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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:mononeuropathy
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Accession:DOID:1188 term browser browse the term
Definition:Disease or trauma involving a single peripheral nerve in isolation, or out of proportion to evidence of diffuse peripheral nerve dysfunction. Mononeuropathy multiplex refers to a condition characterized by multiple isolated nerve injuries. Mononeuropathies may result from a wide variety of causes, including ISCHEMIA; traumatic injury; compression; CONNECTIVE TISSUE DISEASES; CUMULATIVE TRAUMA DISORDERS; and other conditions.
Synonyms:exact_synonym: mononeuropathies;   mononeuropathy multiplex syndrome;   mononeuropathy multiplex syndromes
 primary_id: MESH:D020422
 alt_id: RDO:0007406
 xref: ICD10CM:G58.9
For additional species annotation, visit the Alliance of Genome Resources.


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mononeuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide ISO RGD PMID:17383023 RGD:1624339 NCBI chrNW_004955422:17,202,770...17,207,948
Ensembl chrNW_004955422:17,202,946...17,207,948
JBrowse link
carpal tunnel syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin ISO ClinVar Annotator: match by term: Carpal tunnel syndrome
ClinVar Annotator: match by term: AMYOTROPHY, THENAR, OF CARPAL ORIGIN
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Carpal tunnel syndrome, familial
ClinVar
CTD
PMID:192115 PMID:1351039 PMID:1353008 PMID:1358785 PMID:1490495 More... NCBI chrNW_004955402:18,921,235...18,927,976
Ensembl chrNW_004955402:18,921,274...18,928,108
JBrowse link
Carpal Tunnel Syndrome 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttr transthyretin ISO OMIM NCBI chrNW_004955402:18,921,235...18,927,976
Ensembl chrNW_004955402:18,921,274...18,928,108
JBrowse link
lesion of sciatic nerve term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag1 BAG cochaperone 1 ISO RGD PMID:23108487 RGD:13506903 NCBI chrNW_004955472:2,394,317...2,405,199 JBrowse link
G Rgs3 regulator of G protein signaling 3 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chrNW_004955419:13,918,274...14,042,090
Ensembl chrNW_004955419:13,919,051...14,056,521
JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO mRNA:decreased expression:dorsal root ganglion RGD PMID:14550772 RGD:13524539 NCBI chrNW_004955462:13,340,812...13,347,598
Ensembl chrNW_004955462:13,338,960...13,347,610
JBrowse link
median neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor ISO RGD PMID:18845940 RGD:126790486 NCBI chrNW_004955456:321,222...456,431 JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19296522 RGD:10449020 NCBI chrNW_004955451:14,442,816...14,456,009
Ensembl chrNW_004955451:14,442,816...14,459,379
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 ISO RGD PMID:18845940 PMID:19296522 RGD:10449020 RGD:126790486 NCBI chrNW_004955458:3,683,126...3,701,752
Ensembl chrNW_004955458:3,683,126...3,702,978
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:18845940 PMID:19296522 RGD:10449020 RGD:126790486 NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558
JBrowse link
G Npy neuropeptide Y ISO RGD PMID:19456245 RGD:10448955 NCBI chrNW_004955410:26,348,388...26,355,232
Ensembl chrNW_004955410:26,348,504...26,355,297
JBrowse link
G Nrg1 neuregulin 1 ISO RGD PMID:19296522 RGD:10449020 NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116
JBrowse link
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 ISO ClinVar Annotator: match by term: Mononeuropathy of the Median Nerve ClinVar PMID:25741868 PMID:26467025 PMID:28492532 NCBI chrNW_004955415:5,286,475...5,354,880
Ensembl chrNW_004955415:5,303,311...5,355,672
JBrowse link
Mononeuropathy of the Median Nerve, Mild term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sh3tc2 SH3 domain and tetratricopeptide repeats 2 ISO OMIM NCBI chrNW_004955415:5,286,475...5,354,880
Ensembl chrNW_004955415:5,303,311...5,355,672
JBrowse link
sciatic neuropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chrNW_004955413:17,385,966...17,510,220
Ensembl chrNW_004955413:17,382,564...17,510,132
JBrowse link
G Adrb2 adrenoceptor beta 2 treatment ISO RGD PMID:19912227 RGD:8548489 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980
JBrowse link
G Agt angiotensinogen ISO RGD PMID:20886512 RGD:5129198 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357
JBrowse link
G Akap12 A-kinase anchoring protein 12 ISO mRNA,protein:increased expression:spinal cord: RGD PMID:19937403 RGD:14348968 NCBI chrNW_004955439:10,241,298...10,262,416
Ensembl chrNW_004955439:10,238,664...10,263,081
JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 ISO protein:increased expression:dorsal root ganglion (rat) RGD PMID:23613963 RGD:14390159 NCBI chrNW_004955532:1,618,659...1,621,706
Ensembl chrNW_004955532:1,619,532...1,621,064
JBrowse link
G Apoa1 apolipoprotein A1 ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chrNW_004955412:18,170,331...18,172,298
Ensembl chrNW_004955412:18,170,331...18,172,298
JBrowse link
G Apoe apolipoprotein E ISO protein:increased expression:sciatic nerve: RGD PMID:2493483 RGD:7495790 NCBI chrNW_004955555:1,998,170...2,002,003
Ensembl chrNW_004955555:1,999,711...2,001,888
JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:18182225 RGD:5129227 NCBI chrNW_004955438:16,500,219...16,505,394
Ensembl chrNW_004955438:16,500,633...16,501,691
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:18182225 RGD:5129227 NCBI chrNW_004955438:16,514,300...16,537,160
Ensembl chrNW_004955438:16,511,759...16,537,172
JBrowse link
G Bdnf brain derived neurotrophic factor treatment ISO protein:increased expression:dorsal root ganglion: RGD PMID:22309829 PMID:24388817 RGD:10059363 RGD:8657100 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588
JBrowse link
G C3 complement C3 ISO protein:increased expression:sciatic nerve RGD PMID:18052971 RGD:5129535 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO mRNA:decreased expression:spinal cord dorsal horn RGD PMID:16026470 RGD:6906922 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chrNW_004955442:16,047,965...16,108,862
Ensembl chrNW_004955442:16,045,895...16,108,862
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I ISO mRNA:increased expression:dorsal root ganglion RGD PMID:22972512 RGD:15042903 NCBI chrNW_004955413:25,440,533...25,538,367
Ensembl chrNW_004955413:25,453,703...25,535,530
JBrowse link
G Capn1 calpain 1 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chrNW_004955422:20,006,448...20,026,984
Ensembl chrNW_004955422:20,004,426...20,025,708
JBrowse link
G Capn2 calpain 2 ISO protein:increased expression:skeletal muscle tissue of tibialis anterior RGD PMID:24745757 RGD:13792589 NCBI chrNW_004955520:1,287,829...1,315,318
Ensembl chrNW_004955520:1,286,356...1,315,328
JBrowse link
G Casp3 caspase 3 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chrNW_004955403:24,315,712...24,326,271 JBrowse link
G Casp7 caspase 7 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chrNW_004955431:18,685,408...18,723,221
Ensembl chrNW_004955431:18,686,190...18,723,524
JBrowse link
G Casp8 caspase 8 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:29659443 RGD:13782273 NCBI chrNW_004955403:322,082...348,591
Ensembl chrNW_004955403:322,555...347,053
JBrowse link
G Cat catalase ISO protein:decreased activity:sciatic nerve, spinal cord, dorsal root ganglion: RGD PMID:19675389 RGD:9479064 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
JBrowse link
G Cav1 caveolin 1 ISO protein:decreased expression:spinal cord, blood vessel RGD PMID:21795534 RGD:6784526 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:19152028 RGD:4890004 NCBI chrNW_004955481:10,293,758...10,301,118
Ensembl chrNW_004955481:10,293,399...10,301,143
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 ISO RGD PMID:24907405 RGD:8661781 NCBI chrNW_004955420:25,641,184...25,664,413 JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B ISO protein:decreased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chrNW_004955413:9,615,542...9,620,542
Ensembl chrNW_004955413:9,615,542...9,620,542
JBrowse link
G Cnr2 cannabinoid receptor 2 treatment ISO RGD PMID:19345493 RGD:2316195 NCBI chrNW_004955452:3,763,742...3,795,069
Ensembl chrNW_004955452:3,763,742...3,795,069
JBrowse link
G Crcp CGRP receptor component ISO RGD PMID:12895509 RGD:727768 NCBI chrNW_004955456:8,431,161...8,479,866
Ensembl chrNW_004955456:8,431,161...8,483,181
JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO protein:increased phosphorylation:nucleus RGD PMID:19918364 RGD:10059430 NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149
JBrowse link
G Crh corticotropin releasing hormone ISO mRNA:increased expression:central nucleus of amygdala, bed nucleus of stria terminalis (rat) RGD PMID:21684787 RGD:5490542 NCBI chrNW_004955444:12,989,210...12,991,300 JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 treatment ISO RGD PMID:15341587 PMID:20524966 PMID:20921832 RGD:1358720 RGD:9354422 RGD:9491396 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
JBrowse link
G Dbn1 drebrin 1 ISO protein:increased expression:neuron: RGD PMID:11578820 RGD:10398813 NCBI chrNW_004955408:29,695,442...29,705,417
Ensembl chrNW_004955408:29,696,266...29,705,416
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha ISO protein:increased expression:brain: RGD PMID:22031875 RGD:9589072 NCBI chrNW_004955469:7,264,431...7,367,059
Ensembl chrNW_004955469:7,269,952...7,367,059
JBrowse link
G Elavl4 ELAV like RNA binding protein 4 ISO RGD PMID:12957493 RGD:1579851 NCBI chrNW_004955464:8,699,142...8,847,289
Ensembl chrNW_004955464:8,699,088...8,788,878
JBrowse link
G Fas Fas cell surface death receptor ISO RGD PMID:29970988 RGD:13792563 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:increased expression:neuron: RGD PMID:8971765 RGD:10402092 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
JBrowse link
G Fubp1 far upstream element binding protein 1 ISO RGD PMID:23939805 RGD:13673880 NCBI chrNW_004955423:15,245,645...15,278,628
Ensembl chrNW_004955423:15,245,610...15,278,628
JBrowse link
G Gc GC vitamin D binding protein ISO protein:increased expression:nerve RGD PMID:15509515 RGD:2316214 NCBI chrNW_004955447:1,361,698...1,400,633
Ensembl chrNW_004955447:1,361,566...1,402,491
JBrowse link
G Gdnf glial cell derived neurotrophic factor ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chrNW_004955426:22,386,613...22,412,324
Ensembl chrNW_004955426:22,386,450...22,412,324
JBrowse link
G Gfra1 GDNF family receptor alpha 1 ISO protein:increased expression:spinal cord dorsal horn RGD PMID:20533358 RGD:6218963 NCBI chrNW_004955431:20,859,152...21,070,886
Ensembl chrNW_004955431:20,866,685...21,070,853
JBrowse link
G Gfra3 GDNF family receptor alpha 3 ISO mRNA:increased expression:sciatic nerve RGD PMID:10852218 RGD:6218977 NCBI chrNW_004955418:2,152,887...2,162,883
Ensembl chrNW_004955418:2,143,169...2,163,286
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 ISO RGD PMID:26656067 RGD:13792690 NCBI chrNW_004955513:5,154,864...5,178,636
Ensembl chrNW_004955513:5,154,864...5,178,636
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B ISO RGD PMID:26656067 RGD:13792690 NCBI chrNW_004955413:10,358,931...10,780,004
Ensembl chrNW_004955413:10,376,597...10,779,145
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO RGD PMID:27125978 RGD:13792740 NCBI chrNW_004955427:19,489,972...19,671,137
Ensembl chrNW_004955427:19,495,422...19,671,137
JBrowse link
G Hgf hepatocyte growth factor treatment ISO RGD PMID:18941443 RGD:8548631 NCBI chrNW_004955410:4,114,280...4,181,953
Ensembl chrNW_004955410:4,114,778...4,182,058
JBrowse link
G Hmgb1 high mobility group box 1 treatment ISO RGD PMID:23991202 RGD:10402062 NCBI chrNW_004955431:15,373,207...15,377,339
Ensembl chrNW_004955431:15,373,207...15,377,339
JBrowse link
G Hmox1 heme oxygenase 1 treatment ISO RGD PMID:23224421 RGD:10755722 NCBI chrNW_004955405:43,124,447...43,128,873
Ensembl chrNW_004955405:43,124,510...43,130,979
JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:17350523 RGD:1626418 NCBI chrNW_004955528:1,819,247...1,826,707
Ensembl chrNW_004955528:1,819,247...1,826,707
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO RGD PMID:20546684 RGD:8547739 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Il10 interleukin 10 treatment ISO associated with Constriction, Pathologic RGD PMID:22173123 PMID:22889616 RGD:7364826 RGD:7364836 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il1b interleukin 1 beta treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO rat model treated with human protein RGD PMID:12574433 RGD:7175064 NCBI chrNW_004955470:1,145,022...1,159,413
Ensembl chrNW_004955470:1,144,810...1,159,471
JBrowse link
G Il6 interleukin 6 ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Il6r interleukin 6 receptor ISO protein:increased expression:dorsal root ganglion RGD PMID:20519054 RGD:5128675 NCBI chrNW_004955545:932,814...979,359
Ensembl chrNW_004955545:950,765...981,762
JBrowse link
G Jam3 junctional adhesion molecule 3 ISO RGD PMID:22950044 RGD:7488944 NCBI chrNW_004955412:34,901,850...34,967,394
Ensembl chrNW_004955412:34,901,681...34,967,394
JBrowse link
G Kars1 lysyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chrNW_004955484:1,924,523...1,939,777
Ensembl chrNW_004955484:1,924,523...1,940,552
JBrowse link
G Kcnc4 potassium voltage-gated channel subfamily C member 4 ISO RGD PMID:17855600 RGD:10411908 NCBI chrNW_004955435:13,728,272...13,750,420
Ensembl chrNW_004955435:13,728,708...13,750,660
JBrowse link
G Kcnj11 potassium inwardly rectifying channel subfamily J member 11 ISO mRNA:increased expression:dorsal root ganglion RGD PMID:17108688 RGD:7297043 NCBI chrNW_004955414:32,209,426...32,212,424
Ensembl chrNW_004955414:32,210,545...32,211,717
JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 ISO protein:decreased expression:spinal cord RGD PMID:21907492 RGD:12791994 NCBI chrNW_004955413:17,364,447...17,371,255
Ensembl chrNW_004955413:17,364,213...17,371,255
JBrowse link
G Lamp2 lysosomal associated membrane protein 2 treatment ISO RGD PMID:30015858 RGD:13703060 NCBI chrNW_004955572:1,423,048...1,464,443
Ensembl chrNW_004955572:1,422,981...1,462,622
JBrowse link
G LOC102011010 steroid 17-alpha-hydroxylase/17,20 lyase ISO mRNA:decreased expression:spinal cord (rat) RGD PMID:17720801 RGD:4889112 NCBI chrNW_004955485:7,615,132...7,652,899
Ensembl chrNW_004955485:7,645,363...7,650,658
JBrowse link
G LOC102014960 cholesterol side-chain cleavage enzyme, mitochondrial ISO protein:increased expression:spinal cord dorsal horn (rat) RGD PMID:16632873 RGD:4889134 NCBI chrNW_004955450:3,433,310...3,484,462
Ensembl chrNW_004955450:3,474,491...3,484,232
JBrowse link
G Lrp1 LDL receptor related protein 1 treatment ISO RGD PMID:18060043 PMID:26656067 RGD:13792690 RGD:13800561 NCBI chrNW_004955458:4,861,431...4,941,939
Ensembl chrNW_004955458:4,861,431...4,941,146
JBrowse link
G Mag myelin associated glycoprotein treatment ISO RGD PMID:17705198 RGD:9685295 NCBI chrNW_004955468:4,584,068...4,598,772
Ensembl chrNW_004955468:4,584,162...4,598,914
JBrowse link
G Map2 microtubule associated protein 2 ISO protein:decrease expression:dorsal root ganglion RGD PMID:21933624 RGD:6483083 NCBI chrNW_004955457:5,678,826...5,816,114
Ensembl chrNW_004955457:5,678,436...5,875,024
JBrowse link
G Mc4r melanocortin 4 receptor ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:21985621 RGD:6484557 NCBI chrNW_004955402:44,453,973...44,456,689
Ensembl chrNW_004955402:44,455,294...44,456,292
JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment ISO RGD PMID:25172308 RGD:13207330 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link
G Mpz myelin protein zero treatment ISO RGD PMID:23545781 RGD:9685778 NCBI chrNW_004955468:13,041,911...13,047,026
Ensembl chrNW_004955468:13,041,011...13,047,284
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO RGD PMID:20452291 RGD:10041037 NCBI chrNW_004955486:2,487,642...2,599,694
Ensembl chrNW_004955486:2,487,642...2,599,694
JBrowse link
G Myh4 myosin heavy chain 4 treatment ISO RGD PMID:14973145 RGD:9686059 NCBI chrNW_004955467:6,719,572...6,744,147 JBrowse link
G Nefh neurofilament heavy chain treatment ISO RGD PMID:3135913 PMID:12445968 RGD:9693730 RGD:9743941 NCBI chrNW_004955455:3,735,330...3,744,714
Ensembl chrNW_004955455:3,735,410...3,744,107
JBrowse link
G Nefl neurofilament light chain ISO associated with Diabetes Mellitus, Type 1 RGD PMID:3135913 PMID:12445968 PMID:12638730 RGD:9693730 RGD:9743941 RGD:9743948 NCBI chrNW_004955403:47,946,413...47,951,734
Ensembl chrNW_004955403:47,946,353...47,952,026
JBrowse link
G Nefm neurofilament medium chain treatment ISO associated with Diabetes Mellitus, Type 1 RGD PMID:3135913 PMID:12445968 PMID:12638730 RGD:9693730 RGD:9743941 RGD:9743948 NCBI chrNW_004955403:47,920,408...47,926,922 JBrowse link
G Nf1 neurofibromin 1 ISO protein:increased expression:sciatic nerve: RGD PMID:8847098 RGD:12790590 NCBI chrNW_004955481:6,145,855...6,404,179
Ensembl chrNW_004955481:6,145,855...6,404,179
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment ISO RGD PMID:18938092 RGD:10413869 NCBI chrNW_004955409:25,691,673...25,695,151
Ensembl chrNW_004955409:25,691,534...25,697,520
JBrowse link
G Ngf nerve growth factor treatment ISO RGD PMID:22776032 RGD:7242913 NCBI chrNW_004955435:18,581,889...18,633,330
Ensembl chrNW_004955435:18,581,808...18,601,059
JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:17576803 PMID:23138653 RGD:10414078 RGD:5144067 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305
JBrowse link
G Nlgn2 neuroligin 2 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chrNW_004955467:9,504,974...9,520,059
Ensembl chrNW_004955467:9,504,974...9,520,059
JBrowse link
G Nlgn3 neuroligin 3 ISO mRNA:decreased expression:sciatic nerve RGD PMID:17492651 RGD:9831149 NCBI chrNW_004955475:10,712,170...10,735,857
Ensembl chrNW_004955475:10,712,170...10,735,857
JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO mRNA:increased expression:dorsal root ganglion: RGD PMID:16914673 RGD:13781948 NCBI chrNW_004955486:3,637,794...3,655,744
Ensembl chrNW_004955486:3,637,794...3,655,598
JBrowse link
G Nrg1 neuregulin 1 treatment ISO RGD PMID:20957456 RGD:10449012 NCBI chrNW_004955463:8,009,436...9,037,116
Ensembl chrNW_004955463:8,009,530...9,037,116
JBrowse link
G Nts neurotensin ISO RGD PMID:8518953 RGD:9743903 NCBI chrNW_004955405:23,696,258...23,758,487
Ensembl chrNW_004955405:23,748,280...23,758,529
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO mRNA:increased expression:brain: RGD PMID:15862535 RGD:9835022 NCBI chrNW_004955528:161,673...184,515
Ensembl chrNW_004955528:161,673...167,937
JBrowse link
G Pcna proliferating cell nuclear antigen ISO RGD PMID:23014974 RGD:10448976 NCBI chrNW_004955415:15,744,601...15,748,910
Ensembl chrNW_004955415:15,744,601...15,749,673
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO mRNA,protein:increased expression:nerve: RGD PMID:9729404 RGD:11556234 NCBI chrNW_004955512:2,914,834...3,333,440
Ensembl chrNW_004955512:2,917,243...3,333,688
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha ISO RGD PMID:19909480 RGD:11080976 NCBI chrNW_004955447:16,570,652...16,613,410
Ensembl chrNW_004955447:16,569,909...16,612,373
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO RGD PMID:19909480 RGD:11080976 NCBI chrNW_004955415:4,365,848...4,403,317
Ensembl chrNW_004955415:4,365,743...4,403,587
JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:18716863 RGD:6483827 NCBI chrNW_004955536:730,962...754,333
Ensembl chrNW_004955536:730,981...756,394
JBrowse link
G Plau plasminogen activator, urokinase treatment ISO mRNA:increased expression:sciatic nerve (rat) RGD PMID:18716863 PMID:21151668 RGD:6483827 RGD:7241585 NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
JBrowse link
G Pmp22 peripheral myelin protein 22 ISO RGD PMID:1556154 RGD:1358785 NCBI chrNW_004955467:2,422,181...2,456,925
Ensembl chrNW_004955467:2,423,659...2,457,307
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO associated with Diabetes Mellitus, Experimental RGD PMID:22996345 RGD:7242051 NCBI chrNW_004955480:543,397...1,188,376
Ensembl chrNW_004955480:1,078,322...1,188,435
JBrowse link
G Ptafr platelet activating factor receptor ISO mRNA:increased expression:spinal cord, microglia (rat) RGD PMID:22296727 RGD:9999207 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
JBrowse link
G Ptn pleiotrophin ISO mRNA:altered expression:dorsal root ganglia (rat) RGD PMID:18365878 RGD:9831453 NCBI chrNW_004955494:5,580,264...5,681,848
Ensembl chrNW_004955494:5,580,422...5,684,190
JBrowse link
G Qars1 glutaminyl-tRNA synthetase 1 ISO mRNA,protein:decreased expression:dorsal root ganglion: RGD PMID:25467976 RGD:12910554 NCBI chrNW_004955532:1,093,444...1,100,591
Ensembl chrNW_004955532:1,092,125...1,100,603
JBrowse link
G Ran RAN, member RAS oncogene family ISO RGD PMID:18667152 RGD:9835000 NCBI chrNW_004955482:1,222,944...1,223,891 JBrowse link
G Ranbp1 RAN binding protein 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:18667152 RGD:9835000 NCBI chrNW_004955442:17,985,456...17,992,945
Ensembl chrNW_004955442:17,985,544...17,992,759
JBrowse link
G Rangap1 Ran GTPase activating protein 1 ISO protein:increased expression:sciatic nerve, axon, cytoplasm (rat) RGD PMID:18667152 RGD:9835000 NCBI chrNW_004955413:26,869,487...26,894,192
Ensembl chrNW_004955413:26,867,812...26,890,284
JBrowse link
G Rara retinoic acid receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chrNW_004955451:14,876,663...14,917,134
Ensembl chrNW_004955451:14,897,726...14,917,134
JBrowse link
G Rarb retinoic acid receptor beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chrNW_004955430:17,067,536...17,457,558
Ensembl chrNW_004955430:17,295,174...17,460,045
JBrowse link
G Rchy1 ring finger and CHY zinc finger domain containing 1 ISO protein:increased expression:sciatic nerve RGD PMID:21959983 RGD:10045367 NCBI chrNW_004955474:1,463,817...1,475,677
Ensembl chrNW_004955474:1,463,817...1,475,690
JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a ISO RGD PMID:16863689 RGD:9850145 NCBI chrNW_004955416:21,221,023...21,261,831
Ensembl chrNW_004955416:21,221,023...21,261,831
JBrowse link
G Rpsa ribosomal protein SA ISO RGD PMID:19196078 RGD:11041651 NCBI chrNW_004955420:29,978,160...29,983,544 JBrowse link
G Rxra retinoid X receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16782282 NCBI chrNW_004955513:3,313,544...3,386,544
Ensembl chrNW_004955513:3,335,897...3,386,994
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 ISO RGD PMID:21965668 RGD:6484251 NCBI chrNW_004955427:25,157,179...25,244,020
Ensembl chrNW_004955427:25,157,179...25,243,473
JBrowse link
G Serpine1 serpin family E member 1 treatment ISO RGD PMID:25967608 RGD:11075075 NCBI chrNW_004955456:16,147,523...16,157,040
Ensembl chrNW_004955456:16,145,944...16,157,142
JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO human protein in a mouse model RGD PMID:10441236 RGD:8554886 NCBI chrNW_004955481:1,414,930...1,426,436
Ensembl chrNW_004955481:1,414,930...1,426,241
JBrowse link
G Slc17a7 solute carrier family 17 member 7 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chrNW_004955559:1,399,182...1,409,074
Ensembl chrNW_004955559:1,399,182...1,409,134
JBrowse link
G Slc17a8 solute carrier family 17 member 8 ISO protein:decreased expression:nucleus accumbens RGD PMID:23835161 RGD:9999206 NCBI chrNW_004955405:36,063,688...36,115,312
Ensembl chrNW_004955405:36,063,688...36,115,312
JBrowse link
G Snw1 SNW domain containing 1 ISO protein:increased expression:sciatic nerve (rat) RGD PMID:23389663 RGD:11035242 NCBI chrNW_004955438:1,561,562...1,601,492
Ensembl chrNW_004955438:1,561,568...1,601,492
JBrowse link
G Sod1 superoxide dismutase 1 treatment
severity
ISO human gene in a rat model;DNA:missense mutation:cds:p.G93A (human) RGD PMID:15707675 PMID:21489258 RGD:8655638 RGD:8655979 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA:increased expression:sciatic nerve: RGD PMID:21125644 RGD:8553062 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA:increased expression:spinal cord: RGD PMID:18615568 PMID:22173123 RGD:7364836 RGD:7815041 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:22173123 RGD:7364836 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:9582261 PMID:11240015 RGD:5130898 RGD:5130963 NCBI chrNW_004955413:3,982,670...3,996,320
Ensembl chrNW_004955413:3,981,400...3,996,021
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:dorsal root ganglia (rat) RGD PMID:11240015 RGD:5130963 NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
JBrowse link
Sciatica term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 ISO RGD PMID:16176350 RGD:2302154 NCBI chrNW_004955507:6,138,511...6,144,823
Ensembl chrNW_004955507:6,138,071...6,144,823
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B treatment ISO RGD PMID:22425187 RGD:7245944 NCBI chrNW_004955486:1,790,531...1,817,986
Ensembl chrNW_004955486:1,792,115...1,818,362
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12757
    disease of anatomical entity 12441
      nervous system disease 10337
        peripheral nervous system disease 2330
          mononeuropathy 126
            Mononeuropathy of the Median Nerve, Mild 1
            femoral neuropathy 0
            median neuropathy + 8
            mononeuritis + 125
            peroneal nerve paralysis + 0
            peroneal neuropathy 0
            radial neuropathy + 0
            tibial neuropathy + 0
            ulnar neuropathy + 0
Path 2
Term Annotations click to browse term
  disease 12757
    disease of anatomical entity 12441
      nervous system disease 10337
        peripheral nervous system disease 2330
          neuropathy 2160
            mononeuropathy 126
              Mononeuropathy of the Median Nerve, Mild 1
              femoral neuropathy 0
              median neuropathy + 8
              mononeuritis + 125
              peroneal nerve paralysis + 0
              peroneal neuropathy 0
              radial neuropathy + 0
              tibial neuropathy + 0
              ulnar neuropathy + 0
paths to the root