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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:esophagitis
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Accession:DOID:11963 term browser browse the term
Definition:INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Synonyms:exact_synonym: acute esophagitis;   esophagitides
 primary_id: MESH:D004941
 xref: ICD10CM:K20;   ICD10CM:K20.9;   ICD9CM:530.1;   NCI:C9224
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:20543112 RGD:4145528 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G Il4r interleukin 4 receptor susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP: :rs1801275(human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004624782:11,981,781...12,008,362 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO associated with carcinoma, non-small-cell lung; RGD PMID:20811626 RGD:5131286 NCBI chrNW_004624814:6,897,818...6,904,890
Ensembl chrNW_004624814:6,897,857...6,903,728 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 ISO protein:increased expression:epithelium RGD PMID:28370814 RGD:151361286 NCBI chrNW_004624746:1,325,368...1,349,616 JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 NCBI chrNW_004624855:3,260,800...3,271,864
Ensembl chrNW_004624855:3,260,809...3,271,367 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16091555 NCBI chrNW_004624786:6,231,494...6,249,001
Ensembl chrNW_004624786:6,231,494...6,249,001 		JBrowse link
eosinophilic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd27 ankyrin repeat domain 27 ISO DNA:SNPs:intron: (rs3815700, rs10410895) (human) RGD PMID:25407941 RGD:11100048 NCBI chrNW_004624794:7,494,275...7,544,671 JBrowse link
G Capn14 calpain 14 ISO CTD Direct Evidence: marker/mechanism
DNA:snps:multiple (human)
mRNA:increased expression:esophagus		 CTD
RGD		 PMID:25017104 PMID:25407941 RGD:11100048 RGD:11100049 NCBI chrNW_004624738:12,975,145...13,033,344
Ensembl chrNW_004624738:12,978,086...13,006,327 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO RGD PMID:1316818 RGD:6893390 NCBI chrNW_004624730:74,768,668...74,769,749
Ensembl chrNW_004624730:74,768,668...74,769,798 		JBrowse link
G Cd40lg CD40 ligand ISO protein:decreased expression:plasma RGD PMID:21211656 RGD:5490306 NCBI chrNW_004624808:10,472,028...10,484,407
Ensembl chrNW_004624808:10,472,572...10,484,338 		JBrowse link
G Il5 interleukin 5 ISO RGD PMID:23161496 RGD:11354947 NCBI chrNW_004624733:39,544,487...39,558,943
Ensembl chrNW_004624733:39,556,797...39,559,119 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:esophagus (human) RGD PMID:22331014 RGD:6771318 NCBI chrNW_004624870:33,293...122,536 JBrowse link
G Tgfb1 transforming growth factor beta 1 ISO RGD PMID:24486052 RGD:11073602 NCBI chrNW_004624907:162,567...175,696
Ensembl chrNW_004624907:161,569...176,605 		JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chrNW_004624731:15,262,480...15,269,196
Ensembl chrNW_004624731:15,263,274...15,269,743 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chrNW_004624875:3,334,136...3,342,085
Ensembl chrNW_004624875:3,334,078...3,341,614 		JBrowse link
G Cldn3 claudin 3 ISO protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chrNW_004624740:14,065,172...14,066,432
Ensembl chrNW_004624740:14,065,478...14,066,137 		JBrowse link
G Cldn4 claudin 4 ISO protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chrNW_004624740:14,033,848...14,035,854 JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18193101 NCBI chrNW_004624730:1,744,097...1,747,206
Ensembl chrNW_004624730:1,743,916...1,747,293 		JBrowse link
G Egfr epidermal growth factor receptor ISO mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chrNW_004624740:584,133...713,205
Ensembl chrNW_004624740:589,606...713,271 		JBrowse link
G F11r F11 receptor treatment ISO RGD PMID:19478094 RGD:7488941 NCBI chrNW_004624794:346,281...367,132
Ensembl chrNW_004624794:346,387...367,428 		JBrowse link
G Il13 interleukin 13 ISO associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chrNW_004624733:39,427,189...39,430,019
Ensembl chrNW_004624733:39,428,095...39,429,843 		JBrowse link
G Il5 interleukin 5 ISO associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chrNW_004624733:39,544,487...39,558,943
Ensembl chrNW_004624733:39,556,797...39,559,119 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chrNW_004624754:23,811,008...23,815,432
Ensembl chrNW_004624754:23,807,272...23,815,417 		JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chrNW_004624760:5,643,549...5,653,747
Ensembl chrNW_004624760:5,643,501...5,654,475 		JBrowse link
G Tjp1 tight junction protein 1 ISO RGD PMID:19653339 RGD:2325133 NCBI chrNW_004624768:2,826,848...3,034,195
Ensembl chrNW_004624768:2,828,324...3,034,302 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:15942680 RGD:1580209 NCBI chrNW_004624754:24,623,059...24,625,647
Ensembl chrNW_004624754:24,623,425...24,625,531 		JBrowse link
G Vdr vitamin D receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chrNW_004624816:4,314,146...4,423,946
Ensembl chrNW_004624816:4,365,961...4,424,514 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      gastrointestinal system disease 6045
        gastroenteritis 494
          esophagitis 25
            bacterial esophagitis 0
            eosinophilic esophagitis 7
            fungal esophagitis 0
            peptic esophagitis + 14
            viral esophagitis 0
Path 2
Term Annotations click to browse term
  disease 14208
    disease of anatomical entity 13924
      Immune & Inflammatory Diseases 4781
        Inflammation 2287
          gastroenteritis 494
            esophagitis 25
              bacterial esophagitis 0
              eosinophilic esophagitis 7
              fungal esophagitis 0
              peptic esophagitis + 14
              viral esophagitis 0
paths to the root