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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:diabetic angiopathy
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Accession:DOID:11713 term browser browse the term
Definition:A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes. (DO)
Synonyms:exact_synonym: Diabetic Microangiopathy;   diabetic angiopathies;   diabetic microangiopathies;   diabetic peripheral angiopathy;   diabetic vascular complication;   diabetic vascular complications;   diabetic vascular disease;   diabetic vascular diseases;   diabetic vascular disorder
 related_synonym: END-STAGE RENAL DISEASE, DIABETIC, SUSCEPTIBILITY TO;   MVCD1;   MVCD2;   MVCD3;   MVCD4;   MVCD5;   MVCD6;   MVCD7;   SUPEROXIDE DISMUTASE 2 POLYMORPHISM;   diabetic neuropathy, susceptibility to;   diabetic nonproliferative retinopathy, susceptibility to;   diabetic proliferative retinopathy, susceptibility to;   diabetic retinopathy, susceptibility to;   macrovascular complications of diabetes;   microvascular complications of diabetes, protection against;   microvascular complications of diabetes, susceptibility to;   microvascular complications of diabetes, susceptibility to, 1;   microvascular complications of diabetes, susceptibility to, 2;   microvascular complications of diabetes, susceptibility to, 3;   microvascular complications of diabetes, susceptibility to, 4;   microvascular complications of diabetes, susceptibility to, 5;   microvascular complications of diabetes, susceptibility to, 6;   microvascular complications of diabetes, susceptibility to, 7
 primary_id: MESH:D003925
 alt_id: DOID:10182;   OMIM:603933;   OMIM:612623;   OMIM:612624;   OMIM:612628;   OMIM:612633;   OMIM:612634;   OMIM:612635
 xref: EFO:0010977;   EFO:1000896;   ICD9CM:250.7;   NCI:C35610;   OMIM:PS603933
For additional species annotation, visit the Alliance of Genome Resources.

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diabetic angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy3 adenylate cyclase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936493:7,250,194...7,333,433
Ensembl chrNW_004936493:7,250,194...7,335,691 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936470:17,831,644...18,047,868
Ensembl chrNW_004936470:17,831,639...18,047,868 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20372816 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Ass1 argininosuccinate synthase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25033204 NCBI chrNW_004936487:17,482,307...17,527,407
Ensembl chrNW_004936487:17,486,826...17,527,435 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:15878326 RGD:7241570 NCBI chrNW_004936604:551,774...567,014 JBrowse link
G Casp3 caspase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Cd28 CD28 molecule ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:decreased expression:T cell RGD PMID:15504310 RGD:2307197 NCBI chrNW_004936631:335,411...363,407
Ensembl chrNW_004936631:335,411...363,407 		JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:serum RGD PMID:14963650 RGD:2314223 NCBI chrNW_004936513:10,607,617...10,620,403
Ensembl chrNW_004936513:10,607,617...10,620,403 		JBrowse link
G Crem cAMP responsive element modulator ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936574:3,478,969...3,546,738
Ensembl chrNW_004936574:3,479,060...3,548,951 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 susceptibility ISO associated with Diabetic Foot;DNA:polymorphism:3' utr (human) RGD PMID:16723689 RGD:2306558 NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796 		JBrowse link
G Epo erythropoietin ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 2 OMIM
ClinVar		 PMID:18458324 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
protein:increased expression:plasma		 RGD PMID:9285207 PMID:16371118 RGD:2313861 RGD:2313868 NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916 		JBrowse link
G Fas Fas cell surface death receptor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:15803113 RGD:2315753 NCBI chrNW_004936735:209,369...234,582 JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent		 CTD
RGD		 PMID:15803113 PMID:25381014 RGD:2315753 NCBI chrNW_004936481:14,789,547...14,795,780 JBrowse link
G Fn1 fibronectin 1 ISO RGD PMID:12716757 RGD:1601179 NCBI chrNW_004936586:1,708,803...1,773,372
Ensembl chrNW_004936586:1,708,684...1,773,383 		JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO associated with type 2 diabetes mellitus;DNA:SNV: :C59038T (human) RGD PMID:19515581 RGD:329961327 NCBI chrNW_004936697:232,048...275,420 JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha ISO RGD PMID:21411989 RGD:7242686 NCBI chrNW_004936677:2,774,076...2,779,660 JBrowse link
G Gpx1 glutathione peroxidase 1 ISO cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood RGD PMID:16338763 RGD:1600708 NCBI chrNW_004936529:997,943...999,123
Ensembl chrNW_004936529:998,150...998,987 		JBrowse link
G Gsr glutathione-disulfide reductase ISO cardiovascular complications in type 2 diabetics; protein:reduced_activity:blood RGD PMID:16338763 RGD:1600708 NCBI chrNW_004936792:531,076...579,083
Ensembl chrNW_004936792:531,756...579,166 		JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 7 | ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 7 ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580 		JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:16959961 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Diabetes Mellitus, Experimental;mRNA:increased expression:aorta RGD PMID:18093596 PMID:18796303 RGD:2306988 RGD:2313473 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Igfbp1 insulin like growth factor binding protein 1 ISO DNA:SNPs RGD PMID:16306374 RGD:1625238 NCBI chrNW_004936478:20,494,190...20,499,001
Ensembl chrNW_004936478:20,494,203...20,499,001 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 4 OMIM
ClinVar		 PMID:25741868 PMID:28492532 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:neutrophil (human) RGD PMID:18496641 RGD:329901826 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 3 ClinVar PMID:1313972 PMID:1319114 PMID:1328889 PMID:1386652 PMID:1976655 More... NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G LOC101976500 haptoglobin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16597321 NCBI chrNW_004936475:21,841,054...21,845,821 JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:12477149 RGD:1582581 NCBI chrNW_004936722:1,447,189...1,457,632
Ensembl chrNW_004936722:1,447,335...1,457,611 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16681562 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea RGD PMID:19241604 PMID:19587355 RGD:2313210 RGD:4891384 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment ISO associated with Diabetes Mellitus, Experimental; protein:increased expression:cochlea
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12124201 PMID:19241604 PMID:29329611 RGD:13504708 RGD:4891384 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased tyrosine phosphorylation:conceptus RGD PMID:10329590 RGD:2311657 NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500 		JBrowse link
G Plat plasminogen activator, tissue type ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:18945481 RGD:2311663 NCBI chrNW_004936785:476,200...503,371
Ensembl chrNW_004936785:476,078...503,321 		JBrowse link
G Polr1c RNA polymerase I and III subunit C ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 1 ClinVar PMID:11978667 NCBI chrNW_004936476:16,483,203...16,487,360
Ensembl chrNW_004936476:16,480,835...16,487,424 		JBrowse link
G Pon1 paraoxonase 1 ISO ClinVar Annotator: match by term: RETINOPATHY, DIABETIC, SUSCEPTIBILITY TO ClinVar PMID:9011577 PMID:9661650 PMID:11335891 PMID:11788650 PMID:11889198 More... NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta treatment ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21926342 RGD:10041069 NCBI chrNW_004936675:216,970...325,670
Ensembl chrNW_004936675:275,288...324,810 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human) RGD PMID:33294897 RGD:329853310 NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936599:3,800,142...3,810,583
Ensembl chrNW_004936599:3,801,636...3,809,813 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:deletion, haplotype:promoter:g.-676_-674delG (human) RGD PMID:9844142 RGD:8547700 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Serpinf1 serpin family F member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936538:7,885,816...7,898,308
Ensembl chrNW_004936538:7,885,475...7,899,113 		JBrowse link
G Sod1 superoxide dismutase 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:16338763 RGD:1600708 NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867 		JBrowse link
G Sod2 superoxide dismutase 2 ISO ClinVar Annotator: match by term: SUPEROXIDE DISMUTASE 2 POLYMORPHISM OMIM
ClinVar		 PMID:8633092 PMID:10425186 PMID:12624725 PMID:15591282 PMID:16538174 More... NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Sparc secreted protein acidic and cysteine rich ISO associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:mesentery, blood vessel RGD PMID:10625572 RGD:2300063 NCBI chrNW_004936515:11,026,156...11,046,812
Ensembl chrNW_004936515:11,025,724...11,046,849 		JBrowse link
G Thbs1 thrombospondin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
G Thbs2 thrombospondin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25381014 NCBI chrNW_004936489:17,874,064...17,907,255
Ensembl chrNW_004936489:17,874,052...17,907,393 		JBrowse link
G Tnf tumor necrosis factor susceptibility ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:promoter:c.-308G>A (human) RGD PMID:18575614 RGD:2313255 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO ClinVar Annotator: match by term: Microvascular complications of diabetes, susceptibility to, 1 OMIM
ClinVar		 PMID:11978667 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
background diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase ISO associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum: RGD PMID:24092995 RGD:9068931 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO protein:decreased expression:aqueous humor: RGD PMID:23853629 RGD:10402120 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G LOC101959212 alpha-2-macroglobulin treatment ISO RGD PMID:10848441 RGD:10046010 NCBI chrNW_004936870:424,832...468,303
Ensembl chrNW_004936870:424,951...468,167 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO protein:increased activity:serum: RGD PMID:28724746 RGD:151356966 NCBI chrNW_004936613:3,791,684...3,813,857
Ensembl chrNW_004936613:3,791,681...3,813,892 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:decreased expression:vitreous: RGD PMID:19799585 RGD:10449447 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
Cleft Palate, Proliferative Retinopathy, and Developmental Delay term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrc32 leucine rich repeat containing 32 ISO ClinVar Annotator: match by term: Cleft palate, proliferative retinopathy, and developmental delay OMIM
ClinVar		 PMID:25741868 PMID:30976112 NCBI chrNW_004936498:5,305,680...5,315,580
Ensembl chrNW_004936498:5,305,545...5,315,539 		JBrowse link
Diabetic Foot term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:20836881 RGD:5686889 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood RGD PMID:21941211 RGD:6767555 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:blood: RGD PMID:22712631 RGD:6906887 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Gja1 gap junction protein alpha 1 ISO protein:increased expression:dermis RGD PMID:22455314 RGD:7207269 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO mRNA,protein:decreased expression:blood serum, foot (human) RGD PMID:34293021 RGD:155260332 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Igf1 insulin like growth factor 1 ISO protein:decreased expression:fibroblast of dermis,stratum basale of epidermis: RGD PMID:10727985 RGD:8549356 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
G Il15 interleukin 15 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell RGD PMID:17014667 RGD:2313575 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Itgam integrin subunit alpha M ISO protein:increased expression:pes (human) RGD PMID:37087778 RGD:329853756 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 severity ISO DNA:polymorphism: :1538G>A (human) RGD PMID:19731315 RGD:8662463 NCBI chrNW_004936727:1,718,952...1,721,691 JBrowse link
G Mmp9 matrix metallopeptidase 9 severity ISO RGD PMID:22688339 RGD:8547813 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Notch1 notch receptor 1 ISO protein:increased expression:skin, epidermis: RGD PMID:30886104 RGD:155646129 NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Plat plasminogen activator, tissue type ISO RGD PMID:17275886 RGD:2311669 NCBI chrNW_004936785:476,200...503,371
Ensembl chrNW_004936785:476,078...503,321 		JBrowse link
G Ptx3 pentraxin 3 ISO protein:decreased expression:plasma (human) RGD PMID:30767386 RGD:38501100 NCBI chrNW_004936519:4,303,549...4,309,143
Ensembl chrNW_004936519:4,303,464...4,309,173 		JBrowse link
G Tlr4 toll like receptor 4 susceptibility ISO DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human); RGD PMID:23936790 RGD:7777174 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment ISO CTD Direct Evidence: therapeutic
human gene in a mouse model
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:21792177 PMID:31380462 RGD:40818278 RGD:8548900 NCBI chrNW_004936470:4,964,526...5,011,808
Ensembl chrNW_004936470:4,965,332...5,011,702 		JBrowse link
G Acp1 acid phosphatase 1 ISO associated with Diabetes Mellitus, Insulin-Dependent RGD PMID:12495297 RGD:2313184 NCBI chrNW_004936532:130,799...145,285
Ensembl chrNW_004936532:132,350...145,285 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing disease_progression ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2;DNA:SNP: :g.45T>G (human)		 RGD PMID:17970779 PMID:24655058 RGD:8694412 RGD:8694475 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Adm adrenomedullin ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:19216096 RGD:2313312 NCBI chrNW_004936528:8,005,223...8,007,586
Ensembl chrNW_004936528:8,005,189...8,007,643 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO associated with Diabetes Mellitus, Type 2; DNA:missense mutation:cds:p.W64R rs4994 (human) RGD PMID:9313761 RGD:5684400 NCBI chrNW_004936710:1,410,589...1,413,279
Ensembl chrNW_004936710:1,411,446...1,413,098 		JBrowse link
G Ager advanced glycosylation end-product specific receptor treatment
susceptibility
no_association
severity		 ISO associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:missense mutation, snp, haplotype:cds, intron:p.G82S, g.1704G>T (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :2245G>A (human)
associated with Diabetes Mellitus, Type 2;DNA:polymorphisms:promoter, cds, intron:g.-443T>C, p.G82S, g.1704G>T (rs1800625, rs2070600, rs184003) (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A, - 429T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-374T>A (human)
protein:increased expression:retina inner nuclear layer, retinal ganglion cell (rat)
associated with Diabetes Mellitus, Type 1;DNA:SNP:promoter:-374T>A (human)
associated with Diabetes Mellitus, Type 2;DNA:polymorphisms: :p.G82S, 1704G>T, 2184A>G (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum
associated with Diabetes Mellitus, Type 2;DNA:SNP:promoter:-429T>C (human)		 RGD PMID:11375354 PMID:14704946 PMID:16969646 PMID:19542745 PMID:22116960 More... RGD:7244174 RGD:7244175 RGD:7244176 RGD:7244248 RGD:7244369 RGD:8695958 RGD:8695965 RGD:8695966 RGD:8695967 RGD:8695979 RGD:8695983 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Agt angiotensinogen treatment ISO CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Type 1;DNA:polymorphism: :p.M235T (human)
associated with Diabetes Mellitus, Experimental		 CTD
RGD		 PMID:10862638 PMID:15387897 PMID:21792177 RGD:8548872 RGD:8548900 NCBI chrNW_004936484:19,713,299...19,721,144
Ensembl chrNW_004936484:19,716,165...19,721,261 		JBrowse link
G Agtr1 angiotensin II receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16601577 NCBI chrNW_004936519:6,831,096...6,873,977
Ensembl chrNW_004936519:6,831,096...6,873,985 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2;DNA:snp:promoter:g.-106C>T (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:promoter:repeat:g.-2008(AC)n (rs35839483) (human)
protein:increased expression:retinal astrocyte (rat)
associated with Diabetes Mellitus;DNA:repeats, snp:promoter:multiple (human)		 RGD PMID:8150024 PMID:16701918 PMID:17003340 PMID:19587357 PMID:21067572 RGD:1626080 RGD:8548640 RGD:8548668 RGD:8548676 RGD:8548684 NCBI chrNW_004936579:1,312,175...1,328,397 JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Ang angiogenin ISO associated with Diabetes Mellitus, Type 2;protein:decreased tyrosine phosphorylation:vitreous humor RGD PMID:18978347 RGD:2307061 NCBI chrNW_004936880:39,372...40,070 JBrowse link
G Angpt1 angiopoietin 1 ISO associated with Diabetes Mellitus, Experimental RGD PMID:12000720 RGD:2313818 NCBI chrNW_004936470:37,105,469...37,328,183
Ensembl chrNW_004936470:37,105,466...37,328,190 		JBrowse link
G Angpt2 angiopoietin 2 ISO RGD PMID:16520919 RGD:2314216 NCBI chrNW_004936615:4,472,261...4,524,537
Ensembl chrNW_004936615:4,472,247...4,524,556 		JBrowse link
G Apoa4 apolipoprotein A4 ISO protein:increased expression:vitreous humor (human) RGD PMID:19081814 RGD:5685692 NCBI chrNW_004936542:2,098,683...2,101,127
Ensembl chrNW_004936542:2,098,683...2,101,127 		JBrowse link
G Apob apolipoprotein B ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:19448981 RGD:2313976 NCBI chrNW_004936493:10,509,118...10,549,144
Ensembl chrNW_004936493:10,509,118...10,549,144 		JBrowse link
G Apoc3 apolipoprotein C3 severity ISO protein:increased expression:serum RGD PMID:15642486 RGD:2306768 NCBI chrNW_004936542:2,106,927...2,108,412
Ensembl chrNW_004936542:2,106,318...2,108,603 		JBrowse link
G Apoe apolipoprotein E susceptibility
no_association		 ISO associated with Diabetic Mellitus type 2;DNA:polymorphism:exon: RGD PMID:11495633 PMID:16862278 RGD:7771553 RGD:7771557 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G Apoh apolipoprotein H ISO protein:increased expression:vitreous humor RGD PMID:18695102 RGD:2313982 NCBI chrNW_004936541:6,683,483...6,695,094
Ensembl chrNW_004936541:6,683,534...6,695,066 		JBrowse link
G Aqp4 aquaporin 4 ISO RGD PMID:22449442 RGD:8695996 NCBI chrNW_004936550:5,931,201...5,943,999
Ensembl chrNW_004936550:5,931,194...5,941,354 		JBrowse link
G Bdkrb1 bradykinin receptor B1 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:18311190 RGD:2313334 NCBI chrNW_004936604:551,774...567,014 JBrowse link
G Bdnf brain derived neurotrophic factor ISO associated with Diabetes Mellitus, Experimental;protein:decreased expression:retina: RGD PMID:15331553 RGD:8655657 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014 		JBrowse link
G Casp3 caspase 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Experimental;protein:increased expresssion:retina		 RGD
CTD		 PMID:19013511 PMID:19187597 PMID:20654064 RGD:2311444 RGD:2311448 NCBI chrNW_004936554:4,571,072...4,593,765 JBrowse link
G Casp9 caspase 9 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased activation:retina RGD PMID:18369072 RGD:2311244 NCBI chrNW_004936474:3,178,097...3,196,130 JBrowse link
G Cat catalase ISO protein:decreased expression:retina RGD PMID:21314438 RGD:5130875 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 severity ISO protein:increased expression:serum
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor		 RGD PMID:16249511 PMID:18978347 RGD:2307061 RGD:2307104 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccn2 cellular communication network factor 2 ISO associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat) RGD PMID:19450451 RGD:2314507 NCBI chrNW_004936560:42,561...45,748
Ensembl chrNW_004936560:42,537...45,807 		JBrowse link
G Cd34 CD34 molecule ISO mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chrNW_004936557:5,030,788...5,051,864
Ensembl chrNW_004936557:5,030,441...5,051,868 		JBrowse link
G Cd59 CD59 molecule (CD59 blood group) ISO protein:decreased expression:retina RGD PMID:12453906 RGD:1600487 NCBI chrNW_004936533:4,242,589...4,263,136 JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1 like 1 disease_progression ISO DNA:SNP:intron: (rs7756992) (human) RGD PMID:28821857 RGD:401850599 NCBI chrNW_004936552:5,903,042...6,347,498
Ensembl chrNW_004936552:5,833,409...6,347,017 		JBrowse link
G Cfb complement factor B no_association ISO associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs1048709 (human)
associated with Diabetes Mellitus, Type 2;DNA:SNP: :rs537160, rs4151657, rs2072633 (human)		 RGD PMID:23864767 RGD:7365019 NCBI chrNW_004936727:1,595,872...1,602,274
Ensembl chrNW_004936727:1,595,499...1,602,215 		JBrowse link
G Cldn1 claudin 1 treatment ISO RGD PMID:25685822 RGD:11341734 NCBI chrNW_004936578:98,489...113,125
Ensembl chrNW_004936578:98,273...113,153 		JBrowse link
G Clu clusterin treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:19875648 RGD:9068395 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Crp C-reactive protein ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:20012460 RGD:8547537 NCBI chrNW_004936740:885,855...888,854
Ensembl chrNW_004936740:883,272...890,606 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:17194635 RGD:2311361 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 severity ISO protein:increased expression:vitreous humor RGD PMID:15630447 RGD:2306559 NCBI chrNW_004936617:4,224,131...4,239,080
Ensembl chrNW_004936617:4,224,131...4,238,796 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 severity ISO mRNA,protein:increased expression:retina: RGD PMID:30787185 PMID:34362349 RGD:155663348 RGD:155663356 NCBI chrNW_004936471:4,320,235...4,330,251
Ensembl chrNW_004936471:4,320,933...4,330,253 		JBrowse link
G Edn1 endothelin 1 ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:increased secretion:plasma
mRNA:increased expression:retina (rat)
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism:exon:p.K198N (human)		 RGD PMID:18806884 PMID:19293263 PMID:20628425 RGD:2313279 RGD:2313281 RGD:9068929 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Egfr epidermal growth factor receptor treatment ISO protein:increased expression:retina
associated with Diabetes Mellitus, Experimental		 RGD PMID:7947554 PMID:23831329 RGD:10059675 RGD:1580957 NCBI chrNW_004936678:365,005...560,546
Ensembl chrNW_004936678:365,834...436,528 		JBrowse link
G Eln elastin ISO RGD PMID:11707314 RGD:9585734 NCBI chrNW_004936543:3,135,169...3,165,023 JBrowse link
G Eng endoglin ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased expression:plasma,vitreous body RGD PMID:16202216 RGD:1580961 NCBI chrNW_004936487:15,467,165...15,499,180
Ensembl chrNW_004936487:15,467,835...15,477,488 		JBrowse link
G Ep300 E1A binding protein p300 ISO associated with Diabetes Mellitus, Experimental RGD PMID:21885871 RGD:7349382 NCBI chrNW_004936492:696,982...778,132
Ensembl chrNW_004936492:696,960...778,138 		JBrowse link
G Epo erythropoietin susceptibility ISO associated with Diabetes Mellitus, Experimental
protein:increased expression:serum,vitreous body
DNA:snp:promoter:-1125T>G(rs1617640)(human)		 RGD PMID:18235022 PMID:18458324 PMID:18670462 PMID:24508793 RGD:10400906 RGD:2313837 RGD:2313838 RGD:2313890 NCBI chrNW_004936543:742,722...745,332
Ensembl chrNW_004936543:743,537...745,343 		JBrowse link
G F13a1 coagulation factor XIII A chain ISO protein:increased expression:optic choroid vascular plexus: RGD PMID:11375345 RGD:8693344 NCBI chrNW_004936534:6,199,066...6,360,374
Ensembl chrNW_004936534:6,199,066...6,361,476 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression:aqueous humor,serum RGD PMID:12417540 RGD:2313865 NCBI chrNW_004936537:4,637,028...4,647,915
Ensembl chrNW_004936537:4,636,667...4,647,916 		JBrowse link
G F7 coagulation factor VII ISO associated with Diabetes Mellitus, Insulin-Dependent; protein:increased activity:plasma (human) RGD PMID:10837382 RGD:2312398 NCBI chrNW_004936472:505,751...515,375
Ensembl chrNW_004936472:505,751...514,339 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 treatment ISO RGD PMID:17143550 PMID:18174522 RGD:10402119 RGD:2313721 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G Fuca1 alpha-L-fucosidase 1 ISO associated with Diabetes Mellitus, Experimental;protein:increased activity:retina RGD PMID:10353622 RGD:2315932 NCBI chrNW_004936474:8,995,525...9,012,396
Ensembl chrNW_004936474:8,996,129...9,012,310 		JBrowse link
G Gad2 glutamate decarboxylase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21412422 NCBI chrNW_004936484:1,737,806...1,810,378
Ensembl chrNW_004936484:1,737,520...1,810,398 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO associated with Diabetes Mellitus, Experimental RGD PMID:18852331 RGD:2315975 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Gc GC vitamin D binding protein ISO protein:increased expression:vitreous body RGD PMID:16080911 RGD:2315548 NCBI chrNW_004936598:3,220,029...3,256,091
Ensembl chrNW_004936598:3,219,991...3,261,629 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO associated with Diabetes Mellitus,Insulin-Dependent;protein:increased activity:serum RGD PMID:11311965 RGD:2315614 NCBI chrNW_004936619:762,278...791,610 JBrowse link
G Glo1 glyoxalase I ISO DNA:SNP:promoter:-7C>T (human) RGD PMID:21738003 RGD:7242569 NCBI chrNW_004936476:20,910,696...20,928,583
Ensembl chrNW_004936476:20,910,629...20,930,295 		JBrowse link
G Glul glutamate-ammonia ligase treatment ISO associated with Experimental Diabetes Mellitus RGD PMID:34133251 RGD:401794594 NCBI chrNW_004936481:7,293,301...7,301,416
Ensembl chrNW_004936481:7,293,091...7,306,202 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO mRNA:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chrNW_004936711:640,002...642,580
Ensembl chrNW_004936711:639,905...642,622 		JBrowse link
G Hey2 hes related family bHLH transcription factor with YRPW motif 2 ISO mRNA:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chrNW_004936639:3,705,225...3,714,696
Ensembl chrNW_004936639:3,703,447...3,716,820 		JBrowse link
G Hfe homeostatic iron regulator ISO associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.C282Y (human) RGD PMID:15347835 RGD:8694362 NCBI chrNW_004936671:1,940,079...1,947,574
Ensembl chrNW_004936671:1,940,101...1,947,580 		JBrowse link
G Hgf hepatocyte growth factor disease_progression ISO associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum RGD PMID:15525877 PMID:18335393 RGD:2313565 RGD:8548539 NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha severity
treatment		 ISO protein:increased expression:retina, vascular endothelial cell (human)
associated with Diabetes Mellitus, Experimental;protein:increased expression:retina (rat)		 RGD PMID:17229797 PMID:20515763 PMID:22110070 RGD:7364887 RGD:8694462 RGD:8696025 NCBI chrNW_004936495:5,770,988...5,816,157
Ensembl chrNW_004936495:5,770,669...5,816,157 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO RGD PMID:14988264 RGD:1358731 NCBI chrNW_004936888:375,372...378,125
Ensembl chrNW_004936888:375,377...377,958 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K469E (human)
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:10485912 PMID:18834676 PMID:18942221 PMID:25066112 RGD:11354984 RGD:2313471 RGD:2313472 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Igf1 insulin like growth factor 1 susceptibility ISO protein:decreased expression:serum RGD PMID:16873705 PMID:17194636 RGD:1598424 RGD:2313764 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
G Igf1r insulin like growth factor 1 receptor disease_progression ISO mRNA:increased expression:retina: RGD PMID:12781065 RGD:10046008 NCBI chrNW_004936483:4,563,995...4,860,231
Ensembl chrNW_004936483:4,564,512...4,852,925 		JBrowse link
G Il10 interleukin 10 susceptibility ISO associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor		 RGD PMID:16696964 PMID:18978347 PMID:18988929 PMID:22105495 RGD:1598486 RGD:2307061 RGD:2307272 RGD:7364856 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il18 interleukin 18 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum RGD PMID:16260350 PMID:19011009 RGD:4889417 RGD:8655907 NCBI chrNW_004936612:2,306,963...2,325,086
Ensembl chrNW_004936612:2,306,875...2,325,189 		JBrowse link
G Il1a interleukin 1 alpha ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased tyrosine phosphorylation:vitreous humor RGD PMID:18978347 RGD:2307061 NCBI chrNW_004936783:1,210,715...1,218,315
Ensembl chrNW_004936783:1,210,809...1,218,315 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:serum, vitreous humour
associated with Diabetes Mellitus, Type 2; protein:decreased tyrosine phosphorylation:vitreous humor		 RGD PMID:16284605 PMID:18978347 RGD:2307061 RGD:7401212 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il6 interleukin 6 susceptibility ISO associated with Diabetes Mellitus; DNA:polymorphism:promoter:-174G>C (human)
associated with Diabetes Mellitus, Type1;DNA:polymorphism:promoter:-174G>C(human)
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
associated with Diabetes Mellitus, Typpe 1;protein:increased expression:serum:		 RGD PMID:17725274 PMID:18988929 PMID:19140096 PMID:19542902 RGD:2307267 RGD:2307272 RGD:7829749 RGD:7829816 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Ins insulin ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22046295 PMID:30463601 RGD:6902909 NCBI chrNW_004936816:1,002,137...1,003,357
Ensembl chrNW_004936816:1,002,137...1,003,357 		JBrowse link
G Insr insulin receptor ISO MouseDO NCBI chrNW_004936588:4,345,306...4,453,380
Ensembl chrNW_004936588:4,345,306...4,453,668 		JBrowse link
G Itga2 integrin subunit alpha 2 severity
susceptibility
no_association		 ISO associated with Diabetes Mellitus; DNA:transition:cds:807C>T (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS7+3160A>G (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:intron:IVS8-1059T>C (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:cds:c.807T>C (human)		 RGD PMID:12540964 PMID:18806884 PMID:21632096 PMID:23776381 RGD:2307419 RGD:2313281 RGD:7777103 RGD:8686431 NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786 		JBrowse link
G Itga4 integrin subunit alpha 4 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:19553613 RGD:9698417 NCBI chrNW_004936509:10,215,283...10,293,653
Ensembl chrNW_004936509:10,215,283...10,292,252 		JBrowse link
G Itgam integrin subunit alpha M ISO mRNA, protein:increased expression:retina (rat) RGD PMID:33614447 RGD:329901937 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Itgb3 integrin subunit beta 3 ISO protein:increased expression:optic choroid vascular plexus: RGD PMID:11375345 RGD:8693344 NCBI chrNW_004936541:2,822,789...2,871,069
Ensembl chrNW_004936541:2,815,738...2,871,035 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO mRNA,protein:increased expression:retina: RGD PMID:30787185 RGD:155663348 NCBI chrNW_004936485:8,857,688...8,894,270
Ensembl chrNW_004936485:8,857,669...8,895,315 		JBrowse link
G Kcnj10 potassium inwardly rectifying channel subfamily J member 10 treatment ISO associated with Diabetes Mellitus, Experimental RGD PMID:21672350 PMID:22143324 RGD:8662869 RGD:8662907 NCBI chrNW_004936740:555,948...589,219
Ensembl chrNW_004936740:555,998...586,353 		JBrowse link
G Kdm1a lysine demethylase 1A ISO mRNA:increased expression:retina (human)
mRNA, protein:increased expression:retina (rat)		 RGD PMID:23423566 RGD:8547881 NCBI chrNW_004936474:8,262,913...8,319,089
Ensembl chrNW_004936474:8,262,885...8,319,092 		JBrowse link
G Keap1 kelch like ECH associated protein 1 ISO associated with Diabetes Mellitus, Experimental;mRNA, protein:increased expression:retina RGD PMID:23633659 RGD:10412733 NCBI chrNW_004936659:785,059...793,775
Ensembl chrNW_004936659:782,340...793,688 		JBrowse link
G LOC101967032 cytochrome b-245 light chain ISO associated with Diabetes Mellitus, Experimental RGD PMID:19685553 RGD:2317854 NCBI chrNW_004936641:1,036,967...1,044,954
Ensembl chrNW_004936641:1,036,967...1,044,991 		JBrowse link
G LOC101968921 angiotensin-converting enzyme no_association
susceptibility		 ISO associated with Diabetes Mellitus, Type 1;DNA:deletion:intron:IVS16+1464-1751del (human)
associated with Diabetes Mellitus, Type 2;protein:increased expression:serum (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:g.2350G>A (rs4343) (human)
associated with Diabetes Mellitus, Type 2;DNA:deletion:intron:IVS16+1464-1751del (human)		 RGD PMID:2157294 PMID:7729604 PMID:11106834 PMID:23065222 RGD:7829780 RGD:7829783 RGD:7829794 RGD:8142360 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G LOC101969021 somatotropin ISO RGD PMID:3183302 RGD:2315688 NCBI chrNW_004936541:4,524,397...4,528,234 JBrowse link
G LOC101973421 amine oxidase copper containing 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:11522499 RGD:2313826 NCBI chrNW_004936490:17,549,836...17,564,867 JBrowse link
G Lta lymphotoxin alpha susceptibility
no_association		 ISO associated with Diabetes Mellitus, Type 2;DNA:polymorphism:
associated with Diabetes Mellitus, Type 2;DNA:polymorphism:intron, exon:252A>G, 804C>A (human)		 RGD PMID:11399938 PMID:16979413 RGD:8548772 RGD:8548797 NCBI chrNW_004936727:1,940,081...1,941,022
Ensembl chrNW_004936727:1,940,081...1,941,022 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO associated with type 2 diabetes mellitus;DNA:increased expression:plasma (human) RGD PMID:33221518 RGD:242905212 NCBI chrNW_004936483:15,533,264...15,534,576
Ensembl chrNW_004936483:15,533,522...15,534,576 		JBrowse link
G Mfn2 mitofusin 2 ISO associated with Diabetes Mellitus, Experimental;mRNA, protein:decreased expression:retina (rat) RGD PMID:28487236 RGD:12910715 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:increased expression:plasma RGD PMID:12714657 PMID:18552985 RGD:1582582 RGD:8547849 NCBI chrNW_004936475:7,801,356...7,825,831
Ensembl chrNW_004936475:7,801,277...7,825,851 		JBrowse link
G Mmp9 matrix metallopeptidase 9 disease_progression ISO associated with Diabetes Mellitus, Type 2
associated with Diabetes Mellitus, Experimental		 RGD PMID:10374894 PMID:16643893 PMID:21933988 RGD:1582616 RGD:8547815 RGD:8547857 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO associated with Diabetes Mellitus, Type 2; DNA:transition:cds:g.677C>T (human) RGD PMID:9040583 RGD:6893525 NCBI chrNW_004936474:623,438...637,849
Ensembl chrNW_004936474:623,291...638,193 		JBrowse link
G Mysm1 Myb like, SWIRM and MPN domains 1 susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:snps:introns: IVS1-1269C>T, IVS6+1700G>A (rs2811893, rs12092121) (human) RGD PMID:21310492 RGD:9589162 NCBI chrNW_004936522:3,105,018...3,143,215
Ensembl chrNW_004936522:3,104,996...3,144,087 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO associated with Diabetes Mellitus, Experimental;protein:decreased activity:retina RGD PMID:23633659 RGD:10412733 NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262 		JBrowse link
G Ngf nerve growth factor ISO protein:increased expression:serum
associated with Experimental Diabetes Mellitus		 RGD PMID:18282491 PMID:24030532 RGD:405100241 RGD:7242804 NCBI chrNW_004936627:635,784...641,290
Ensembl chrNW_004936627:635,788...645,364 		JBrowse link
G Nos1 nitric oxide synthase 1 ISO mRNA, protein:decreased expression:retina RGD PMID:17545029 RGD:1642141 NCBI chrNW_004936558:5,162,471...5,302,488
Ensembl chrNW_004936558:5,233,459...5,301,414 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment
susceptibility
onset
no_association
severity		 ISO associated with Diabetes Mellitus, Type 1;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental
associated with Diabetes Mellitus, Type 2;DNA:snps, duplication, haplotype:promoter, cds, intron:g.-786T>C, p.E298N, IVS4?-?+27 (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:exon:c.894G>T (human)
DNA:snps:promoter, exon:c.-786T>C, c.774C>T (human)
associated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina (rat)		 RGD PMID:11918626 PMID:15890549 PMID:16581274 PMID:17558849 PMID:17973941 More... RGD:7421531 RGD:7421532 RGD:7421533 RGD:7771565 RGD:7771568 RGD:7771569 RGD:7771606 RGD:7775042 RGD:7777101 RGD:7777103 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Notch1 notch receptor 1 treatment ISO RGD PMID:30787185 RGD:155663348 NCBI chrNW_004936669:1,292,016...1,334,061
Ensembl chrNW_004936669:1,292,088...1,332,428 		JBrowse link
G Nppa natriuretic peptide A ISO protein:increased expression:vitreous humor RGD PMID:15273657 RGD:2313589 NCBI chrNW_004936474:671,362...673,610 JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO mRNA:decreased expression:retina (rat) RGD PMID:15789000 RGD:1580773 NCBI chrNW_004936518:8,093,111...8,158,862
Ensembl chrNW_004936518:8,093,561...8,158,868 		JBrowse link
G Nrp1 neuropilin 1 treatment ISO RGD PMID:26554379 RGD:401901170 NCBI chrNW_004936574:1,694,433...1,834,720
Ensembl chrNW_004936574:1,694,336...1,834,720 		JBrowse link
G Nutf2 nuclear transport factor 2 treatment ISO mRNA:decreased expression:peripheral blood: RGD PMID:19404486 RGD:9831377 NCBI chrNW_004936475:18,214,593...18,232,406
Ensembl chrNW_004936475:18,214,267...18,232,442 		JBrowse link
G Ocln occludin treatment ISO RGD PMID:25685822 RGD:11341734 NCBI chrNW_004936480:99,516...152,834
Ensembl chrNW_004936480:98,371...152,413 		JBrowse link
G Pgf placental growth factor ISO associated with Diabetes Mellitus, Type 2 RGD PMID:21408222 RGD:6483775 NCBI chrNW_004936488:4,098,187...4,111,108
Ensembl chrNW_004936488:4,098,225...4,111,142 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma ISO mRNA, protein:increased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chrNW_004936479:17,084,006...17,112,264
Ensembl chrNW_004936479:17,084,920...17,112,258 		JBrowse link
G Plk4 polo like kinase 4 treatment ISO RGD PMID:33416109 RGD:401850543 NCBI chrNW_004936642:2,837,041...2,855,369
Ensembl chrNW_004936642:2,837,022...2,855,103 		JBrowse link
G Pon1 paraoxonase 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:g.-907C>G (human)
associated with Diabetes Mellitus;DNA:missense mutation:cds:p.L55M (rs854560) (human)
associated with Diabetes Mellitus, Type 2;DNA:missense mutation:cds:p.Q192R (human)
associated with Diabetes Mellitus, Type 1;protein:decreased activity:serum (human)		 CTD
RGD		 PMID:9661650 PMID:15270786 PMID:16949520 PMID:20012460 PMID:24100645 RGD:2313272 RGD:8547537 RGD:8547548 RGD:8547572 NCBI chrNW_004936585:4,954,871...4,979,560
Ensembl chrNW_004936585:4,954,869...4,979,591 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO Retinal Leukostasis;associated with Diabetes Mellitus, Experimental RGD PMID:17003451 RGD:8552824 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO associated with Diabetes Mellitus, Experimental; mRNA:increased expression:retina (rat) RGD PMID:20566666 PMID:22003111 RGD:5686899 RGD:6484532 NCBI chrNW_004936477:4,881,230...5,488,208
Ensembl chrNW_004936477:5,199,881...5,488,226 		JBrowse link
G Pten phosphatase and tensin homolog ISO mRNA, protein:decreased expression:retina RGD PMID:31759996 RGD:41410819 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Rbp4 retinol binding protein 4 severity ISO protein:increased expression:blood plasma (human) RGD PMID:30135138 RGD:329849110 NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208 		JBrowse link
G Retn resistin ISO associated with Diabetes Mellitus, Type 2 RGD PMID:17303077 RGD:7207162 NCBI chrNW_004936588:4,705,295...4,706,653
Ensembl chrNW_004936588:4,705,119...4,706,656 		JBrowse link
G Robo1 roundabout guidance receptor 1 ISO mRNA,protein:increased expression:retina RGD PMID:28973045 RGD:243048421 NCBI chrNW_004936505:4,329,428...4,711,310
Ensembl chrNW_004936505:4,330,303...4,709,655 		JBrowse link
G Serpine1 serpin family E member 1 no_association
susceptibility		 ISO associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human)
associated with Diabetes Mellitus;repeat, snp:intron, 3' utr:g.7844(CA)1-6, ? (human)
associated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human)
associated with Diabetes Mellitus, Type 2;DNA:snp, deletion:promoter:g.-844G>A, g.-676_-674delG (human)		 RGD PMID:7974340 PMID:9201602 PMID:12660488 PMID:19419896 PMID:23281898 RGD:8547697 RGD:8547699 RGD:8547710 RGD:8547740 RGD:8547741 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Serpinf1 serpin family F member 1 severity ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:vitreous humor
associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:retina
protein:alternative form:vitreous humor
associated with Diabetes Mellitus, Insulin-Dependent;protein:increased expression:serum
associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:SNPs:promoter:g.-5740T>C, g.-5308G>A (rs12150053, rs12948385) (human)		 RGD PMID:15059706 PMID:16054135 PMID:17658465 PMID:18025835 PMID:18455830 More... RGD:1580135 RGD:2312337 RGD:2312341 RGD:2312344 RGD:2312346 RGD:2312348 NCBI chrNW_004936538:7,885,816...7,898,308
Ensembl chrNW_004936538:7,885,475...7,899,113 		JBrowse link
G Sgf29 SAGA complex associated factor 29 severity ISO associated with Diabetes Mellitus, Type 1; DNA:SNP:intron: rs10521145(human) RGD PMID:21441570 RGD:9587455 NCBI chrNW_004936501:12,008,601...12,024,113
Ensembl chrNW_004936501:12,008,425...12,028,239 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24894401 NCBI chrNW_004936521:10,296,097...10,316,673
Ensembl chrNW_004936521:10,296,097...10,322,215 		JBrowse link
G Slit2 slit guidance ligand 2 ISO mRNA,protein:increased expression:retina RGD PMID:28973045 RGD:243048421 NCBI chrNW_004936477:8,111,212...8,448,567
Ensembl chrNW_004936477:8,109,228...8,446,653 		JBrowse link
G Sod1 superoxide dismutase 1 ISO human gene in a mouse model
CTD Direct Evidence: therapeutic		 RGD
CTD		 PMID:19074809 RGD:8655572 NCBI chrNW_004936500:10,345,154...10,352,873
Ensembl chrNW_004936500:10,345,154...10,352,867 		JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 treatment ISO associated with type 2 diabetes mellitus RGD PMID:30096827 RGD:155631301 NCBI chrNW_004936471:33,224,174...33,245,076
Ensembl chrNW_004936471:33,224,859...33,245,030 		JBrowse link
G Thbs1 thrombospondin 1 ISO associated with Diabetes Mellitus, Experimental
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17117553 RGD:2317943 NCBI chrNW_004936471:3,064,466...3,081,125
Ensembl chrNW_004936471:3,064,422...3,081,949 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 ISO associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina RGD PMID:22003103 RGD:13463597 NCBI chrNW_004936588:4,902,462...4,917,081
Ensembl chrNW_004936588:4,902,424...4,917,081 		JBrowse link
G Tlr4 toll like receptor 4 onset ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.N299G (human) RGD PMID:19135114 RGD:2312487 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tnf tumor necrosis factor no_association
disease_progression		 ISO protein:increased expression:serum, vitreous humour
associated with Diabetes Mellitus, Type 2;DNA:polymorphism:promoter:-302A>G (human)
associated with Diabetes Mellitus, Type 1;protein:increased expression:platelet:		 RGD PMID:10540181 PMID:16284605 PMID:16979413 PMID:22105495 RGD:7364856 RGD:7394805 RGD:7401212 RGD:8548772 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Uts2 urotensin 2 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:plasma RGD PMID:18338983 RGD:2306795 NCBI chrNW_004936623:2,339,259...2,345,717
Ensembl chrNW_004936623:2,340,778...2,345,700 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:vitreous humor, serum RGD PMID:19237221 RGD:2312762 NCBI chrNW_004936748:785,491...802,791
Ensembl chrNW_004936748:785,455...803,048 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:15899948 RGD:1580363 NCBI chrNW_004936512:5,741,836...5,800,999
Ensembl chrNW_004936512:5,740,748...5,801,109 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA, protein:increased expression:retina
associated with Diabetes Mellitus, type 2; protein:increased expression:aqueous humor of eyeball:
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9852717 PMID:11978667 PMID:15788408 PMID:16636650 PMID:17513698 More... RGD:1580565 RGD:2301992 RGD:41410819 RGD:8547996 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
G Vps26a VPS26, retromer complex component A susceptibility ISO DNA:SNP:: (rs1802295) (Human) RGD PMID:28821857 RGD:401850599 NCBI chrNW_004936521:9,269,714...9,308,016
Ensembl chrNW_004936521:9,269,287...9,308,153 		JBrowse link
G Vtn vitronectin ISO associated with Diabetes Mellitus, Experimental RGD PMID:7536680 PMID:8804356 RGD:10040982 RGD:1580818 NCBI chrNW_004936538:4,522,275...4,525,245
Ensembl chrNW_004936538:4,522,074...4,525,336 		JBrowse link
G Vwf von Willebrand factor ISO RGD PMID:10077454 RGD:1580648 NCBI chrNW_004936709:1,578,137...1,741,877
Ensembl chrNW_004936709:1,579,096...1,741,754 		JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein susceptibility ISO DNA:SNP:: (rs10010131) (Human) RGD PMID:28821857 RGD:401850599 NCBI chrNW_004936477:18,339,915...18,364,973
Ensembl chrNW_004936477:18,339,827...18,364,998 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 susceptibility ISO DNA:SNP:cd: p.R399Q G>A (rs25487) (human) RGD PMID:30472145 RGD:401827275 NCBI chrNW_004936706:752,571...783,746
Ensembl chrNW_004936706:751,108...783,777 		JBrowse link
proliferative diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:aqueous humor RGD PMID:22563689 RGD:8694466 NCBI chrNW_004936578:3,168,599...3,179,369
Ensembl chrNW_004936578:3,168,331...3,171,928 		JBrowse link
G Ager advanced glycosylation end-product specific receptor ISO protein:increased expression:vitreous humor RGD PMID:16364297 RGD:8695978 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G Bcor BCL6 corepressor susceptibility ISO associated with type 1 diabetes mellitus;DNA:hypomethylation:5'UTR RGD PMID:26248552 RGD:155631276 NCBI chrNW_004936502:6,764,043...6,812,194
Ensembl chrNW_004936502:6,764,907...6,792,916 		JBrowse link
G Cald1 caldesmon 1 ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chrNW_004936579:868,681...1,046,198
Ensembl chrNW_004936579:868,500...1,046,257 		JBrowse link
G Calu calumenin ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chrNW_004936479:15,665,979...15,697,016
Ensembl chrNW_004936479:15,665,946...15,698,560 		JBrowse link
G Cat catalase ISO associated withDiabetes Mellitus, Type 2; mRNA,protein:decreased expression, decreased activity:blood,l serum: RGD PMID:24092995 RGD:9068931 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Ccn1 cellular communication network factor 1 ISO protein:increased expression:vitreous body (human) RGD PMID:22160564 RGD:329845551 NCBI chrNW_004936608:152,174...155,123
Ensembl chrNW_004936608:151,838...155,358 		JBrowse link
G Col5a2 collagen type V alpha 2 chain ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chrNW_004936506:8,739,475...8,873,073
Ensembl chrNW_004936506:8,822,517...8,870,836 		JBrowse link
G Col6a3 collagen type VI alpha 3 chain ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chrNW_004936525:905,419...983,486
Ensembl chrNW_004936525:921,725...983,377 		JBrowse link
G Coro1c coronin 1C ISO mRNA:increased expression:retina (human) RGD PMID:35692390 RGD:401851065 NCBI chrNW_004936769:555,719...637,420
Ensembl chrNW_004936769:553,642...637,008 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 disease_progression ISO protein:decreased expression:vitreous: RGD PMID:22864860 RGD:9685437 NCBI chrNW_004936470:26,994,549...27,099,758
Ensembl chrNW_004936470:26,994,215...27,100,999 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO protein:increased expression:vitreous: RGD PMID:22868384 RGD:10402118 NCBI chrNW_004936472:23,442,946...23,617,523
Ensembl chrNW_004936472:23,440,088...23,617,041 		JBrowse link
G Il6r interleukin 6 receptor ISO protein:increased expression:serum RGD PMID:17401618 RGD:10402814 NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 ISO protein:increased activity:serum: RGD PMID:28724746 RGD:151356966 NCBI chrNW_004936613:3,791,684...3,813,857
Ensembl chrNW_004936613:3,791,681...3,813,892 		JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO protein:increased expression:vitreous: RGD PMID:19799585 RGD:10449447 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma susceptibility
onset		 ISO DNA:snp:cds:p.P12A (rs1801282) (human)
associated with Diabetes Mellitus, Type 2;DNA:snp:promoter:c.-2819A>G (human)		 RGD PMID:18541841 PMID:19125195 PMID:23559865 RGD:2301854 RGD:8552820 RGD:8699508 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Ptpn1 protein tyrosine phosphatase non-receptor type 1 ISO protein:increased expression:vitreous humor (human) RGD PMID:33627831 RGD:401976389 NCBI chrNW_004936514:4,065,455...4,083,847
Ensembl chrNW_004936514:4,068,238...4,084,009 		JBrowse link
G Rbp4 retinol binding protein 4 disease_progression ISO protein:increased expression:blood serum (human) RGD PMID:20233518 RGD:329853306 NCBI chrNW_004936601:1,401,215...1,410,195
Ensembl chrNW_004936601:1,402,691...1,410,208 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility
disease_progression		 ISO associated with Diabetes Mellitus, Type 2;DNA:deletion:promoter:g.-676_-674delG (human)
protein:increased expression:plasma (human)		 RGD PMID:16416371 PMID:23304115 RGD:8699494 RGD:8699497 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Serpinf1 serpin family F member 1 treatment ISO protein:increased expression:vitreous fluid (human) RGD PMID:11723044 PMID:15059706 RGD:1580135 RGD:8554895 NCBI chrNW_004936538:7,885,816...7,898,308
Ensembl chrNW_004936538:7,885,475...7,899,113 		JBrowse link
G Slit2 slit guidance ligand 2 ISO associated with eye disease; protein:increased expression:vitreous RGD PMID:28973045 RGD:243048421 NCBI chrNW_004936477:8,111,212...8,448,567
Ensembl chrNW_004936477:8,109,228...8,446,653 		JBrowse link
G Srsf6 serine and arginine rich splicing factor 6 ISO DNA:snp:exon:p.P281P (rs2235611) (human) RGD PMID:21309690 RGD:11039452 NCBI chrNW_004936530:3,086,944...3,092,780
Ensembl chrNW_004936530:3,086,680...3,092,828 		JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 ISO mRNA:decreased expression:retina RGD PMID:22003103 RGD:13463597 NCBI chrNW_004936588:4,902,462...4,917,081
Ensembl chrNW_004936588:4,902,424...4,917,081 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO associated with Diabetes Mellitus, Type 2; protein:increased expression:retina RGD PMID:16054135 RGD:2312348 NCBI chrNW_004936476:16,245,134...16,261,180
Ensembl chrNW_004936476:16,247,100...16,260,673 		JBrowse link
severe nonproliferative diabetic retinopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfrb platelet derived growth factor receptor beta ISO MouseDO NCBI chrNW_004936504:4,762,251...4,799,789
Ensembl chrNW_004936504:4,762,184...4,799,829 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14117
      endocrine system disease 5609
        diabetes mellitus 1284
          Diabetes Complications 467
            diabetic angiopathy 175
              Diabetic Foot 14
              diabetic retinopathy + 144
Path 2
Term Annotations click to browse term
  disease 16465
    Developmental Disease 16381
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 16324
        genetic disease 16311
          inherited metabolic disorder 5214
            carbohydrate metabolic disorder 2562
              glucose metabolism disease 1424
                diabetes mellitus 1284
                  Diabetes Complications 467
                    diabetic angiopathy 175
                      Diabetic Foot 14
                      diabetic retinopathy + 144
paths to the root