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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:Hantavirus hemorrhagic fever with renal syndrome
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Accession:DOID:11266 term browser browse the term
Definition:A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Orthohantavirus dobravaense, has_material_basis_in Orthohantavirus hantanense, has_material_basis_in Orthohantavirus puumalaense, has_material_basis_in Orthohantavirus seoulense, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom proteinuria, and has symptom renal failure. (DO)
Synonyms:exact_synonym: HFRS;   Puumala virus nephropathy;   Russian hemorrhagic fever;   epidemic hemorrhagic fever;   epidemic hemorrhagic fevers;   hemorrhagic fever with renal syndrome;   hemorrhagic nephroso nephritis;   hemorrhagic nephroso-nephritides;   hemorrhagic nephrosonephritis
 primary_id: MESH:D006480
 xref: EFO:0007299;   ICD10CM:A98.5;   ICD9CM:078.6;   NCI:C84753
For additional species annotation, visit the Alliance of Genome Resources.



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Hantavirus hemorrhagic fever with renal syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin severity IEP RGD PMID:14555823 RGD:11035280 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G APOC3 apolipoprotein C3 disease_progression IEP RGD PMID:20797315 RGD:7207210 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G CD163 CD163 molecule exacerbates IEP protein:increased expression:blood plasma (human)
protein:increased expression:CD14-positive, CD16-positive monocyte, blood plasma (human)
protein:increased expression:CD14-positive monocyte (human)
RGD PMID:25789628 PMID:25392926 PMID:29857122 RGD:127285679, RGD:127345131, RGD:127285683 NCBI chr12:7,470,811...7,503,777
Ensembl chr12:7,470,811...7,503,893
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 susceptibility IAGP DNA:polymorphism:cds:HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202 and HLA-DRB1*1305 (human) RGD PMID:25169964 RGD:40818303 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
JBrowse link
G HLA-DRB5 major histocompatibility complex, class II, DR beta 5 susceptibility IAGP DNA:polymorphism:cds:HLA-DRB5*0101-0201 (human) RGD PMID:25169964 RGD:40818303 NCBI chr 6:32,517,353...32,530,287
Ensembl chr 6:32,517,353...32,530,287
JBrowse link
G IFNG interferon gamma severity IEP protein:increased expression:serum RGD PMID:22613426 RGD:6893374 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL1RL1 interleukin 1 receptor like 1 severity IEP RGD PMID:25658420 RGD:40400702 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha IEP protein:increased expression:T cell RGD PMID:21436245 RGD:5147436 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL33 interleukin 33 severity IEP RGD PMID:25658420 RGD:40400702 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G ITGB3 integrin subunit beta 3 severity IEP protein:increased expression:platelet RGD PMID:18419255 RGD:6907404 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743
JBrowse link
Korean hemorrhagic fever term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXP3 forkhead box P3 ISO mRNA:increased expression:lung RGD PMID:17878294 RGD:2325989 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha treatment ISO RGD PMID:17878294 RGD:2325989 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
polyomavirus-associated nephropathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KIR3DS1 killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 susceptibility IAGP DNA:deletion (human) RGD PMID:23486513 RGD:150340577

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 40716
    syndrome 17691
      Hantavirus hemorrhagic fever with renal syndrome 12
        Balkan hemorrhagic fever 0
        Hantavirosis 0
        Korean hemorrhagic fever 2
        nephropathia epidemica 0
        polyomavirus-associated nephropathy 1
Path 2
Term Annotations click to browse term
  disease 40716
    disease by infectious agent 2735
      viral infectious disease 2056
        RNA Virus Infections 1744
          Bunyaviridae Infections 16
            Hantavirus Infections 13
              Hantavirus hemorrhagic fever with renal syndrome 12
                Balkan hemorrhagic fever 0
                Hantavirosis 0
                Korean hemorrhagic fever 2
                nephropathia epidemica 0
                polyomavirus-associated nephropathy 1
paths to the root