Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:primary biliary cirrhosis
go back to main search page
Accession:DOID:12236 term browser browse the term
Definition:FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cirrhosis involves the destruction of small intra-hepatic bile ducts and bile secretion. Secondary biliary cirrhosis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.
Synonyms:exact_synonym: Liver Cirrhoses, Biliary;   PBC;   biliary cirrhosis;   biliary liver cirrhosis;   cholestatic cirrhosis;   chronic nonsuppurative destructive cholangitis;   obstructive liver cirrhosis;   secondary biliary cirrhosis
 primary_id: MESH:D008105
 alt_id: RDO:0004489
 xref: GARD:7459;   ICD10CM:K74.3;   ICD10CM:K74.5;   ICD9CM:571.6;   NCI:C27167;   NCI:C51225;   OMIM:PS109720;   ORDO:186
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants       view all columns           Sort by:
 
primary biliary cirrhosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB4 ATP binding cassette subfamily B member 4 JBrowse link 7 87,398,988 87,476,722 RGD:11554173
RGD:14694982
G ABCC2 ATP binding cassette subfamily C member 2 JBrowse link 10 99,782,602 99,853,741 RGD:11554173
RGD:14700810
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 4 88,090,264 88,231,626 RGD:11554173
G ACE angiotensin I converting enzyme JBrowse link 17 63,477,061 63,498,373 RGD:2325226
G ACE2 angiotensin I converting enzyme 2 JBrowse link X 15,494,520 15,602,158 RGD:9685452
G AGT angiotensinogen JBrowse link 1 230,702,523 230,714,122 RGD:9685452
G ALB albumin JBrowse link 4 73,404,287 73,421,482 RGD:11554173
G AQP4 aquaporin 4 JBrowse link 18 26,852,038 26,865,803 RGD:5148030
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 35,871,491 35,880,360 RGD:11554173
RGD:14995336
G CCN2 cellular communication network factor 2 JBrowse link 6 131,948,176 131,951,372 RGD:2314517
G CD3D CD3d molecule JBrowse link 11 118,338,954 118,342,744 RGD:11554173
G CD80 CD80 molecule JBrowse link 3 119,524,293 119,559,614 RGD:11554173
G CDH5 cadherin 5 JBrowse link 16 66,366,657 66,404,784 RGD:11554173
G CDKN1A cyclin dependent kinase inhibitor 1A JBrowse link 6 36,676,463 36,687,332 RGD:8662434
G CLEC16A C-type lectin domain containing 16A JBrowse link 16 10,944,488 11,193,272 RGD:11554173
G COL1A1 collagen type I alpha 1 chain JBrowse link 17 50,184,096 50,201,649 RGD:8552731
G CPEB1 cytoplasmic polyadenylation element binding protein 1 JBrowse link 15 82,543,201 82,648,795 RGD:11528851
G CPEB4 cytoplasmic polyadenylation element binding protein 4 JBrowse link 5 173,888,328 173,961,980 RGD:11528851
G CTLA4 cytotoxic T-lymphocyte associated protein 4 JBrowse link 2 203,867,771 203,873,965 RGD:2301998
RGD:14398744
RGD:14398743
RGD:14398725
G CXCL10 C-X-C motif chemokine ligand 10 JBrowse link 4 76,021,118 76,023,497 RGD:11554173
G CXCL9 C-X-C motif chemokine ligand 9 JBrowse link 4 76,001,275 76,007,509 RGD:11554173
G CXCR5 C-X-C motif chemokine receptor 5 JBrowse link 11 118,883,892 118,897,787 RGD:11554173
G CYGB cytoglobin JBrowse link 17 76,527,356 76,557,692 RGD:11554173
G DAG1 dystroglycan 1 JBrowse link 3 49,468,703 49,535,618 RGD:2314895
G DENND1B DENN domain containing 1B JBrowse link 1 197,504,748 197,782,138 RGD:11554173
G ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 JBrowse link 9 137,048,107 137,054,061 RGD:9685530
RGD:11554173
G FAS Fas cell surface death receptor JBrowse link 10 88,968,429 89,017,059 RGD:14700711
G HAMP hepcidin antimicrobial peptide JBrowse link 19 35,282,528 35,285,143 RGD:11041639
RGD:11041732
G HHIP hedgehog interacting protein JBrowse link 4 144,646,154 144,745,271 RGD:11552599
G HIF1A hypoxia inducible factor 1 subunit alpha JBrowse link 14 61,695,513 61,748,259 RGD:11554173
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 JBrowse link 6 32,637,406 32,654,846 RGD:14401562
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:625603
G ICAM1 intercellular adhesion molecule 1 JBrowse link 19 10,271,120 10,286,615 RGD:11520783
G ICAM3 intercellular adhesion molecule 3 JBrowse link 19 10,333,776 10,339,624 RGD:11554173
G IGFBP1 insulin like growth factor binding protein 1 JBrowse link 7 45,888,488 45,893,660 RGD:11554173
G IL12A interleukin 12A JBrowse link 3 159,988,835 159,996,019 RGD:11554173
G IL12B interleukin 12B JBrowse link 5 159,314,780 159,330,487 RGD:11554173
G IL12RB1 interleukin 12 receptor subunit beta 1 JBrowse link 19 18,058,994 18,099,027 RGD:14700865
G IL4 interleukin 4 JBrowse link 5 132,673,986 132,682,678 RGD:7829828
G IL7R interleukin 7 receptor JBrowse link 5 35,856,891 35,879,603 RGD:11554173
G JAK2 Janus kinase 2 JBrowse link 9 4,985,086 5,129,948 RGD:10403061
G KEAP1 kelch like ECH associated protein 1 JBrowse link 19 10,486,125 10,503,356 RGD:11554173
G KRT18 keratin 18 JBrowse link 12 52,948,871 52,952,906 RGD:18337483
G KRT7 keratin 7 JBrowse link 12 52,233,243 52,252,667 RGD:11554173
G LBR lamin B receptor JBrowse link 1 225,401,502 225,428,855 RGD:9588625
G LEP leptin JBrowse link 7 128,241,201 128,257,629 RGD:10411894
G LEPR leptin receptor JBrowse link 1 65,420,652 65,641,559 RGD:10411894
G LOX lysyl oxidase JBrowse link 5 122,063,195 122,078,259 RGD:11554173
G LOXL2 lysyl oxidase like 2 JBrowse link 8 23,296,897 23,404,120 RGD:11554173
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 17 45,263,119 45,317,048 RGD:13592920
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,027,677 36,122,964 RGD:11554173
G MAS1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 6 159,889,220 159,917,447 RGD:9685452
G MET MET proto-oncogene, receptor tyrosine kinase JBrowse link 7 116,672,196 116,798,386 RGD:14694826
G MMEL1 membrane metalloendopeptidase like 1 JBrowse link 1 2,590,639 2,633,042 RGD:11554173
G MMP13 matrix metallopeptidase 13 JBrowse link 11 102,942,995 102,955,732 RGD:8552731
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:8552731
G MMP3 matrix metallopeptidase 3 JBrowse link 11 102,835,801 102,843,609 RGD:8552731
G MMP9 matrix metallopeptidase 9 JBrowse link 20 46,008,908 46,016,561 RGD:8552731
G MUC2 mucin 2, oligomeric mucus/gel-forming JBrowse link 11 1,074,875 1,110,508 RGD:2324885
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:11554173
G NFKB1 nuclear factor kappa B subunit 1 JBrowse link 4 102,501,266 102,617,302 RGD:11554173
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:5509055
RGD:11554173
G NOS3 nitric oxide synthase 3 JBrowse link 7 150,991,017 151,014,588 RGD:11554173
G NR1H4 nuclear receptor subfamily 1 group H member 4 JBrowse link 12 100,473,866 100,564,414 RGD:14928336
G NR3C1 nuclear receptor subfamily 3 group C member 1 JBrowse link 5 143,277,931 143,435,512 RGD:4892607
G NSA2 NSA2 ribosome biogenesis factor JBrowse link 5 74,767,249 74,780,113 RGD:11554173
G NUP62 nucleoporin 62 JBrowse link 19 49,906,825 49,929,504 RGD:9831196
G PDE5A phosphodiesterase 5A JBrowse link 4 119,494,395 119,628,804 RGD:2314466
G PPARGC1A PPARG coactivator 1 alpha JBrowse link 4 23,792,021 24,472,905 RGD:6484526
G RELA RELA proto-oncogene, NF-kB subunit JBrowse link 11 65,653,596 65,662,972 RGD:11554173
G REN renin JBrowse link 1 204,154,819 204,166,337 RGD:6892690
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:1642977
G SLC4A2 solute carrier family 4 member 2 JBrowse link 7 151,058,200 151,076,527 RGD:11554173
G SLC51A solute carrier family 51 subunit alpha JBrowse link 3 196,216,534 196,233,427 RGD:11554173
G SLC51B solute carrier family 51 subunit beta JBrowse link 15 65,045,387 65,053,397 RGD:11554173
G SLCO1C1 solute carrier organic anion transporter family member 1C1 JBrowse link 12 20,681,800 20,753,386 RGD:14700810
G SOD2 superoxide dismutase 2 JBrowse link 6 159,669,069 159,762,281 RGD:2317411
G SPIB Spi-B transcription factor JBrowse link 19 50,418,938 50,431,314 RGD:11554173
G SPINT1 serine peptidase inhibitor, Kunitz type 1 JBrowse link 15 40,844,043 40,858,207 RGD:10043111
G SPINT2 serine peptidase inhibitor, Kunitz type 2 JBrowse link 19 38,264,573 38,292,615 RGD:10043111
G STAT4 signal transducer and activator of transcription 4 JBrowse link 2 191,029,576 191,172,684 RGD:11554173
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:11554173
G TLR9 toll like receptor 9 JBrowse link 3 52,221,080 52,226,163 RGD:18337477
G TNF tumor necrosis factor JBrowse link 6 31,575,565 31,578,336 RGD:14995307
G TNFRSF1A TNF receptor superfamily member 1A JBrowse link 12 6,328,771 6,342,076 RGD:11554173
G TYK2 tyrosine kinase 2 JBrowse link 19 10,350,528 10,380,572 RGD:11554173
G UBD ubiquitin D JBrowse link 6 29,555,515 29,559,732 RGD:11554173
G UTP4 UTP4 small subunit processome component JBrowse link 16 69,132,596 69,169,034 RGD:1600653
G VDR vitamin D receptor JBrowse link 12 47,841,537 47,905,022 RGD:1331525
RGD:14402024
RGD:14401750
G VEGFA vascular endothelial growth factor A JBrowse link 6 43,770,209 43,786,487 RGD:11528851
RGD:11538286
North American Indian Childhood Cirrhosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G UTP4 UTP4 small subunit processome component JBrowse link 16 69,132,596 69,169,034 RGD:8554872
RGD:7240710
Reynolds Syndrome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LBR lamin B receptor JBrowse link 1 225,401,502 225,428,855 RGD:7240710
RGD:8554872

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16528
    disease of anatomical entity 15507
      endocrine system disease 4768
        liver disease 2384
          liver cirrhosis 1074
            primary biliary cirrhosis 90
              Familial Primary Biliary Cirrhosis 0
              North American Indian Childhood Cirrhosis 1
              Primary Biliary Cirrhosis 1 0
              Primary Biliary Cirrhosis 2 0
              Primary Biliary Cirrhosis 3 0
              Primary Biliary Cirrhosis 4 0
              Primary Biliary Cirrhosis 5 0
              Reynolds Syndrome 1
Path 2
Term Annotations click to browse term
  disease 16528
    disease of anatomical entity 15507
      gastrointestinal system disease 4344
        hepatobiliary disease 2481
          biliary tract disease 430
            bile duct disease 398
              cholestasis 302
                intrahepatic cholestasis 116
                  primary biliary cirrhosis 90
                    Familial Primary Biliary Cirrhosis 0
                    North American Indian Childhood Cirrhosis 1
                    Primary Biliary Cirrhosis 1 0
                    Primary Biliary Cirrhosis 2 0
                    Primary Biliary Cirrhosis 3 0
                    Primary Biliary Cirrhosis 4 0
                    Primary Biliary Cirrhosis 5 0
                    Reynolds Syndrome 1
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.