Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:otitis media
go back to main search page
Accession:DOID:10754 term browser browse the term
Definition:A otitis which involves inflammation of the middle ear. (DO)
Synonyms:exact_synonym: A2ML1-RELATED CONDITION;   COME/ROM;   Middle Ear Inflammation;   OMS
 narrow_synonym: FAMILIAL OTITIS MEDIA;   Nonsyndromic otitis media;   OTITIS MEDIA, CHRONIC/RECURRENT
 related_synonym: OTITIS MEDIA, SUSCEPTIBILITY TO;   SUSCEPTIBILITY TO NONSYNDROMIC OTITIS MEDIA
 primary_id: MESH:D010033
 alt_id: MIM:166760
 xref: EFO:0004992;   ICD10CM:H66.9;   ICD9CM:382.9;   NCI:C34885
For additional species annotation, visit the Alliance of Genome Resources.

GViewer not supported for the selected species.

show annotations for term's descendants           Sort by:
otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bpifa1 BPI fold containing family A member 1 ISO OMIM:166760 MouseDO NCBI chrNW_004955422:28,063,077...28,069,939 JBrowse link
G Btc betacellulin ISO mRNA:decreased expression:middle ear RGD PMID:12148846 RGD:2306978 NCBI chrNW_004955474:895,573...946,152
Ensembl chrNW_004955474:895,573...946,894 		JBrowse link
G C2 complement C2 ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004955437:449,171...460,898
Ensembl chrNW_004955437:448,672...460,519 		JBrowse link
G C3 complement C3 IDA RGD PMID:19139190 RGD:11554035 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Cat catalase treatment ISO protein:decreased activity:cochlea,serum: RGD PMID:22173336 RGD:7401215 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464 		JBrowse link
G Cby1 chibby 1, beta catenin antagonist ISO OMIM:166760 MouseDO NCBI chrNW_004955413:24,781,102...24,794,537
Ensembl chrNW_004955413:24,781,102...24,794,537 		JBrowse link
G Cdhr3 cadherin related family member 3 ISO ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media ClinVar PMID:25741868 PMID:34322716 NCBI chrNW_004955410:10,457,078...10,520,429
Ensembl chrNW_004955410:10,457,072...10,519,826 		JBrowse link
G Cfb complement factor B ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464 		JBrowse link
G Ctsb cathepsin B ISO mRNA:increased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chrNW_004955403:53,086,236...53,100,217
Ensembl chrNW_004955403:53,085,574...53,093,809 		JBrowse link
G Ctsk cathepsin K ISO mRNA:decreased expression:middle ear RGD PMID:15179208 RGD:1342442 NCBI chrNW_004955588:149,036...158,093
Ensembl chrNW_004955588:148,748...158,093 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 susceptibility ISO DNA:missense mutation:cds:p.T280M (human) RGD PMID:24718616 RGD:9491764 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230 		JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643 		JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955431:2,203,342...2,282,635
Ensembl chrNW_004955431:2,263,698...2,282,635 		JBrowse link
G Dnah5 dynein axonemal heavy chain 5 ISO OMIM:166760 MouseDO NCBI chrNW_004955426:3,105,631...3,406,587
Ensembl chrNW_004955426:3,106,410...3,353,502 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO RGD PMID:22610099 RGD:7771533 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381 		JBrowse link
G E2f4 E2F transcription factor 4 ISO OMIM:166760 MouseDO NCBI chrNW_004955484:9,421,396...9,427,826
Ensembl chrNW_004955484:9,421,396...9,427,825 		JBrowse link
G Eda ectodysplasin A ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955475:9,177,911...9,592,150
Ensembl chrNW_004955475:9,178,234...9,588,440 		JBrowse link
G Edar ectodysplasin A receptor treatment ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955470:12,310,680...12,362,555
Ensembl chrNW_004955470:12,309,048...12,362,570 		JBrowse link
G Edaradd EDAR associated via death domain ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955492:3,709,819...3,777,506
Ensembl chrNW_004955492:3,711,549...3,777,528 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO OMIM:166760 MouseDO NCBI chrNW_004955436:12,416,147...12,477,214
Ensembl chrNW_004955436:12,415,737...12,480,359 		JBrowse link
G Eya4 EYA transcriptional coactivator and phosphatase 4 ISO OMIM:166760 MouseDO NCBI chrNW_004955436:13,710,366...13,982,379
Ensembl chrNW_004955436:13,709,806...13,982,380 		JBrowse link
G Fbxo11 F-box protein 11 ISO OMIM:166760 MouseDO NCBI chrNW_004955441:14,471,283...14,495,508
Ensembl chrNW_004955441:14,471,283...14,553,916 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO OMIM:166760 MouseDO NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
G Fut2 fucosyltransferase 2 (H blood group) ISO ClinVar Annotator: match by term: Familial Otitis Media ClinVar PMID:7876234 PMID:7876235 PMID:8621666 PMID:8755920 PMID:8928486 More... NCBI chrNW_004955559:1,857,138...1,868,315 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:20926702 RGD:8547580 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755 		JBrowse link
G Idua alpha-L-iduronidase ISO OMIM:166760 MouseDO NCBI chrNW_004955514:474,830...488,007
Ensembl chrNW_004955514:475,731...488,007 		JBrowse link
G Ifng interferon gamma ISO associated with adenoidal hypertrophy; protein:decreased expression:T cell:
associated with Pneumococcal infections; 		RGD PMID:16730398 PMID:18266836 RGD:7987910 RGD:8142343 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Il10 interleukin 10 susceptibility ISO associated with Pneumococcal Infections;protein:increased expression:middle ear, serum
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human)
associated with Haemophilus Infections
DNA:SNP:promoter:-1082G>A (human) 		RGD PMID:14500471 PMID:17908769 PMID:18524391 PMID:18560870 PMID:18771082 More... RGD:4891398 RGD:7364816 RGD:7365029 RGD:7365038 RGD:7365054 RGD:7365082 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779 		JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:24664502 RGD:8698659 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Il1a interleukin 1 alpha ISO associated with Haemophilus Infections;mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466 		JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il2 interleukin 2 disease_progression ISO RGD PMID:7769948 RGD:8662922 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265 		JBrowse link
G Il6 interleukin 6 susceptibility IEP
ISO 		DNA:polymorphism:promoter:-174G>C(human) RGD PMID:17908769 PMID:10085040 RGD:7365054, RGD:11553900 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G Lmna lamin A/C ISO OMIM:166760 MouseDO NCBI chrNW_004955545:2,290,076...2,310,982
Ensembl chrNW_004955545:2,290,037...2,313,033 		JBrowse link
G LOC102004444 beta-defensin 1-like IMP RGD PMID:22072973 RGD:11554036 NCBI chrNW_004955403:53,643,328...53,644,361
Ensembl chrNW_004955403:53,643,300...53,644,505 		JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like treatment IEP RGD PMID:2473673 PMID:2459981 RGD:11553864, RGD:11553918 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G LOC102021956 alpha-2-macroglobulin treatment IEP RGD PMID:2473673 PMID:2459981 RGD:11553864, RGD:11553918 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529 		JBrowse link
G Lta4h leukotriene A4 hydrolase IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955405:32,345,005...32,377,685
Ensembl chrNW_004955405:32,344,925...32,378,384 		JBrowse link
G Ltb4r leukotriene B4 receptor IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955409:35,984,757...35,991,492
Ensembl chrNW_004955409:35,984,933...35,985,976 		JBrowse link
G Ltc4s leukotriene C4 synthase IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955408:788,856...791,505 JBrowse link
G Mbl2 mannose binding lectin 2 ISO DNA:haplotype,SNP:promoter,exons: RGD PMID:16750996 RGD:8693692 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006 		JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO OMIM:166760 RGD
MouseDO		 PMID:26611891 RGD:11054805 NCBI chrNW_004955448:18,259,847...18,542,085
Ensembl chrNW_004955448:18,259,083...18,439,646 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 RGD:2303743 NCBI chrNW_004955545:1,657,728...1,662,112 JBrowse link
G Muc4 mucin 4, cell surface associated ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 PMID:14690056 RGD:2303743 RGD:7349395 NCBI chrNW_004955420:12,228,801...12,274,840 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO associated with CHARGE Syndrome
mRNA:increased expression:ear 		RGD PMID:11425202 PMID:22539951 RGD:2324973 RGD:7349405 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO associated with CHARGE Syndrome
mRNA:increased expression:middle ear 		RGD PMID:14690056 PMID:22539951 RGD:7349395 RGD:7349405 NCBI chrNW_004955476:11,021,665...11,049,239 JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase ISO OMIM:166760 MouseDO NCBI chrNW_004955451:16,445,338...16,449,243
Ensembl chrNW_004955451:16,445,338...16,450,062 		JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor ISO OMIM:166760 MouseDO NCBI chrNW_004955455:3,862,804...3,950,669
Ensembl chrNW_004955455:3,862,347...3,951,891 		JBrowse link
G Nisch nischarin ISO OMIM:166760 MouseDO NCBI chrNW_004955430:2,443,029...2,488,267
Ensembl chrNW_004955430:2,443,029...2,491,123 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked ISO OMIM:166760 MouseDO NCBI chrNW_004955509:2,357,263...2,546,802
Ensembl chrNW_004955509:2,357,263...2,546,802 		JBrowse link
G Plau plasminogen activator, urokinase treatment IEP RGD PMID:2473673 RGD:11553864 NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209 		JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: OTITIS MEDIA, CHRONIC/RECURRENT | ClinVar Annotator: match by term: Otitis media, susceptibility to ClinVar PMID:10233898 PMID:12850227 PMID:12876630 PMID:15269832 PMID:16849641 More... NCBI chrNW_004955439:20,317,814...20,366,724
Ensembl chrNW_004955439:20,317,552...20,366,475 		JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23543299 RGD:7242409 NCBI chrNW_004955414:28,828,389...28,831,417
Ensembl chrNW_004955414:28,825,651...28,831,117 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Rpl38 ribosomal protein L38 ISO OMIM:166760 MouseDO NCBI chrNW_004955553:1,129,607...1,133,896
Ensembl chrNW_004955553:1,129,633...1,133,896 		JBrowse link
G Sall4 spalt like transcription factor 4 ISO OMIM:166760 MouseDO NCBI chrNW_004955445:6,824,797...6,841,141
Ensembl chrNW_004955445:6,824,770...6,842,187 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO mRNA,protein:increased expression:epithelial cell RGD PMID:15799573 RGD:5144051 NCBI chrNW_004955599:688,414...690,644 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO RGD PMID:12206256 RGD:6484586 NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062 		JBrowse link
G Sh3pxd2b SH3 and PX domains 2B ISO OMIM:166760 MouseDO NCBI chrNW_004955408:25,103,278...25,169,934
Ensembl chrNW_004955408:25,103,278...25,170,003 		JBrowse link
G Spink5 serine peptidase inhibitor Kazal type 5 ISO ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media ClinVar PMID:11511292 PMID:25741868 PMID:26865388 PMID:28492532 PMID:32709676 NCBI chrNW_004955415:6,118,616...6,186,632 JBrowse link
G Tbx1 T-box transcription factor 1 ISO OMIM:166760 MouseDO NCBI chrNW_004955442:18,320,674...18,327,062
Ensembl chrNW_004955442:18,319,762...18,325,337 		JBrowse link
G Tgif1 TGFB induced factor homeobox 1 ISO OMIM:166760 MouseDO NCBI chrNW_004955402:7,130,809...7,138,945
Ensembl chrNW_004955402:7,129,484...7,138,340 		JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal:
associated with Pneumococcal Infections;
protein:increased expression:middle ear:
associated with Haemophilus Infections; 		RGD PMID:19414550 PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552783 RGD:8552995 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO associated with Haemophilus Infections;
protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal: 		RGD PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552995 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tnf tumor necrosis factor IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Tp73 tumor protein p73 ISO OMIM:166760 MouseDO NCBI chrNW_004955486:7,914,608...7,961,992
Ensembl chrNW_004955486:7,914,440...7,952,982 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA,protein:increased expression:middle ear,inner ear:
mRNA:increased expression:middle ear: 		RGD PMID:21271590 PMID:22104377 RGD:8547975 RGD:8547980 NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664 		JBrowse link
Acute Otitis Media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc4 actin related protein 2/3 complex subunit 4 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955561:1,314,299...1,327,300
Ensembl chrNW_004955561:1,314,299...1,327,300 		JBrowse link
G Bmp1 bone morphogenetic protein 1 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955403:45,660,591...45,693,724
Ensembl chrNW_004955403:45,660,588...45,693,724 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303 		JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377 		JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955445:2,154,057...2,235,594
Ensembl chrNW_004955445:2,153,170...2,235,795 		JBrowse link
G Cald1 caldesmon 1 IEP mRNA, protein:decreased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955494:7,578,162...7,675,558
Ensembl chrNW_004955494:7,578,028...7,765,758 		JBrowse link
G Col3a1 collagen type III alpha 1 chain IEP RGD PMID:10453785 RGD:11556224 NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887 		JBrowse link
G Dstn destrin, actin depolymerizing factor IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955415:26,567,457...26,598,978
Ensembl chrNW_004955415:26,569,264...26,600,862 		JBrowse link
G Fgf10 fibroblast growth factor 10 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955446:18,163,117...18,244,840
Ensembl chrNW_004955446:18,163,117...18,245,199 		JBrowse link
G Fgf3 fibroblast growth factor 3 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955422:16,333,363...16,339,853
Ensembl chrNW_004955422:16,333,363...16,339,853 		JBrowse link
G Fgf6 fibroblast growth factor 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955413:2,246,965...2,257,883
Ensembl chrNW_004955413:2,246,965...2,257,883 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111 		JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:10453785 RGD:11556224 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975 		JBrowse link
G Il17a interleukin 17A disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962 		JBrowse link
G Il22 interleukin 22 disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004955458:14,747,339...14,755,602
Ensembl chrNW_004955458:14,747,084...14,752,553 		JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955518:3,815,181...3,863,440
Ensembl chrNW_004955518:3,814,840...3,891,299 		JBrowse link
G LOC102005867 protein S100-A8 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955592:72,594...73,659
Ensembl chrNW_004955592:73,154...73,843 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21307808 RGD:150340689 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955406:22,355,717...22,384,746
Ensembl chrNW_004955406:22,355,724...22,384,864 		JBrowse link
G S100a9 S100 calcium binding protein A9 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955592:90,647...93,842 JBrowse link
mastoiditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516 		JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Otitis Media with Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 disease_progression ISO RGD PMID:11037838 RGD:7401253 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697 		JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472 		JBrowse link
G Glb1 galactosidase beta 1 IEP RGD PMID:2837976 RGD:11557999 NCBI chrNW_004955421:230,957...311,504
Ensembl chrNW_004955421:231,076...312,500 		JBrowse link
G Gusb glucuronidase beta IEP RGD PMID:2837976 RGD:11557999 NCBI chrNW_004955456:8,377,161...8,392,298
Ensembl chrNW_004955456:8,378,654...8,392,252 		JBrowse link
G Ifng interferon gamma ISO protein:decreased expression:middle ear:
protein:decreased expression:serum: 		RGD PMID:15938212 PMID:16055981 RGD:7987911 RGD:8142354 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:8302123 RGD:11554174 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947 		JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:middle ear RGD PMID:18975780 RGD:2317282 NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185 		JBrowse link
G Il4r interleukin 4 receptor treatment ISO RGD PMID:12297806 RGD:11530017 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422 		JBrowse link
G Kdr kinase insert domain receptor ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583 		JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like IEP RGD PMID:2454602 RGD:11560528 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G LOC102021956 alpha-2-macroglobulin IEP RGD PMID:2454602 RGD:11560528 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529 		JBrowse link
G Ltf lactotransferrin treatment ISS RGD PMID:21079169 RGD:11554025 NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331 		JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:decreased expression:ear
mRNA:increased expression:middle ear 		RGD PMID:20713760 PMID:22336013 RGD:7364731 RGD:7364764 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear 		RGD PMID:16540890 PMID:22336013 RGD:7364744 RGD:7364764 NCBI chrNW_004955476:11,021,665...11,049,239 JBrowse link
G Oxgr1 oxoglutarate receptor 1 ISO RGD PMID:23200873 RGD:7775025 NCBI chrNW_004955404:13,337,607...13,344,789
Ensembl chrNW_004955404:13,337,607...13,344,789 		JBrowse link
G Ptafr platelet activating factor receptor treatment IMP RGD PMID:14759570 RGD:11554333 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929 		JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:middle ear effusion: RGD PMID:18568516 RGD:7394746 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:mucosa of middle ear: RGD PMID:22907120 RGD:8547964 NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664 		JBrowse link
suppurative otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin IEP RGD PMID:1696441 RGD:11556250 NCBI chrNW_004955447:9,327...21,212 JBrowse link
G Ifng interferon gamma disease_progression ISO RGD PMID:19640314 RGD:8142346 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045 		JBrowse link
G LOC102021956 alpha-2-macroglobulin IEP RGD PMID:1696441 RGD:11556250 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529 		JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258 		JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14355
    sensory system disease 6525
      auditory system disease 971
        middle ear disease 105
          otitis media 98
            Acute Otitis Media 22
            Otitis Media with Effusion 20
            adhesive otitis media 0
            mastoiditis 3
            middle ear cholesterol granuloma 0
            non-suppurative otitis media + 0
            petrositis 0
            suppurative otitis media + 5
Path 2
Term Annotations click to browse term
  disease 14355
    Pathological Conditions, Signs and Symptoms 11351
      Signs and Symptoms 9497
        Neurologic Manifestations 9198
          sensory system disease 6525
            Otorhinolaryngologic Diseases 1635
              auditory system disease 971
                middle ear disease 105
                  otitis media 98
                    Acute Otitis Media 22
                    Otitis Media with Effusion 20
                    adhesive otitis media 0
                    mastoiditis 3
                    middle ear cholesterol granuloma 0
                    non-suppurative otitis media + 0
                    petrositis 0
                    suppurative otitis media + 5
paths to the root