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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:otitis media
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Accession:DOID:10754 term browser browse the term
Definition:Inflammation of the MIDDLE EAR including the AUDITORY OSSICLES and the EUSTACHIAN TUBE.
Synonyms:exact_synonym: COME/ROM;   Middle Ear Inflammation;   OMS;   OTITIS MEDIA, CHRONIC/RECURRENT
 narrow_synonym: FAMILIAL OTITIS MEDIA;   Nonsyndromic otitis media
 related_synonym: OTITIS MEDIA, SUSCEPTIBILITY TO
 primary_id: MESH:D010033
 alt_id: OMIM:166760;   RDO:0006074
 xref: ICD10CM:H66.9;   ICD9CM:382.9;   NCI:C34885
For additional species annotation, visit the Alliance of Genome Resources.


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otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actl6a actin like 6A ISO ClinVar Annotator: match by term: Susceptibility to otitis media ClinVar PMID:25741868 PMID:28649782 NCBI chrNW_004955420:8,745,390...8,764,993
Ensembl chrNW_004955420:8,744,597...8,764,993
JBrowse link
G Btc betacellulin ISO mRNA:decreased expression:middle ear RGD PMID:12148846 RGD:2306978 NCBI chrNW_004955474:895,573...946,152
Ensembl chrNW_004955474:895,573...946,894
JBrowse link
G C2 complement C2 ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004955437:449,171...460,898
Ensembl chrNW_004955437:448,672...460,519
JBrowse link
G C3 complement C3 IDA RGD PMID:19139190 RGD:11554035 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
JBrowse link
G Cat catalase treatment ISO protein:decreased activity:cochlea,serum: RGD PMID:22173336 RGD:7401215 NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
JBrowse link
G Cfb complement factor B ISO associated with Pneumococcal Infections RGD PMID:20065024 RGD:7411716 NCBI chrNW_004955437:461,235...466,908 JBrowse link
G Ctsb cathepsin B ISO mRNA:increased expression:middle ear mucosa (rat) RGD PMID:15179208 RGD:1342442 NCBI chrNW_004955403:53,086,236...53,100,217
Ensembl chrNW_004955403:53,085,574...53,093,809
JBrowse link
G Ctsk cathepsin K ISO mRNA:decreased expression:middle ear RGD PMID:15179208 RGD:1342442 NCBI chrNW_004955588:149,036...158,093
Ensembl chrNW_004955588:148,748...158,093
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 susceptibility ISO DNA:missense mutation:cds:p.T280M (human) RGD PMID:24718616 RGD:9491764 NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
JBrowse link
G Cxcl8 C-X-C motif chemokine ligand 8 IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
JBrowse link
G Cysltr2 cysteinyl leukotriene receptor 2 IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955431:2,203,342...2,282,635
Ensembl chrNW_004955431:2,263,698...2,282,635
JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment ISO RGD PMID:22610099 RGD:7771533 NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381
JBrowse link
G Eda ectodysplasin A ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955475:9,177,911...9,592,150
Ensembl chrNW_004955475:9,178,234...9,588,440
JBrowse link
G Edar ectodysplasin A receptor treatment ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955470:12,310,680...12,362,555
Ensembl chrNW_004955470:12,309,048...12,362,570
JBrowse link
G Edaradd EDAR associated death domain ISO RGD PMID:31028034 RGD:14398763 NCBI chrNW_004955492:3,709,819...3,777,506
Ensembl chrNW_004955492:3,711,549...3,777,528
JBrowse link
G Fut2 fucosyltransferase 2 ISO ClinVar Annotator: match by term: Familial Otitis Media ClinVar PMID:7876234 PMID:7876235 PMID:8755920 PMID:8928486 PMID:12692541 More... NCBI chrNW_004955559:1,857,138...1,868,315 JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO protein:increased expression:serum RGD PMID:20926702 RGD:8547580 NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
JBrowse link
G Ifng interferon gamma ISO associated with adenoidal hypertrophy; protein:decreased expression:T cell:
associated with Pneumococcal infections;
RGD PMID:16730398 PMID:18266836 RGD:7987910 RGD:8142343 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Il10 interleukin 10 susceptibility ISO DNA:SNP:promoter:-1082G>A (human)
associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human)
associated with Haemophilus Infections
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
associated with Pneumococcal Infections;protein:increased expression:middle ear, serum
RGD PMID:14500471 PMID:17908769 PMID:18524391 PMID:18560870 PMID:18771082 More... RGD:4891398 RGD:7364816 RGD:7365029 RGD:7365038 RGD:7365054 RGD:7365082 NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
JBrowse link
G Il17a interleukin 17A severity ISO RGD PMID:24664502 RGD:8698659 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
JBrowse link
G Il1a interleukin 1 alpha ISO associated with Haemophilus Infections;mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il2 interleukin 2 disease_progression ISO RGD PMID:7769948 RGD:8662922 NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
JBrowse link
G Il6 interleukin 6 susceptibility IEP
ISO
DNA:polymorphism:promoter:-174G>C(human) RGD PMID:17908769 PMID:10085040 RGD:7365054, RGD:11553900 NCBI chrNW_004955410:25,079,835...25,084,390 JBrowse link
G LOC102004444 beta-defensin 1-like IMP RGD PMID:22072973 RGD:11554036 NCBI chrNW_004955403:53,643,328...53,644,361
Ensembl chrNW_004955403:53,643,300...53,644,505
JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like treatment IEP RGD PMID:2473673 PMID:2459981 RGD:11553864, RGD:11553918 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G LOC102021956 alpha-2-macroglobulin treatment IEP RGD PMID:2473673 PMID:2459981 RGD:11553864, RGD:11553918 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Lta4h leukotriene A4 hydrolase IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955405:32,345,005...32,377,685
Ensembl chrNW_004955405:32,344,925...32,378,384
JBrowse link
G Ltb4r leukotriene B4 receptor IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955409:35,984,757...35,991,492
Ensembl chrNW_004955409:35,984,933...35,985,976
JBrowse link
G Ltc4s leukotriene C4 synthase IEP RGD PMID:20433028 RGD:11553910 NCBI chrNW_004955408:788,856...791,505 JBrowse link
G Mbl2 mannose binding lectin 2 ISO DNA:haplotype,SNP:promoter,exons: RGD PMID:16750996 RGD:8693692 NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
JBrowse link
G Mecom MDS1 and EVI1 complex locus ISO RGD PMID:26611891 RGD:11054805 NCBI chrNW_004955448:18,259,847...18,542,085
Ensembl chrNW_004955448:18,259,083...18,439,646
JBrowse link
G Muc1 mucin 1, cell surface associated ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 RGD:2303743 NCBI chrNW_004955545:1,657,728...1,662,112 JBrowse link
G Muc4 mucin 4, cell surface associated ISO associated with Pneumococcal Infections;mRNA:increased expression:middle ear RGD PMID:11576628 PMID:14690056 RGD:2303743 RGD:7349395 NCBI chrNW_004955420:12,228,801...12,274,840 JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:ear
associated with CHARGE Syndrome
RGD PMID:11425202 PMID:22539951 RGD:2324973 RGD:7349405 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
associated with CHARGE Syndrome
RGD PMID:14690056 PMID:22539951 RGD:7349395 RGD:7349405 NCBI chrNW_004955476:11,021,665...11,049,239 JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear RGD PMID:18524391 RGD:4891398 NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
JBrowse link
G Plau plasminogen activator, urokinase treatment IEP RGD PMID:2473673 RGD:11553864 NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: Otitis media, susceptibility to ClinVar PMID:10233898 PMID:12850227 PMID:16849641 PMID:25741868 PMID:28492532 More... NCBI chrNW_004955439:20,317,814...20,366,724
Ensembl chrNW_004955439:20,317,552...20,366,475
JBrowse link
G Pth parathyroid hormone ISO protein:increased expression:serum (human) RGD PMID:23543299 RGD:7242409 NCBI chrNW_004955414:28,828,389...28,831,417
Ensembl chrNW_004955414:28,825,651...28,831,117
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO mRNA,protein:increased expression:epithelial cell RGD PMID:15799573 RGD:5144051 NCBI chrNW_004955599:688,414...690,644 JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 ISO RGD PMID:12206256 RGD:6484586 NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062
JBrowse link
G Spink5 serine peptidase inhibitor Kazal type 5 ISO ClinVar Annotator: match by term: OTITIS MEDIA, CHRONIC/RECURRENT ClinVar PMID:28492532 PMID:32709676 NCBI chrNW_004955415:6,118,616...6,186,632 JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal:
associated with Pneumococcal Infections;
associated with Haemophilus Infections;
protein:increased expression:middle ear:
RGD PMID:19414550 PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552783 RGD:8552995 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 ISO associated with Haemophilus Infections;
protein:increased expression:middle ear:
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD PMID:19586996 PMID:23380629 PMID:24690988 RGD:7777086 RGD:7800666 RGD:8552995 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tnf tumor necrosis factor IEP RGD PMID:10085040 RGD:11553900 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Vegfa vascular endothelial growth factor A ISO mRNA,protein:increased expression:middle ear,inner ear:
mRNA:increased expression:middle ear:
RGD PMID:21271590 PMID:22104377 RGD:8547975 RGD:8547980 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
Acute Otitis Media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc4 actin related protein 2/3 complex subunit 4 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955561:1,314,299...1,327,300
Ensembl chrNW_004955561:1,314,299...1,327,300
JBrowse link
G Bmp1 bone morphogenetic protein 1 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955403:45,660,591...45,693,724
Ensembl chrNW_004955403:45,660,588...45,693,724
JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303
JBrowse link
G Bmp6 bone morphogenetic protein 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377
JBrowse link
G Bmp7 bone morphogenetic protein 7 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955445:2,154,057...2,235,594
Ensembl chrNW_004955445:2,153,170...2,235,795
JBrowse link
G Cald1 caldesmon 1 IEP mRNA, protein:decreased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955494:7,578,162...7,675,558 JBrowse link
G Col3a1 collagen type III alpha 1 chain IEP RGD PMID:10453785 RGD:11556224 NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887
JBrowse link
G Dstn destrin, actin depolymerizing factor IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955415:26,567,457...26,598,978
Ensembl chrNW_004955415:26,569,264...26,600,862
JBrowse link
G Fgf10 fibroblast growth factor 10 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955446:18,163,117...18,244,840
Ensembl chrNW_004955446:18,163,117...18,245,199
JBrowse link
G Fgf3 fibroblast growth factor 3 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955422:16,333,363...16,339,853
Ensembl chrNW_004955422:16,333,363...16,339,853
JBrowse link
G Fgf6 fibroblast growth factor 6 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955413:2,246,965...2,257,883
Ensembl chrNW_004955413:2,246,965...2,257,883
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
JBrowse link
G Fn1 fibronectin 1 IEP RGD PMID:10453785 RGD:11556224 NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
JBrowse link
G Il17a interleukin 17A disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
JBrowse link
G Il22 interleukin 22 disease_progression ISO protein:increased expression:serum (rat) RGD PMID:27497403 RGD:40818299 NCBI chrNW_004955458:14,747,339...14,755,602
Ensembl chrNW_004955458:14,747,084...14,752,553
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955518:3,815,181...3,863,440
Ensembl chrNW_004955518:3,814,840...3,891,299
JBrowse link
G LOC102005867 protein S100-A8 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955592:72,594...73,659
Ensembl chrNW_004955592:73,154...73,843
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO mRNA:decreased expression:middle ear (mouse) RGD PMID:21307808 RGD:150340689 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO mRNA:increased expression:middle ear (mouse) RGD PMID:21889218 RGD:127284853 NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
JBrowse link
G Ncf2 neutrophil cytosolic factor 2 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955406:22,355,717...22,384,746
Ensembl chrNW_004955406:22,355,724...22,384,864
JBrowse link
G S100a9 S100 calcium binding protein A9 IEP mRNA, protein:increased expression:mucosa of middle ear RGD PMID:26711468 RGD:11553828 NCBI chrNW_004955592:90,647...93,842 JBrowse link
mastoiditis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rela RELA proto-oncogene, NF-kB subunit ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
JBrowse link
G Tlr2 toll like receptor 2 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 ISO protein:increased expression:mucosa of middle ear,skin of ear canal: RGD PMID:24690988 RGD:8552995 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
Otitis Media with Effusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 disease_progression ISO RGD PMID:11037838 RGD:7401253 NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
JBrowse link
G Flt1 fms related receptor tyrosine kinase 1 ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472
JBrowse link
G Glb1 galactosidase beta 1 IEP RGD PMID:2837976 RGD:11557999 NCBI chrNW_004955421:230,957...311,504
Ensembl chrNW_004955421:231,076...312,500
JBrowse link
G Gusb glucuronidase beta IEP RGD PMID:2837976 RGD:11557999 NCBI chrNW_004955456:8,377,161...8,392,298
Ensembl chrNW_004955456:8,378,654...8,392,252
JBrowse link
G Ifng interferon gamma ISO protein:decreased expression:middle ear:
protein:decreased expression:serum:
RGD PMID:15938212 PMID:16055981 RGD:7987911 RGD:8142354 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:8302123 RGD:11554174 NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
JBrowse link
G Il4 interleukin 4 ISO protein:increased expression:middle ear RGD PMID:18975780 RGD:2317282 NCBI chrNW_004955408:4,058,052...4,065,999 JBrowse link
G Il4r interleukin 4 receptor treatment ISO RGD PMID:12297806 RGD:11530017 NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
JBrowse link
G Kdr kinase insert domain receptor ISO mRNA:increased expression:mucosa of the middle ear; RGD PMID:12875575 RGD:8547977 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
JBrowse link
G LOC102021597 alpha-1-antiproteinase S-like IEP RGD PMID:2454602 RGD:11560528 NCBI chrNW_004955438:17,920,200...17,929,105 JBrowse link
G LOC102021956 alpha-2-macroglobulin IEP RGD PMID:2454602 RGD:11560528 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Ltf lactotransferrin treatment ISS RGD PMID:21079169 RGD:11554025 NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:20713760 PMID:22336013 RGD:7364731 RGD:7364764 NCBI chrNW_004955476:11,061,405...11,084,294 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming ISO mRNA:increased expression:middle ear
mRNA:decreased expression:ear
RGD PMID:16540890 PMID:22336013 RGD:7364744 RGD:7364764 NCBI chrNW_004955476:11,021,665...11,049,239 JBrowse link
G Oxgr1 oxoglutarate receptor 1 ISO RGD PMID:23200873 RGD:7775025 NCBI chrNW_004955404:13,337,607...13,344,789
Ensembl chrNW_004955404:13,337,607...13,344,789
JBrowse link
G Ptafr platelet activating factor receptor treatment IMP RGD PMID:14759570 RGD:11554333 NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:22336013 RGD:7364764 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link
G Tnf tumor necrosis factor ISO protein:increased expression:middle ear effusion: RGD PMID:18568516 RGD:7394746 NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
JBrowse link
G Vegfa vascular endothelial growth factor A ISO protein:increased expression:mucosa of middle ear: RGD PMID:22907120 RGD:8547964 NCBI chrNW_004955437:9,527,445...9,541,908 JBrowse link
suppurative otitis media term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin IEP RGD PMID:1696441 RGD:11556250 NCBI chrNW_004955447:9,327...21,212 JBrowse link
G Ifng interferon gamma disease_progression ISO RGD PMID:19640314 RGD:8142346 NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
JBrowse link
G LOC102021956 alpha-2-macroglobulin IEP RGD PMID:1696441 RGD:11556250 NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
JBrowse link
G Tlr2 toll like receptor 2 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
JBrowse link
G Tlr4 toll like receptor 4 ISO mRNA,protein:increased expression:mucosa: RGD PMID:22883581 RGD:7800662 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 12744
    sensory system disease 4857
      auditory system disease 750
        middle ear disease 84
          otitis media 79
            Acute Otitis Media 22
            Otitis Media with Effusion 20
            adhesive otitis media 0
            mastoiditis 3
            middle ear cholesterol granuloma 0
            non-suppurative otitis media + 0
            petrositis 0
            suppurative otitis media + 5
Path 2
Term Annotations click to browse term
  disease 12744
    disease of anatomical entity 12425
      nervous system disease 10321
        sensory system disease 4857
          Otorhinolaryngologic Diseases 1137
            auditory system disease 750
              middle ear disease 84
                otitis media 79
                  Acute Otitis Media 22
                  Otitis Media with Effusion 20
                  adhesive otitis media 0
                  mastoiditis 3
                  middle ear cholesterol granuloma 0
                  non-suppurative otitis media + 0
                  petrositis 0
                  suppurative otitis media + 5
paths to the root