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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pyelonephritis
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Accession:DOID:11400 term browser browse the term
Definition:Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.
Synonyms:exact_synonym: Necrotizing Pyelonephritis;   Pyelonephritides;   Pyelonephritis, Acute Necrotizing
 primary_id: MESH:D011704
 xref: EFO:1001141;   ICD10CM:N16;   ICD9CM:590.80;   NCI:C34965
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
pyelonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme ISO protein:decreased expression:kidney, brush border epithelial cell (human) RGD PMID:10504496 RGD:8158033 NCBI chr10:91,410,129...91,430,246 JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO RGD PMID:19205372 RGD:6904156 NCBI chr 5:76,568,094...76,578,416 JBrowse link
G B2m beta-2 microglobulin IEP protein:increased expression:urine RGD PMID:21797109 RGD:6482315 NCBI chr 3:129,549,236...129,555,354 JBrowse link
G Bmp7 bone morphogenetic protein 7 IEP protein:decreased expression:kidney RGD PMID:16034630 RGD:2289039 NCBI chr 3:182,059,318...182,135,273 JBrowse link
G Calca calcitonin-related polypeptide alpha ISO RGD PMID:15286264 RGD:7205498 NCBI chr 1:178,312,636...178,317,588 JBrowse link
G Cfb complement factor B ISO associated with pregnancy complications;protein:increased activity:plasma RGD PMID:20218820 RGD:7242756 NCBI chr20:3,970,643...3,976,510 JBrowse link
G Crp C-reactive protein IEP RGD PMID:21797109 RGD:6482315 NCBI chr13:87,694,062...87,695,978 JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 ISO DNA:SNP: :2608G>C (human)
DNA:mutations, polymorphisms: :multiple
RGD PMID:22325052 PMID:17786197 RGD:7207860, RGD:7207864 NCBI chr 9:83,216,040...83,220,225 JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO RGD PMID:21814172 RGD:7257675 NCBI chr 9:75,729,493...75,735,868 JBrowse link
G Cyb5a cytochrome b5 type A IEP RGD PMID:9848217 RGD:1599663 NCBI chr18:78,213,067...78,245,677 JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:urine (human) RGD PMID:8640042 RGD:6907372 NCBI chr 3:27,509,836...27,525,738 JBrowse link
G Il3 interleukin 3 IEP mRNA:increased expression:kidney RGD PMID:18214547 RGD:2317665 NCBI chr10:38,906,460...38,908,810 JBrowse link
G Pgf placental growth factor ISO protein:decreased expression:plasma RGD PMID:20213923 RGD:6483586 NCBI chr 6:110,547,165...110,557,747 JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23565217 NCBI chr20:7,556,496...7,560,747 JBrowse link
G Retn resistin ISO protein:increased expression:plasma RGD PMID:20178460 RGD:7207160 NCBI chr12:6,508,653...6,511,115 JBrowse link
G Tlr1 toll-like receptor 1 susceptibility ISO DNA:snp:cds:p.S602I (human) RGD PMID:19543401 RGD:7246906 NCBI chr14:43,737,761...43,750,389 JBrowse link
acute pyelonephritis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcr2 C-X-C motif chemokine receptor 2 susceptibility ISO DNA:polymorphism: :1208C>T (human) RGD PMID:22325052 RGD:7207860 NCBI chr 9:75,729,493...75,735,868 JBrowse link
G Rbp4 retinol binding protein 4 ISO protein:decreased expression:blood plasma (human) RGD PMID:20163326 RGD:329853301 NCBI chr 1:235,893,917...235,901,315 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    Pathological Conditions, Signs and Symptoms 13623
      Pathologic Processes 8325
        Inflammation 2843
          nephritis 496
            pyelitis 17
              pyelonephritis 17
                acute pyelonephritis 2
                chronic pyelonephritis + 0
                xanthogranulomatous pyelonephritis 0
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18450
      Urogenital Diseases 5391
        urinary system disease 2832
          kidney disease 2580
            nephritis 496
              interstitial nephritis 42
                pyelonephritis 17
                  acute pyelonephritis 2
                  chronic pyelonephritis + 0
                  xanthogranulomatous pyelonephritis 0
paths to the root