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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:esophagitis
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Accession:DOID:11963 term browser browse the term
Definition:INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA.
Synonyms:exact_synonym: acute esophagitis;   esophagitides
 primary_id: MESH:D004941
 xref: ICD10CM:K20;   ICD10CM:K20.9;   ICD9CM:530.1;   NCI:C9224
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr24:31,097,673...31,104,774
Ensembl chr24:31,097,538...31,101,225 		JBrowse link
G IL13 interleukin 13 ISO RGD PMID:20543112 RGD:4145528 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL4R interleukin 4 receptor susceptibility ISO associated with carcinoma, non-small-cell lung;DNA:SNP: :rs1801275(human) RGD PMID:20811626 RGD:5131286 NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO associated with carcinoma, non-small-cell lung; RGD PMID:20811626 RGD:5131286 NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 ISO protein:increased expression:epithelium RGD PMID:28370814 RGD:151361286 NCBI chr 5:73,229,953...73,269,801
Ensembl chr 5:73,229,951...73,269,754 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: therapeutic CTD PMID:11121210 NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO associated with carcinoma, non-small-cell lung: DNA:SNPs: :rs1799724(human) RGD PMID:20811626 RGD:5131286
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16091555 NCBI chr16:3,071,158...3,091,068
Ensembl chr16:3,071,526...3,090,330 		JBrowse link
eosinophilic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANG angiogenin ISO RGD PMID:22331014 RGD:6771318 NCBI chr29:21,215,985...21,226,927 JBrowse link
G ANKRD27 ankyrin repeat domain 27 ISO DNA:SNPs:intron: (rs3815700, rs10410895) (human) RGD PMID:25407941 RGD:11100048 NCBI chr 6:27,645,474...27,724,829
Ensembl chr 6:27,644,597...27,724,819 		JBrowse link
G CAPN14 calpain 14 ISO mRNA:increased expression:esophagus
DNA:snps:multiple (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:25017104 PMID:25407941 RGD:11100048 RGD:11100049 NCBI chr14:76,271,701...76,334,737
Ensembl chr14:76,302,648...76,335,341 		JBrowse link
G CCL26 C-C motif chemokine ligand 26 treatment ISO protein:increased expression:esophagus (human) RGD PMID:18844613 PMID:24704289 RGD:11081156 RGD:11081157 NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875 		JBrowse link
G CCR3 C-C motif chemokine receptor 3 ISO RGD PMID:1316818 RGD:6893390 NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135 		JBrowse link
G CD40LG CD40 ligand ISO protein:decreased expression:plasma RGD PMID:21211656 RGD:5490306 NCBI chr  X:111,655,301...111,667,602
Ensembl chr  X:111,655,397...111,666,639 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 treatment ISO DNA:polymorphisms:: RGD PMID:26416193 RGD:11352743 NCBI chr 9:87,981,300...88,025,007 JBrowse link
G IL5 interleukin 5 ISO RGD PMID:23161496 RGD:11354947 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO protein:increased expression:esophagus (human) RGD PMID:22331014 RGD:6771318 NCBI chr16:56,863,763...56,947,479
Ensembl chr16:56,880,934...56,950,999 		JBrowse link
G TGFB1 transforming growth factor beta 1 ISO RGD PMID:24486052 RGD:11073602 NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365 		JBrowse link
G TSLP thymic stromal lymphopoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:20208534 NCBI chr23:14,419,820...14,423,331 JBrowse link
peptic esophagitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP4 bone morphogenetic protein 4 ISO protein:increased expression:esophagus: RGD PMID:17570215 RGD:8699511 NCBI chr24:31,097,673...31,104,774
Ensembl chr24:31,097,538...31,101,225 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 ISO associated with Asthma;mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr16:29,351,214...29,361,317 JBrowse link
G CLDN3 claudin 3 ISO protein:altered expression:epithelial cell, esophagus: RGD PMID:21373849 RGD:11344880 NCBI chr28:9,301,312...9,303,496
Ensembl chr28:9,302,446...9,303,108 		JBrowse link
G CLDN4 claudin 4 ISO protein:altered localization:esophagus epithelium, cytoplasm RGD PMID:16143882 RGD:2317602 NCBI chr28:9,242,054...9,244,972
Ensembl chr28:9,242,909...9,243,538 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18193101 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G EGFR epidermal growth factor receptor ISO mRNA, protein:increased expression:esophagus, basal cell RGD PMID:11966524 RGD:10395244 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
G F11R F11 receptor treatment ISO RGD PMID:19478094 RGD:7488941 NCBI chr20:2,966,019...2,986,177
Ensembl chr20:2,966,164...2,984,269 		JBrowse link
G IL13 interleukin 13 ISO associated with asthma; mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid RGD PMID:18222984 RGD:2307110 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869 		JBrowse link
G IL5 interleukin 5 ISO associated with asthma; mRNA:increased expression:esophagus RGD PMID:18222984 RGD:2307110 NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 ISO protein:decreased expression:esophageal epithelium (rat) RGD PMID:23942904 RGD:9854630 NCBI chr17:39,246,356...39,251,852
Ensembl chr17:39,245,854...39,251,842 		JBrowse link
G PTGES prostaglandin E synthase ISO protein:increased expression:esophagus RGD PMID:16210398 RGD:2300085 NCBI chr12:8,393,462...8,408,441
Ensembl chr12:8,393,550...8,408,435 		JBrowse link
G TJP1 tight junction protein 1 ISO RGD PMID:19653339 RGD:2325133 NCBI chr26:52,623,751...52,750,037
Ensembl chr26:52,622,743...52,749,950 		JBrowse link
G TNF tumor necrosis factor ISO RGD PMID:15942680 RGD:1580209
G VDR vitamin D receptor susceptibility ISO DNA:SNPs,haplotype:exon:rs1989969,rs2238135 (human) RGD PMID:25910066 RGD:11055189 NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15388
    disease of anatomical entity 15074
      gastrointestinal system disease 6448
        gastroenteritis 519
          esophagitis 29
            bacterial esophagitis 0
            eosinophilic esophagitis 11
            fungal esophagitis 0
            peptic esophagitis + 14
            viral esophagitis 0
Path 2
Term Annotations click to browse term
  disease 15388
    disease of anatomical entity 15074
      Immune & Inflammatory Diseases 5133
        Inflammation 2443
          gastroenteritis 519
            esophagitis 29
              bacterial esophagitis 0
              eosinophilic esophagitis 11
              fungal esophagitis 0
              peptic esophagitis + 14
              viral esophagitis 0
paths to the root