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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chagas disease
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Accession:DOID:12140 term browser browse the term
Definition:A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis. (DO)
Synonyms:exact_synonym: American trypanosomiasis;   Chagas' disease with digestive system involvement;   Chagas' disease with nervous system involvement;   Chagas' disease with other organ involvement;   South American trypanosomiasis
 primary_id: MESH:D014355
 xref: EFO:0008559;   GARD:6030;   ICD9CM:086.2;   ORDO:3386
For additional species annotation, visit the Alliance of Genome Resources.


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Chagas disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 ISO RGD PMID:16844401 RGD:2307145 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 ISO RGD PMID:16844401 RGD:2307145 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO RGD PMID:20452453 RGD:4889906 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 IDA RGD PMID:9148906 RGD:5509585 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255 		JBrowse link
G F2 coagulation factor II, thrombin IEP protein:increased expression:blood plasma (human) RGD PMID:20699256 PMID:21866301 RGD:5147778, RGD:40818435 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP DNA:polymorphisms:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G HSPA4 heat shock protein family A (Hsp70) member 4 IDA RGD PMID:21801456 RGD:6218957 NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449 		JBrowse link
G IFNG interferon gamma ISO RGD PMID:10684988 RGD:10755744 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL23A interleukin 23 subunit alpha susceptibility ISO RGD PMID:23182712 RGD:39457956 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G PRG2 proteoglycan 2, pro eosinophil major basic protein IEP mRNA:increased expression:plancenta (human) RGD PMID:29545200 RGD:40902989 NCBI chr11:57,386,780...57,390,650
Ensembl chr11:57,386,780...57,390,650 		JBrowse link
G SOAT1 sterol O-acyltransferase 1 ameliorates IAGP DNA:SNP:exon: rs1044925 (human) RGD PMID:31236660 RGD:126925205 NCBI chr 1:179,293,797...179,358,680
Ensembl chr 1:179,293,714...179,358,680 		JBrowse link
G VIM vimentin severity ISO
IEP		 protein:increased expression:plasma RGD PMID:22199233 PMID:22199233 RGD:6480538, RGD:6480538 NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593 		JBrowse link
Chagas Cardiomyopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 disease_progression IAGP DNA:SNP:promoter:g.-251A>T (rs4073) (human) RGD PMID:22537745 RGD:39939013 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP DNA:polymorphism:exon (human) RGD PMID:19811437 RGD:5147589 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848 		JBrowse link
G IL10 interleukin 10 treatment ISO RGD PMID:24055715 RGD:7364866 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL23A interleukin 23 subunit alpha ISO RGD PMID:28356392 RGD:39457935 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G MBL2 mannose binding lectin 2 severity IAGP RGD PMID:26745156 RGD:11076757 NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784 		JBrowse link
G PCNA proliferating cell nuclear antigen ISO protein:increased expression:myocardium: RGD PMID:12435130 RGD:10448990 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma disease_progression ISO
IEP		 mRNA:increased expression:heart (mouse)
mRNA:increased expression:heart (human)		 RGD PMID:29666415 PMID:29666415 PMID:29666415 RGD:38599151, RGD:38599151, RGD:38599151 NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease by infectious agent 2738
      parasitic infectious disease 338
        parasitic protozoa infectious disease 173
          trypanosomiasis 27
            Chagas disease 17
              Chagas Cardiomyopathy 7
Path 2
Term Annotations click to browse term
  disease 41189
    disease by infectious agent 2738
      parasitic infectious disease 338
        parasitic protozoa infectious disease 173
          Euglenozoa Infections 85
            trypanosomiasis 27
              Chagas disease 17
                Chagas Cardiomyopathy 7
paths to the root