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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:onchocerciasis
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Accession:DOID:11678 term browser browse the term
Definition:A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. (DO)
Synonyms:exact_synonym: Onchocerca volvulus infection;   Onchocerciases;   infection by Onchocerca volvulus;   volvulosis
 primary_id: MESH:D009855
 xref: EFO:0007402;   GARD:7252;   ICD10CM:B73;   ICD9CM:125.3;   NCI:C34861
For additional species annotation, visit the Alliance of Genome Resources.


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show annotations for term's descendants           Sort by:
onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL13 interleukin 13 severity ISO protein:increased expression:serum RGD PMID:22805723 RGD:8549600 NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
JBrowse link
G MHC-DPA1 major histocompatibility complex, class II, DP alpha 1 ISO RGD PMID:8854084 RGD:6480649 NCBI chr17:39,009,361...39,017,978 JBrowse link
G MHC-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility ISO DNA:polymorphisms: :HLA-DQA1*0401, HLA-DQA1*0102,HLA-DQA1*0103; RGD PMID:22117902 RGD:8547660 NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871
JBrowse link
Ocular Onchocerciasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1R1 interleukin 1 receptor type 1 ISO RGD PMID:19168746 RGD:8662882 NCBI chr14:5,781,486...5,852,872
Ensembl chr14:5,781,479...5,855,942
JBrowse link
G TLR4 toll like receptor 4 ISO RGD PMID:11884755 RGD:7794682 NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15415
    sensory system disease 6934
      skin disease 4058
        filariasis 7
          onchocerciasis 5
            Ocular Onchocerciasis 2
Path 2
Term Annotations click to browse term
  disease 15415
    Pathological Conditions, Signs and Symptoms 12061
      Signs and Symptoms 10141
        Neurologic Manifestations 9818
          sensory system disease 6934
            skin disease 4058
              Infectious Skin Diseases 268
                Parasitic Skin Diseases 66
                  onchocerciasis 5
                    Ocular Onchocerciasis 2
paths to the root