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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:adult respiratory distress syndrome
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Accession:DOID:11394 term browser browse the term
Definition:A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. (DO)
Synonyms:exact_synonym: ARDS;   ARDSs, Human;   Acute Respiratory Distress Syndrome;   Human ARDS;   Shock Lung;   adult RDS;   non-cardiogenic pulmonary edema
 primary_id: MESH:D012128
 xref: EFO:1000637;   GARD:5698;   ICD10CM:J80;   NCI:C3353
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
adult respiratory distress syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD PMID:12204859 PMID:22009550 PMID:15118671 RGD:1331525 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22009550 NCBI chr  X:33,925,458...33,972,851
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Aco2 aconitase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP protein:increased expression:lung RGD PMID:16456142 RGD:1625343 NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Alad aminolevulinate dehydratase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alb albumin ISO CTD Direct Evidence: therapeutic CTD PMID:12394941 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor ISO RGD PMID:15710155 RGD:6904148 NCBI chr 5:81,583,621...81,593,938
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G C3 complement C3 ISO protein:increased activation:respiratory system fluid/secretion
protein:increased expression:plasma		 RGD PMID:3826891 PMID:2784515 RGD:5130153, RGD:5129694 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C3ar1 complement C3a receptor 1 treatment IMP RGD PMID:16782534 RGD:2303017 NCBI chr 4:157,747,419...157,756,609
Ensembl chr 4:156,075,389...156,084,701 		JBrowse link
G C5 complement C5 ISO
IDA		 protein:increased activation:respiratory system fluid/secretion
associated with Burns (epidermis)
associated with Sepsis;protein:increased activation:plasma		 RGD PMID:3826891 PMID:10486240 PMID:3264125 RGD:5130153, RGD:1600658, RGD:5130150 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C5ar1 complement C5a receptor 1 treatment IMP RGD PMID:16782534 RGD:2303017 NCBI chr 1:86,077,309...86,088,001 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ces3a carboxylesterase 3a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr19:49,902,312...49,910,484 JBrowse link
G Chpt1 choline phosphotransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16292752 NCBI chr 7:24,753,880...24,802,529
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IMP RGD PMID:9288136 RGD:2311389 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 ISO RGD PMID:8810593 RGD:4143190 NCBI chr14:17,594,959...17,596,417
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cyb5a cytochrome b5 type A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Ebf1 EBF transcription factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr10:29,597,221...29,990,571
Ensembl chr10:29,099,933...29,487,665 		JBrowse link
G Edn1 endothelin 1 treatment IEP
ISO
IDA		 protein:increased secretion:plasma (rat)
CTD Direct Evidence: marker/mechanism
protein:increased secretion:plasma (human)		 CTD
RGD		 PMID:16625121 PMID:1618274 PMID:16741035 PMID:8256914 RGD:4145073, RGD:8662284, RGD:4145079 NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egr1 early growth response 1 ISO protein:increased expression:lung (mouse) RGD PMID:16713977 RGD:5131902 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif2ak1 eukaryotic translation initiation factor 2 alpha kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr12:15,824,431...15,858,266
Ensembl chr12:10,705,874...10,744,573 		JBrowse link
G F3 coagulation factor III, tissue factor ISO protein:increased expression:plasma RGD PMID:10528607 RGD:11340213 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fbln5 fibulin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 6:126,664,100...126,742,847
Ensembl chr 6:120,899,224...120,977,755 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242 		JBrowse link
G G8 G8 gene EXP CTD Direct Evidence: marker/mechanism CTD PMID:25070658
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948 		JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr15:46,147,878...46,152,086
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581 		JBrowse link
G Hmox1 heme oxygenase 1 susceptibility ISO DNA:polymorphism:promoter RGD PMID:19526221 RGD:4145346 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 IDA RGD PMID:12235111 RGD:5688755 NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Icam1 intercellular adhesion molecule 1 severity ISO protein:increased secretion:plasma (human) RGD PMID:19858233 RGD:4145485 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifrd1 interferon-related developmental regulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 6:62,996,560...63,044,996
Ensembl chr 6:57,269,384...57,288,990 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:135,154,919...135,159,550
Ensembl chr 7:133,276,234...133,280,966 		JBrowse link
G Il10 interleukin 10 treatment IEP associated with Sepsis RGD PMID:22037734 RGD:11049486 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il15 interleukin 15 ISO associated with Influenza;protein:increased expression:serum RGD PMID:21062445 RGD:5128683 NCBI chr19:42,536,160...42,611,349
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il1b interleukin 1 beta disease_progression ISO protein:increased expression:lung
protein:increased expression:bronchioalveolar lavage fluid (human)		 RGD PMID:18065658 PMID:8810593 RGD:4142869, RGD:4143190 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist disease_progression ISO
IDA		 RGD PMID:8686976 PMID:22810359 PMID:8810593 RGD:4143191, RGD:6909177, RGD:4143190 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il9 interleukin 9 ISO associated with Influenza;protein:increased expression:serum RGD PMID:21062445 RGD:5128683 NCBI chr17:8,117,028...8,120,151
Ensembl chr17:8,111,772...8,114,895 		JBrowse link
G Lcn2 lipocalin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lct lactase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr13:42,334,347...42,376,872
Ensembl chr13:39,781,929...39,824,456 		JBrowse link
G Lep leptin disease_progression ISO respiratory system fluid/secretion RGD PMID:21317313 RGD:5128773 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lim2 lens intrinsic membrane protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 1:102,974,188...102,980,358
Ensembl chr 1:93,837,597...93,843,769 		JBrowse link
G Lta lymphotoxin alpha ISO DNA:polymorhpism:blood: RGD PMID:16135717 RGD:4143247 NCBI chr20:3,622,291...3,625,852
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Mbl2 mannose binding lectin 2 susceptibility ISO DNA:missense mutation:exon:p.G54N (human) RGD PMID:17133182 RGD:4889476 NCBI chr 1:237,429,873...237,465,567 JBrowse link
G Mdh1 malate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mfn1 mitofusin 1 treatment IEP RGD PMID:27830717 RGD:12910765 NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Mir126a microRNA 126a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 3:29,813,150...29,813,267
Ensembl chr 3:9,415,063...9,415,180 		JBrowse link
G Mir127 microRNA 127 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 6:134,328,454...134,328,550
Ensembl chr 6:128,546,215...128,546,311 		JBrowse link
G Mir128-2 microRNA 128-2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 8:120,963,795...120,963,878
Ensembl chr 8:112,085,467...112,085,550 		JBrowse link
G Mir135b microRNA 135b ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr13:46,191,018...46,191,114
Ensembl chr13:43,638,857...43,638,953 		JBrowse link
G Mir155 microRNA 155 ISO associated with sepsis;miRNA:increased expression:lung RGD PMID:28125526 RGD:24922218 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir18a microRNA 18a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir19a microRNA 19a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr15:98,588,131...98,588,212
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir210 microRNA 210 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 1:205,755,923...205,756,032
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:Bronchoalveolar lavage RGD PMID:28931657 RGD:21408568 NCBI chr  X:65,151,383...65,151,492
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mir26a microRNA 26a EXP CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir30a microRNA 30a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 9:33,233,941...33,234,011
Ensembl chr 9:25,737,600...25,737,670 		JBrowse link
G Mir30b microRNA 30b ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:102,021,543...102,021,629
Ensembl chr 7:100,132,589...100,132,675 		JBrowse link
G Mir337 microRNA 337 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 6:134,321,142...134,321,238
Ensembl chr 6:128,538,902...128,538,998 		JBrowse link
G Mir344-1 microRNA 344-1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 1:124,718,754...124,718,851 JBrowse link
G Mir346 microRNA 346 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr16:10,224,300...10,224,397
Ensembl chr16:10,218,118...10,218,215 		JBrowse link
G Mir349 microRNA 349 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:122,122,951...122,123,047
Ensembl chr 7:120,243,311...120,243,407 		JBrowse link
G Mir99a microRNA 99a ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr11:29,687,392...29,687,472
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mirlet7b microRNA let-7b ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:118,684,038...118,684,122
Ensembl chr 7:116,804,186...116,804,270 		JBrowse link
G Mirlet7d microRNA let-7d ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr17:16,322,260...16,322,357
Ensembl chr17:16,115,893...16,115,990 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:lung RGD PMID:21211006 RGD:5129208 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mt2 metallothionein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mt3 metallothionein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO associated with critical illness; protein:increased expression:plasma RGD PMID:16779848 RGD:5131171 NCBI chr 2:176,933,312...176,938,497
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Mylk myosin light chain kinase ISO DNA:missense mutations, silent mutation:CDS:p.H21P, p.P147S, p.T335T (human) RGD PMID:18828194 RGD:4891491 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nppb natriuretic peptide B ISO associated with Ventilator-Induced Lung Injury;protein:increased expression:serum: RGD PMID:23837838 RGD:7247620 NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO RGD PMID:19741160 RGD:5683903 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdpn podoplanin IEP RGD PMID:11790662 RGD:2292244 NCBI chr 5:160,884,995...160,919,112
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:22173044 RGD:6482717 NCBI chr 5:156,359,725...156,362,302
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g4a phospholipase A2 group 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:10881173 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:61,877,813...62,022,266 		JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:17994220 RGD:4892109 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:plasma, respiratory system fluid/secretion : RGD PMID:8498526 RGD:401794588 NCBI chr14:17,586,495...17,587,299
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Prdx6 peroxiredoxin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr13:76,062,082...76,072,631
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Pros1 protein S ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr11:13,676,310...13,757,858
Ensembl chr11:230,696...311,286 		JBrowse link
G Psma4 proteasome 20S subunit alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 8:64,236,520...64,243,980
Ensembl chr 8:55,340,386...55,347,890 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO RGD PMID:22363101 RGD:6483444 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
G Ramp2 receptor activity modifying protein 2 IEP
ISO		 mRNA:decreased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:25070658 PMID:17068622 RGD:1642683 NCBI chr10:86,689,148...86,690,956
Ensembl chr10:86,188,812...86,231,829 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 ISO associated with avian influenza;mRNA, protein:increased expression, increased phosphorylation:lung (human) RGD PMID:31080811 RGD:127229928 NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G S100a4 S100 calcium-binding protein A4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254 		JBrowse link
G S100a9 S100 calcium binding protein A9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Septin5 septin 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr11:95,877,946...95,883,738
Ensembl chr11:82,369,754...82,379,393 		JBrowse link
G Serpina3n serpin family A member 3N IMP
ISO		 associated with pancreatitis
protein:increased expression:serum		 RGD PMID:8574716 PMID:2432615 RGD:5147448, RGD:5147458 NCBI chr 6:129,088,392...129,095,950
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpinc1 serpin family C member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8810955 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Serpine1 serpin family E member 1 ISO protein:increased expression:plasma
associated with Pneumonia, aspiration; protein:increased expression:Bronchoalveolar Lavage Fluid		 RGD PMID:17667242 PMID:16284739 RGD:4144037, RGD:4144039 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Serpinh1 serpin family H member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Sftpa1 surfactant protein A1 ISO protein:decreased expression:lung
protein:increased expression:serum		 RGD PMID:17662121 PMID:10588595 RGD:4143379, RGD:4143436 NCBI chr16:17,042,264...17,045,770
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sftpb surfactant protein B susceptibility ISO protein:increased expression:plasma
protein:decreased expression:lung
associated with Pneumonia;DNA:polymorphism: :1580C>T (human)
associated with Lung Injury;DNA:polymorphism:intron (human)		 RGD PMID:9351625 PMID:17662121 PMID:15190959 PMID:14718442 RGD:4143447, RGD:4143379, RGD:4143404, RGD:4143408 NCBI chr 4:105,917,495...105,926,631
Ensembl chr 4:104,359,396...104,368,436 		JBrowse link
G Sftpc surfactant protein C ISO protein:decreased expression:lung RGD PMID:17662121 PMID:9720777 RGD:4143379, RGD:4144159 NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777 		JBrowse link
G Sftpd surfactant protein D ISO protein:increased expression:serum RGD PMID:10588595 RGD:4143436 NCBI chr16:17,080,575...17,093,047
Ensembl chr16:17,046,483...17,059,927 		JBrowse link
G Slc25a11 solute carrier family 25 member 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr10:55,856,209...55,859,060
Ensembl chr10:55,357,597...55,360,410 		JBrowse link
G Sod2 superoxide dismutase 2 IEP
ISO		 mRNA:increased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:25070658 PMID:25070658 RGD:11035305 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tbxa2r thromboxane A2 receptor treatment IMP RGD PMID:1934328 RGD:11059533 NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176 		JBrowse link
G Thbd thrombomodulin IEP
ISO		 protein:decreased expression:lung
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12707536 PMID:12707536 RGD:1601651 NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr3 toll-like receptor 3 ISO RGD PMID:18849495 RGD:5129134 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:46,822,039...46,836,545 		JBrowse link
G Tlr5 toll-like receptor 5 ISO mRNA:decreased expression:lung (mouse) RGD PMID:12763043 RGD:5129557 NCBI chr13:97,166,430...97,190,642
Ensembl chr13:94,634,801...94,657,738 		JBrowse link
G Tlr9 toll-like receptor 9 ISO RGD PMID:17925007 RGD:5130709 NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:serum
associated lung injury; DNA:polymorphism:promoter:		 RGD PMID:21062445 PMID:16135717 RGD:5128683, RGD:4143247 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A severity ISO protein:increased expression:lung (mouse)
protein:increased expression:plasma (human)		 RGD PMID:21512145 PMID:21070800 PMID:21283009 RGD:5131206, RGD:5131145, RGD:5131096 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B severity ISO protein:increased expression:lung (mouse)
human protein in rat model		 RGD PMID:21512145 PMID:19916860 PMID:11159038 RGD:5131206, RGD:5131423, RGD:5131147 NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
G Tspan8 tetraspanin 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25070658 NCBI chr 7:53,331,019...53,365,402
Ensembl chr 7:51,445,074...51,479,356 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19139
    syndrome 11404
      adult respiratory distress syndrome 108
Path 2
Term Annotations click to browse term
  disease 19139
    disease of anatomical entity 18451
      respiratory system disease 5245
        lower respiratory tract disease 2361
          lung disease 2322
            respiratory failure 391
              adult respiratory distress syndrome 108
paths to the root