RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: otitis media
Accession: DOID:10754
browse the term
Definition: A otitis which involves inflammation of the middle ear. (DO)
Synonyms: exact_synonym: A2ML1-RELATED CONDITION; COME/ROM; Middle Ear Inflammation; OMS
narrow_synonym: FAMILIAL OTITIS MEDIA; Nonsyndromic otitis media; OTITIS MEDIA, CHRONIC/RECURRENT
related_synonym: OTITIS MEDIA, SUSCEPTIBILITY TO; SUSCEPTIBILITY TO NONSYNDROMIC OTITIS MEDIA
primary_id: MESH:D010033
alt_id: MIM:166760
xref: EFO:0004992 ; ICD10CM:H66.9 ; ICD9CM:382.9 ; NCI:C34885
For additional species annotation, visit the
Alliance of Genome Resources .
GViewer not supported for the selected species.
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Bpifa1
BPI fold containing family A member 1
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955422:28,063,077...28,069,939
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Btc
betacellulin
ISO
mRNA:decreased expression:middle ear
RGD
PMID:12148846
RGD:2306978
NCBI chrNW_004955474:895,573...946,152
Ensembl chrNW_004955474:895,573...946,894
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C2
complement C2
ISO
associated with Pneumococcal Infections
RGD
PMID:20065024
RGD:7411716
NCBI chrNW_004955437:449,171...460,898
Ensembl chrNW_004955437:448,672...460,519
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C3
complement C3
IDA
RGD
PMID:19139190
RGD:11554035
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Cat
catalase
treatment
ISO
protein:decreased activity:cochlea,serum:
RGD
PMID:22173336
RGD:7401215
NCBI chrNW_004955422:11,783,973...11,826,970
Ensembl chrNW_004955422:11,781,835...11,827,464
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Cby1
chibby 1, beta catenin antagonist
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955413:24,781,102...24,794,537
Ensembl chrNW_004955413:24,781,102...24,794,537
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Cdhr3
cadherin related family member 3
ISO
ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media
ClinVar
PMID:25741868 PMID:34322716
NCBI chrNW_004955410:10,457,078...10,520,429
Ensembl chrNW_004955410:10,457,072...10,519,826
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Cfb
complement factor B
ISO
associated with Pneumococcal Infections
RGD
PMID:20065024
RGD:7411716
NCBI chrNW_004955437:461,235...466,908
Ensembl chrNW_004955437:461,235...470,464
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Ctsb
cathepsin B
ISO
mRNA:increased expression:middle ear mucosa (rat)
RGD
PMID:15179208
RGD:1342442
NCBI chrNW_004955403:53,086,236...53,100,217
Ensembl chrNW_004955403:53,085,574...53,093,809
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Ctsk
cathepsin K
ISO
mRNA:decreased expression:middle ear
RGD
PMID:15179208
RGD:1342442
NCBI chrNW_004955588:149,036...158,093
Ensembl chrNW_004955588:148,748...158,093
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Cx3cr1
C-X3-C motif chemokine receptor 1
susceptibility
ISO
DNA:missense mutation:cds:p.T280M (human)
RGD
PMID:24718616
RGD:9491764
NCBI chrNW_004955427:24,691,206...24,705,599
Ensembl chrNW_004955427:24,701,073...24,707,230
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Cxcl8
C-X-C motif chemokine ligand 8
IEP
RGD
PMID:10085040
RGD:11553900
NCBI chrNW_004955474:247,326...250,355
Ensembl chrNW_004955474:241,501...250,643
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Cysltr2
cysteinyl leukotriene receptor 2
IEP
RGD
PMID:20433028
RGD:11553910
NCBI chrNW_004955431:2,203,342...2,282,635
Ensembl chrNW_004955431:2,263,698...2,282,635
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Dnah5
dynein axonemal heavy chain 5
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955426:3,105,631...3,406,587
Ensembl chrNW_004955426:3,106,410...3,353,502
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Dusp1
dual specificity phosphatase 1
treatment
ISO
RGD
PMID:22610099
RGD:7771533
NCBI chrNW_004955408:25,481,294...25,484,381
Ensembl chrNW_004955408:25,481,294...25,484,381
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E2f4
E2F transcription factor 4
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955484:9,421,396...9,427,826
Ensembl chrNW_004955484:9,421,396...9,427,825
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Eda
ectodysplasin A
ISO
RGD
PMID:31028034
RGD:14398763
NCBI chrNW_004955475:9,177,911...9,592,150
Ensembl chrNW_004955475:9,178,234...9,588,440
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Edar
ectodysplasin A receptor
treatment
ISO
RGD
PMID:31028034
RGD:14398763
NCBI chrNW_004955470:12,310,680...12,362,555
Ensembl chrNW_004955470:12,309,048...12,362,570
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Edaradd
EDAR associated via death domain
ISO
RGD
PMID:31028034
RGD:14398763
NCBI chrNW_004955492:3,709,819...3,777,506
Ensembl chrNW_004955492:3,711,549...3,777,528
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Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955436:12,416,147...12,477,214
Ensembl chrNW_004955436:12,415,737...12,480,359
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Eya4
EYA transcriptional coactivator and phosphatase 4
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955436:13,710,366...13,982,379
Ensembl chrNW_004955436:13,709,806...13,982,380
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Fbxo11
F-box protein 11
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955441:14,471,283...14,495,508
Ensembl chrNW_004955441:14,471,283...14,553,916
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Fgfr1
fibroblast growth factor receptor 1
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
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Fut2
fucosyltransferase 2 (H blood group)
ISO
ClinVar Annotator: match by term: Familial Otitis Media
ClinVar
PMID:7876234 PMID:7876235 PMID:8621666 PMID:8755920 PMID:8928486 PMID:12692541 PMID:18776911 PMID:25741868 PMID:30401457 More...
NCBI chrNW_004955559:1,857,138...1,868,315
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Icam1
intercellular adhesion molecule 1
ISO
protein:increased expression:serum
RGD
PMID:20926702
RGD:8547580
NCBI chrNW_004955495:1,561,464...1,573,282
Ensembl chrNW_004955495:1,561,714...1,574,755
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Idua
alpha-L-iduronidase
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955514:474,830...488,007
Ensembl chrNW_004955514:475,731...488,007
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Ifng
interferon gamma
ISO
associated with adenoidal hypertrophy; protein:decreased expression:T cell: associated with Pneumococcal infections;
RGD
PMID:16730398 PMID:18266836
RGD:7987910 RGD:8142343
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il10
interleukin 10
susceptibility
ISO
associated with Pneumococcal Infections;protein:increased expression:middle ear, serum associated with Pneumococcal Infections;mRNA:increased expression:middle ear associated with respiratory syncytial virus infectious disease, associated with common cold;DNA:SNPs, haplotypes:promoter:-1082G>A, -819T>C, -592A>C (human) associated with Haemophilus Infections DNA:SNP:promoter:-1082G>A (human)
RGD
PMID:14500471 PMID:17908769 PMID:18524391 PMID:18560870 PMID:18771082 PMID:23404508 More...
RGD:4891398 RGD:7364816 RGD:7365029 RGD:7365038 RGD:7365054 RGD:7365082
NCBI chrNW_004955406:42,307,789...42,312,255
Ensembl chrNW_004955406:42,307,664...42,312,779
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Il17a
interleukin 17A
severity
ISO
RGD
PMID:24664502
RGD:8698659
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il1a
interleukin 1 alpha
ISO
associated with Haemophilus Infections;mRNA, protein:increased expression:middle ear
RGD
PMID:18524391
RGD:4891398
NCBI chrNW_004955470:1,527,710...1,538,418
Ensembl chrNW_004955470:1,527,674...1,538,466
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Il1b
interleukin 1 beta
IEP
RGD
PMID:10085040
RGD:11553900
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il2
interleukin 2
disease_progression
ISO
RGD
PMID:7769948
RGD:8662922
NCBI chrNW_004955428:18,163,010...18,168,157
Ensembl chrNW_004955428:18,162,467...18,168,265
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Il6
interleukin 6
susceptibility
IEP ISO
DNA:polymorphism:promoter:-174G>C(human)
RGD
PMID:17908769 PMID:10085040
RGD:7365054 , RGD:11553900
NCBI chrNW_004955410:25,079,835...25,084,390
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Lmna
lamin A/C
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955545:2,290,076...2,310,982
Ensembl chrNW_004955545:2,290,037...2,313,033
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LOC102004444
beta-defensin 1-like
IMP
RGD
PMID:22072973
RGD:11554036
NCBI chrNW_004955403:53,643,328...53,644,361
Ensembl chrNW_004955403:53,643,300...53,644,505
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LOC102021597
alpha-1-antiproteinase S-like
treatment
IEP
RGD
PMID:2473673 PMID:2459981
RGD:11553864 , RGD:11553918
NCBI chrNW_004955438:17,920,200...17,929,105
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LOC102021956
alpha-2-macroglobulin
treatment
IEP
RGD
PMID:2473673 PMID:2459981
RGD:11553864 , RGD:11553918
NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
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Lta4h
leukotriene A4 hydrolase
IEP
RGD
PMID:20433028
RGD:11553910
NCBI chrNW_004955405:32,345,005...32,377,685
Ensembl chrNW_004955405:32,344,925...32,378,384
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Ltb4r
leukotriene B4 receptor
IEP
RGD
PMID:20433028
RGD:11553910
NCBI chrNW_004955409:35,984,757...35,991,492
Ensembl chrNW_004955409:35,984,933...35,985,976
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Ltc4s
leukotriene C4 synthase
IEP
RGD
PMID:20433028
RGD:11553910
NCBI chrNW_004955408:788,856...791,505
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Mbl2
mannose binding lectin 2
ISO
DNA:haplotype,SNP:promoter,exons:
RGD
PMID:16750996
RGD:8693692
NCBI chrNW_004955425:7,704,371...7,708,951
Ensembl chrNW_004955425:7,702,137...7,709,006
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Mecom
MDS1 and EVI1 complex locus
ISO
OMIM:166760
RGD MouseDO
PMID:26611891
RGD:11054805
NCBI chrNW_004955448:18,259,847...18,542,085
Ensembl chrNW_004955448:18,259,083...18,439,646
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Muc1
mucin 1, cell surface associated
ISO
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
RGD
PMID:11576628
RGD:2303743
NCBI chrNW_004955545:1,657,728...1,662,112
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Muc4
mucin 4, cell surface associated
ISO
associated with Pneumococcal Infections;mRNA:increased expression:middle ear
RGD
PMID:11576628 PMID:14690056
RGD:2303743 RGD:7349395
NCBI chrNW_004955420:12,228,801...12,274,840
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
associated with CHARGE Syndrome mRNA:increased expression:ear
RGD
PMID:11425202 PMID:22539951
RGD:2324973 RGD:7349405
NCBI chrNW_004955476:11,061,405...11,084,294
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
associated with CHARGE Syndrome mRNA:increased expression:middle ear
RGD
PMID:14690056 PMID:22539951
RGD:7349395 RGD:7349405
NCBI chrNW_004955476:11,021,665...11,049,239
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Naglu
N-acetyl-alpha-glucosaminidase
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955451:16,445,338...16,449,243
Ensembl chrNW_004955451:16,445,338...16,450,062
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Nf2
NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955455:3,862,804...3,950,669
Ensembl chrNW_004955455:3,862,347...3,951,891
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Nisch
nischarin
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955430:2,443,029...2,488,267
Ensembl chrNW_004955430:2,443,029...2,491,123
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Nos2
nitric oxide synthase 2
ISO
associated with Haemophilus Infections; mRNA, protein:increased expression:middle ear
RGD
PMID:18524391
RGD:4891398
NCBI chrNW_004955481:5,197,957...5,232,406
Ensembl chrNW_004955481:5,201,234...5,231,961
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Phex
phosphate regulating endopeptidase X-linked
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955509:2,357,263...2,546,802
Ensembl chrNW_004955509:2,357,263...2,546,802
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Plau
plasminogen activator, urokinase
treatment
IEP
RGD
PMID:2473673
RGD:11553864
NCBI chrNW_004955437:17,995,726...18,000,542
Ensembl chrNW_004955437:17,994,537...18,000,209
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Plg
plasminogen
ISO
ClinVar Annotator: match by term: OTITIS MEDIA, CHRONIC/RECURRENT | ClinVar Annotator: match by term: Otitis media, susceptibility to
ClinVar
PMID:10233898 PMID:12850227 PMID:12876630 PMID:15269832 PMID:16849641 PMID:20981092 PMID:22995991 PMID:23629776 PMID:25741868 PMID:26340456 PMID:27976734 PMID:28492532 PMID:28795768 PMID:30487145 PMID:31064749 PMID:31589614 PMID:31980526 PMID:34355501 More...
NCBI chrNW_004955439:20,317,814...20,366,724
Ensembl chrNW_004955439:20,317,552...20,366,475
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Pth
parathyroid hormone
ISO
protein:increased expression:serum (human)
RGD
PMID:23543299
RGD:7242409
NCBI chrNW_004955414:28,828,389...28,831,417
Ensembl chrNW_004955414:28,825,651...28,831,117
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD
PMID:24690988
RGD:8552995
NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
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Rpl38
ribosomal protein L38
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955553:1,129,607...1,133,896
Ensembl chrNW_004955553:1,129,633...1,133,896
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Sall4
spalt like transcription factor 4
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955445:6,824,797...6,841,141
Ensembl chrNW_004955445:6,824,770...6,842,187
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Scgb1a1
secretoglobin family 1A member 1
ISO
mRNA,protein:increased expression:epithelial cell
RGD
PMID:15799573
RGD:5144051
NCBI chrNW_004955599:688,414...690,644
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Scn2b
sodium voltage-gated channel beta subunit 2
ISO
RGD
PMID:12206256
RGD:6484586
NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062
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Sh3pxd2b
SH3 and PX domains 2B
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955408:25,103,278...25,169,934
Ensembl chrNW_004955408:25,103,278...25,170,003
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Spink5
serine peptidase inhibitor Kazal type 5
ISO
ClinVar Annotator: match by term: Susceptibility to nonsyndromic otitis media
ClinVar
PMID:11511292 PMID:25741868 PMID:26865388 PMID:28492532 PMID:32709676
NCBI chrNW_004955415:6,118,616...6,186,632
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Tbx1
T-box transcription factor 1
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955442:18,320,674...18,327,062
Ensembl chrNW_004955442:18,319,762...18,325,337
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Tgif1
TGFB induced factor homeobox 1
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955402:7,130,809...7,138,945
Ensembl chrNW_004955402:7,129,484...7,138,340
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Tlr2
toll like receptor 2
ISO
protein:increased expression:mucosa of middle ear,skin of ear canal: associated with Pneumococcal Infections; protein:increased expression:middle ear: associated with Haemophilus Infections;
RGD
PMID:19414550 PMID:19586996 PMID:23380629 PMID:24690988
RGD:7777086 RGD:7800666 RGD:8552783 RGD:8552995
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
associated with Haemophilus Infections; protein:increased expression:middle ear: protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD
PMID:19586996 PMID:23380629 PMID:24690988
RGD:7777086 RGD:7800666 RGD:8552995
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnf
tumor necrosis factor
IEP
RGD
PMID:10085040
RGD:11553900
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Tp73
tumor protein p73
ISO
OMIM:166760
MouseDO
NCBI chrNW_004955486:7,914,608...7,961,992
Ensembl chrNW_004955486:7,914,440...7,952,982
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Vegfa
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:middle ear,inner ear: mRNA:increased expression:middle ear:
RGD
PMID:21271590 PMID:22104377
RGD:8547975 RGD:8547980
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
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Arpc4
actin related protein 2/3 complex subunit 4
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955561:1,314,299...1,327,300
Ensembl chrNW_004955561:1,314,299...1,327,300
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Bmp1
bone morphogenetic protein 1
ISO
mRNA:increased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955403:45,660,591...45,693,724
Ensembl chrNW_004955403:45,660,588...45,693,724
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Bmp4
bone morphogenetic protein 4
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955409:9,432,835...9,439,680
Ensembl chrNW_004955409:9,432,841...9,440,303
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Bmp6
bone morphogenetic protein 6
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955465:6,053,600...6,201,254
Ensembl chrNW_004955465:6,054,931...6,200,377
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Bmp7
bone morphogenetic protein 7
ISO
mRNA:increased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955445:2,154,057...2,235,594
Ensembl chrNW_004955445:2,153,170...2,235,795
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Cald1
caldesmon 1
IEP
mRNA, protein:decreased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955494:7,578,162...7,675,558
Ensembl chrNW_004955494:7,578,028...7,765,758
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Col3a1
collagen type III alpha 1 chain
IEP
RGD
PMID:10453785
RGD:11556224
NCBI chrNW_004955403:9,720,831...9,758,019
Ensembl chrNW_004955403:9,721,114...9,757,887
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Dstn
destrin, actin depolymerizing factor
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955415:26,567,457...26,598,978
Ensembl chrNW_004955415:26,569,264...26,600,862
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Fgf10
fibroblast growth factor 10
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955446:18,163,117...18,244,840
Ensembl chrNW_004955446:18,163,117...18,245,199
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Fgf3
fibroblast growth factor 3
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955422:16,333,363...16,339,853
Ensembl chrNW_004955422:16,333,363...16,339,853
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Fgf6
fibroblast growth factor 6
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955413:2,246,965...2,257,883
Ensembl chrNW_004955413:2,246,965...2,257,883
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Fgfr1
fibroblast growth factor receptor 1
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955463:14,013,247...14,064,354
Ensembl chrNW_004955463:14,013,247...14,064,111
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Fn1
fibronectin 1
IEP
RGD
PMID:10453785
RGD:11556224
NCBI chrNW_004955457:629,599...694,948
Ensembl chrNW_004955457:629,518...696,975
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Il17a
interleukin 17A
disease_progression
ISO
protein:increased expression:serum (rat)
RGD
PMID:27497403
RGD:40818299
NCBI chrNW_004955411:5,896,435...5,899,911
Ensembl chrNW_004955411:5,896,702...5,900,962
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Il22
interleukin 22
disease_progression
ISO
protein:increased expression:serum (rat)
RGD
PMID:27497403
RGD:40818299
NCBI chrNW_004955458:14,747,339...14,755,602
Ensembl chrNW_004955458:14,747,084...14,752,553
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Lcp1
lymphocyte cytosolic protein 1
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955518:3,815,181...3,863,440
Ensembl chrNW_004955518:3,814,840...3,891,299
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LOC102005867
protein S100-A8
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955592:72,594...73,659
Ensembl chrNW_004955592:73,154...73,843
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Mapk8
mitogen-activated protein kinase 8
ISO
mRNA:decreased expression:middle ear (mouse)
RGD
PMID:21307808
RGD:150340689
NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784
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Mmp2
matrix metallopeptidase 2
ISO
mRNA:increased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775
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Mmp9
matrix metallopeptidase 9
ISO
mRNA:increased expression:middle ear (mouse)
RGD
PMID:21889218
RGD:127284853
NCBI chrNW_004955445:11,295,500...11,303,322
Ensembl chrNW_004955445:11,295,448...11,303,288
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Ncf2
neutrophil cytosolic factor 2
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955406:22,355,717...22,384,746
Ensembl chrNW_004955406:22,355,724...22,384,864
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S100a9
S100 calcium binding protein A9
IEP
mRNA, protein:increased expression:mucosa of middle ear
RGD
PMID:26711468
RGD:11553828
NCBI chrNW_004955592:90,647...93,842
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Rela
RELA proto-oncogene, NF-kB subunit
ISO
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD
PMID:24690988
RGD:8552995
NCBI chrNW_004955422:19,602,930...19,612,263
Ensembl chrNW_004955422:19,603,345...19,611,516
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Tlr2
toll like receptor 2
ISO
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD
PMID:24690988
RGD:8552995
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
protein:increased expression:mucosa of middle ear,skin of ear canal:
RGD
PMID:24690988
RGD:8552995
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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C3
complement C3
disease_progression
ISO
RGD
PMID:11037838
RGD:7401253
NCBI chrNW_004955495:2,796,601...2,824,233
Ensembl chrNW_004955495:2,796,663...2,824,697
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Flt1
fms related receptor tyrosine kinase 1
ISO
mRNA:increased expression:mucosa of the middle ear;
RGD
PMID:12875575
RGD:8547977
NCBI chrNW_004955497:7,653,309...7,831,737
Ensembl chrNW_004955497:7,653,248...7,831,472
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Glb1
galactosidase beta 1
IEP
RGD
PMID:2837976
RGD:11557999
NCBI chrNW_004955421:230,957...311,504
Ensembl chrNW_004955421:231,076...312,500
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Gusb
glucuronidase beta
IEP
RGD
PMID:2837976
RGD:11557999
NCBI chrNW_004955456:8,377,161...8,392,298
Ensembl chrNW_004955456:8,378,654...8,392,252
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Ifng
interferon gamma
ISO
protein:decreased expression:middle ear: protein:decreased expression:serum:
RGD
PMID:15938212 PMID:16055981
RGD:7987911 RGD:8142354
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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Il1b
interleukin 1 beta
IEP
RGD
PMID:8302123
RGD:11554174
NCBI chrNW_004955470:1,486,936...1,491,888
Ensembl chrNW_004955470:1,486,967...1,491,947
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Il4
interleukin 4
ISO
protein:increased expression:middle ear
RGD
PMID:18975780
RGD:2317282
NCBI chrNW_004955408:4,058,052...4,065,999
Ensembl chrNW_004955408:4,058,052...4,064,185
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Il4r
interleukin 4 receptor
treatment
ISO
RGD
PMID:12297806
RGD:11530017
NCBI chrNW_004955493:5,546,340...5,580,745
Ensembl chrNW_004955493:5,545,944...5,582,422
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Kdr
kinase insert domain receptor
ISO
mRNA:increased expression:mucosa of the middle ear;
RGD
PMID:12875575
RGD:8547977
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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LOC102021597
alpha-1-antiproteinase S-like
IEP
RGD
PMID:2454602
RGD:11560528
NCBI chrNW_004955438:17,920,200...17,929,105
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LOC102021956
alpha-2-macroglobulin
IEP
RGD
PMID:2454602
RGD:11560528
NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
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Ltf
lactotransferrin
treatment
ISS
RGD
PMID:21079169
RGD:11554025
NCBI chrNW_004955420:25,580,449...25,604,277
Ensembl chrNW_004955420:25,580,359...25,604,331
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Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA:decreased expression:ear mRNA:increased expression:middle ear
RGD
PMID:20713760 PMID:22336013
RGD:7364731 RGD:7364764
NCBI chrNW_004955476:11,061,405...11,084,294
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Muc5b
mucin 5B, oligomeric mucus/gel-forming
ISO
mRNA:increased expression:middle ear mRNA:decreased expression:ear
RGD
PMID:16540890 PMID:22336013
RGD:7364744 RGD:7364764
NCBI chrNW_004955476:11,021,665...11,049,239
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Oxgr1
oxoglutarate receptor 1
ISO
RGD
PMID:23200873
RGD:7775025
NCBI chrNW_004955404:13,337,607...13,344,789
Ensembl chrNW_004955404:13,337,607...13,344,789
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Ptafr
platelet activating factor receptor
treatment
IMP
RGD
PMID:14759570
RGD:11554333
NCBI chrNW_004955452:7,309,854...7,345,579
Ensembl chrNW_004955452:7,311,901...7,312,929
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Tlr2
toll like receptor 2
ISO
RGD
PMID:22336013
RGD:7364764
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
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Tlr4
toll like receptor 4
ISO
RGD
PMID:22336013
RGD:7364764
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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Tnf
tumor necrosis factor
ISO
protein:increased expression:middle ear effusion:
RGD
PMID:18568516
RGD:7394746
NCBI chrNW_004955437:117,267...119,899
Ensembl chrNW_004955437:117,206...120,700
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Vegfa
vascular endothelial growth factor A
ISO
protein:increased expression:mucosa of middle ear:
RGD
PMID:22907120
RGD:8547964
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
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Alb
albumin
IEP
RGD
PMID:1696441
RGD:11556250
NCBI chrNW_004955447:9,327...21,212
G
Ifng
interferon gamma
disease_progression
ISO
RGD
PMID:19640314
RGD:8142346
NCBI chrNW_004955458:14,643,333...14,648,020
Ensembl chrNW_004955458:14,643,313...14,648,045
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LOC102021956
alpha-2-macroglobulin
IEP
RGD
PMID:1696441
RGD:11556250
NCBI chrNW_004955413:6,019,457...6,062,366
Ensembl chrNW_004955413:6,019,082...6,062,529
G
Tlr2
toll like receptor 2
ISO
mRNA,protein:increased expression:mucosa:
RGD
PMID:22883581
RGD:7800662
NCBI chrNW_004955471:8,011,710...8,019,063
Ensembl chrNW_004955471:8,014,910...8,017,258
G
Tlr4
toll like receptor 4
ISO
mRNA,protein:increased expression:mucosa:
RGD
PMID:22883581
RGD:7800662
NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135
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