Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:intracranial aneurysm
go back to main search page
Accession:DOID:10941 term browser browse the term
Definition:Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)
Synonyms:exact_synonym: Anterior Cerebral Artery Aneurysm;   Anterior Communicating Artery Aneurysm;   Basilar Artery Aneurysm;   Basilar Artery Aneurysms;   Berry Aneurysm;   Berry Aneurysms;   Brain Aneurysm;   Brain Aneurysms;   Cerebral Aneurysm;   Cerebral Aneurysms;   Giant Intracranial Aneurysm;   Giant Intracranial Aneurysms;   Intracranial Aneurysms;   Intracranial Mycotic Aneurysm;   Intracranial Mycotic Aneurysms;   Middle Cerebral Artery Aneurysm;   Posterior Cerebral Artery Aneurysm;   Posterior Communicating Artery Aneurysm
 primary_id: MESH:D002532;   RDO:0001920
 xref: NCI:C34458
For additional species annotation, visit the Alliance of Genome Resources.

show annotations for term's descendants           Sort by:
intracranial aneurysm term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor ISO associated with Diabetes Mellitus, Experimental RGD PMID:23844137 RGD:8547935 NCBI chrNW_004936727:1,418,342...1,422,005 JBrowse link
G Aoc3 amine oxidase copper containing 3 ISO protein:decreased expression:cerebral artery RGD PMID:18312104 RGD:2313912 NCBI chrNW_004936490:17,549,836...17,564,867 JBrowse link
G Bcl2 BCL2 apoptosis regulator treatment ISO RGD PMID:25316629 RGD:11522723 NCBI chrNW_004936497:2,209,136...2,373,580 JBrowse link
G Col1a2 collagen type I alpha 2 chain ISO RGD PMID:14739420 RGD:1581199 NCBI chrNW_004936585:5,650,322...5,686,393 JBrowse link
G Col22a1 collagen type XXII alpha 1 chain susceptibility ISO DNA:SNPs:cds:multiple(human) RGD PMID:30541770 RGD:13831344 NCBI chrNW_004936470:11,762,312...11,994,041 JBrowse link
G Ctsk cathepsin K ISO protein:increased expression:brain, artery
mRNA:increased expression:brain, artery
RGD PMID:18635848 RGD:2306495 NCBI chrNW_004936580:1,022,762...1,038,020 JBrowse link
G Ctss cathepsin S ISO mRNA:increased expression:brain, artery
protein:increased expression:brain, artery
RGD PMID:18635848 RGD:2306495 NCBI chrNW_004936580:963,176...991,732 JBrowse link
G Eng endoglin ISO RGD PMID:10223461 RGD:1580964 NCBI chrNW_004936487:15,467,165...15,499,180 JBrowse link
G Fbn2 fibrillin 2 ISO ClinVar Annotator: match by term: Brain Aneurysm ClinVar PMID:16835936 PMID:19006240 PMID:25525159 PMID:25741868 PMID:26038974 PMID:28492532 NCBI chrNW_004936504:1,535,629...1,757,386 JBrowse link
G Mmp12 matrix metallopeptidase 12 no_association ISO RGD PMID:11546917 RGD:1582365 NCBI chrNW_004936551:5,107,567...5,117,843 JBrowse link
G Mmp14 matrix metallopeptidase 14 ISO RGD PMID:9724118 RGD:1582590 NCBI chrNW_004936722:1,447,189...1,457,632 JBrowse link
G Mmp2 matrix metallopeptidase 2 susceptibility ISO mRNA:increased expression:blood vessel RGD PMID:9724118 PMID:16961137 PMID:17569872 RGD:1582590 RGD:1582646 RGD:2290352 NCBI chrNW_004936475:7,801,356...7,825,831 JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment
ISO associated with Diabetes Mellitus, Experimental
mRNA:increased expression:blood vessel
mRNA, protein:increased expression:artery
RGD PMID:9310982 PMID:16961137 PMID:17122420 PMID:17569872 PMID:21937941 PMID:23844137 RGD:13204853 RGD:13204858 RGD:1582646 RGD:1642055 RGD:2290352 RGD:8547935 NCBI chrNW_004936514:7,038,240...7,045,873 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19381132 NCBI chrNW_004936543:3,617,369...3,630,990 JBrowse link
G Nos1 nitric oxide synthase 1 ISO RGD PMID:21321533 RGD:5131897 NCBI chrNW_004936558:5,162,471...5,302,488 JBrowse link
G Nos3 nitric oxide synthase 3 ISO RGD PMID:21321533 RGD:5131897 NCBI chrNW_004936527:6,427,147...6,445,770 JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting susceptibility ISO DNA:mutations:multiple (human)
ClinVar Annotator: match by term: Brain aneurysm
PMID:12842373 PMID:25741868 RGD:1580867 NCBI chrNW_004936694:1,923,383...1,958,160 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel susceptibility ISO DNA:mutations:multiple (human) RGD PMID:12842373 RGD:1580867 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Plau plasminogen activator, urokinase ISO RGD PMID:21786025 RGD:6483795 NCBI chrNW_004936521:5,238,128...5,243,829 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO RGD PMID:17569872 RGD:2290352 NCBI chrNW_004936502:13,345,936...13,350,170 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO mRNA:increased expression:blood vessel RGD PMID:17569872 RGD:2290352 NCBI chrNW_004936594:3,232,433...3,244,241 JBrowse link
G Tnf tumor necrosis factor treatment ISO RGD PMID:24628611 RGD:10450592 NCBI chrNW_004936727:1,936,066...1,937,766 JBrowse link
G Vcan versican ISO DNA:SNP: :rs173686 (human) RGD PMID:16917090 RGD:1598495 NCBI chrNW_004936469:2,585,142...2,688,029 JBrowse link
Intracranial Berry Aneurysm 12 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Thsd1 thrombospondin type 1 domain containing 1 ISO OMIM NCBI chrNW_004936565:4,925,400...4,952,210 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12006
    disease of anatomical entity 11571
      cardiovascular system disease 3154
        vascular disease 2269
          Aneurysm 141
            intracranial aneurysm 24
              intracranial berry aneurysm + 1
Path 2
Term Annotations click to browse term
  disease 12006
    disease of anatomical entity 11571
      nervous system disease 9482
        central nervous system disease 8007
          brain disease 7396
            cerebrovascular disease 737
              intracranial arterial disease 238
                cerebral arterial disease 188
                  intracranial aneurysm 24
                    intracranial berry aneurysm + 1
paths to the root