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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:esophagitis
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Accession:DOID:11963 term browser browse the term
Definition:INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Synonyms:exact_synonym: acute esophagitis;   esophagitides
 primary_id: MESH:D004941
 xref: ICD10CM:K20;   ICD10CM:K20.9;   ICD9CM:530.1;   NCI:C9224
For additional species annotation, visit the Alliance of Genome Resources.


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esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Il13 interleukin 13 IMP RGD PMID:20543112 RGD:4145528 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il4ra interleukin 4 receptor, alpha susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP: :rs1801275(human) RGD PMID:20811626 RGD:5131286 NCBI chr 7:125,151,443...125,178,646
Ensembl chr 7:125,151,292...125,178,646 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO associated with carcinoma, non-small-cell lung; RGD PMID:20811626 RGD:5131286 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Slc7a5 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 ISO protein:increased expression:epithelium RGD PMID:28370814 RGD:151361286 NCBI chr 8:122,607,885...122,634,425
Ensembl chr 8:122,607,889...122,634,433 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16091555 NCBI chr11:73,124,975...73,152,148
Ensembl chr11:73,125,118...73,152,068 		JBrowse link
eosinophilic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ang angiogenin, ribonuclease, RNase A family, 5 ISO RGD PMID:22331014 RGD:6771318 NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466 		JBrowse link
G Ankrd27 ankyrin repeat domain 27 ISO DNA:SNPs:intron: (rs3815700, rs10410895) (human) RGD PMID:25407941 RGD:11100048 NCBI chr 7:35,285,652...35,338,662
Ensembl chr 7:35,285,669...35,338,651 		JBrowse link
G Ccl26 C-C motif chemokine ligand 26 treatment ISO protein:increased expression:esophagus (human) RGD PMID:18844613 PMID:24704289 RGD:11081156, RGD:11081157 NCBI chr 5:135,589,302...135,592,423
Ensembl chr 5:135,589,302...135,592,423 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 IMP RGD PMID:1316818 RGD:6893390 NCBI chr 9:123,817,799...123,831,729
Ensembl chr 9:123,822,009...123,831,726 		JBrowse link
G Cd40lg CD40 ligand ISO protein:decreased expression:plasma RGD PMID:21211656 RGD:5490306 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 treatment ISO DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 treatment ISO DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr19:39,102,342...39,175,200
Ensembl chr19:39,102,342...39,175,516 		JBrowse link
G Il5 interleukin 5 IMP RGD PMID:23161496 RGD:11354947 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO protein:increased expression:esophagus (human) RGD PMID:22331014 RGD:6771318 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:24486052 RGD:11073602 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tslp thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20208534 NCBI chr18:32,948,436...32,952,852
Ensembl chr18:32,948,436...32,952,850 		JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Cldn3 claudin 3 ISO protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chr 5:135,015,068...135,016,330
Ensembl chr 5:135,015,068...135,016,326 		JBrowse link
G Cldn4 claudin 4 ISO protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chr 5:134,973,977...134,975,788
Ensembl chr 5:134,973,973...134,975,788 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18193101 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Egfr epidermal growth factor receptor ISO mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G F11r F11 receptor treatment ISO RGD PMID:19478094 RGD:7488941 NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171 		JBrowse link
G Il13 interleukin 13 ISO associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il5 interleukin 5 ISO associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression: esophagus RGD PMID:28757556 RGD:25824949 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mir29a microRNA 29a ISO RGD PMID:28757556 RGD:25824949 NCBI chr 6:31,039,595...31,039,682
Ensembl chr 6:31,039,595...31,039,682 		JBrowse link
G Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) ISO protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chr17:34,401,006...34,406,347
Ensembl chr17:34,400,961...34,406,738 		JBrowse link
G Ptges prostaglandin E synthase ISO protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chr 2:30,779,483...30,793,309
Ensembl chr 2:30,779,483...30,819,875 		JBrowse link
G Tjp1 tight junction protein 1 ISO RGD PMID:19653339 RGD:2325133 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:15942680 RGD:1580209 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16223
    disease of anatomical entity 15842
      gastrointestinal system disease 6869
        gastroenteritis 542
          esophagitis 31
            bacterial esophagitis 0
            eosinophilic esophagitis 11
            fungal esophagitis 0
            peptic esophagitis + 16
            viral esophagitis 0
Path 2
Term Annotations click to browse term
  disease 16223
    disease of anatomical entity 15842
      Immune & Inflammatory Diseases 5364
        Inflammation 2595
          gastroenteritis 542
            esophagitis 31
              bacterial esophagitis 0
              eosinophilic esophagitis 11
              fungal esophagitis 0
              peptic esophagitis + 16
              viral esophagitis 0
paths to the root