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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:dengue disease
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Accession:DOID:12205 term browser browse the term
Definition:A viral infectious disease that results in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding. (DO)
Synonyms:exact_synonym: Break Bone Fever;   Breakbone Fever;   Classical Dengue;   Classical Dengue Fever;   Classical Dengue Fevers;   Classical Dengues;   Dengue Fever;   classic dengue;   dengue
 narrow_synonym: DENGUE FEVER, SUSCEPTIBILITY TO;   DENGUE HEMORRHAGIC FEVER, SUSCEPTIBILITY TO;   DENGUE SHOCK SYNDROME, SUSCEPTIBILITY TO
 related_synonym: dengue fever, protection against;   dengue virus, susceptibility to
 primary_id: MESH:D003715
 alt_id: OMIM:614371
 xref: EFO:0005547;   GARD:6254;   ICD10CM:A90;   ICD9CM:061;   NCI:C34528
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
dengue disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD209 CD209 molecule severity
susceptibility		 ISO DNA:SNP:promoter: -336G>A (human)
ClinVar Annotator: match by term: Dengue fever, protection against | ClinVar Annotator: match by term: Dengue virus, susceptibility to		 RGD
OMIM
ClinVar		 PMID:15564514 PMID:15838506 PMID:16274635 PMID:16379498 PMID:25741868 RGD:39939064 NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr37:24,831,351...24,846,387
Ensembl chr37:24,843,171...24,844,247 		JBrowse link
G F2 coagulation factor II, thrombin ISO RGD PMID:22138554 RGD:40818430 NCBI chr18:42,782,744...42,799,531
Ensembl chr18:42,782,751...42,799,459 		JBrowse link
G GC GC vitamin D binding protein ISO protein:increased expression:plasma RGD PMID:19845402 RGD:5509870 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 treatment ISO RGD PMID:31821895 RGD:39939074 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 treatment ISO RGD PMID:30098206 RGD:39938828 NCBI chr10:40,658,191...40,732,097
Ensembl chr10:40,659,041...40,677,357 		JBrowse link
G IL29L interleukin 29-like ameliorates ISO protein:increased expression:blood serum (human) RGD PMID:28238051 RGD:126848771 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
G IL33 interleukin 33 severity ISO RGD PMID:30098206 RGD:39938828 NCBI chr11:27,219,878...27,256,723
Ensembl chr11:27,219,878...27,256,721 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO protein:increased phosphorylation:liver (mouse) RGD PMID:28188818 RGD:150340680 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MIR21 microRNA mir-21 ISO RNA:increased expression:serum: RGD PMID:26941580 RGD:41404658 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 susceptibility ISO RGD PMID:21075352 PMID:21379341 RGD:41789625 RGD:41789629 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546 		JBrowse link
dengue hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule disease_progression ISO protein:increased expression:cd14-positive monocyte (human) RGD PMID:24945350 RGD:127345113 NCBI chr38:23,489,169...23,491,712 JBrowse link
G CD209 CD209 molecule susceptibility
severity		 ISO DNA:SNP:promoter: -336 A>G (rs4804803) (human)
DNA:SNPs:introns, promoter:multiple (human)		 RGD PMID:15838506 PMID:21245921 RGD:39938993 RGD:41410809 NCBI chr20:52,517,759...52,542,085
Ensembl chr20:52,518,036...52,520,942 		JBrowse link
G CLEC5A C-type lectin domain containing 5A ISO CTD Direct Evidence: therapeutic CTD PMID:18496526 NCBI chr16:7,242,424...7,269,986
Ensembl chr16:7,243,018...7,269,418 		JBrowse link
G IL21 interleukin 21 severity ISO protein:increased expression:blood serum (human) RGD PMID:24858204 RGD:127285368 NCBI chr19:17,641,833...17,651,275
Ensembl chr19:17,641,833...17,651,266 		JBrowse link
G IL29L interleukin 29-like ameliorates ISO DNA:SNP:enhancer:-1043C>T (rs7247086) (human) RGD PMID:31981768 RGD:126848742 NCBI chr24:36,440,445...36,441,017
Ensembl chr24:36,440,445...36,441,017 		JBrowse link
G OSBP oxysterol binding protein ISO mRNA:increased expression:peripheral blood mononuclear cell RGD PMID:28241052 RGD:41404654 NCBI chr18:37,159,511...37,191,720
Ensembl chr18:37,159,576...37,189,731 		JBrowse link
G PLCE1 phospholipase C epsilon 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22001756 NCBI chr28:8,209,707...8,484,427
Ensembl chr28:8,210,058...8,481,770 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 severity ISO DNA;polymorphism:5'utr: (rs25531) (human) RGD PMID:30452889 RGD:38676265 NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member susceptibility ISO DNA:SNPs: : RGD PMID:18071882 RGD:6482261 NCBI chr12:2,407,512...2,417,469
Ensembl chr12:2,378,126...2,432,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    disease by infectious agent 2127
      viral infectious disease 1623
        Arbovirus Infections 52
          dengue disease 18
            asymptomatic dengue 0
            dengue hemorrhagic fever + 9
Path 2
Term Annotations click to browse term
  disease 17773
    disease by infectious agent 2127
      viral infectious disease 1623
        RNA Virus Infections 1362
          Flaviviridae Infections 150
            Flavivirus Infections 42
              dengue disease 18
                asymptomatic dengue 0
                dengue hemorrhagic fever + 9
paths to the root