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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:premature menopause
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Accession:DOID:10787 term browser browse the term
Definition:The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.
Synonyms:exact_synonym: menopause praecox
 primary_id: MESH:D008594
 alt_id: RDO:0001726
 xref: ICD10CM:E28.31;   ICD9CM:256.31;   NCI:C80099
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
premature menopause term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 IEP mRNA:increased expression:liver, jejunum (rat) RGD PMID:24619822 RGD:19165129 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Cideb cell death-inducing DFFA-like effector b IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr15:29,252,203...29,256,759
Ensembl chr15:29,252,213...29,256,605
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 IEP mRNA:decreased:expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
JBrowse link
G Fgf10 fibroblast growth factor 10 treatment ISO RGD PMID:27679811 RGD:126928135 NCBI chr 2:50,801,897...50,875,428
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 PMID:24619822 RGD:15045610, RGD:19165129 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IEP mRNA:decreased expression:liver (rat) RGD PMID:25263431 RGD:15045610 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Polg DNA polymerase gamma, catalytic subunit ISO associated with Ophthalmoplegia, Chronic Progressive External;DNA:mutations: : RGD PMID:15351195 RGD:8694175 NCBI chr 1:133,382,764...133,399,578
Ensembl chr 1:133,382,766...133,398,567
JBrowse link
G Rad51c RAD51 paralog C ISO ClinVar Annotator: match by term: Premature menopause ClinVar PMID:21537932 PMID:22538716 PMID:23117857 PMID:25186627 PMID:25318351 More... NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Stag3 stromal antigen 3 ISO ClinVar Annotator: match by term: Premature menopause ClinVar PMID:25741868 NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935
JBrowse link
Blepharophimosis Syndrome Type 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxl2 forkhead box L2 ISO ClinVar Annotator: match by term: Blepharophimosis syndrome type 1
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:11175783 PMID:11468277 PMID:11776388 PMID:12400065 PMID:12529855 More... NCBI chr 8:99,512,971...99,514,500
Ensembl chr 8:99,513,303...99,514,427
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      endocrine system disease 5840
        gonadal disease 1032
          ovarian disease 797
            premature menopause 14
              Blepharophimosis Syndrome Type 1 1
Path 2
Term Annotations click to browse term
  disease 17289
    disease of anatomical entity 16625
      Urogenital Diseases 4386
        Female Urogenital Diseases and Pregnancy Complications 2068
          Female Urogenital Diseases 1762
            female reproductive system disease 1758
              Adnexal Diseases 806
                ovarian disease 797
                  ovarian dysfunction 184
                    premature menopause 14
                      Blepharophimosis Syndrome Type 1 1
paths to the root