_id: MESH:D014646
 xref: ICD10CM:I86.1;   ICD9CM:456.4
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
varicocele term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP9 caspase 9 ISO protein:increased expression:testis RGD PMID:19145435 RGD:2311432 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G FAS Fas cell surface death receptor ISO protein:decreased expression:Leydig cell, spermatid RGD PMID:16616089 RGD:1600348 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO protein:increased expression:epididymus (rat) RGD PMID:25095617 RGD:9068459 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HMOX1 heme oxygenase 1 severity ISO RGD PMID:15878918 RGD:1598403
G HSPD1 heat shock protein family D (Hsp60) member 1 ISO mRNA:increased expression:spermatid RGD PMID:15804863 RGD:1624240 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526 		JBrowse link
G IL1A interleukin 1 alpha ISO protein:increased expression:testis RGD PMID:16616101 RGD:2311094 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO protein:increased expression:testis RGD PMID:16616101 RGD:2311094
G PDCD10 programmed cell death 10 ISO protein:increased expression:testis (rat) RGD PMID:19647235 RGD:401827162 NCBI chr13:106,517,408...106,558,959
Ensembl chr13:106,517,432...106,558,895 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      cardiovascular system disease 4329
        vascular disease 3053
          varicocele 8
Path 2
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      cardiovascular system disease 4329
        vascular disease 3053
          vein disease 117
            varicose veins 28
              pelvic varices 9
                varicocele 8
paths to the root