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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:hypertension
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Accession:DOID:10763 term browser browse the term
Definition:Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Synonyms:exact_synonym: HTN;   High Blood Pressure;   High Blood Pressures;   hyperpiesia;   vascular hypertensive disorder
 related_synonym: hypertensive disease;   increased aldosterone to renin ratio
 primary_id: MESH:D006973
 xref: ICD9CM:401-405.99;   NCI:C3117
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abat 4-aminobutyrate aminotransferase IDA RGD PMID:1570022 RGD:1598531 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17272743 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 ISO associated with obesity;DNA:polymorphism:exon: RGD PMID:11030411 RGD:737749 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 IEP protein:decreased expression:aorta RGD PMID:15964031 PMID:18471810 RGD:1598644, RGD:2301909 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abo ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase susceptibility ISO associated with COVID-19; DNA:polymorphism:cds:allele A (human) RGD PMID:32379894 RGD:35668862 NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423
JBrowse link
G Ace angiotensin I converting enzyme susceptibility
treatment
ISO
IEP
IMP
IDA
DNA:polymorphism
CTD Direct Evidence: marker/mechanism
protein:increased activity:lung (rat)
CTD PMID:15773232 PMID:17473847 PMID:20237592 PMID:27847271 PMID:17283861 More... RGD:1601114, RGD:40400899, RGD:1581743, RGD:11039415, RGD:8157611, RGD:1331525, RGD:1601113 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ace2 angiotensin I converting enzyme 2 treatment ISO
IEP
associated with Metabolic Syndrome X (MeSH:D024821)
mRNA, protein:decreased expression:kidney (rat)
CTD Direct Evidence: marker/mechanism|therapeutic
mRNA, protein:decreased expression:aorta
CTD PMID:12075344 PMID:15833808 PMID:17473847 PMID:18391097 PMID:19221212 More... RGD:1642828, RGD:629626, RGD:9685442, RGD:9685435, RGD:9685433 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 IAGP RGD PMID:8094726 PMID:8507454 RGD:61050, RGD:634023 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 IEP RGD PMID:16343576 RGD:1598724 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
JBrowse link
G Ada adenosine deaminase IDA RGD PMID:9605386 RGD:1624292 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
JBrowse link
G Adamts16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 IMP RGD PMID:23185005 RGD:9685162 NCBI chr 1:32,430,436...32,562,481
Ensembl chr 1:32,430,436...32,560,494
JBrowse link
G Adamts16em1Bj ADAM metallopeptidase with thrombospondin type 1 motif, 16; ZFN mutant1,Bj IMP RGD PMID:23185005 RGD:9685162
G Adcy5 adenylate cyclase 5 ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:heart left ventricle
CTD PMID:12717102 PMID:12717102 RGD:13464134 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Add1 adducin 1 IAGP
ISO
IDA
CTD Direct Evidence: marker/mechanism
DNA:polymorphism: :p.G460W (human)
CTD PMID:15773232 PMID:19199261 PMID:15474463 PMID:8543181 PMID:9149697 RGD:1302895, RGD:631736, RGD:1624953 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Add2 adducin 2 no_association IDA
ISO
DNA:SNP: :rs4852706 (human)
DNA:polymorphism
RGD
GAD
PMID:2059221 PMID:24652215 PMID:15118671 PMID:16497648 RGD:631712, RGD:10047131, RGD:1331525, RGD:1625293 NCBI chr 4:118,444,594...118,538,505
Ensembl chr 4:118,497,416...118,538,505
JBrowse link
G Add3 adducin 3 IDA RGD PMID:12364392 RGD:704369 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO CTD Direct Evidence: marker/mechanism CTD PMID:12860835 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adm adrenomedullin IEP
ISO
mRNA, protein:increased expression:myocardium, aorta
protein:increased expression:plasma
RGD PMID:16450076 PMID:16625237 RGD:1625300, RGD:1625298 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adora1 adenosine A1 receptor treatment
no_association
IMP
IDA
ISO
associated with diabetes mellitus, experimental RGD PMID:8998253 PMID:9597368 PMID:15257174 RGD:1625366, RGD:1625365, RGD:1625367 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor no_association ISO RGD
GAD
PMID:15257174 PMID:15118671 RGD:1625367, RGD:1331525 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adra1a adrenoceptor alpha 1A IEP
ISO
mRNA:decreased expression:aorta RGD PMID:16371063 PMID:19011682 RGD:1625770, RGD:5688340 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B ISO RGD PMID:16095979 RGD:1625771 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra2a adrenoceptor alpha 2A no_association ISO
IEP
DNA:polymorphism
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:adrenal gland medulla
CTD PMID:10694191 PMID:16636200 PMID:20691504 RGD:1625183, RGD:6480490 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Adra2b adrenoceptor alpha 2B ISO
IMP
DNA:polymorphism (human) RGD PMID:18953403 PMID:17070424 RGD:2313541, RGD:2313548 NCBI chr 3:114,585,174...114,589,220
Ensembl chr 3:114,585,169...114,589,355
JBrowse link
G Adrb1 adrenoceptor beta 1 IEP
ISO
protein:increased expression:aorta
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Type 2;
CTD PMID:9260993 PMID:10673262 PMID:19060223 PMID:20398560 RGD:5129127, RGD:7241549 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 no_association
susceptibility
ISO
IEP
DNA:polymorphisms: :p.R16G, p.Q27E
DNA:polymorphisms: :pG16R, p.Q27E, p.T164I (human)
associated with Kidney Failure, Chronic; DNA:SNP:cds:p.R16G (human)
DNA:polymorphisms: :46A>G, 79C>G (human)
RGD
GAD
PMID:17221209 PMID:16041242 PMID:15118671 PMID:2471888 PMID:20484896 More... RGD:1601119, RGD:1578728, RGD:1331525, RGD:7175287, RGD:7175066, RGD:4144883, RGD:1601123 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.W64R (human) RGD PMID:10981554 RGD:2313166 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEP
ISO
protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism
CTD PMID:32147540 PMID:19018797 RGD:2325653 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agt angiotensinogen treatment
no_association
susceptibility
IEP
ISO
IDA
IMP
protein:increased expression:plasma, urine
CTD Direct Evidence: marker/mechanism|therapeutic
DNA:polymorphisms: :p.T174M, p.M235T (human)
DNA:polymorphisms: :-6G>A, p.M235T, p.T174M
DNA:polymorphism: :p.M235T
DNA:polymorphism:promoter:-20C>A (human)
DNA:polymorphism: :p.M268T (human)
CTD PMID:43064 PMID:1394429 PMID:1432030 PMID:1849535 PMID:1860718 More... RGD:5129176, RGD:11039415, RGD:8549470, RGD:8549469, RGD:8549458, RGD:8548902, RGD:1331525, RGD:1300393, RGD:1358275, RGD:1601143, RGD:1601130, RGD:1601141, RGD:1601139, RGD:5129166 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a no_association
susceptibility
IMP
ISO
IEP
associated with Sleep Apnea Syndromes
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:aortic endothelial cell
DNA:polymorphism:3' utr:1166A>C
DNA:polymorphism:3' utr:g.1166A>C
CTD PMID:8952600 PMID:19047579 PMID:23603059 PMID:27292124 PMID:21040717 More... RGD:5129169, RGD:8549458, RGD:1331525, RGD:5147456, RGD:1601152, RGD:1601148, RGD:5129176 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Agtr1b angiotensin II receptor, type 1b IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22728133 PMID:27847271 PMID:10994756 RGD:1598885 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232
JBrowse link
G Agtr2 angiotensin II receptor, type 2 IMP
ISO
IEP
associated with Sleep Apnea Syndromes
CTD Direct Evidence: marker/mechanism
mRNA, protein:decreased expression:kidney
CTD PMID:15710752 PMID:21040717 PMID:11924718 PMID:19680135 RGD:5129169, RGD:6903865, RGD:6903372 NCBI chr  X:112,119,673...112,124,060
Ensembl chr  X:112,120,228...112,124,057
JBrowse link
G Agtrap angiotensin II receptor-associated protein IEP protein:increased expression:kidney RGD PMID:18725581 RGD:2314351 NCBI chr 5:158,507,427...158,519,036
Ensembl chr 5:158,508,749...158,519,036
JBrowse link
G Ahcy adenosylhomocysteinase ISO associated with hyperhomocysteinemia RGD PMID:16815886 RGD:1601153 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:21115475 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aif1 allograft inflammatory factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32147540 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA protein:increased serine phosphorylation:kidney RGD PMID:23323219 RGD:10041025 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEP mRNA:increased expression:cerebral cortex (rat) RGD PMID:12902546 RGD:2313350 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Alad aminolevulinate dehydratase no_association ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism
CTD PMID:20123609 PMID:11335187 RGD:1601156 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alb albumin ISO CTD Direct Evidence: therapeutic CTD PMID:2526952 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member susceptibility
no_association
ISO RGD PMID:11510748 PMID:12484509 RGD:1601164, RGD:1601163 NCBI chr12:34,949,549...34,982,527 JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type IEP mRNA:decreased expression:medulla oblongata RGD PMID:16445702 RGD:5509789 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22467300 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alox5 arachidonate 5-lipoxygenase IDA RGD PMID:16331105 RGD:1626151 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Angpt1 angiopoietin 1 ISO protein:increased expression:plasma, platelet RGD PMID:16942942 PMID:18285514 RGD:1626157, RGD:2316068 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Anxa1 annexin A1 IEP
ISO
protein:altered localization:vascular associated smooth muscle cell
CTD Direct Evidence: marker/mechanism
CTD PMID:22228705 PMID:16109804 RGD:1599668 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Aoc1 amine oxidase, copper containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6218830 NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840
JBrowse link
G Aoc3 amine oxidase, copper containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23154672 NCBI chr10:86,272,757...86,280,702 JBrowse link
G Apln apelin IEP mRNA:decreased expression:aorta, heart RGD PMID:15664402 RGD:1626176 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:127,203,823...127,213,391
JBrowse link
G Apoa1 apolipoprotein A1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:18224302 PMID:23401751 RGD:7241867 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apob apolipoprotein B ISO GAD PMID:15118671 RGD:1331525 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Apoe apolipoprotein E onset ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:multiple (rat)
CTD PMID:20720404 PMID:22228705 PMID:15118671 PMID:20585107 RGD:1331525, RGD:6904214 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein IEP RGD PMID:29713228 RGD:13703136 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22228705 PMID:20156423 RGD:5148031 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Aqp2 aquaporin 2 IEP protein:decreased expression:kidney medulla
protein:increased expression:kidney medulla
RGD PMID:16788141 PMID:16582573 RGD:1601242, RGD:1601243 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp4 aquaporin 4 IEP RGD PMID:20156423 RGD:5148031 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Ar androgen receptor treatment IDA
ISO
IMP
CTD Direct Evidence: marker/mechanism CTD PMID:10523385 PMID:15746697 PMID:12397037 RGD:1601245, RGD:10043316 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arg1 arginase 1 IMP
IEP
mRNA:increased expression:aorta (rat) RGD PMID:18475148 PMID:17223136 RGD:4142834, RGD:1626296 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arg2 arginase 2 IMP
IEP
mRNA:increased expression:lung
mRNA:increased expression:aorta (rat)
RGD PMID:18475148 PMID:20039818 PMID:17223136 RGD:4142834, RGD:4143278, RGD:1626296 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha IEP mRNA:decreased expression:urinary bladder
protein:decreased expression:cortical collecting duct
RGD PMID:19689474 PMID:25164814 RGD:9684972, RGD:9684979 NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023
JBrowse link
G Arid1b AT-rich interaction domain 1B treatment IEP RGD PMID:17489020 RGD:9587762 NCBI chr 1:45,567,991...45,923,644
Ensembl chr 1:45,563,623...45,923,493
JBrowse link
G Arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 ISO DNA:SNPs: :rs6486121, rs3789327, rs969485(human) RGD PMID:17728404 RGD:2314371 NCBI chr 4:179,699,432...179,747,710
Ensembl chr 4:179,699,502...179,746,949
JBrowse link
G Arrb2 arrestin, beta 2 IEP protein:decreased expression:rostral ventrolateral medulla RGD PMID:27861247 RGD:13506896 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850
JBrowse link
G Atf2 activating transcription factor 2 IDA RGD PMID:11358932 RGD:10047414 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atg7 autophagy related 7 IEP protein:increased expression:skeletal muscle RGD PMID:24119246 RGD:11557985 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Atox1 antioxidant 1 copper chaperone ISO CTD Direct Evidence: therapeutic CTD PMID:22753205 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 IAGP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:23416519 PMID:8082931 RGD:1579862 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 susceptibility IEP
ISO
protein:decreased expression:adrenal gland cortex zone
CTD Direct Evidence: marker/mechanism
CTD PMID:16166162 PMID:16243970 PMID:11768735 PMID:11257061 PMID:16243970 RGD:1601253, RGD:1601254, RGD:1601251 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 IEP RGD PMID:11208768 RGD:68726 NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 IEP
ISO
mRNA:increased expression:vascular associated smooth muscle cell
CTD Direct Evidence: marker/mechanism
CTD PMID:19430479 PMID:20137670 RGD:2317726 NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23416519 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha IEP protein:decreased expression:heart left ventricle (rat) RGD PMID:24388463 RGD:7800726 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 IEP RGD PMID:21321306 RGD:5132599 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Avp arginine vasopressin IEP
ISO
protein:increased expression:carotid artery
CTD Direct Evidence: marker/mechanism
protein:increased expression:plasma
CTD PMID:1663982 PMID:3346065 PMID:4040330 PMID:6367368 PMID:19133994 More... RGD:1601305, RGD:1601243 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1a arginine vasopressin receptor 1A IEP
ISO
mRNA, protein:increased expression:paraventricular hypothalamic nucleus
mRNA, protein:increased expression:kidney, arteriole
DNA:SNP
RGD PMID:15475662 PMID:15657301 PMID:17653244 RGD:2300330, RGD:2300322, RGD:2300319 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Avpr2 arginine vasopressin receptor 2 severity IDA RGD PMID:12072411 RGD:1298694 NCBI chr  X:151,633,501...151,636,000
Ensembl chr  X:151,633,522...151,635,989
JBrowse link
G B2m beta-2 microglobulin ISO protein:increased expression:serum RGD PMID:15957539 RGD:1601306 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bad BCL2-associated agonist of cell death treatment IEP RGD PMID:20065158 RGD:10053702 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:20065158 RGD:10053702 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase ISO RGD PMID:12387587 RGD:1601322 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:10075388 PMID:20065158 RGD:10053702 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb1 bradykinin receptor B1 IMP
IEP
ISO
RGD PMID:17988733 PMID:12025958 PMID:15643125 RGD:5129214, RGD:704378, RGD:1625732 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bdkrb2 bradykinin receptor B2 IEP
ISO
protein:increased expression:spinal cord
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:hypothalamus
DNA:SNP:promoter:-58T>C (human)
CTD PMID:10614985 PMID:11934804 PMID:15118671 PMID:12025958 PMID:10904024 RGD:4890455, RGD:1331525, RGD:704378, RGD:4891034 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497
JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:brain RGD PMID:23499735 RGD:11561939 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Brca1 BRCA1, DNA repair associated treatment ISO RGD PMID:24239235 RGD:8693672 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brs3 bombesin receptor subtype 3 ISO RGD PMID:9367152 RGD:734661 NCBI chr  X:134,906,817...134,932,321
Ensembl chr  X:134,906,784...134,930,983
JBrowse link
G C3 complement C3 IEP RGD PMID:22416803 RGD:11040890 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO CTD Direct Evidence: marker/mechanism CTD PMID:22949532 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22949532 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 susceptibility ISO DNA:SNP: :rs4373814(human) RGD PMID:24338417 RGD:13513987 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Calca calcitonin-related polypeptide alpha ISO CTD Direct Evidence: therapeutic CTD PMID:1849535 PMID:9887042 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 treatment IDA
IEP
RGD PMID:20065158 PMID:27929425 RGD:10053702, RGD:13782308 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 IEP RGD PMID:27929425 RGD:13782308 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 IEP RGD PMID:27929425 RGD:13782308 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:11479740 PMID:20667508 PMID:21593737 PMID:22228705 PMID:16716903 RGD:1580833 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 IEP
ISO
protein:increased expression:artery smooth muscle, blood vessel endothelial cell
CTD Direct Evidence: marker/mechanism
CTD PMID:1798635 PMID:17986358 RGD:2289116 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Cbs cystathionine beta synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18224302 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IEP
ISO
IDA
protein:increased expression:urine
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent;mRNA, protein:increased expression:kidney cortex, urine
CTD PMID:20667508 PMID:27292124 PMID:17989143 PMID:17922026 PMID:18459944 RGD:2307054, RGD:8549771, RGD:2307029 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl28 C-C motif chemokine ligand 28 no_association IEP mRNA, protein:decreased expression:kidney (rat)
protein:increased expression:kidney (rat)
RGD PMID:19829664 PMID:16840655 RGD:4892132, RGD:2298761 NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum RGD PMID:15668187 RGD:2307105 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16685210 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccne1 cyclin E1 IEP protein:increased expression:vascular associated smooth muscle cell RGD PMID:12847112 RGD:2289296 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 IEP
ISO
mRNA:increased expression:aorta (rat)
DNA:frameshift mutation:cds:p.S185_T195del rs333 (human)
RGD PMID:20044442 PMID:12680626 RGD:4890416, RGD:1581182 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd14 CD14 molecule ISO associated with Glomerulonephritis, IGA; DNA:polymorphism: :-159C>T (human) RGD PMID:22072187 RGD:7204129 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd36 CD36 molecule IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:18587397 PMID:18587397 RGD:2300254 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd82 Cd82 molecule IEP mRNA:increased expression:thymus RGD PMID:10321446 RGD:2289422 NCBI chr 3:79,387,361...79,431,847
Ensembl chr 3:79,385,887...79,431,809
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A IEP protein:increased expression:kidney RGD PMID:18504326 RGD:2316082 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdo1 cysteine dioxygenase type 1 IEP protein:decreased expression:brain RGD PMID:6726227 RGD:2301363 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Cela2a chymotrypsin like elastase 2A ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: High blood pressure
CTD
ClinVar
PMID:21602471 PMID:31358993 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632
JBrowse link
G Chga chromogranin A no_association ISO
IEP
protein:creased expression:adrenal gland
mRNA, protein:increased expression:adrenal gland medulla, plasma
DNA:polymorphisms:promoter
RGD PMID:21061160 PMID:10803489 PMID:10803489 PMID:20113265 PMID:20729505 RGD:6906897, RGD:6907055, RGD:6907055, RGD:6906902, RGD:6906900 NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398
JBrowse link
G Chi3l1 chitinase 3 like 1 IEP mRNA:increased expression:brainstem, solitary tract nucleus (rat) RGD PMID:18703386 RGD:4892597 NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
JBrowse link
G Chst12 carbohydrate sulfotransferase 12 IEP mRNA:decreased expression:renal cortex and medulla (rat) RGD PMID:25001272 RGD:8693701 NCBI chr12:14,110,631...14,129,099
Ensembl chr12:14,110,393...14,129,057
JBrowse link
G Clcnka chloride voltage-gated channel Ka ISO CTD Direct Evidence: marker/mechanism CTD PMID:18480177 NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148
JBrowse link
G Clcnkb chloride voltage-gated channel Kb no_association ISO DNA:polymorphism:T481S RGD PMID:15148291 PMID:16003175 RGD:1600684, RGD:1600683 NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
JBrowse link
G Cldn16 claudin 16 IDA Protein:decreased serine phosphorylation:kidney RGD PMID:16959063 RGD:1599616 NCBI chr11:74,290,298...74,309,588
Ensembl chr11:74,290,298...74,309,588
JBrowse link
G Clock clock circadian regulator IEP mRNA:altered expression:gastrocnemius muscle (rat) RGD PMID:22076133 RGD:9686076 NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400
JBrowse link
G Clu clusterin ISO DNA:SNP:exon:866C>T (human) RGD PMID:15925890 RGD:1581195 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cma1 chymase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14620933 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19133994 RGD:2314680 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Col1a1 collagen type I alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:11682445 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:11682445 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col4a4 collagen type IV alpha 4 chain ISO ClinVar Annotator: match by term: Hypertension
ClinVar Annotator: match by term: High blood pressure
ClinVar PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 9:83,833,173...83,875,436
Ensembl chr 9:83,755,515...83,875,876
JBrowse link
G Col4a5 collagen type IV alpha 5 chain ISO ClinVar Annotator: match by term: Hypertension ClinVar PMID:9848783 PMID:11223851 PMID:17396119 PMID:19728970 PMID:19965530 More... NCBI chr  X:105,118,762...105,322,699
Ensembl chr  X:105,118,820...105,322,692
JBrowse link
G Comt catechol-O-methyltransferase susceptibility IEP
IDA
ISO
protein:increased expression:cerebral cortex
DNA:polymorphism: :-1187G>C, 186C>T
RGD PMID:17978496 PMID:17510509 PMID:17143180 PMID:14714585 RGD:2289729, RGD:8662344, RGD:2289742, RGD:2289787 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Corin corin, serine peptidase ISO RGD PMID:17485366 PMID:16216958 RGD:1626338, RGD:1581219 NCBI chr14:35,680,601...35,910,703
Ensembl chr14:35,681,304...35,909,503
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B IEP protein:decreased expression:heart left ventricle RGD PMID:16132109 RGD:2301377 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 IEP protein:decreased expression:liver, mitochondrion RGD PMID:19135993 RGD:2303405 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 IDA corticotropin releasing hormone-induced RGD PMID:11036160 RGD:1581302 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10742107 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
JBrowse link
G Crp C-reactive protein IEP
ISO
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
protein:increased expression:serum:
CTD PMID:14620923 PMID:16680063 PMID:19770776 PMID:20667508 PMID:19905982 More... RGD:5131461, RGD:9586008, RGD:9491754 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Ctf1 cardiotrophin 1 ISO
IEP
protein:increased expression:plasma
mRNA:increased expression:cardiac ventricle
RGD PMID:15716706 PMID:8604995 RGD:1626411, RGD:69823 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335
JBrowse link
G Ctsc cathepsin C IEP RGD PMID:657443 RGD:1599651 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27678262 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cyba cytochrome b-245 alpha chain IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:increased expression:kidney cortex
CTD PMID:16685210 PMID:17324946 PMID:20505675 PMID:32147540 PMID:17109653 More... RGD:4775206, RGD:1580276, RGD:2317853 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cybb cytochrome b-245 beta chain IEP
ISO
Protein:increased expression:brain
CTD Direct Evidence: marker/mechanism
CTD PMID:16685210 PMID:21593737 PMID:27659729 PMID:27847271 PMID:32147540 More... RGD:1599685 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 IEP mRNA:increased expression:hypothalamus RGD PMID:16116051 RGD:1599701 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 IEP
IAGP
mRNA:decreased expression:hypothalamus, cerebellum, cortex (rat) RGD PMID:19837774 PMID:7981756 RGD:4891156, RGD:69709 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO
IMP
IEP
DNA:transition:5' utr:-344C>T (human)
mRNA:increased expression:brainstem, hippocampus, cortex (rat)
RGD PMID:10024332 PMID:18495825 PMID:19837774 RGD:4891152, RGD:2307304, RGD:4891156 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 ISO ClinVar Annotator: match by term: Aldosterone to renin ratio, increased ClinVar PMID:12213905 PMID:12788845 PMID:17003099 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP mRNA:decreased expression:ovary (rat) RGD PMID:19228890 RGD:4761326 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20634294 PMID:22995157 PMID:20634294 RGD:7257731 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 ISO
IEP
RGD PMID:19669737 PMID:18829737 RGD:6903909, RGD:6903915 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 susceptibility ISO DNA:SNP RGD PMID:17286575 PMID:20501636 RGD:1625379, RGD:7243136 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 ISO
IEP
mRNA:decreased expression:kidney cortex RGD PMID:16144986 PMID:16339392 PMID:18952718 RGD:1625567, RGD:2303383, RGD:2303381 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 IEP mRNA:decreased expression:kidney cortex RGD PMID:18952718 PMID:16339392 RGD:2303381, RGD:2303383 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 IEP mRNA:increased expression:kidney RGD PMID:16182239 RGD:2301709 NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
JBrowse link
G Dars2 aspartyl-tRNA synthetase 2 (mitochondrial) ISO ClinVar Annotator: match by term: High blood pressure ClinVar PMID:17384640 PMID:19592391 PMID:22843165 PMID:23065766 PMID:23652419 More... NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
JBrowse link
G Dbh dopamine beta-hydroxylase resistance IEP
ISO
mRNA:increased expression:heart, adrenal gland (rat)
DNA:polymorphism:5' utr:g.-2073C>T rs1989787 (human)
RGD PMID:20596792 PMID:20814407 RGD:5129234, RGD:5129211 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 susceptibility ISO RGD PMID:16444868 RGD:1625582 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Dio2 iodothyronine deiodinase 2 susceptibility ISO RGD PMID:17224473 RGD:1626437 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:10948075 PMID:8636408 RGD:1580869, RGD:1300303 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism
CTD PMID:11566895 PMID:15939106 PMID:11494094 RGD:1600905, RGD:1580874 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 IDA RGD PMID:11675403 RGD:1580882 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:12486173 RGD:1580887 NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774
JBrowse link
G Dusp1 dual specificity phosphatase 1 IEP mRNA, protein:increased expression:aorta RGD PMID:9231829 RGD:2298678 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp5 dual specificity phosphatase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25397684 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dynll1 dynein light chain LC8-type 1 treatment IMP RGD PMID:24035314 RGD:13207430 NCBI chr12:41,312,367...41,314,742
Ensembl chr12:41,312,367...41,314,741
JBrowse link
G Ece1 endothelin converting enzyme 1 IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression,increased activity:kidney medulla
CTD PMID:12566389 PMID:12193123 PMID:10894793 RGD:1580907, RGD:7244182 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Edn1 endothelin 1 IEP
ISO
protein:increased secretion:plasma (rat)
CTD Direct Evidence: marker/mechanism
human gene in a rat model
associated with Diabetic Nephropathies;protein:increased secretion:plasma
DNA:polymorphism:exon:p.K198N (human)
CTD PMID:7721406 PMID:8152482 PMID:8440307 PMID:10474778 PMID:10669576 More... RGD:4144829, RGD:8661804, RGD:2313283, RGD:1625065 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn2 endothelin 2 ISO mRNA:increased expression:leukocyte RGD PMID:10976780 PMID:10489105 PMID:15007037 RGD:1580916, RGD:1580917, RGD:1625402 NCBI chr 5:133,751,316...133,756,814
Ensembl chr 5:133,751,217...133,756,814
JBrowse link
G Edn3 endothelin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:2059916 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Ednra endothelin receptor type A IEP
ISO
IDA
associated with Uremia
CTD Direct Evidence: marker/mechanism
CTD PMID:12600921 PMID:20144075 PMID:14616768 PMID:16157796 RGD:4892284, RGD:1580950, RGD:1581830 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Ednrb endothelin receptor type B IEP
IMP
associated with Uremia RGD PMID:20144075 PMID:10749572 RGD:4892284, RGD:628518 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Egfr epidermal growth factor receptor IEP mRNA, protein:increased expression:renal cortex RGD PMID:15827348 RGD:1580953 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 IMP RGD PMID:22686466 RGD:11252087 NCBI chr19:52,867,914...52,907,169 JBrowse link
G Eif4g2 eukaryotic translation initiation factor 4, gamma 2 IEP mRNA:increased expression:heart left ventricle RGD PMID:12708758 RGD:10755511 NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588
JBrowse link
G Eln elastin ISO CTD Direct Evidence: marker/mechanism CTD PMID:17039479 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Emilin1 elastin microfibril interfacer 1 ISO RGD PMID:16530041 RGD:1580958 NCBI chr 6:25,455,974...25,463,736
Ensembl chr 6:25,445,298...25,463,698
JBrowse link
G Eng endoglin IEP mRNA:decreased expression:kidney (rat) RGD PMID:19829664 RGD:4892132 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Eno1 enolase 1 IEP RGD PMID:16485256 RGD:1598909 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Eno2 enolase 2 severity ISO protein:increased expression:serum RGD PMID:21130083 RGD:5508770 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 IEP RGD PMID:20655932 RGD:9685529 NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
JBrowse link
G Ep300 E1A binding protein p300 IEP protein:increased expression:left ventricle (rat) RGD PMID:18292809 RGD:2312265 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Ephx2 epoxide hydrolase 2 susceptibility IDA
IMP
ISO
DNA:missense mutation:cds:p.K55R (human) RGD PMID:16157792 PMID:21720266 PMID:19553349 PMID:20065888 RGD:1580985, RGD:5688733, RGD:5688730, RGD:5688727 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:1516988 PMID:10694834 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor susceptibility ISO induced by erythropoietin; RGD PMID:19458615 RGD:11041646 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:13678427 NCBI chr 2:3,931,817...3,970,735
Ensembl chr 2:3,931,904...3,972,447
JBrowse link
G Esr2 estrogen receptor 2 ISO
IMP
RGD PMID:11799247 PMID:23608653 PMID:11185739 PMID:15167447 RGD:734949, RGD:7364951, RGD:1581015, RGD:1581017 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G F11 coagulation factor XI ISO CTD Direct Evidence: marker/mechanism CTD PMID:6383834 NCBI chr16:46,986,107...47,009,015
Ensembl chr16:46,986,107...47,008,437
JBrowse link
G F11r F11 receptor susceptibility ISO
IEP
DNA:SNPs: :rs790056, rs2774276 (human) RGD PMID:18067551 PMID:17420334 RGD:7488938, RGD:7488939 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G F12 coagulation factor XII ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: High blood pressure
CTD
ClinVar
PMID:6383834 PMID:16638441 PMID:25741868 NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
JBrowse link
G F2r coagulation factor II (thrombin) receptor IDA RGD PMID:9168786 RGD:1581034 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor treatment IEP RGD PMID:21423288 RGD:11341709 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F7 coagulation factor VII ISO
IEP
protein:increased activity:plasma (human)
protein:increased activity:plasma (rat)
RGD PMID:10450539 PMID:8123879 PMID:812575 RGD:2312402, RGD:2312412, RGD:2312323 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fabp1 fatty acid binding protein 1 ISO possibly associated with arteriosclerosis (MeSH:D001161) RGD PMID:15830271 RGD:1626441 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fabp3 fatty acid binding protein 3 susceptibility ISO DNA:SNPs RGD PMID:18437121 RGD:2307331 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fadd Fas associated via death domain treatment IEP RGD PMID:24355328 RGD:11344883 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fads1 fatty acid desaturase 1 IEP RGD PMID:12144877 RGD:1625415 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fah fumarylacetoacetate hydrolase IEP mRNA:decreased expression:kidney RGD PMID:15731461 RGD:1559295 NCBI chr 1:138,548,830...138,571,599
Ensembl chr 1:138,548,834...138,571,505
JBrowse link
G Fbn1 fibrillin 1 IEP protein:increased expression:renal glomerulus (rat) RGD PMID:16380460 RGD:7365080 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889
JBrowse link
G Fgf2 fibroblast growth factor 2 IEP associated with Aortic Coarctation RGD PMID:17562191 RGD:8655614 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf21 fibroblast growth factor 21 ISO CTD Direct Evidence: therapeutic CTD PMID:29706566 NCBI chr 1:96,083,495...96,084,738
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 no_association ISO associated with trimethylaminuria, OMIM:602079 RGD PMID:9536088 PMID:16324215 RGD:1626461, RGD:1626466 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 ISO
IEP
IAGP
CTD Direct Evidence: marker/mechanism
mRNA:increased expression:kidney (SHRSP/A3N rat)
CTD PMID:11682445 PMID:17324946 PMID:11907153 PMID:11682445 RGD:28912746, RGD:30296650 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fndc5 fibronectin type III domain containing 5 ISO CTD Direct Evidence: therapeutic CTD PMID:32165127 NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:12044476 PMID:24039778 PMID:16696897 RGD:7242185 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxp3 forkhead box P3 treatment IEP RGD PMID:24420551 RGD:38549366 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:45,712,887...45,720,032
Ensembl chr 8:45,712,903...45,720,203
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 IEP mRNA:increased expression:brain RGD PMID:18338268 RGD:2315462 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gad1 glutamate decarboxylase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32165127 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gal galanin and GMAP prepropeptide IEP
ISO
mRNA:decreased expression:paraventricular hypothalamic nucleus, solitary tract nucleus
CTD Direct Evidence: marker/mechanism
CTD PMID:10818254 PMID:15275958 RGD:1624333 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959
JBrowse link
G Gcg glucagon ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gch1 GTP cyclohydrolase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12855421 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
JBrowse link
G Gck glucokinase susceptibility ISO RGD PMID:9324112 RGD:1581877 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Ghsr growth hormone secretagogue receptor ISO associated with Obesity RGD PMID:24760503 RGD:12910115 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:16448880 PMID:16448880 PMID:23719203 RGD:7207810, RGD:8662439 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja4 gap junction protein, alpha 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16448880 NCBI chr 5:139,633,324...139,635,857
Ensembl chr 5:139,633,287...139,635,925
JBrowse link
G Gja5 gap junction protein, alpha 5 treatment IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
protein:decreased expression:artery endothelium
CTD PMID:19109587 PMID:19686729 PMID:11821709 RGD:7207417, RGD:7207848 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gjc1 gap junction protein, gamma 1 ISO CTD Direct Evidence: therapeutic CTD PMID:19109587 NCBI chr10:87,758,192...87,785,443
Ensembl chr10:87,760,528...87,785,867
JBrowse link
G Glp1r glucagon-like peptide 1 receptor IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22228705 PMID:12093887 RGD:625448 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
JBrowse link
G Gnai2 G protein subunit alpha i2 treatment IMP
IEP
RGD PMID:27912212 PMID:15106810 RGD:13507308, RGD:13508592 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Gnai3 G protein subunit alpha i3 treatment IEP RGD PMID:15106810 RGD:13508592 NCBI chr 2:195,742,765...195,780,720
Ensembl chr 2:195,742,642...195,780,742
JBrowse link
G Gnas GNAS complex locus ISO CTD Direct Evidence: marker/mechanism CTD PMID:9506701 PMID:12215464 PMID:15118671 RGD:1580404, RGD:1331525 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Gnb3 G protein subunit beta 3 susceptibility
no_association
ISO DNA:SNP:cds:825C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:cds: 825C>T (human)
DNA:polymorphism: :multiple (human)
CTD PMID:15961981 PMID:16141801 PMID:10526907 PMID:11230982 PMID:16908025 RGD:1580410, RGD:1580408, RGD:2313206 NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gp1ba glycoprotein Ib platelet subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
JBrowse link
G Gpx1 glutathione peroxidase 1 treatment ISO
IDA
IEP
CTD Direct Evidence: marker/mechanism CTD PMID:21593737 PMID:17198913 PMID:21210316 PMID:23752977 RGD:1600704, RGD:11353777, RGD:11352825 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 treatment IEP
ISO
protein:increased expression:lymphocyte, vascular associated smooth muscle cell
CTD Direct Evidence: marker/mechanism
CTD PMID:11901213 PMID:10642272 PMID:23913704 RGD:1625788, RGD:13792716 NCBI chr 1:201,581,480...201,601,580
Ensembl chr 1:201,581,480...201,601,582
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP mRNA:increased expression:heart left ventricle, kidney (rat) RGD PMID:26248277 RGD:11535540 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IEP mRNA:increased expression:heart left ventricle, kidney (rat) RGD PMID:26248277 RGD:11535540 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22982863 PMID:22982863 RGD:10045670 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase ISO RGD PMID:17198913 RGD:1600704 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstm1 glutathione S-transferase mu 1 IEP mRNA:decreased expression:kidney (rat) RGD PMID:15699453 RGD:7495838 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 IEP mRNA:decreased expression:kidney (rat) RGD PMID:18008142 PMID:12624007 RGD:2302178, RGD:631154 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24915237 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 ISO associated with scleroderma, systemic;DNA:deletion: :
CTD Direct Evidence: marker/mechanism
CTD PMID:22228705 PMID:11477481 RGD:5490587 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gstt2 glutathione S-transferase, theta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18339647 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G H2ax H2A.X variant histone treatment IDA RGD PMID:24239235 RGD:8693672 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 IEP protein:increased expression:urine RGD PMID:23085980 RGD:7245484 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hdac6 histone deacetylase 6 IEP protein:increased expression, activity:heart: RGD PMID:23868068 RGD:9681716 NCBI chr  X:14,550,645...14,572,445
Ensembl chr  X:14,551,044...14,572,441
JBrowse link
G Hdac8 histone deacetylase 8 IEP protein:decreased expression:heart (mouse, rat) RGD PMID:28567090 RGD:13208602 NCBI chr  X:67,385,288...67,593,014
Ensembl chr  X:67,385,289...67,592,923
JBrowse link
G Hgf hepatocyte growth factor susceptibility ISO DNA:polymorphism:intron13:C/A RGD PMID:15127882 PMID:15127882 RGD:1642064, RGD:1642064 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO
IEP
Hypertension, Pregnancy-Induced;mRNA, protein:increased expression:placenta
CTD Direct Evidence: therapeutic
associated with Hypercholesterolemia;protein:increased expression:aorta
protein:increased expression:brain
CTD PMID:22349312 PMID:15862159 PMID:11882589 PMID:16955051 RGD:1626322, RGD:1626330, RGD:1626317 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmgb1 high mobility group box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:32147540 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmox1 heme oxygenase 1 susceptibility
treatment
ISO
IDA
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16959961 PMID:22349312 PMID:22352330 PMID:12872043 PMID:20836698 More... RGD:1598400, RGD:10755717, RGD:1580453 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin susceptibility
onset
ISO
IEP
DNA:polymorphism
CTD Direct Evidence: marker/mechanism
CTD PMID:16597321 PMID:7606649 PMID:23401751 PMID:8228210 RGD:1626351, RGD:7241867, RGD:1626352 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hrh2 histamine receptor H 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30310171 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hrh3 histamine receptor H3 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:9050021 PMID:9050021 RGD:1626409 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:9683905 PMID:15199296 PMID:21786805 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 IEP
ISO
associated with Diabetes Mellitus, Experimental;mRNA:decreased expression:kidney
CTD Direct Evidence: marker/mechanism
apparent mineralocorticoid excess syndrome, OMIM:218030
CTD PMID:7670488 PMID:9683905 PMID:9707624 PMID:11082157 PMID:10792625 More... RGD:2308925, RGD:1625078 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 IEP mRNA:decreased expression:renal cortex (rat) RGD PMID:18430809 RGD:2292646 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 susceptibility IEP
ISO
mRNA:decreased expression:ovary (rat)
DNA:polymorphism:exon
RGD PMID:19228890 PMID:12054649 RGD:4761326, RGD:1626438 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 IEP mRNA:increased expression:hypothalamus (rat) RGD PMID:16116051 RGD:1599701 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO mRNA: increased expression: leukocyte RGD PMID:17341625 RGD:6480224 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 IEP mRNA:increased expression:brain, blood vessel RGD PMID:15729290 PMID:18948349 RGD:1624213, RGD:10402862 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 IEP mRNA:increased expression:aorta RGD PMID:8225534 RGD:1624258 NCBI chr 5:149,677,437...149,778,594 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IEP protein:increased expression:aorta RGD PMID:11882579 RGD:1626447 NCBI chr 8:82,513,572...82,534,892
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A susceptibility
no_association
ISO DNA:polymorphism: :102T>C
DNA:polymorphism: :g.102T>C
RGD
GAD
PMID:11378836 PMID:15118671 PMID:15659047 RGD:1624375, RGD:1331525, RGD:1624371 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:8627522 NCBI chr 9:86,735,793...86,756,640
Ensembl chr 9:86,742,102...86,755,108
JBrowse link
G Htra1 HtrA serine peptidase 1 ISO associated with Macular Degeneration; DNA:snp:cds:g.102C>T (rs1049331) (human) RGD PMID:21682878 RGD:7394697 NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:increased expression:serum
CTD Direct Evidence: marker/mechanism
CTD PMID:12149661 PMID:12425201 PMID:18619052 RGD:2312765 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ier3 immediate early response 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20713914 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Igf1 insulin-like growth factor 1 severity ISO
IEP
IAGP
mRNA:increased expression:aorta (rat)
CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:19502719 PMID:22228705 PMID:16431135 PMID:8418983 PMID:15996002 RGD:1598427, RGD:12904968, RGD:1580474 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor IEP protein:increased expression:aorta: RGD PMID:21854769 RGD:10046007 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 IEP mRNA, protein:decreased expression:liver, plasma RGD PMID:9396554 RGD:1626482 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:27659729 PMID:32147540 PMID:19246475 RGD:7495780 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 IEP RGD PMID:19398662 RGD:2311047 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta IEP
ISO
IDA
mRNA, protein:increased expression:aorta, plasma
CTD Direct Evidence: marker/mechanism
associated with Obesity;protein:increased expression:plasma
CTD PMID:27292124 PMID:27659729 PMID:27847271 PMID:32147540 PMID:32165127 More... RGD:1626635, RGD:7175338, RGD:1626638 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility IDA
ISO
DNA:polymorphisms RGD PMID:11585563 PMID:11840488 RGD:1626668, RGD:1626667 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il6 interleukin 6 susceptibility ISO associated with end stage renal disease; DNA:polymorphisms:promoter: -174G>C (human)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Non-Insulin-Dependent; protein:increased expression:extracellular space (human)
CTD PMID:27292124 PMID:27659729 PMID:27847271 PMID:32147540 PMID:32165127 More... RGD:1580485, RGD:2307283 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor severity ISO Hypertension, Pregnancy-Induced;protein:increased expression:serum RGD PMID:11778537 RGD:1625432 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer severity ISO Hypertension, Pregnancy-Induced;protein:increased expression:serum RGD PMID:11778537 RGD:1625432 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO DNA:SNPs: :rs2276047,snp8,rs9886(human)
CTD Direct Evidence: marker/mechanism
CTD PMID:15220217 PMID:15220217 RGD:1626127 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Ins2 insulin 2 IDA
ISO
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:9719048 PMID:18360027 PMID:9095092 RGD:6902896 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Itga9 integrin subunit alpha 9 susceptibility ISO DNA:SNP: :rs155524(human) RGD PMID:20479155 RGD:13602005 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754
JBrowse link
G Itgav integrin subunit alpha V IEP protein:increased expression:artery RGD PMID:16380536 RGD:1627642 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itm2b integral membrane protein 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:24039778 PMID:11358932 RGD:10047414 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 IEP mRNA:increased expression:heart RGD PMID:11358947 RGD:1627659 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Kcnab1 potassium voltage-gated channel subfamily A regulatory beta subunit 1 IEP mRNA:increased expression:aorta, arteries (rat) RGD PMID:11358947 RGD:1627659 NCBI chr 2:149,137,025...149,603,540
Ensembl chr 2:149,137,041...149,603,534
JBrowse link
G Kcnj1 potassium inwardly-rectifying channel, subfamily J, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:30,779,883...30,808,607
Ensembl chr 8:30,753,617...30,813,796
JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 IEP RGD PMID:15964031 RGD:1598644 NCBI chr 1:96,591,048...96,594,574
Ensembl chr 1:96,591,049...96,594,082
JBrowse link
G Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 IDA RGD PMID:16051697 RGD:1581698 NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 IDA
ISO
IEP
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:aorta, mesenteric artery
CTD PMID:17700361 PMID:14551242 PMID:16814121 PMID:16293791 RGD:1298970, RGD:10412046, RGD:1581718 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 IAGP DNA:deletion:exon (rat) RGD PMID:16368876 RGD:1581602 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Kcnq1dfk potassium voltage-gated channel subfamily Q member 1;deafness Kyoto IAGP RGD PMID:16368876 RGD:1581602
G Kdr kinase insert domain receptor treatment IEP
ISO
DNA:polymorphism:cds:p.H472Q(human) RGD PMID:15838270 PMID:20630084 RGD:5684418, RGD:8552374 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kl Klotho treatment IDA
IEP
ISO
mRNA,protein:decreased expression:kidney: RGD PMID:10892340 PMID:21051829 PMID:23225045 RGD:1581732, RGD:10403063, RGD:10403062 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
JBrowse link
G Klk1 kallikrein 1 no_association
susceptibility
ISO
IEP
DNA:polymorphisms
CTD Direct Evidence: therapeutic
mRNA:decreased expression:kidney
RGD
CTD
PMID:14568997 PMID:15905889 PMID:15167446 PMID:15809361 RGD:1641795, RGD:1581751, RGD:1358144 NCBI chr 1:94,642,722...94,646,714
Ensembl chr 1:94,642,687...94,646,754
JBrowse link
G Klk1b3 kallikrein 1-related peptidase B3 IAGP RGD PMID:15809361 RGD:1358144 NCBI chr 1:94,709,105...94,713,308
Ensembl chr 1:94,709,105...94,713,308
JBrowse link
G Klk1c12 kallikrein 1-related peptidase C12 ISO DNA:polymorphisms RGD PMID:15905889 PMID:17272402 RGD:1641795, RGD:1641794 NCBI chr 1:94,378,103...94,382,140
Ensembl chr 1:94,378,054...94,382,176
JBrowse link
G Klkb1 kallikrein B1 ISO associated with Diabetes Mellitus, Type 1; protein:increased expression:plasma: RGD PMID:12716755 RGD:7327151 NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053
JBrowse link
G Kng2 kininogen 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7027322 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Kras KRAS proto-oncogene, GTPase ISO RGD PMID:15864294 RGD:1581757 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Kynu kynureninase IAGP RGD PMID:11924719 RGD:631322 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
JBrowse link
G Lep leptin ISO
IDA
DNA:SNPs: :
CTD Direct Evidence: marker/mechanism
CTD PMID:12050272 PMID:16827954 PMID:25205467 PMID:27226618 PMID:19204185 More... RGD:5128788, RGD:5128597 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor disease_progression ISO
IMP
DNA:polymorphisms:exons
CTD Direct Evidence: marker/mechanism
CTD PMID:22949526 PMID:10999797 PMID:27465994 RGD:5129161, RGD:12911217 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Leprem2Mcwi leptin receptor; zinc finger nuclease induced mutant 2, Medical College of Wisconsin disease_progression IMP RGD PMID:27465994 RGD:12911217
G Lgals3 galectin 3 treatment IEP RGD PMID:23117656 RGD:9685203 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhb luteinizing hormone subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:6350720 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lipe lipase E, hormone sensitive type ISO gestational hypertension;DNA:polymorphism:promoter:-60C>G RGD PMID:17318300 RGD:1625026 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
JBrowse link
G Lipg lipase G, endothelial type IDA RGD PMID:15914124 RGD:1581875 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260
JBrowse link
G Lox lysyl oxidase ISO
IDA
RGD PMID:8562290 PMID:24127 RGD:1581896, RGD:1581899 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lpl lipoprotein lipase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 PMID:16132104 RGD:1580535 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp2 LDL receptor related protein 2 IDA protein:altered localization:apical plasma membrane RGD PMID:10919857 RGD:1641827 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
JBrowse link
G Lta lymphotoxin alpha no_association ISO RGD PMID:15533732 RGD:1580415 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltf lactotransferrin ISO CTD Direct Evidence: therapeutic CTD PMID:24587916 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP RGD PMID:23499735 RGD:11561939 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IDA RGD PMID:15302844 RGD:1582315 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor IMP associated with Sleep Apnea Syndromes RGD PMID:21040717 RGD:5129169 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mc2r melanocortin 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11082157 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Mdh1 malate dehydrogenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mfn2 mitofusin 2 treatment IEP protein:decreased expression:aorta (rat) RGD PMID:27847271 PMID:25464244 RGD:12910764, RGD:13204764 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mif macrophage migration inhibitory factor IDA RGD PMID:19799867 RGD:4890974 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mir214 microRNA 214 treatment IMP RGD PMID:30049682 RGD:38500245 NCBI chr13:74,588,374...74,588,481 JBrowse link
G Mme membrane metallo-endopeptidase treatment IMP RGD PMID:12011651 RGD:13801039 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO protein:decreased expression:renal glomerulus (human) RGD PMID:15363819 PMID:19506087 RGD:1582532, RGD:2312464 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp2 matrix metallopeptidase 2 IEP
ISO
mRNA, protein:increased expression:kidney
CTD Direct Evidence: marker/mechanism
CTD PMID:18836702 PMID:17977875 PMID:16840178 RGD:2290351, RGD:1582612 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp7 matrix metallopeptidase 7 treatment IMP
IEP
RGD PMID:19398663 PMID:19398663 RGD:9685347, RGD:9685347 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mmp9 matrix metallopeptidase 9 susceptibility ISO
IEP
protein:decreased expression:internal mammary artery
CTD Direct Evidence: marker/mechanism
associated with Aneurysm, Dissecting;DNA:polymorphism:promoter:-1562C>T
CTD PMID:21051829 PMID:15363819 PMID:16780738 PMID:16840178 PMID:17977875 RGD:1582532, RGD:1642029, RGD:1582612, RGD:2290351 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mov10 Mov10 RISC complex RNA helicase susceptibility ISO DNA:SNP: :rs2932538(human) RGD PMID:24338417 RGD:13513987 NCBI chr 2:192,292,041...192,315,142
Ensembl chr 2:192,293,470...192,315,083
JBrowse link
G Moxd2 monooxygenase, DBH-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:3814904 NCBI chr 4:69,724,693...69,733,188
Ensembl chr 4:69,724,239...69,733,299
JBrowse link
G Msx2 msh homeobox 2 IEP RGD PMID:18270471 RGD:5132616 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879
JBrowse link
G Mtor mechanistic target of rapamycin kinase IDA
ISO
protein:increased serine phosphorylation:kidney
CTD Direct Evidence: marker/mechanism
CTD PMID:19289642 PMID:23323219 RGD:10041025 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mtpn myotrophin IEP
IDA
RGD PMID:12419325 PMID:12031792 RGD:632799, RGD:1581046 NCBI chr 4:64,159,273...64,186,686
Ensembl chr 4:64,157,641...64,186,724
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:15148588 RGD:1581050 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Mttp microsomal triglyceride transfer protein onset ISO DNA:polymorphism:promoter:-493G>T RGD PMID:16328015 RGD:1625485 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Mybph myosin binding protein H IAGP DNA:missense mutations:cds:p.I?T, p.R?K (rat) RGD PMID:23460292 RGD:12802369 NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:27292124 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh7 myosin heavy chain 7 IEP
ISO
protein:decreased expression:heart left ventricle, arteriole
CTD Direct Evidence: marker/mechanism
CTD PMID:32147540 PMID:9686760 RGD:9835388 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myo6 myosin VI IDA protein:altered localization:renal proximal tubule, microvillus RGD PMID:16107581 RGD:2314963 NCBI chr 8:81,087,157...81,242,022
Ensembl chr 8:81,087,139...81,239,292
JBrowse link
G Myod1 myogenic differentiation 1 IEP mRNA:decreased expression:gastrocnemius RGD PMID:22076133 RGD:9686076 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16331104 PMID:17324946 PMID:19018797 PMID:32165127 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP protein:increased expression:heart left ventricle RGD PMID:19307699 RGD:2314430 NCBI chr13:64,955,502...64,986,289
Ensembl chr13:64,955,503...64,986,277
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18524855 PMID:23348737 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 treatment IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:32165127 PMID:23775684 RGD:10412717 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha treatment IEP RGD PMID:19246475 RGD:7495780 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor IEP RGD PMID:10797303 RGD:5144109 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor IAGP DNA,protein:missense mutation:CDS:c.28G>A, p.A10T (rat strains: SHR/Izm, SHRSP/Izm, WKHT) RGD PMID:8762194 RGD:5508800 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nisch nischarin IMP RGD PMID:12021582 RGD:1581128 NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668
JBrowse link
G Nos1 nitric oxide synthase 1 treatment IEP
IDA
IMP
mRNA:decreased expression:bladder, penis RGD PMID:17574276 PMID:23201071 PMID:15913838 PMID:16093913 PMID:15775788 More... RGD:1642127, RGD:7257668, RGD:1581142, RGD:1581141, RGD:1581143, RGD:5132600 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 IEP
ISO
protein:increased expression, increased activity:kidney
CTD Direct Evidence: marker/mechanism
CTD PMID:18605955 PMID:25101153 PMID:27292124 PMID:15773227 PMID:11702222 RGD:1580264, RGD:1298023 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 treatment
no_association
IEP
IDA
ISO
associated with Pregnancy Complications
CTD Direct Evidence: marker/mechanism|therapeutic
DNA:duplication, snp:intron, cds:IVS4?-?+27, p.E298D (human)
DNA:snp:cds:p.E298D (human)
protein:decreased phosphorylation:brain
CTD PMID:11457755 PMID:12947532 PMID:16331104 PMID:19008412 PMID:19407804 More... RGD:2292113, RGD:13504683, RGD:13446414, RGD:1580278, RGD:1580271, RGD:1580282, RGD:4891993 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nox4 NADPH oxidase 4 IEP
ISO
IMP
protein:increased expression:aorta, vascular associated smooth muscle cell
CTD Direct Evidence: marker/mechanism
CTD PMID:27659729 PMID:27847271 PMID:32147540 PMID:18418428 PMID:26644237 RGD:2324669, RGD:11085830 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nppa natriuretic peptide A IEP
ISO
protein:increased expression:plasma:
CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:2526952 PMID:7839143 PMID:8188982 PMID:9869009 PMID:12940879 More... RGD:7248593 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B treatment
susceptibility
IEP
ISO
IDA
CTD Direct Evidence: marker/mechanism|therapeutic
DNA:repeats
CTD PMID:9194512 PMID:19219041 PMID:24039778 PMID:30310171 PMID:32147540 More... RGD:70484, RGD:5685657, RGD:1642191 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nppc natriuretic peptide C severity ISO associated with Pregnancy Complications;protein:increased expression:plasma RGD PMID:11775888 PMID:12452325 RGD:1642292, RGD:1580150 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Npr1 natriuretic peptide receptor 1 IAGP
ISO
DNA:repeat:promoter: (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:20881240 PMID:12511524 RGD:628585 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO DNA:snp:promoter:g.-55C>A (human) RGD PMID:12872042 RGD:1580175 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G Nptn neuroplastin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:58,996,876...59,063,402
Ensembl chr 8:58,996,887...59,063,401
JBrowse link
G Npy neuropeptide Y IMP
IEP
ISO
DNA:missense mutation:cds:p.L7P (human) RGD PMID:15699473 PMID:18835922 PMID:11689216 RGD:1357410, RGD:10448968, RGD:1580177 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Npy1r neuropeptide Y receptor Y1 IMP RGD PMID:15699473 RGD:1357410 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IDA RGD PMID:21502369 RGD:11035215 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 IMP RGD PMID:25687237 RGD:10401852 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031
JBrowse link
G Nr2f2em1Mcwi nuclear receptor subfamily 2, group F, member 2; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25687237 RGD:10401852
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IMP
ISO
associated with fetal nutrition disorder
CTD Direct Evidence: marker/mechanism
CTD PMID:18434569 PMID:20659135 PMID:20674672 PMID:20659135 RGD:4892208, RGD:7174714 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nudt1 nudix hydrolase 1 IEP RGD PMID:17280880 RGD:10449166 NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 IEP
ISO
mRNA:increased expression:aorta (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:22352330 PMID:9494115 RGD:633385 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP protein:increased expression:heart left ventricle (rat) RGD PMID:24388463 RGD:7800726 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19897708 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G Oxsr1 oxidative stress responsive kinase 1 ISO CTD Direct Evidence: therapeutic CTD PMID:22949526 NCBI chr 8:118,972,754...119,062,102
Ensembl chr 8:118,972,754...119,062,027
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide IMP
ISO
IEP
CTD Direct Evidence: therapeutic
mRNA:decreased expression:paraventricular hypothalamic nucleus
CTD PMID:9334988 PMID:18562099 PMID:18562099 PMID:16157794 RGD:2304105, RGD:2304174 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Oxtr oxytocin receptor IEP mRNA:decreased expression:brainstem RGD PMID:16157794 RGD:2304174 NCBI chr 4:145,598,549...145,614,674
Ensembl chr 4:145,599,561...145,614,674
JBrowse link
G Pappa1 pappalysin 1 ISO associated with Pregnancy Complications, Cardiovascular;protein:decreased expression:serum RGD PMID:12224070 RGD:1642331 NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666
JBrowse link
G Pdgfb platelet derived growth factor subunit B IEP RGD PMID:8869081 RGD:10449484 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha IEP RGD PMID:1657776 RGD:11080972 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta IEP protein:increased tyrosine phosphorylation:glomerulus RGD PMID:12047046 PMID:1657776 RGD:2292214, RGD:11080972 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pgf placental growth factor ISO associated with Pregnancy Complications, Cardiovascular;mRNA:decreased expression:placenta RGD PMID:12808329 RGD:1642387 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEP
IMP
protein:decreased expression:ventricular myocyte (rat) RGD PMID:18300869 PMID:19015400 RGD:4108492, RGD:4108483 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:21810655 RGD:8693428 NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
JBrowse link
G Pkd1 polycystin 1, transient receptor potential channel interacting ISO ClinVar Annotator: match by term: Hypertension ClinVar PMID:11115377 PMID:12482949 PMID:16430766 PMID:17574468 PMID:17582161 More... NCBI chr10:13,573,779...13,621,138
Ensembl chr10:13,573,021...13,621,128
JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plcd1 phospholipase C, delta 1 IEP
IDA
protein:increased expression:aorta, arteriole, glomerulus
protein:increased activity:aorta
RGD PMID:17198910 PMID:1313006 RGD:2300421, RGD:2300423 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plekha7 pleckstrin homology domain containing A7 ameliorates IMP RGD PMID:25136115 PMID:25136115 RGD:11079199, RGD:11079199 NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775
JBrowse link
G Plekha7em4Mcwi pleckstrin homology domain containing, family A member 7; zinc finger nuclease induced mutant 4, Medical College of Wisconsin ameliorates IMP RGD PMID:25136115 PMID:25136115 RGD:11079199, RGD:11079199
G Plg plasminogen ISO CTD Direct Evidence: marker/mechanism CTD PMID:6383834 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase no_association ISO
IEP
DNA:snps:5' utr:g.-390G>A, g.-184G>A rs876493 (human)
protein:decreased activity:adrenal gland (rat)
DNA:snp:5' utr:g.-390G>A (human)
RGD PMID:17645789 PMID:20378607 PMID:14553966 RGD:5130172, RGD:5130152, RGD:5130164 NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
JBrowse link
G Pomc proopiomelanocortin ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:76749 PMID:187612 PMID:216942 PMID:323586 PMID:1316127 More... NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Postn periostin IEP associated with Renal Insufficiency, Chronic; protein:increased expression:left ventricle: RGD PMID:21712488 RGD:10041050 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha treatment IEP
ISO
IMP
mRNA:increased expression:skeletal muscle
CTD Direct Evidence: marker/mechanism|therapeutic
CTD PMID:16054168 PMID:19834340 PMID:19763017 PMID:15967866 RGD:2313778, RGD:1580222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IMP
ISO
IEP
IDA
CTD Direct Evidence: marker/mechanism|therapeutic
protein:decreased expression:rostral ventrolateral medulla (rat)
human gene in a mouse model
CTD PMID:15199296 PMID:19666838 PMID:27292124 PMID:18437150 PMID:20404217 More... RGD:2301888, RGD:7175297, RGD:2301864, RGD:1580690, RGD:1580684 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppbp pro-platelet basic protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:6192689 PMID:15513305 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
JBrowse link
G Ppia peptidylprolyl isomerase A ISO mRNA:increased expression:alveolar system (human) RGD PMID:32496587 RGD:150383342 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: High blood pressure ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta ISO RGD PMID:11161799 RGD:619653 NCBI chr12:15,492,233...15,624,942
Ensembl chr12:15,511,801...15,624,942
JBrowse link
G Prkca protein kinase C, alpha IAGP RGD PMID:15792354 RGD:1581271 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta IDA RGD PMID:15804434 RGD:1625513 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta IEP
ISO
IAGP
protein:increased expression:heart, fibroblast
CTD Direct Evidence: marker/mechanism
CTD PMID:23973649 PMID:10756122 PMID:15792354 RGD:1642534, RGD:1581271 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkce protein kinase C, epsilon IAGP RGD PMID:15792354 RGD:1581271 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 IEP mRNA, protein:splice variant, alternative form:basilar artery RGD PMID:14512447 RGD:7775067 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Prlhr prolactin releasing hormone receptor ISO DNA:SNP, missense mutation:promoter, cds:-62G>A, 914C>T (p.P305L) (human) RGD PMID:14691196 RGD:1641832 NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:259,606,704...259,608,391
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa ISO CTD Direct Evidence: marker/mechanism CTD PMID:22352330 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Pten phosphatase and tensin homolog ISO CTD Direct Evidence: marker/mechanism CTD PMID:15646324 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgds prostaglandin D2 synthase ISO protein:increased expression:serum, urine RGD PMID:11882588 RGD:1642584 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
JBrowse link
G Ptgis prostaglandin I2 synthase ISO RGD PMID:12372404 RGD:1298040 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IAGP
ISO
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:14757778 PMID:15834289 PMID:20667508 PMID:22349312 PMID:15775781 More... RGD:1581285, RGD:1580671 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:1930854 PMID:23460043 RGD:7242420 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530
JBrowse link
G Ptk2 protein tyrosine kinase 2 IAGP
IEP
protein:increased expression:aorta RGD PMID:12732587 PMID:21068519 RGD:729831, RGD:10041072 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta susceptibility ISO
IEP
DNA:polymorphism:promoter:-22A>G
protein:increased expression:aorta
RGD PMID:18075463 PMID:21068519 RGD:2292575, RGD:10041072 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO CTD Direct Evidence: therapeutic CTD PMID:28899902 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J IAGP RGD PMID:15710778 RGD:1357414 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Ptpru protein tyrosine phosphatase, receptor type, U susceptibility ISO RGD PMID:11086029 RGD:1642652 NCBI chr 5:143,950,542...144,024,791
Ensembl chr 5:143,950,965...144,024,768
JBrowse link
G Qdpr quinoid dihydropteridine reductase IEP protein:decreased expression:aorta smooth muscle (rat) RGD PMID:19743417 RGD:5128580 NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
JBrowse link
G Rad51 RAD51 recombinase treatment IDA RGD PMID:24239235 RGD:8693672 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rag1 recombination activating 1 IMP RGD PMID:23364523 RGD:7207429 NCBI chr 3:87,917,061...87,928,158
Ensembl chr 3:87,917,004...87,928,291
JBrowse link
G Ralbp1 ralA binding protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23821548 NCBI chr 9:105,456,425...105,492,711
Ensembl chr 9:105,456,425...105,492,707
JBrowse link
G Ramp2 receptor activity modifying protein 2 susceptibility ISO
IEP
DNA:SNP:intron
associated with Pregnancy Complications
mRNA, protein:increased expression:heart myocardium, aorta
RGD PMID:15797661 PMID:11600589 PMID:16450076 RGD:1642679, RGD:1642682, RGD:1625300 NCBI chr10:86,187,366...86,190,692 JBrowse link
G Rasgrp3 RAS guanyl releasing protein 3 ISO RGD PMID:19421330 RGD:2314812 NCBI chr 6:19,895,366...19,993,945
Ensembl chr 6:19,895,390...19,958,578
JBrowse link
G Reg3g regenerating family member 3 gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:27798352 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:19018797 PMID:27659729 PMID:32147540 PMID:16840655 RGD:2298761 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin IDA
ISO
CTD Direct Evidence: marker/mechanism
protein:decreased activity:plasma (mouse)
CTD PMID:45830 PMID:62162 PMID:998518 PMID:1071603 PMID:1149188 More... RGD:1580671, RGD:6892655, RGD:6784501, RGD:1580697 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Resp18 regulated endocrine-specific protein 18 IMP RGD PMID:29570433 RGD:14348960 NCBI chr 9:76,765,179...76,771,824
Ensembl chr 9:76,764,590...76,778,722
JBrowse link
G Resp18em2Mcwi regulated endocrine-specific protein 18; zinc finger nuclease induced mutant 2, Medical College of Wisconsin IMP RGD PMID:29570433 RGD:14348960
G Retn resistin ISO DNA:SNP:3' utr:*62A>G (human) RGD PMID:12629116 RGD:1624968 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase IEP mRNA,protein:increased expression:heart RGD PMID:21357277 RGD:13442502 NCBI chr10:67,740,711...67,803,694
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO
IEP
CTD Direct Evidence: therapeutic CTD PMID:1798635 PMID:14608379 PMID:17986358 RGD:13524579, RGD:2289116 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rgs4 regulator of G-protein signaling 4 treatment IEP RGD PMID:21825230 RGD:7207400 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rgs5 regulator of G-protein signaling 5 treatment ISO
IEP
CTD Direct Evidence: therapeutic CTD PMID:1798635 PMID:21825230 RGD:7207400 NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
JBrowse link
G Rhoa ras homolog family member A IEP protein:altered localization:mesenteric artery RGD PMID:17620967 RGD:1642801 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO associated with Diabetes Mellitus Type 2; DNA:SNPs: : rs2296545,rs2576178 (human)
associated with kidney Failure,Chronic;DNA:SNPs: : rs2576178, rs10887800 (human)
RGD PMID:21964580 PMID:21178975 PMID:21617193 RGD:7327172, RGD:7327174, RGD:7327173 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
JBrowse link
G Rnpep arginyl aminopeptidase IEP
IMP
protein:increased expression:adrenal gland, neurohypophysis RGD PMID:9660082 PMID:3001599 RGD:2325942, RGD:2325950 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19289642 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G RT1-Ba RT1 class II, locus Ba ISO DNA:polymorphisms (human) RGD PMID:11798899 RGD:5147807 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G S100b S100 calcium binding protein B ISO protein:increased expression:serum RGD PMID:21130083 RGD:5508770 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 disease_progression IAGP associated with SHRSP;mRNA,protein:increased expression, decreased expression:kidney (rat) RGD PMID:17938382 RGD:1643008 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Scnn1a sodium channel epithelial 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:11752024 PMID:23348737 NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181
JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:15174897 PMID:15198480 PMID:19344079 NCBI chr 1:176,430,063...176,484,451
Ensembl chr 1:176,430,103...176,484,451
JBrowse link
G Scnn1g sodium channel epithelial 1 subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:15198480 NCBI chr 1:176,304,942...176,338,816
Ensembl chr 1:176,304,942...176,338,816
JBrowse link
G Selp selectin P ISO CTD Direct Evidence: marker/mechanism CTD PMID:15513305 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Serpina1 serpin family A member 1 ISO protein:increased expression:urine RGD PMID:10353322 RGD:1643147 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpine1 serpin family E member 1 treatment ISO
IEP
IDA
protein:increased expression:plasma (human)
mRNA:increased expression:kidney (SHRSP/A3N rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:21051829 PMID:22352330 PMID:8355419 PMID:11907153 PMID:16645728 RGD:8547753, RGD:28912746, RGD:11081003 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Serpine2 serpin family E member 2 IEP mRNA, protein:increased expression:blood vessel RGD PMID:12524238 RGD:729767 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Serpinf2 serpin family F member 2 ISO RGD PMID:9361364 RGD:1625531 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 no_association
susceptibility
ISO DNA:snps:exon, intron: (human) RGD PMID:15304560 PMID:16221215 RGD:1580969, RGD:1580968 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sh2b3 SH2B adaptor protein 3 IMP RGD PMID:25776069 RGD:13442483 NCBI chr12:34,749,849...34,753,616
Ensembl chr12:34,731,911...34,753,616
JBrowse link
G Sh2b3em1Mcwi SH2B adaptor protein 3; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP RGD PMID:25776069 RGD:13442483
G Slc12a2 solute carrier family 12 member 2 IEP
ISO
IDA
mRNA:increased expression:aorta
CTD Direct Evidence: marker/mechanism
CTD PMID:17259435 PMID:15020309 PMID:21814290 RGD:1580582, RGD:9587757 NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
JBrowse link
G Slc12a3 solute carrier family 12 member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18480177 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Slc26a4 solute carrier family 26 member 4 ISO RGD PMID:17120771 RGD:7411553 NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703
JBrowse link
G Slc2a1 solute carrier family 2 member 1 IEP protein:increased expression:renal glomerulus RGD PMID:12771048 RGD:12879474 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a3 solute carrier family 2 member 3 IEP protein:decreased expression:hippocampus, parietal cortex; protein:increased expression:hypothalamus, thalamus RGD PMID:7598707 RGD:1642812 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
JBrowse link
G Slc34a1 solute carrier family 34 member 1 ISO ClinVar Annotator: match by term: High blood pressure ClinVar PMID:16638441 PMID:25741868 NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852
JBrowse link
G Slc4a4 solute carrier family 4 member 4 IEP protein:increased expression:kidney cortex RGD PMID:15340004 RGD:1600028 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
JBrowse link
G Slc5a2 solute carrier family 5 member 2 IDA RGD PMID:14506074 RGD:1599050 NCBI chr 1:182,847,185...182,853,309
Ensembl chr 1:182,847,106...182,853,306
JBrowse link
G Slc6a18 solute carrier family 6 member 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15121838 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925
JBrowse link
G Slc6a19 solute carrier family 6 member 19 IEP mRNA:increased expression RGD PMID:17264310 RGD:1600036 NCBI chr 1:29,586,205...29,604,960
Ensembl chr 1:29,586,195...29,604,962
JBrowse link
G Slc6a2 solute carrier family 6 member 2 ISO DNA:polymorphism:1287G>A
CTD Direct Evidence: marker/mechanism
CTD PMID:22533655 PMID:17124432 RGD:1624279 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357
JBrowse link
G Slc6a3 solute carrier family 6 member 3 IEP protein:increased expression:caudate-putamen RGD PMID:9074541 RGD:1625656 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slc8a1 solute carrier family 8 member A1 IEP
ISO
DNA:snps:intron:g.-23200T>C, g.-23181T>C (human)
DNA:SNP: :1784C>T
RGD PMID:16343576 PMID:15785003 PMID:15824464 RGD:1598724, RGD:1580732, RGD:1580586 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc9a3 solute carrier family 9 member A3 IDA RGD PMID:11880335 PMID:12372791 RGD:737665, RGD:727447 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 IEP RGD PMID:15311100 RGD:1580741 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G Slc9a3r2 SLC9A3 regulator 2 IEP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22228705 PMID:15311100 RGD:1580741 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049
JBrowse link
G Sod1 superoxide dismutase 1 treatment ISO
IEP
associated with Hydronephrosis
CTD Direct Evidence: marker/mechanism|therapeutic
human gene in a rat model
mRNA:decreased expression:rostral ventrolateral medulla (rat)
CTD PMID:9024144 PMID:25101153 PMID:32165127 PMID:19403858 PMID:16716903 More... RGD:2312366, RGD:1580833, RGD:1581232, RGD:1580833, RGD:1600704 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 IDA
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:11834524 PMID:21593737 PMID:25101153 PMID:16716903 RGD:1580833 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 IDA
ISO
CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:16864745 PMID:17023265 PMID:12600899 PMID:16864745 RGD:1580845, RGD:1581232 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Sqstm1 sequestosome 1 IEP protein:decreased expression:brain RGD PMID:23499735 RGD:11561939 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:16157790 RGD:1601372 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srf serum response factor IDA RGD PMID:16822834 RGD:1580749 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Sst somatostatin IEP protein:altered expression:stomach RGD PMID:17928643 RGD:2303191 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Stim1 stromal interaction molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19897708 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Stk11 serine/threonine kinase 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19289642 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
JBrowse link
G Stk39 serine threonine kinase 39 ISO CTD Direct Evidence: therapeutic CTD PMID:22949526 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060
JBrowse link
G Sts steroid sulfatase IEP protein:increased expression:multiple organs RGD PMID:8539776 RGD:1601393 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tac3 tachykinin precursor 3 IEP protein:increased expression:supraoptic nucleus, medulla oblongata RGD PMID:2478257 RGD:2305983 NCBI chr 7:63,562,552...63,569,170
Ensembl chr 7:63,562,552...63,569,170
JBrowse link
G Tacr1 tachykinin receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21294877 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tacr3 tachykinin receptor 3 IDA RGD PMID:2471579 RGD:2305984 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Tbxas1 thromboxane A synthase 1 IDA associated with hyperinsulinism RGD PMID:9370383 PMID:16192456 RGD:1601472, RGD:1601439 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Tf transferrin ISO protein:decreased expression RGD PMID:14974364 RGD:1601524 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP
IAGP
ISO
protein:increased expression:vascular associated smooth muscle cell
mRNA:increased expression:kidney (SHRSP/A3N rat)
protein:increased expression:renal glomerulus
CTD Direct Evidence: marker/mechanism
CTD PMID:11682445 PMID:19018797 PMID:17364610 PMID:11907153 PMID:11682445 More... RGD:1601552, RGD:28912746, RGD:30296650, RGD:12879474, RGD:1331525 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 no_association ISO DNA:polymorphism, SNPs RGD PMID:15924806 RGD:1625704 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgm2 transglutaminase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17898543 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
G Th tyrosine hydroxylase susceptibility IEP
ISO
mRNA:increased expression:brain
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:intron:g.1090T>C rs2070762 (human)
CTD PMID:27659729 PMID:32147540 PMID:32165127 PMID:16650497 PMID:16636198 RGD:1601630, RGD:1601631 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thbd thrombomodulin treatment IEP
ISO
associated with Experimental Diabetes Mellitus
protein:increased expression:plasma
protein:decreased expression:plasma
RGD PMID:14737039 PMID:16095049 PMID:17401180 PMID:12611420 RGD:1601646, RGD:5685017, RGD:1601636, RGD:1601652 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ISO
IEP
protein:decreased expression:glomerulus
CTD Direct Evidence: marker/mechanism
mRNA, protein:increased expression:kidney
CTD PMID:21051829 PMID:19506087 PMID:17977875 RGD:2312464, RGD:2290351 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tjp2 tight junction protein 2 IEP protein:decreased expression:brain RGD PMID:17234953 RGD:1600163 NCBI chr 1:221,709,745...221,838,383
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27292124 PMID:32147540 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor treatment IAGP
ISO
IMP
CTD Direct Evidence: marker/mechanism CTD PMID:18605955 PMID:27292124 PMID:27659729 PMID:27847271 PMID:32147540 More... RGD:1357163, RGD:1580207 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B severity ISO protein:increased expression:serum RGD PMID:22050177 RGD:7205512 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tp53 tumor protein p53 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpm1 tropomyosin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802
JBrowse link
G Trh thyrotropin releasing hormone IDA
ISO
protein:decreased expression:diencephalon
CTD Direct Evidence: marker/mechanism
CTD PMID:6350720 PMID:17227965 RGD:1600406 NCBI chr 4:124,742,111...124,777,094
Ensembl chr 4:124,742,111...124,744,637
JBrowse link
G Trhr thyrotropin releasing hormone receptor IDA RGD PMID:7554113 RGD:1580745 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:75,348,672...75,393,309
JBrowse link
G Trpc3 transient receptor potential cation channel, subfamily C, member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17351372 NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17351372 NCBI chr  X:107,946,163...108,230,978
Ensembl chr  X:107,939,131...108,230,991
JBrowse link
G Ucn urocortin ISO associated with Pregnancy Complications;protein:increased expression:plasma
CTD Direct Evidence: therapeutic
CTD PMID:20237592 PMID:16915033 RGD:1642775 NCBI chr 6:25,238,120...25,238,950
Ensembl chr 6:25,238,120...25,238,950
JBrowse link
G Ucn2 urocortin 2 ISO human protein in rat model RGD PMID:19204182 RGD:5508437 NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172
JBrowse link
G Ucp1 uncoupling protein 1 ISO DNA:polymorphism: :-3826A>G (human) RGD PMID:17635070 RGD:2313626 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852
JBrowse link
G Ucp2 uncoupling protein 2 treatment ISO
IDA
CTD Direct Evidence: marker/mechanism CTD PMID:16685210 PMID:15106800 PMID:20404217 RGD:1580794, RGD:7175297 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Ucp3 uncoupling protein 3 IEP RGD PMID:10994754 RGD:1580795 NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
JBrowse link
G Umod uromodulin ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228705 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
G Uts2 urotensin 2 ISO
IDA
protein:increased expression:plasma
CTD Direct Evidence: marker/mechanism
CTD PMID:16160878 PMID:15201550 PMID:14621188 RGD:1580808, RGD:1580812 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
JBrowse link
G Uts2r urotensin 2 receptor IDA RGD PMID:14621188 RGD:1580812 NCBI chr10:106,438,092...106,439,252
Ensembl chr10:106,438,092...106,439,252
JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21115475 NCBI chr 2:197,011,901...197,354,321
Ensembl chr 2:197,011,831...197,354,321
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 disease_progression IEP
IAGP
ISO
mRNA:increased expression:multiple organs
associated with SHRSP;mRNA,protein:increased expression:kidney, membrane fraction (rat)
CTD Direct Evidence: marker/mechanism
associated with Diabetes Mellitus, Type1; protein:increased expression:serum:
CTD PMID:11834524 PMID:19018797 PMID:19080338 PMID:17938382 PMID:20569722 RGD:2313107, RGD:1643008, RGD:7241235 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vdr vitamin D receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11335187 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A treatment ISO associated with Prostatic Neoplasms RGD PMID:16164572 PMID:20630084 RGD:1580573, RGD:8552374 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:12500216 RGD:1580371 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vwf von Willebrand factor treatment ISO
IEP
CTD Direct Evidence: marker/mechanism
associated with Experimental Diabetes Mellitus
CTD PMID:12149661 PMID:12425201 PMID:22352330 PMID:14737039 RGD:1601646 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22949526 PMID:16301342 RGD:1580829 NCBI chr 4:153,128,334...153,253,905
Ensembl chr 4:153,128,334...153,253,905
JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 no_association IAGP
ISO
CTD Direct Evidence: marker/mechanism CTD PMID:22949526 PMID:12642508 PMID:15110905 RGD:629611, RGD:1580830 NCBI chr10:86,202,552...86,219,655
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Xdh xanthine dehydrogenase treatment IDA
IEP
ISO
DNA:SNPs:exon, intron:47686C>T, 69901A>C, 67873A>C (p.N1109T) (human) RGD PMID:23746952 PMID:12826072 PMID:18712049 PMID:18728266 RGD:7247630, RGD:13210518, RGD:7247654, RGD:7247653 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta treatment IEP RGD PMID:22984478 RGD:9587480 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
JBrowse link
angle-closure glaucoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E susceptibility ISO DNA:polymorphism:exon: RGD PMID:17706090 RGD:7771556 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cat catalase severity ISO DNA:SNP:promoter:g.4760C>T(rs1001179)(human) RGD PMID:23961996 RGD:9068947 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chat choline O-acetyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27064256 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Col11a1 collagen type XI alpha 1 chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:22922875 PMID:27064256 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain ISO ClinVar Annotator: match by term: GLAUCOMA, PRIMARY CLOSED-ANGLE ClinVar PMID:19390655 PMID:21862674 PMID:23667181 PMID:25741868 PMID:28041643 More... NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Edn1 endothelin 1 ISO protein:increased expression:plasma (human) RGD PMID:21946544 RGD:8661736 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Epdr1 ependymin related 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27064256 NCBI chr17:45,333,677...45,358,597
Ensembl chr17:45,333,956...45,358,594
JBrowse link
G Fermt2 FERM domain containing kindlin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27064256 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811
JBrowse link
G Glis3 GLIS family zinc finger 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27064256 NCBI chr 1:225,976,029...226,395,849
Ensembl chr 1:225,976,326...226,395,899
JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility ISO DNA:deletion, haplotype:cds (human) RGD PMID:18334963 RGD:7488955 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hgf hepatocyte growth factor susceptibility ISO DNA:SNPs,haplotype::rs5745718,rs1742817(human) RGD PMID:23585864 RGD:8548548 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Loxl1 lysyl oxidase-like 1 no_association ISO DNA:SNPs: :rs1048661, rs2165241, rs3825942 (human) RGD PMID:18223248 RGD:7394723 NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Mmp9 matrix metallopeptidase 9 no_association ISO DNA:SNP: :rs2664538 (human)
DNA:SNP:promoter:-1562C>T (human)
DNA:SNP: :c.836A>G (rs17576) (human)
DNA:SNPs: :rs17576, rs3918249 (human)
RGD PMID:17110919 PMID:23441116 PMID:23441116 PMID:21655354 RGD:8547816, RGD:8549724, RGD:8549724, RGD:8547830 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:SNPs: :677C>T,1298A>C(human) RGD PMID:19936026 RGD:7387250 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with Cataract;protein:decreased expression:tear RGD PMID:21139981 RGD:7364742 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Nos3 nitric oxide synthase 3 susceptibility ISO DNA:duplication:intron:IVS4?-?+27 (human)
DNA:snps:introns:g.IVS5+1182G>A, g.IVS25+11C>A (rs3793342, rs7830) (human)
RGD PMID:20069064 PMID:23422825 RGD:7771573, RGD:7775046 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Plekha7 pleckstrin homology domain containing A7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22922875 PMID:27064256 NCBI chr 1:170,364,524...170,547,843
Ensembl chr 1:170,365,135...170,547,775
JBrowse link
G Prss56 serine protease 56 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21532570 NCBI chr 9:87,842,806...87,859,978
Ensembl chr 9:87,854,805...87,859,978
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:28719234 NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
JBrowse link
G Slc19a1 solute carrier family 19 member 1 ISO ClinVar Annotator: match by term: GLAUCOMA, PRIMARY CLOSED-ANGLE ClinVar PMID:19390655 PMID:21862674 PMID:23667181 PMID:25741868 PMID:28041643 More... NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Tfap2b transcription factor AP-2 beta ISS MouseDO NCBI chr 9:21,786,250...21,815,785
Ensembl chr 9:21,786,258...21,814,520
JBrowse link
anterior segment dysgenesis 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc1 forkhead box C1 ISO ClinVar Annotator: match by term: Anterior segment dysgenesis 3
ClinVar Annotator: match by term: Iridogoniodysgenesis type1
ClinVar Annotator: match by OMIM:601631
OMIM
ClinVar
PMID:9620769 PMID:9792859 PMID:11007653 PMID:11170889 PMID:12036988 More... NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803
JBrowse link
anterior segment dysgenesis 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pitx2 paired-like homeodomain 2 ISO ClinVar Annotator: match by term: Anterior segment dysgenesis 4
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: ANTERIOR SEGMENT DYSGENESIS 4
ClinVar Annotator: match by term: Iridogoniodysgenesis, dominant type
ClinVar Annotator: match by OMIM:137600
OMIM
ClinVar
CTD
PMID:7581385 PMID:8942889 PMID:9437321 PMID:9618168 PMID:10502778 More... NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293
JBrowse link
buphthalmos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 susceptibility ISO ClinVar Annotator: match by term: Glaucoma 3, primary congenital, A
ClinVar Annotator: match by term: Congenital glaucoma
ClinVar Annotator: match by term: Glaucoma, congenital
ClinVar Annotator: match by term: Glaucoma, primary open angle, juvenile-onset
ClinVar Annotator: match by OMIM:231300
DNA:missense mutation:cds:p.A388T (human)
DNA:missense mutation, deletion:exon:p.R390H, g.4633delC (human)
DNA:duplication:exon:g.1546-1555dupTCATGCCACC (human)
DNA:missense mutations:exons:p.G61E, p.R368H, p.D374N (human)
DNA:missense mutations:exons:p.G61E, p.R469W, p.R523K (human)
DNA:deletion, snp:exons:g.4339delG, p.G61E (human)
DNA:snp:cds:p.E387K (human)
DNA:polymorphisms:multiple (human)
OMIM
ClinVar
PMID:9097971 PMID:9463332 PMID:9497261 PMID:9536098 PMID:10227395 More... RGD:7800719, RGD:7800711, RGD:7800707, RGD:7800689, RGD:7800688, RGD:7800680, RGD:7800670, RGD:7800657, RGD:734869 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Foxc1 forkhead box C1 ISS OMIM:231300 MouseDO NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 ISO ClinVar Annotator: match by term: Glaucoma, congenital ClinVar PMID:19656777 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
JBrowse link
G Myoc myocilin ISO ClinVar Annotator: match by term: Glaucoma 3, primary congenital, a, digenic ClinVar PMID:12447164 PMID:15025728 PMID:15723004 PMID:15733270 PMID:16288197 More... NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Rmdn2 regulator of microtubule dynamics 2 ISO ClinVar Annotator: match by term: Glaucoma 3, primary congenital, A ClinVar NCBI chr 6:15,372,569...15,443,000
Ensembl chr 6:15,375,496...15,441,480
JBrowse link
G Tyr tyrosinase ISS OMIM:231300 MouseDO NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
Charcot-Marie-Tooth disease type 4B2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sbf2 SET binding factor 2 ISO ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 4B2 with early-onset glaucoma
ClinVar Annotator: match by term: Charcot-Marie-Tooth disease, type 4B2
ClinVar Annotator: match by OMIM:604563
ClinVar Annotator: match by null
OMIM
ClinVar
PMID:9521281 PMID:10932274 PMID:12554688 PMID:12687498 PMID:15304601 More... NCBI chr 1:164,352,892...164,719,883
Ensembl chr 1:164,353,444...164,719,807
JBrowse link
Diastolic Hypertension, Resistance to term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnip1 potassium voltage-gated channel interacting protein 1 ISO ClinVar Annotator: match by null ClinVar PMID:15057310 PMID:16155733 NCBI chr10:18,219,519...18,588,833
Ensembl chr10:18,219,519...18,589,045
JBrowse link
G Kcnmb1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 ISO ClinVar Annotator: match by OMIM:608622 OMIM
ClinVar
PMID:15057310 PMID:16155733 NCBI chr10:18,557,510...18,614,824
Ensembl chr10:18,557,904...18,565,798
JBrowse link
Dursun Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc3 glucose 6 phosphatase catalytic subunit 3 ISO ClinVar Annotator: match by term: Dursun syndrome ClinVar PMID:19011569 PMID:19118303 PMID:20799326 PMID:25491320 PMID:25741868 More... NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221
JBrowse link
eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 treatment IDA RGD PMID:27106269 RGD:11062145 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
essential hypertension term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsm3 acyl-CoA synthetase medium-chain family member 3 no_association ISO RGD PMID:11592044 RGD:1579978 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Add1 adducin 1 ISO ClinVar Annotator: match by term: Hypertension, salt-sensitive essential, susceptibility to OMIM
ClinVar
PMID:9149697 PMID:9607177 PMID:10024330 PMID:21692745 PMID:22992668 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Agt angiotensinogen ISO ClinVar Annotator: match by term: Hypertension, essential, susceptibility to OMIM
ClinVar
PMID:7649545 PMID:7883995 PMID:8348146 PMID:8513325 PMID:8518804 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment ISO ClinVar Annotator: match by term: Essential hypertension
ClinVar Annotator: match by term: Hypertension, essential, susceptibility to
OMIM
ClinVar
PMID:8021009 PMID:9084931 PMID:15042429 PMID:25741868 PMID:18604484 RGD:10047396 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 ISO OMIM NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 susceptibility ISO DNA:polymorphism:exon:p.A724A (c.2171G>A)(human) RGD PMID:20687374 RGD:13507310 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO protein:increased expression:plasma (human) RGD PMID:14654753 RGD:13800915 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119
JBrowse link
G Cat catalase ISO RGD PMID:15735318 RGD:1581147 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 ISO ClinVar Annotator: match by term: Hypertension, salt-sensitive essential, susceptibility to OMIM
ClinVar
PMID:11279519 PMID:11740341 PMID:12065767 PMID:12754175 PMID:15492926 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Ece1 endothelin converting enzyme 1 ISO OMIM NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Eln elastin ISS OMIM:145500 | OMIM:603918 | OMIM:604329 | OMIM:607329 | OMIM:608742 | OMIM:610261 | OMIM:610262 | OMIM:610948 | OMIM:611014 MouseDO NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Gata5 GATA binding protein 5 ISS OMIM:145500 | OMIM:603918 | OMIM:604329 | OMIM:607329 | OMIM:608742 | OMIM:610261 | OMIM:610262 | OMIM:610948 | OMIM:611014 MouseDO NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751
JBrowse link
G Gnb3 G protein subunit beta 3 ISO OMIM NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
JBrowse link
G Grk4 G protein-coupled receptor kinase 4 susceptibility ISO DNA:SNP,haplotypes:cds: RGD PMID:15097232 PMID:15097232 RGD:1598505, RGD:1598505 NCBI chr14:75,998,554...76,080,808
Ensembl chr14:76,006,218...76,080,693
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 ISO protein:increased expression:urine: RGD PMID:22923545 RGD:7245500 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:urine: RGD PMID:22923545 RGD:7245500 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Nos3 nitric oxide synthase 3 ISO DNA:repeats:intron:IVS13+?-?dupCA (human)
ClinVar Annotator: match by term: Essential hypertension
DNA:snp:cds:p.E298D (human)
ClinVar
OMIM
PMID:25741868 PMID:9084930 PMID:11394896 RGD:1580277, RGD:1580280 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppb natriuretic peptide B ISO protein:increased expression:plasma: RGD PMID:9350073 RGD:7246914 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Npr2 natriuretic peptide receptor 2 ISO DNA:repeat:intron:IVS2+150(GT)10-11 (human) RGD PMID:10082481 RGD:1580772 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
JBrowse link
G Ptgis prostaglandin I2 synthase ISO ClinVar Annotator: match by term: Essential hypertension
ClinVar Annotator: match by OMIM:145500
OMIM
ClinVar
PMID:12372404 PMID:25741868 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Rarres2 retinoic acid receptor responder 2 ISO protein:increased expression:serum: RGD PMID:24047472 RGD:15036820 NCBI chr 4:77,522,549...77,525,733
Ensembl chr 4:77,522,535...77,525,556
JBrowse link
G Ren renin ISO RGD PMID:1152295 RGD:125097505 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO OMIM NCBI chr13:81,848,254...81,885,053
Ensembl chr13:81,836,304...81,885,518
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase ISO DNA:SNPs: :rs2576178, rs2296545,rs2114406 (human) RGD PMID:17216203 RGD:7327177 NCBI chr 1:231,037,481...231,309,855
Ensembl chr 1:231,037,486...231,309,823
JBrowse link
G Slc12a3 solute carrier family 12 member 3 severity ISO DNA:missense mutation:cds:p.R904Q (human)
DNA:snp:intron:g.1784C>T (human)
RGD PMID:15480096 PMID:15824464 RGD:1580589, RGD:1580586 NCBI chr19:10,630,649...10,679,250
Ensembl chr19:10,631,393...10,669,091
JBrowse link
G Umod uromodulin ISO ClinVar Annotator: match by term: Essential hypertension ClinVar NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link
exfoliation syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28553957 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278
JBrowse link
G Apoe apolipoprotein E susceptibility ISO DNA:polymorphism:exon: RGD PMID:15939044 RGD:7771555 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25706626 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cav1 caveolin 1 no_association ISO DNA:SNP:promoter:rs4236601 (human) RGD PMID:20835238 RGD:8661783 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Clu clusterin no_association ISO DNA:SNPs, haplotype: :multiple
DNA:SNP:intron:rs2279590 (human)
RGD PMID:18806885 PMID:25057782 PMID:19182256 PMID:19182256 PMID:16639006 RGD:8699505, RGD:9068391, RGD:8887372, RGD:8887372, RGD:8699516 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Edn1 endothelin 1 ISO associated with Cataract;protein:increased expression:aqueous humor (human) RGD PMID:15031170 RGD:8661674 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Eln elastin ISO RGD PMID:7777294 RGD:9585736 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Gstm1 glutathione S-transferase mu 1 susceptibility
no_association
ISO DNA:deletion, haplotype:cds (human)
DNA:deletion:cds (human)
RGD PMID:18334963 PMID:16020292 RGD:7488955, RGD:7495792 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstt1 glutathione S-transferase theta 1 susceptibility
no_association
ISO DNA:deletion:cds (human)
mRNA:decreased expression:ciliary processes, iris (human)
RGD PMID:21151336 PMID:18055805 PMID:16020292 RGD:7794822, RGD:7794853, RGD:7495792 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Loxl1 lysyl oxidase-like 1 susceptibility
no_association
ISO DNA:SNP: :p.R141L (rs1048661) (human)
ClinVar Annotator: match by term: Exfoliation syndrome, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:CNVs
DNA:SNPs:exon:p.R141L, p.G153D (human)
DNA:SNP, haplotypes:promoter:multiple
DNA:SNP:exon:rs1048661, rs3825942 (human)
DNA:SNP, haplotypes: :rs1048661, rs3825942 (human)
DNA:SNP: :multiple
ClinVar
OMIM
CTD
PMID:17690259 PMID:18037624 PMID:19343041 PMID:25706626 PMID:28553957 More... RGD:7387325, RGD:7394726, RGD:7387333, RGD:7387332, RGD:7387331, RGD:7387329, RGD:7387328, RGD:7387327, RGD:7387326 NCBI chr 8:58,692,592...58,716,356
Ensembl chr 8:58,692,593...58,716,356
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 ISO ClinVar Annotator: match by term: Exfoliation Syndrome
ClinVar Annotator: match by term: Pseudoexfoliation glaucoma
ClinVar PMID:23401661 PMID:28492532 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
JBrowse link
G Lyst lysosomal trafficking regulator ISS OMIM:177650 MouseDO NCBI chr17:86,241,384...86,443,501 JBrowse link
G Mmp1 matrix metallopeptidase 1 no_association ISO DNA:insertion:promoter:g.-1607insG rs1799750 (human) RGD PMID:20808730 RGD:8549725 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 no_association ISO DNA:insertion: :p.Q279R (rs17576) (human) RGD PMID:20808730 RGD:8549725 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Optn optineurin no_association ISO DNA:polymorphism: :p.M98K (human) RGD PMID:16020311 RGD:6480509 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Pomp proteasome maturation protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:28553957 NCBI chr12:7,162,098...7,174,737
Ensembl chr12:7,160,714...7,174,715
JBrowse link
G Pon1 paraoxonase 1 ISO protein:decreased expression:serum (human) RGD PMID:19628957 RGD:8547685 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rbms3 RNA binding motif, single stranded interacting protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28553957 NCBI chr 8:116,308,360...117,625,730
Ensembl chr 8:116,309,882...117,625,423
JBrowse link
G Sod2 superoxide dismutase 2 ISO associated with cataract;mRNA:increased expression:lens epithelium:
associated with glaucoma,primary open angle; mRNA:increased expression: ciliary body, iris:
RGD PMID:23805041 PMID:18055805 RGD:8158048, RGD:7794853 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Tlcd5 TLC domain containing 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28553957 NCBI chr 8:43,481,388...43,486,288
Ensembl chr 8:43,479,016...43,486,290
JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:haplotype:: RGD PMID:22831837 RGD:7794768 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
glaucoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 treatment IDA RGD PMID:23702784 RGD:9685447 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Anxa3 annexin A3 IEP mRNA:increased expression:retina RGD PMID:18055803 RGD:2289160 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Apoa4 apolipoprotein A4 ISO Primary Congenital Glaucoma; protein:increased expression:aqueous humor (human) RGD PMID:21078314 RGD:5685641 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoe apolipoprotein E ISO GAD PMID:15118671 RGD:1331525 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Atf2 activating transcription factor 2 IEP RGD PMID:17586494 RGD:10047416 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Bad BCL2-associated agonist of cell death IEP protein:decreased serine phosphorylation:retina RGD PMID:16103353 RGD:2292690 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEP mRNA:increased expression:optic nerve, retina RGD PMID:24357921 RGD:10054098 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP mRNA:decreased expression:optic nerve, retina RGD PMID:24357921 RGD:10054098 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor treatment ISO
IDA
IEP
protein:decreased expression:eye: RGD PMID:19422885 PMID:21498611 PMID:10711692 RGD:8655601, RGD:8655886, RGD:8655608 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 IEP protein:increased expression:eye RGD PMID:22476098 RGD:6483048 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bex3 brain expressed X-linked 3 IEP mRNA:decreased expression:retina RGD PMID:19682984 RGD:9743977 NCBI chr  X:99,273,238...99,274,799
Ensembl chr  X:99,273,161...99,274,800
JBrowse link
G Ccnd2 cyclin D2 IEP mRNA:increased expression:retina RGD PMID:18055803 RGD:2289160 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO RGD PMID:16159632 RGD:8549757 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEP mRNA, protein:decreased expression:retina, Muller cell RGD PMID:16707124 RGD:2293623 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21532571 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B ISO CTD Direct Evidence: marker/mechanism CTD PMID:21532571 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Cfh complement factor H ISO protein:decreased expression:retina: RGD PMID:20484586 RGD:7364950 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
JBrowse link
G Cntf ciliary neurotrophic factor IDA
ISO
RGD PMID:14725620 PMID:19060281 RGD:1626115, RGD:8655853 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877
JBrowse link
G Crebbp CREB binding protein ISO ClinVar Annotator: match by term: Glaucoma ClinVar PMID:25741868 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:24989686 RGD:9384823 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO associated with Exfoliation Syndrome; RGD PMID:20107165 RGD:10401222 NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183
JBrowse link
G Epo erythropoietin ISO
IEP
protein:increased expression:retina: RGD PMID:19741249 PMID:17554621 PMID:17554621 RGD:10401071, RGD:11041649, RGD:11041649 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Epor erythropoietin receptor IEP protein:increased expression:retina: RGD PMID:17554621 RGD:11041649 NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257
JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:optic nerve head, axon (human) RGD PMID:19043361 RGD:8662440 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Foxc1 forkhead box C1 ISO associated with Axenfeld-Rieger Syndrome;DNA:mutation:cds:p.Q120X(human) RGD PMID:18498376 RGD:12904045 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803
JBrowse link
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 ISS MouseDO NCBI chr 3:96,447,385...96,550,006
Ensembl chr 3:96,447,858...96,548,899
JBrowse link
G Lingo1 leucine rich repeat and Ig domain containing 1 treatment ISO RGD PMID:19422885 RGD:8655601 NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19361779 PMID:27149523 NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha IEP protein:increased expression:optic nerve RGD PMID:24136224 RGD:13782046 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor treatment IMP RGD PMID:23702784 RGD:9685447 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO RGD PMID:16185954 RGD:8547817 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO protein:increased expression:conjunctival epithelial cell RGD PMID:16809382 RGD:7364743 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Mylk myosin light chain kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20375339 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Myoc myocilin TAS
ISO
ClinVar Annotator: match by term: Glaucoma
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
PMID:9535666 PMID:9772276 PMID:9804137 PMID:10196380 PMID:10330365 More... RGD:633384 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Nefh neurofilament heavy chain IEP protein:decreased expression:optic nerve: RGD PMID:28498493 RGD:27226819 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Ngf nerve growth factor IEP protein:decreased expression:cerebrospinal fluid RGD PMID:18938194 RGD:2303806 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor IDA RGD PMID:20943663 RGD:5508695 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nmnat3 nicotinamide nucleotide adenylyltransferase 3 treatment IDA RGD PMID:24136224 RGD:13782046 NCBI chr 8:98,892,168...99,003,912
Ensembl chr 8:98,873,398...99,020,645
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 IEP
IDA
mRNA,protein:decreased expression:eye RGD PMID:18817846 PMID:20943663 RGD:5684379, RGD:5508695 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 IDA
IEP
protein:increased expression:eye: RGD PMID:20357199 PMID:10711692 RGD:5684908, RGD:8655608 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase treatment ISO RGD PMID:18936150 PMID:20664796 RGD:7800698, RGD:7800720 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Optn optineurin susceptibility ISO DNA:SNP:intron: RGD PMID:16148883 RGD:7771548 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Pitx2 paired-like homeodomain 2 ISS MouseDO NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO protein:increased expression:microglia RGD PMID:11391707 RGD:5688244 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 treatment ISO
IMP
IEP
protein:increased phosphorylation:retina
protein:increased expression,increased phosphorylation:retina
RGD PMID:30341011 PMID:30341011 PMID:30341011 RGD:39456090, RGD:39456090, RGD:39456090 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G RT1-Bb RT1 class II, locus Bb susceptibility ISO DNA:polymorphisms, haplotype:cds:HLA-DQB1*0302 (human) RGD PMID:10511023 RGD:7365116 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 susceptibility ISO DNA:Haplotype: :HLA-DRB1*0407(human) RGD PMID:10511023 RGD:7365116 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Ryr1 ryanodine receptor 1 ISO ClinVar Annotator: match by term: Glaucoma ClinVar PMID:25741868 PMID:28492532 NCBI chr 1:84,292,578...84,423,799
Ensembl chr 1:84,292,578...84,423,812
JBrowse link
G Serpine1 serpin family E member 1 ISO protein:increased expression:aqueous humor (human) RGD PMID:15710819 RGD:8547695 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISS MouseDO