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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:lepromatous leprosy
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Accession:DOID:10887 term browser browse the term
Definition:A leprosy that results in early cutaneous lesions which consist of pale macules that are small, diffuse, and symmetric. This form of leprosy is characterized by hypoesthesia over extensor surfaces of the distal extremities, alopecia affecting lateral aspects of the eyebrows, saddle-nose deformity and oral lepromas. (DO)
Synonyms:exact_synonym: Cutaneous Leprosy;   cutaneous leprosies;   lepromatous leprosies;   nodular leprosies;   nodular leprosy;   type L leprosy
 primary_id: MESH:D015440
 xref: EFO:0001057;   ICD10CM:A30.5;   ICD9CM:030.0
For additional species annotation, visit the Alliance of Genome Resources.



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lepromatous leprosy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 severity ISO protein:decreased expression:serum RGD PMID:6342123 RGD:7411735 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228
JBrowse link
G CD163 CD163 molecule exacerbates ISO protein:increased expression:blood serum (human) RGD PMID:22851198 PMID:28355218 RGD:127345133 RGD:39939078 NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498
JBrowse link
G CFB complement factor B severity ISO RGD PMID:6342123 RGD:7411735 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179
JBrowse link
G IL27 interleukin 27 ameliorates ISO mRNA:decreased expression:skin of body (human) RGD PMID:26030183 RGD:126790539 NCBI chr 3:18,421,962...18,427,916
Ensembl chr 3:18,421,981...18,427,915
JBrowse link
G MBL2 mannose binding lectin 2 susceptibility ISO DNA:SNP:cds:161G>A (human) RGD PMID:20650301 RGD:8694069 NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17416
    sensory system disease 6498
      eye disease 3310
        leprosy 32
          lepromatous leprosy 5
Path 2
Term Annotations click to browse term
  disease 17416
    disease by infectious agent 2088
      Bacterial Infections and Mycoses 997
        bacterial infectious disease 792
          Gram-Positive Bacterial Infections 383
            Actinomycetales Infections 310
              Mycobacterium Infections 309
                leprosy 32
                  Multibacillary Leprosy 6
                    lepromatous leprosy 5
paths to the root