RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: trigeminal neuralgia
Accession: DOID:12098
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Definition: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
Synonyms: exact_synonym: Fothergill disease; Idiopathic Trigeminal Neuralgia; Secondary Trigeminal Neuralgia; Secondary Trigeminal Neuralgias; Tic Douloureux; epileptiform neuralgia; epileptiform neuralgias; idiopathic trigeminal neuralgias; trifacial neuralgia; trifacial neuralgias; trifocal neuralgia; trigeminal neuralgias
primary_id: MESH:D014277
alt_id: MIM:190400
xref: EFO:1001219 ; GARD:7805 ; ICD10CM:G50.0 ; ICD9CM:350.1
For additional species annotation, visit the
Alliance of Genome Resources .
G
Aif1
allograft inflammatory factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
G
Bdnf
brain-derived neurotrophic factor
treatment
IEP
RGD
PMID:32193501
RGD:596948422
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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Calca
calcitonin-related polypeptide alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
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Cdk5
cyclin-dependent kinase 5
IDA
RGD
PMID:21161138
RGD:13782378
NCBI chr 4:11,647,098...11,651,606
Ensembl chr 4:10,754,687...10,760,112
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Cdk5r1
cyclin-dependent kinase 5 regulatory subunit 1
IEP
RGD
PMID:21161138
RGD:13782378
NCBI chr10:65,981,692...65,985,831
Ensembl chr10:65,483,941...65,488,456
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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Gabrg1
gamma-aminobutyric acid type A receptor subunit gamma 1
ISS
OMIM:190400
MouseDO
NCBI chr14:37,750,292...37,821,651
Ensembl chr14:37,396,294...37,635,956
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Gfap
glial fibrillary acidic protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
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Il1b
interleukin 1 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Mapk1
mitogen activated protein kinase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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Mir125a
microRNA 125a
IEP
RNA:decreased expression: trigeminal ganglion:
RGD
PMID:25380251
RGD:26884456
NCBI chr 1:67,350,675...67,350,759
Ensembl chr 1:58,677,626...58,677,710
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Ntrk2
neurotrophic receptor tyrosine kinase 2
treatment
IEP
RGD
PMID:32193501
RGD:596948422
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
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Prkcg
protein kinase C, gamma
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384
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Tnf
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27093858
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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