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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:esophagitis
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Accession:DOID:11963 term browser browse the term
Definition:INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Synonyms:exact_synonym: acute esophagitis;   esophagitides
 primary_id: MESH:D004941
 xref: ICD10CM:K20;   ICD10CM:K20.9;   ICD9CM:530.1;   NCI:C9224
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G IL13 interleukin 13 ISO RGD PMID:20543112 RGD:4145528 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL4R interleukin 4 receptor susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP: :rs1801275(human) RGD PMID:20811626 RGD:5131286 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO associated with carcinoma, non-small-cell lung; RGD PMID:20811626 RGD:5131286 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO protein:increased expression:epithelium RGD PMID:28370814 RGD:151361286 NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16091555 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977 		JBrowse link
eosinophilic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANG angiogenin ISO RGD PMID:22331014 RGD:6771318 NCBI chr 7:78,249,479...78,262,846
Ensembl chr 7:78,249,487...78,250,138 		JBrowse link
G ANKRD27 ankyrin repeat domain 27 ISO DNA:SNPs:intron: (rs3815700, rs10410895) (human) RGD PMID:25407941 RGD:11100048 NCBI chr 6:42,501,167...42,559,926
Ensembl chr 6:42,501,165...42,559,912 		JBrowse link
G CAPN14 calpain 14 ISO mRNA:increased expression:esophagus
CTD Direct Evidence: marker/mechanism
DNA:snps:multiple (human)		 RGD
CTD		 PMID:25017104 PMID:25407941 RGD:11100048 RGD:11100049 NCBI chr 3:108,152,053...108,191,391
Ensembl chr 3:108,152,047...108,190,047 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 treatment ISO protein:increased expression:esophagus (human) RGD PMID:18844613 PMID:24704289 RGD:11081156 RGD:11081157 NCBI chr 3:10,381,306...10,385,677
Ensembl chr 3:10,381,306...10,385,677 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO RGD PMID:1316818 RGD:6893390 NCBI chr13:29,251,950...29,286,470
Ensembl chr13:29,285,012...29,286,467 		JBrowse link
G CD40LG CD40 ligand ISO protein:decreased expression:plasma RGD PMID:21211656 RGD:5490306 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CYP2C49 cytochrome P450 2C49 treatment ISO DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G IL5 interleukin 5 ISO RGD PMID:23161496 RGD:11354947 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:esophagus (human) RGD PMID:22331014 RGD:6771318 NCBI chr12:14,667,643...14,723,296
Ensembl chr12:14,649,044...14,723,293 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO RGD PMID:24486052 RGD:11073602 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20208534 NCBI chr 2:115,832,152...115,837,572 JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118 		JBrowse link
G CLDN3 claudin 3 ISO protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102 		JBrowse link
G CLDN4 claudin 4 ISO protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18193101 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G EGFR epidermal growth factor receptor ISO mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G F11R F11 receptor treatment ISO RGD PMID:19478094 RGD:7488941 NCBI chr 4:89,425,101...89,447,889
Ensembl chr 4:89,425,018...89,449,599 		JBrowse link
G IL13 interleukin 13 ISO associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL5 interleukin 5 ISO associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr 2:134,832,143...134,846,141
Ensembl chr 2:134,832,147...134,835,212 		JBrowse link
G MIR29A microRNA mir-29a ISO RGD PMID:28757556 RGD:25824949 NCBI chr18:18,040,032...18,040,117
Ensembl chr18:18,040,032...18,040,118 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 ISO protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chr 7:25,072,133...25,077,508
Ensembl chr 7:25,072,323...25,078,322 		JBrowse link
G PTGES prostaglandin E synthase ISO protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chr 1:269,911,785...269,924,481
Ensembl chr 1:269,911,789...269,924,462 		JBrowse link
G TJP1 tight junction protein 1 ISO RGD PMID:19653339 RGD:2325133 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836 		JBrowse link
G TNF tumor necrosis factor ISO RGD PMID:15942680 RGD:1580209 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415 		JBrowse link
G VDR vitamin D receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15394
    disease of anatomical entity 15088
      gastrointestinal system disease 6548
        gastroenteritis 518
          esophagitis 30
            bacterial esophagitis 0
            eosinophilic esophagitis 11
            fungal esophagitis 0
            peptic esophagitis + 15
            viral esophagitis 0
Path 2
Term Annotations click to browse term
  disease 15394
    disease of anatomical entity 15088
      Immune & Inflammatory Diseases 5144
        Inflammation 2470
          gastroenteritis 518
            esophagitis 30
              bacterial esophagitis 0
              eosinophilic esophagitis 11
              fungal esophagitis 0
              peptic esophagitis + 15
              viral esophagitis 0
paths to the root