RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.
Synonyms:
exact_synonym:
Familial Hyperlipoproteinemia Type 4; Familial Type IV Hyperlipoproteinemia; Fredrickson type IV hyperlipoproteinemia; Fredrickson type IV lipidaemia; Fredrickson type IV lipidemia; Hyper prebeta lipoproteinemia; VLDL hyperlipoproteinemia; carbohydrate inducible hyperlipemia; carbohydrate inducible hyperlipemias; endogenous hyperlipidaemia; hyperprebetalipoproteinemia; type IV hyperlipoproteinemias