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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Alzheimer's disease
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Accession:DOID:10652 term browser browse the term
Definition:A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. (DO)
Synonyms:exact_synonym: AD;   Alzheimer Disease, Susceptibility To;   Alzheimer Sclerosis;   Alzheimer Syndrome;   Alzheimer Type Dementia;   Alzheimer Type Dementia (ATD);   Alzheimer Type Senile Dementia;   Alzheimer dementia (AD);   Alzheimer disease;   Alzheimers dementia;   Early Onset Alzheimer Disease;   Familial Alzheimer Disease (FAD);   Focal Onset Alzheimer's Disease;   SDAT;   acute confusional senile dementia;   presenile Alzheimer dementia;   presenile dementia;   primary senile degenerative dementia;   senile dementia
 narrow_synonym: ALZHEIMER DISEASE, EARLY-ONSET, WITH CEREBRAL AMYLOID ANGIOPATHY;   ALZHEIMER DISEASE, PROTECTION AGAINST;   EARLY-ONSET FAMILIAL ALZHEIMER DISEASE;   Late Onset Alzheimer Disease;   late-onset Alzheimers disease;   presenile and senile dementia
 related_synonym: Alzheimer Disease, Early-Onset, Susceptibility To;   Alzheimer Disease, Late-Onset, Susceptibility To;   Alzheimer disease, association with;   alpha-2-macroglobulin polymorphism;   familial Alzheimer disease;   transferrin variant C1/C2
 primary_id: MESH:D000544
 alt_id: MIM:502500
 xref: EFO:0000249;   EFO:1001870;   GARD:10254;   ICD9CM:331.0;   MONDO:0004975;   NCI:C2866
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
Alzheimer's disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin no_association
onset		 ISO DNA:deletion:splice junction:
DNA:insertion/deletion, substitution
DNA:polymorphism: :p.I1000V (human)
DNA:deletion, polymorphisms, haplotypes: :multiple
DNA:polymorphisms: :multiple
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM		 CTD
ClinVar
RGD		 PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:15023809 More... RGD:1302534, RGD:1300322, RGD:10046012, RGD:10046014, RGD:10046015, RGD:10046016, RGD:10046016 NCBI chr 6:121,612,920...121,656,197
Ensembl chr 6:121,612,335...121,656,186 		JBrowse link
G Abat 4-aminobutyrate aminotransferase ISO RGD PMID:1627256 RGD:10046060 NCBI chr16:8,331,293...8,439,432
Ensembl chr16:8,331,293...8,439,432 		JBrowse link
G Abca1 ATP-binding cassette, sub-family A member 1 ISO RGD PMID:15024730 RGD:1300323 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abca7 ATP-binding cassette, sub-family A member 7 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, early onset		 CTD
ClinVar		 PMID:21460840 PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 More... NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A IMP RGD PMID:25991605 RGD:13801010 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc1 ATP-binding cassette, sub-family C member 1 IMP RGD PMID:25991605 RGD:13801010 NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601 		JBrowse link
G Abi3 ABI family member 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chr11:95,720,898...95,733,302
Ensembl chr11:95,720,900...95,733,302 		JBrowse link
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase IMP
IEP		 protein:increased expression:brain: RGD PMID:19700222 PMID:19700222 RGD:8693570, RGD:8693570 NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239 		JBrowse link
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237 		JBrowse link
G Ace angiotensin I converting enzyme ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9916793 PMID:10643899 PMID:14872014 PMID:17192785 PMID:30820047 More... RGD:2325232, RGD:1331525 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ache acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22944069 PMID:23047022 PMID:16581404 RGD:5509844 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Adam10 a disintegrin and metallopeptidase domain 10 ISO protein:decreased expression:cerebral cortex, hippocampus
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:30820047 PMID:23296102 PMID:24792732 RGD:13703032, RGD:13703037 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 onset ISO protein:decreased expression:cerebral cortex, hippocampus
DNA:missense mutation: :p.R215I (rs142946965) (human)		 RGD PMID:24792732 PMID:29988083 RGD:13703037, RGD:13782143 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Adam2 a disintegrin and metallopeptidase domain 2 ISO protein:increased expression:brain RGD PMID:10686596 RGD:10047127 NCBI chr14:66,264,778...66,315,300
Ensembl chr14:66,264,778...66,315,182 		JBrowse link
G Adam9 ADAM metallopeptidase domain 9 ISO protein:decreased expression:hippocampus RGD PMID:24792732 RGD:13703037 NCBI chr 8:25,439,627...25,507,138
Ensembl chr 8:25,439,627...25,506,943 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease		 CTD
ClinVar		 PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 PMID:30820047 NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif 5 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:85,655,045...85,698,013
Ensembl chr16:85,653,061...85,698,716 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:increased expression:plasma
protein:increased expression:cerebrospinal fluid, plasma		 RGD PMID:22213409 PMID:20727007 RGD:5686377, RGD:5686881 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Adnp activity-dependent neuroprotective protein IMP
IDA		 RGD PMID:17720885 PMID:18199809 RGD:2312792, RGD:2312791 NCBI chr 2:168,022,885...168,049,032
Ensembl chr 2:168,022,906...168,049,032 		JBrowse link
G Adra1a adrenergic receptor, alpha 1a susceptibility ISO RGD PMID:114750 RGD:5688374 NCBI chr14:66,872,705...67,009,549
Ensembl chr14:66,872,700...67,008,617 		JBrowse link
G Adrb3 adrenergic receptor, beta 3 ISO DNA:missense mutation:cds:p.W64R (human) RGD PMID:17440948 RGD:2311642 NCBI chr 8:27,715,804...27,720,833
Ensembl chr 8:27,715,804...27,740,644 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO
IDA
IEP		 protein:increased expression:brain (human)
mRNA:increased expression:hippocampus, cerebral cortex (mouse)
protein:increased expression:hippocampus (rat)		 RGD PMID:8751438 PMID:22415896 PMID:21593432 PMID:23164356 PMID:23396166 More... RGD:1300365, RGD:7245561, RGD:7245965, RGD:7244287, RGD:7244266, RGD:6784502 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen ISO protein:increased expression:cerebrospinal fluid RGD PMID:21297254 RGD:5129180 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a treatment ISO protein:decreased expression:substantia nigra: RGD PMID:21929736 PMID:8666063 RGD:10047395, RGD:10047397 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850 		JBrowse link
G Aif1 allograft inflammatory factor 1 ISO
IEP		 mRNA:increased expression:frontal cortex (human)
protein:altered expression:hippocampus (mouse)		 RGD PMID:16340083 PMID:19084047 RGD:2313045, RGD:2313023 NCBI chr17:35,389,967...35,394,977
Ensembl chr17:35,389,967...35,395,044 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 IEP
ISO		 protein:increased expression:cortex,nucleus:
protein:increased expression:basal forebrain,amygdala:		 RGD PMID:24915960 PMID:22536549 RGD:10053592, RGD:10053593 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Akap5 A kinase anchor protein 5 ISO protein:increased expression:cell soma, dendritic arbor (human) RGD PMID:10460255 RGD:2313287 NCBI chr12:76,371,652...76,380,925
Ensembl chr12:76,371,665...76,380,927 		JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 ISO protein:increased expression:superior, middle temporal gyrus; RGD PMID:11597610 RGD:14349051 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 IEP protein:increased tyrosine phosphorylation:cerebral cortex RGD PMID:18023354 RGD:5509085 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial onset ISO RGD PMID:15126281 RGD:1599042 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase IMP
ISO		 protein:increased expression:brain RGD PMID:20570249 PMID:15111312 RGD:5509595, RGD:5509620 NCBI chr11:70,234,973...70,279,465
Ensembl chr11:70,234,978...70,242,857 		JBrowse link
G Ambra1 autophagy/beclin 1 regulator 1 IEP RGD PMID:23910655 RGD:14390071 NCBI chr 2:91,560,464...91,749,194
Ensembl chr 2:91,560,479...91,749,194 		JBrowse link
G Amfr autocrine motility factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22313999 NCBI chr 8:94,698,216...94,739,301
Ensembl chr 8:94,698,216...94,739,470 		JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 severity ISO protein:decreased expression:serum RGD PMID:22449478 RGD:6892705 NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466 		JBrowse link
G Anxa5 annexin A5 IEP
ISO		 protein:increased expression:brain, plasma
protein:increased expression: plasma		 RGD PMID:20648654 PMID:20648654 RGD:7242030, RGD:7242030 NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043 		JBrowse link
G Aoc3 amine oxidase, copper containing 3 severity ISO protein:increased expression:plasma RGD PMID:17393059 RGD:2313919 NCBI chr11:101,221,432...101,230,256
Ensembl chr11:101,221,431...101,232,764 		JBrowse link
G Apbb1 amyloid beta precursor protein binding family B member 1 susceptibility
no_association		 ISO DNA:mutations::multiple
mRNA:altered expression:brain:
DNA:deletion:intron:
DNA:polymorphism:intron:		 RGD PMID:9799084 PMID:10723070 PMID:12727304 PMID:11099823 RGD:2301212, RGD:10054036, RGD:10054031, RGD:10054028 NCBI chr 7:105,207,691...105,231,151
Ensembl chr 7:105,207,690...105,230,860 		JBrowse link
G Apbb2 amyloid beta precursor protein binding family B member 2 onset ISO DNA:SNPs: :rs13133980,rs17443013(human) RGD PMID:15714520 RGD:9684954 NCBI chr 5:66,456,068...66,779,189
Ensembl chr 5:66,456,046...66,776,127 		JBrowse link
G Apc APC, WNT signaling pathway regulator ISO protein:increased expression:astrocyte RGD PMID:11547943 RGD:6484525 NCBI chr18:34,353,350...34,455,243
Ensembl chr18:34,353,977...34,455,605 		JBrowse link
G Aph1a aph1 homolog A, gamma secretase subunit treatment IEP RGD PMID:28588301 PMID:29926633 RGD:13703122, RGD:13703123 NCBI chr 3:95,801,233...95,805,904
Ensembl chr 3:95,801,281...95,805,600 		JBrowse link
G Aph1b aph1 homolog B, gamma secretase subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr 9:66,682,484...66,704,671
Ensembl chr 9:66,682,484...66,702,772 		JBrowse link
G Aplp2 amyloid beta precursor-like protein 2 ISO RGD PMID:8086458 RGD:734582 NCBI chr 9:31,060,853...31,123,144
Ensembl chr 9:31,060,853...31,123,111 		JBrowse link
G Apoa1 apolipoprotein A-I resistance ISO DNA: : :transgenic model RGD PMID:20847045 PMID:19863188 RGD:5508212, RGD:5508218 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Apoa4 apolipoprotein A-IV no_association IMP
ISO		 DNA:missense mutation:cds:p.Q360H (human)
DNA:snp, haplotype:cds:p.S147N (rs5104) (human)		 RGD PMID:21356380 PMID:10559562 PMID:9272683 PMID:16013913 RGD:5685638, RGD:5685682, RGD:5685681, RGD:5685661 NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757 		JBrowse link
G Apoc1 apolipoprotein C-I ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:29107063 PMID:30319691 PMID:11825674 RGD:1578472 NCBI chr 7:19,423,405...19,426,584
Ensembl chr 7:19,423,406...19,426,585 		JBrowse link
G Apod apolipoprotein D ISO protein:increased expression:cerebrospinal fluid, hippocampus RGD PMID:9751198 RGD:2311209 NCBI chr16:31,115,010...31,133,626
Ensembl chr16:31,115,010...31,133,626 		JBrowse link
G Apoe apolipoprotein E susceptibility
treatment
no_association		 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset
DNA:SNP: :APOEe4(human)
CTD Direct Evidence: marker/mechanism
DNA:polymorphism:promoter:-491A>T,-427T>C(human)
protein:increased expression:hippocampus, synapse (rat)
protein:increased expression:parietal cortex, synapse (human)
DNA:missense mutations, haplotype:cds:p.C112R, (rs7412) (human)		 ClinVar
CTD
RGD		 PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... RGD:1331525, RGD:10427727, RGD:12904712, RGD:7771594, RGD:6903910, RGD:6903910, RGD:6903233 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein susceptibility
treatment		 ISO
IAGP		 ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, early onset | ClinVar Annotator: match by term: Alzheimer disease, protection against | ClinVar Annotator: match by term: Alzheimer's disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
CTD Direct Evidence: marker/mechanism
human transgene in rat model
associated with hypertension
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907
DNA:mutation:p.D678N (human)
protein:increased expression:cerebral spinal fluid fluid,brain:
protein:decreased expression:cerebrospinal fluid:		 ClinVar
CTD
MouseDO
RGD		 PMID:1303172 PMID:1303239 PMID:1303275 PMID:1307241 PMID:1415269 More... RGD:1599199, RGD:2290385, RGD:13782183, RGD:13782049, RGD:13782047, RGD:13782044, RGD:10054280, RGD:1302530, RGD:10054258, RGD:10054257 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Aqp4 aquaporin 4 ISO RGD PMID:21107133 RGD:5148012 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Arc activity regulated cytoskeletal-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:18503570 NCBI chr15:74,540,930...74,544,419
Ensembl chr15:74,540,932...74,544,419 		JBrowse link
G Ass1 argininosuccinate synthetase 1 ISO protein:increased expression:brain, glial cell (human) RGD PMID:11556547 RGD:4139898 NCBI chr 2:31,360,282...31,410,682
Ensembl chr 2:31,360,219...31,410,684 		JBrowse link
G Atf2 activating transcription factor 2 ISO RGD PMID:9138733 PMID:15878807 RGD:10047399, RGD:10047400 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atm ataxia telangiectasia mutated disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040 		JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha treatment
onset		 ISO
IEP		 CTD Direct Evidence: marker/mechanism
protein:increased modification:inferior parietal cortex (human)		 CTD
RGD		 PMID:19374891 PMID:25561935 PMID:19374891 RGD:13703056, RGD:13703046 NCBI chr18:77,861,468...77,870,569
Ensembl chr18:77,861,429...77,870,569 		JBrowse link
G Atp5f1d ATP synthase F1 subunit delta ISO RGD PMID:28474567 RGD:13792588 NCBI chr10:79,974,451...79,981,662
Ensembl chr10:79,974,466...79,981,652 		JBrowse link
G Atp5mg ATP synthase membrane subunit g ISO RGD PMID:28474567 RGD:13792588 NCBI chr 9:44,824,546...44,832,470
Ensembl chr 9:44,823,855...44,832,040 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513 		JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP treatment IDA
ISO		 RGD PMID:30266287 PMID:30266287 RGD:14696823, RGD:14696823 NCBI chr16:91,722,111...91,728,518
Ensembl chr16:91,722,102...91,728,575
Ensembl chr16:91,722,102...91,728,575 		JBrowse link
G Atp6v0e ATPase, H+ transporting, lysosomal V0 subunit E IEP RGD PMID:23211594 RGD:10401913 NCBI chr17:26,895,370...26,918,621
Ensembl chr17:26,882,205...26,918,621 		JBrowse link
G Atp7a ATPase, copper transporting, alpha polypeptide ISO mRNA:decreased expression:pituitary gland, vascular plexus (rat) RGD PMID:20027333 RGD:8657017 NCBI chr  X:105,070,830...105,171,766
Ensembl chr  X:105,070,882...105,168,532 		JBrowse link
G Atr ataxia telangiectasia and Rad3 related ISO RGD PMID:23861893 RGD:10047419 NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 susceptibility
treatment		 ISO
IEP		 CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:12824768 PMID:16407166 PMID:12824768 PMID:28763060 PMID:29038004 RGD:1358439, RGD:1358439, RGD:13782083, RGD:13782077 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 susceptibility ISO mRNA,protein:increased expression:gyrus:
DNA:SNP,haplotype:exon:		 RGD PMID:22074738 PMID:16023140 RGD:13782172, RGD:13782180 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA
ISO		 protein:increased expression:temporal cortex, membrane RGD PMID:15339646 PMID:9507158 RGD:10053639, RGD:10053642 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Baiap2 brain-specific angiogenesis inhibitor 1-associated protein 2 ISO protein:decreased expression:cerebral cortex, postsynaptic density (human) RGD PMID:23537733 RGD:11576299 NCBI chr11:119,833,762...119,897,608
Ensembl chr11:119,833,589...119,897,608 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Barhl1 BarH like homeobox 1 ISO protein:decreased expression:brain RGD PMID:28956815 RGD:14390165 NCBI chr 2:28,797,692...28,807,996
Ensembl chr 2:28,797,691...28,806,680 		JBrowse link
G Bax BCL2-associated X protein treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18077176 PMID:17639989 PMID:8990132 PMID:16265626 PMID:21585051 More... RGD:2293073, RGD:10054039, RGD:10054047, RGD:10054049, RGD:13782186, RGD:13782188 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bcan brevican IEP protein:altered modification:brain RGD PMID:20180882 RGD:14392785 NCBI chr 3:87,894,839...87,908,458
Ensembl chr 3:87,894,838...87,907,537 		JBrowse link
G Bche butyrylcholinesterase severity ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:23022600 PMID:22012848 PMID:16973370 RGD:5687327, RGD:5688056 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO protein:increased expression:temporal cortex, membrane
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18077176 PMID:17639989 PMID:9507158 PMID:16265626 PMID:21585051 More... RGD:2293073, RGD:10053642, RGD:10054047, RGD:10054049, RGD:11522767, RGD:13782186, RGD:13782188 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 ISO protein:increased expression:temporal cortex, membrane RGD PMID:9507158 RGD:10053642 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bcl2l2 BCL2-like 2 treatment ISO protein:increased expression:hippocampus, cortex RGD PMID:15147516 PMID:20460763 RGD:14394419, RGD:14394421 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Bdnf brain derived neurotrophic factor onset
no_association
treatment		 ISO
IEP		 DNA:SNP:CDS:rs1048218 (human)
protein:decreased expression:parietal cortex
DNA:polymorphism: :p.V66M (human)
DNA:polymorphisms, haplotypes: :196G>A (p.V66M), 270C>T, 11757G>C (human)
DNA:polymorphisms: :196G>A (p.V66M), 270C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17344400 PMID:20646587 PMID:15118671 PMID:18780967 PMID:12654514 More... RGD:4891131, RGD:1331525, RGD:5508228, RGD:10058980, RGD:10059343, RGD:10059345, RGD:10059346, RGD:10059402, RGD:405850256 NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352 		JBrowse link
G Becn1 beclin 1, autophagy related ISO
IDA		 protein:decreased expression:gray matter RGD PMID:18497889 PMID:20863706 RGD:6483101, RGD:6483102 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bin1 bridging integrator 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460841 PMID:33589840 NCBI chr18:32,509,671...32,568,793
Ensembl chr18:32,510,283...32,568,790 		JBrowse link
G Bmp4 bone morphogenetic protein 4 IEP RGD PMID:19463786 RGD:10414082 NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126 		JBrowse link
G Bptf bromodomain PHD finger transcription factor ISO protein:increased expression:microglia: RGD PMID:9792236 RGD:9586059 NCBI chr11:106,923,907...107,022,982
Ensembl chr11:106,923,907...107,022,953 		JBrowse link
G Brip1 BRCA1 interacting protein C-terminal helicase 1 ISO associated with Down Syndrome;protein:increased ubiquitination:frontal cortex (human) RGD PMID:25391381 RGD:11252150 NCBI chr11:85,948,957...86,092,041
Ensembl chr11:85,948,964...86,092,019 		JBrowse link
G Btg3 BTG anti-proliferation factor 3 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:78,156,748...78,174,069
Ensembl chr16:78,129,525...78,174,080 		JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide ISO mRNA:increased expression:microglial cell RGD PMID:1362796 RGD:1599518 NCBI chr 4:136,607,437...136,613,511
Ensembl chr 4:136,607,440...136,613,498 		JBrowse link
G C2 complement C2 ISO DNA:SNP, haplotype: :p.E318D (rs9332739) (human) RGD PMID:22300950 RGD:7401250 NCBI chr17:35,081,578...35,101,076
Ensembl chr17:35,081,580...35,117,241 		JBrowse link
G C3 complement component 3 ISO DNA:SNP: :rs22300199 (human) RGD PMID:22300950 RGD:7401250 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G C5ar1 complement component 5a receptor 1 ISO protein:decreased expression:brain RGD PMID:12759460 RGD:5130177 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit IEP protein:decreased expression:brain RGD PMID:23403102 RGD:13782264 NCBI chr 6:118,564,201...119,174,345
Ensembl chr 6:118,564,201...119,173,851 		JBrowse link
G Calm1 calmodulin 1 ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:cerebellar cortex:		 CTD
RGD		 PMID:11470324 PMID:11470324 RGD:13792493 NCBI chr12:100,165,694...100,176,083
Ensembl chr12:100,165,694...100,176,073 		JBrowse link
G Calm4 calmodulin 4 ISO protein:altered expression:neuron,glia RGD PMID:11470324 RGD:13792493 NCBI chr13:3,887,757...3,888,671
Ensembl chr13:3,887,757...3,888,673 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO RGD PMID:15621017 RGD:13681926 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Capn1 calpain 1 onset ISO protein:increased activity:brain: RGD PMID:8622780 PMID:11231011 RGD:13792495, RGD:13792663 NCBI chr19:6,038,573...6,065,855
Ensembl chr19:6,038,573...6,065,927 		JBrowse link
G Capn2 calpain 2 ISO protein:increased expression:cytosol RGD PMID:9654354 RGD:13792661 NCBI chr 1:182,294,818...182,345,175
Ensembl chr 1:182,294,825...182,345,173 		JBrowse link
G Casp1 caspase 1 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp12 caspase 12 treatment ISO RGD PMID:29126976 RGD:13782165 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp2 caspase 2 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 6:42,241,942...42,259,442
Ensembl chr 6:42,241,919...42,259,442 		JBrowse link
G Casp3 caspase 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18077176 PMID:10319819 PMID:29777699 PMID:29587274 PMID:12633148 More... RGD:734692, RGD:13782186, RGD:13782188, RGD:13782269, RGD:13782291 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp6 caspase 6 ISO RGD PMID:12633148 RGD:13782269 NCBI chr 3:129,695,064...129,707,761
Ensembl chr 3:129,695,074...129,707,752 		JBrowse link
G Casp7 caspase 7 ISO DNA:SNPs, haplotype RGD PMID:26621834 PMID:12633148 RGD:11344490, RGD:13782269 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 treatment ISO RGD PMID:16772874 PMID:29642617 PMID:12633148 RGD:13782268, RGD:13782291, RGD:13782269 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 treatment ISO RGD PMID:29777699 PMID:12633148 RGD:13782186, RGD:13782269 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cass4 Cas scaffolding protein family member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 PMID:33589840 NCBI chr 2:172,234,998...172,275,672
Ensembl chr 2:172,235,714...172,275,677 		JBrowse link
G Cast calpastatin IMP
ISO		 protein:decreased expression:brain RGD PMID:20595388 PMID:19020018 RGD:5509799, RGD:5509809 NCBI chr13:74,840,485...74,956,993
Ensembl chr13:74,840,487...74,956,929 		JBrowse link
G Cav1 caveolin 1, caveolae protein IAGP OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Ccdc6 coiled-coil domain containing 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr10:69,932,709...70,029,030
Ensembl chr10:69,932,951...70,029,030 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:cerebrum, blood vessels (human) RGD PMID:18440671 RGD:4890025 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccng1 cyclin G1 ISO protein:increased expression:brain, neuron RGD PMID:12214116 RGD:2316025 NCBI chr11:40,639,379...40,646,044
Ensembl chr11:40,639,379...40,646,138 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 severity ISO RGD PMID:14595653 RGD:5688166 NCBI chr 9:123,762,163...123,768,729
Ensembl chr 9:123,762,161...123,768,729 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 ISO protein:increased expression:brain, microglia (human) RGD PMID:9665462 PMID:15979806 RGD:4890447, RGD:4890446 NCBI chr 9:123,921,557...123,934,153
Ensembl chr 9:123,921,580...123,947,736 		JBrowse link
G Cd2ap CD2-associated protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 PMID:30320580 NCBI chr17:43,059,857...43,187,593
Ensembl chr17:43,103,842...43,187,556 		JBrowse link
G Cd33 CD33 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 NCBI chr 7:43,176,823...43,186,679
Ensembl chr 7:43,173,640...43,193,852 		JBrowse link
G Cd36 CD36 molecule ISO RGD PMID:16563568 RGD:6893531 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799 		JBrowse link
G Cd40 CD40 antigen IEP RGD PMID:21414686 RGD:5490302 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand ISO
IEP		 protein:increased expression:frontal cortex, astrocyte RGD PMID:11755016 PMID:11755016 RGD:8547803, RGD:8547803 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cdc42 cell division cycle 42 ISO RGD PMID:10817927 RGD:5688277 NCBI chr 4:137,047,011...137,085,007
Ensembl chr 4:137,047,007...137,085,031 		JBrowse link
G Cdk5 cyclin dependent kinase 5 treatment ISO
IDA		 DNA:SNP:intron:g.149800G>C (human) RGD PMID:28269780 PMID:28085018 PMID:15917097 RGD:13508590, RGD:13792587, RGD:13782365 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdk5r1 cyclin dependent kinase 5, regulatory subunit 1 ISO
IMP		 DNA:SNP:3' UTR:rs735555 (human) RGD PMID:28578378 PMID:19154537 PMID:24725413 RGD:13782362, RGD:13782364, RGD:13782363 NCBI chr11:80,367,849...80,372,010
Ensembl chr11:80,367,849...80,372,010 		JBrowse link
G Cdk7 cyclin dependent kinase 7 ISO protein:increased expression:neuron: RGD PMID:11124424 RGD:10059352 NCBI chr13:100,833,532...100,867,454
Ensembl chr13:100,839,139...100,867,447 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IEP
ISO		 protein:decreased expression:forebrain, hindbrain (mouse)
mRNA:increased expression:hippocampus (human)		 RGD PMID:21492414 PMID:14769913 RGD:10401190, RGD:10401224 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta treatment ISO
IDA		 mRNA:increased expression:hippocampus CA1 (human) RGD PMID:12391607 PMID:23911420 RGD:10401229, RGD:10401268 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator ISO protein:decreased expression:hypothalamus RGD PMID:14757935 RGD:11566025 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Chat choline O-acetyltransferase ISO DNA:polymorphism:CDS:4G>A (human) RGD PMID:16834974 PMID:12401548 RGD:1600851, RGD:1358495 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Chodl chondrolectin ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:78,727,729...78,748,624
Ensembl chr16:78,727,836...78,748,621 		JBrowse link
G Chrna4 cholinergic receptor, nicotinic, alpha polypeptide 4 ISO RGD PMID:15465084 RGD:1358509 NCBI chr 2:180,664,104...180,685,339
Ensembl chr 2:180,660,173...180,685,339 		JBrowse link
G Chrna7 cholinergic receptor, nicotinic, alpha polypeptide 7 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18071042 PMID:15465084 RGD:1358509 NCBI chr 7:62,748,440...62,862,274
Ensembl chr 7:62,748,440...62,862,317 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chr 3:89,660,755...89,671,939
Ensembl chr 3:89,653,502...89,671,939 		JBrowse link
G Cib1 calcium and integrin binding 1 ISO protein:decreased expression:brain (human) RGD PMID:15885068 RGD:10401854 NCBI chr 7:79,876,904...79,882,367
Ensembl chr 7:79,876,895...79,882,561 		JBrowse link
G Clock clock circadian regulator susceptibility ISO DNA:snp:intron:c.982+247G>C (rs1554483) (human)
DNA:snp:3' utr:c.3111T>C (human)
DNA:snp:intron:c.560-1279C>G (rs4580704) (human)		 RGD PMID:23781009 PMID:23912676 PMID:23357097 RGD:10401861, RGD:10401872, RGD:10401862 NCBI chr 5:76,357,715...76,452,675
Ensembl chr 5:76,357,715...76,452,639 		JBrowse link
G Clu clusterin ISO ClinVar Annotator: match by term: Alzheimer disease
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:19734902 PMID:19734903 PMID:21460841 PMID:28492532 PMID:29476165 More... RGD:8903235 NCBI chr14:66,206,093...66,218,992
Ensembl chr14:66,205,932...66,218,996 		JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase IDA RGD PMID:21918687 RGD:6483333 NCBI chr11:100,465,765...100,472,565
Ensembl chr11:100,465,730...100,482,555 		JBrowse link
G Cox7c cytochrome c oxidase subunit 7C ISO RGD PMID:28474567 RGD:13792588 NCBI chr13:86,192,917...86,194,914
Ensembl chr13:86,192,935...86,195,023 		JBrowse link
G Crebbp CREB binding protein treatment IDA
IEP		 protein:increased phosphorylation:hippocampus: RGD PMID:21149712 PMID:17760871 RGD:10059608, RGD:10059609 NCBI chr16:3,899,198...4,031,864
Ensembl chr16:3,899,192...4,031,861 		JBrowse link
G Crh corticotropin releasing hormone ISO protein:decreased expression:cerebral cortex (human)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:7477348 PMID:7477348 RGD:5508831 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Crp C-reactive protein, pentraxin-related IDA RGD PMID:22202667 RGD:6904208 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:30279455 NCBI chr18:61,238,644...61,264,211
Ensembl chr18:61,233,670...61,265,221 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chr18:61,687,307...61,723,391
Ensembl chr18:61,688,345...61,723,132 		JBrowse link
G Csnk1d casein kinase 1, delta severity ISO protein:increased expression:CA1 field of hippocampus:
mRNA,protein:increased expression:brain:		 RGD PMID:10514399 PMID:10814741 RGD:10395229, RGD:10395230 NCBI chr11:120,848,535...120,882,180
Ensembl chr11:120,849,816...120,882,156 		JBrowse link
G Csnk1e casein kinase 1, epsilon ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:10514399 RGD:10395229 NCBI chr15:79,302,054...79,339,779
Ensembl chr15:79,302,056...79,339,767 		JBrowse link
G Cst3 cystatin C susceptibility ISO protein:decreased expression:serum (human)
CTD Direct Evidence: marker/mechanism|therapeutic
protein:increased expression:plasma		 CTD
RGD		 PMID:17192785 PMID:18026100 PMID:18824671 PMID:15907478 RGD:2314333, RGD:1358533 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Ctnnb1 catenin beta 1 treatment ISO
IEP		 protein:increased expression:neuron,cytoplasm:
protein:decreased expression:hippocampus
protein:decreased expression:nucleus:		 RGD PMID:15781969 PMID:12610652 PMID:11226152 RGD:10395258, RGD:10395276, RGD:1302533 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573 		JBrowse link
G Ctsd cathepsin D ISO RGD PMID:11304834 RGD:1358532 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctss cathepsin S ISO RGD PMID:7717452 RGD:5686914 NCBI chr 3:95,434,097...95,463,716
Ensembl chr 3:95,434,097...95,463,714 		JBrowse link
G Cxadr coxsackie virus and adenovirus receptor ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:78,098,114...78,156,673
Ensembl chr16:78,098,377...78,156,662 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 ISO mRNA:altered expression:cerebellum, hippocampus (human)
DNA:polymorphism		 RGD PMID:18180323 PMID:16882736 RGD:4889108, RGD:1600861 NCBI chr 9:54,073,221...54,175,448
Ensembl chr 9:54,073,221...54,175,394 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 ISO CTD Direct Evidence: marker/mechanism CTD PMID:7574463 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19286353 PMID:12232784 RGD:1358575 NCBI chr12:108,300,568...108,328,497
Ensembl chr12:108,300,640...108,328,493 		JBrowse link
G Cyyr1 cysteine and tyrosine-rich protein 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:85,247,245...85,347,793
Ensembl chr16:85,218,421...85,350,285 		JBrowse link
G D16Ertd472e DNA segment, Chr 16, ERATO Doi 472, expressed ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:78,337,224...78,373,576
Ensembl chr16:78,337,226...78,373,596 		JBrowse link
G Dbn1 drebrin 1 disease_progression ISO
IEP		 protein:decreased expression:hippocampal formation:
mRNA:decreased expression:parietal cortex, temporal cortex, hippocampus:
protein:decreased expression:hippocampus,neuronal spine:		 RGD PMID:8838578 PMID:18338803 PMID:17912741 RGD:10395286, RGD:10398821, RGD:10398820 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924 		JBrowse link
G Ddr1 discoidin domain receptor family, member 1 treatment IMP RGD PMID:28863860 RGD:150519888 NCBI chr17:35,992,459...36,015,633
Ensembl chr17:35,992,459...36,015,513 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:23042211 NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 ISO RGD PMID:24156266 RGD:13792688 NCBI chr11:69,908,029...69,938,107
Ensembl chr11:69,907,768...69,938,348 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase susceptibility ISO DNA:polymorphisms: : RGD PMID:10227647 RGD:1358587 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619 		JBrowse link
G Dnm1 dynamin 1 ISO
IEP		 protein:decreased expression:hippocampus,entorhinal cortex:
mRNA,protein:decreased expression:hippocampus, temporal cortex
denntate gyrus, hippocampus, entorhinal cortex		 RGD PMID:20847448 PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238, RGD:13506238 NCBI chr 2:32,198,483...32,243,361
Ensembl chr 2:32,198,483...32,243,350 		JBrowse link
G Dnm1l dynamin 1-like ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chr14:67,040,313...67,148,490
Ensembl chr14:67,040,313...67,148,410 		JBrowse link
G Drd1 dopamine receptor D1 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 ISO protein:decreased expression:blood, lymphocyte RGD PMID:11087905 RGD:5686416 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Drd3 dopamine receptor D3 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295 		JBrowse link
G Drd4 dopamine receptor D4 ISO protein:decreased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377 		JBrowse link
G Drd5 dopamine receptor D5 ISO protein:increased expression:frontal cortex, neuron RGD PMID:17182012 RGD:5686412 NCBI chr 5:38,476,742...38,479,868
Ensembl chr 5:38,476,710...38,479,861 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 ISO protein:increased expression:brain RGD PMID:9402150 RGD:13207349 NCBI chr12:110,567,829...110,633,378
Ensembl chr12:110,567,886...110,633,379 		JBrowse link
G E2f1 E2F transcription factor 1 ISO protein:increased expression:cerebral cortex,cytoplasm: RGD PMID:11939591 RGD:10401093 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:15340356 RGD:1580902 NCBI chr 4:137,589,548...137,692,540
Ensembl chr 4:137,589,548...137,692,540 		JBrowse link
G Eef1a2 eukaryotic translation elongation factor 1 alpha 2 ISO protein:increased expression:CA1field of hippocampus: RGD PMID:8750861 RGD:10401216 NCBI chr 2:180,783,551...180,798,808
Ensembl chr 2:180,789,446...180,798,807 		JBrowse link
G Eef2 eukaryotic translation elongation factor 2 ISO protein:hyperphosphorylation:brain: RGD PMID:1331687 RGD:10401652 NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332 		JBrowse link
G Eef2k eukaryotic elongation factor-2 kinase ISO RGD PMID:16098202 RGD:10401651 NCBI chr 7:120,442,080...120,506,441
Ensembl chr 7:120,442,054...120,506,673 		JBrowse link
G Egf epidermal growth factor ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Egfr epidermal growth factor receptor treatment IMP RGD PMID:23019586 RGD:10059684 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158 		JBrowse link
G Egr1 early growth response 1 treatment ISO
IEP		 protein:increased expression:temporal cortex, hippocampus (human) RGD PMID:21489990 PMID:21969301 PMID:23642031 RGD:5131647, RGD:10395277, RGD:10395279 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 IDA
ISO		 protein:increased threonine phosphorylation:hippocampus RGD PMID:24315369 PMID:15567511 RGD:10395344, RGD:10395348 NCBI chr17:79,157,933...79,190,001
Ensembl chr17:79,159,993...79,190,002 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha severity ISO
IDA		 CTD Direct Evidence: marker/mechanism
protein:increased phosphorylation:hippocampus		 CTD
RGD		 PMID:17406652 PMID:16691116 PMID:24315369 PMID:16954686 RGD:10395316, RGD:10395344, RGD:10395343 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family ISO RGD PMID:20126313 RGD:7488914 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847 		JBrowse link
G Eno1 enolase 1, alpha non-neuron ISO CTD Direct Evidence: marker/mechanism
protein:increased S-glutathionylation, decreased activity:inferior parietal cortex		 CTD
RGD		 PMID:19374891 PMID:17387692 RGD:13792613 NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336 		JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA:increased expression:temporal cortex (human) RGD PMID:23585551 RGD:7327146 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epha1 Eph receptor A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460840 PMID:21460841 NCBI chr 6:42,335,421...42,350,249
Ensembl chr 6:42,335,421...42,350,202 		JBrowse link
G Epha4 Eph receptor A4 IEP
ISO		 protein:decreased expression:hippocampus RGD PMID:19542617 PMID:19542617 RGD:6218956, RGD:6218956 NCBI chr 1:77,343,819...77,491,763
Ensembl chr 1:77,343,822...77,491,725 		JBrowse link
G Ephb2 Eph receptor B2 ameliorates IDA RGD PMID:21113149 RGD:12859080 NCBI chr 4:136,374,850...136,563,637
Ensembl chr 4:136,374,850...136,563,299 		JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal ISO protein:increased expression:hippocampus RGD PMID:16630050 RGD:5688388 NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22004348 PMID:23813967 RGD:10395389, RGD:10400882 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Epor erythropoietin receptor ISO protein:increased expression:brain, astrocyte RGD PMID:17483696 RGD:10395387 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802 		JBrowse link
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619 		JBrowse link
G Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 ISO protein:increased expression:brain RGD PMID:9714461 RGD:5688738 NCBI chr18:32,373,357...32,403,206
Ensembl chr18:32,373,353...32,403,204 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17192785 PMID:10558867 RGD:1358612 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) susceptibility ISO
IEP		 DNA:SNPs:3' utr: (rs4986938), (rs1255953) (human)
mRNA:increased expression:cerebral cortex
protein:decreased expression:choroid plexus
DNA:snps:introns:IVS3-1880C>T, IVS4+1231C>T (rs1271573, rs1256043) (human)		 RGD PMID:17132983 PMID:15916731 PMID:15082146 PMID:15944651 RGD:5508768, RGD:5508772, RGD:5508784, RGD:8693346 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:8333868 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Fabp3 fatty acid binding protein 3, muscle and heart ISO protein:decreased expression:cerebral cortex (human) RGD PMID:15068254 RGD:1578460 NCBI chr 4:130,202,531...130,209,256
Ensembl chr 4:130,202,388...130,209,256 		JBrowse link
G Fadd Fas associated via death domain ISO RGD PMID:16085017 RGD:13782385 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor ISO protein:increased expression:brain, plaque (human)
DNA:snp:promoter:g.-670G>A (human)		 RGD PMID:12742739 PMID:11129341 RGD:8663481, RGD:1358615 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fgf1 fibroblast growth factor 1 ISO RGD PMID:20079650 RGD:5509878 NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO RGD PMID:9748519 RGD:10402073 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
G Fis1 fission, mitochondrial 1 ISO protein:increased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr 5:136,982,129...136,995,088
Ensembl chr 5:136,982,129...136,995,088 		JBrowse link
G Foxo3 forkhead box O3 ISO
IEP		 protein:increased expression:lymphoblast,nucleus:
protein:increased expression:hippocampal neuron (mouse)
mRNA:increased expression:brain:
protein:altered expression:cortical neuron,nucleus:		 RGD PMID:23153928 PMID:28157684 PMID:23585551 PMID:23661003 RGD:10402185, RGD:11061905, RGD:7327146, RGD:10402187 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Fxyd6 FXYD domain-containing ion transport regulator 6 IEP RGD PMID:19760337 RGD:13801191 NCBI chr 9:45,280,768...45,307,457
Ensembl chr 9:45,281,483...45,307,457 		JBrowse link
G Fyn Fyn proto-oncogene ISO protein:decreased expression:cerebral cortex, soluble fraction (human) RGD PMID:14999081 PMID:15708437 RGD:1358600, RGD:1358602 NCBI chr10:39,245,735...39,441,377
Ensembl chr10:39,244,851...39,441,377 		JBrowse link
G Gabpa GA repeat binding protein, alpha ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:22491860 PMID:24691562 PMID:25741868 More... NCBI chr16:84,631,795...84,660,671
Ensembl chr16:84,631,813...84,660,667 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase onset
susceptibility		 ISO
IDA		 DNA:snps:5' utr, intron: (rs3741916, rs1060621) (human)
DNA:SNP:5' utr:rs3741916 (human)
DNA:SNPs, haplotypes: :rs740850, rs1060620 (human)
protein:increased S-glutathionylation, decreased activity:inferior parietal cortex
protein:decreased activity:cerebral cortex, hippocampus
protein:decreased activity:cerebral cortex, cerebellum		 RGD PMID:15507493 PMID:28087189 PMID:20864222 PMID:18340469 PMID:17387692 More... RGD:1358618, RGD:13792604, RGD:13792611, RGD:13792612, RGD:13792613, RGD:13792614, RGD:13792614 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic onset ISO DNA:snps:promoter, intron: (rs4806173, rs12984928) (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17192785 PMID:15507493 RGD:1358618 NCBI chr 7:30,429,204...30,443,106
Ensembl chr 7:30,429,200...30,443,106 		JBrowse link
G Gcg glucagon ISO RGD PMID:23035082 RGD:10402366 NCBI chr 2:62,304,874...62,313,997
Ensembl chr 2:62,304,874...62,313,994 		JBrowse link
G Gdnf glial cell line derived neurotrophic factor treatment ISO
IEP		 mRNA, protein:alternate form, decreased expression:brain RGD PMID:22081608 PMID:30776009 RGD:5688777, RGD:405850256 NCBI chr15:7,839,529...7,867,061
Ensembl chr15:7,840,327...7,867,056 		JBrowse link
G Ghrh growth hormone releasing hormone treatment IMP RGD PMID:23211425 RGD:10401233 NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426 		JBrowse link
G Glud1 glutamate dehydrogenase 1 ISO protein:increased expression:brain
protein:increased expression, decreased oxidation:brain		 RGD PMID:16341942 PMID:16298240 RGD:6484555, RGD:6484556 NCBI chr14:34,032,684...34,066,990
Ensembl chr14:34,032,684...34,067,222 		JBrowse link
G Glul glutamate-ammonia ligase ISO protein:increased expression:cerebrospinal fluid:significant increase in active protein vs normal patients and controls with other neurological disorders (human)
protein:increased oxidation:brain (human)		 RGD PMID:1361232 PMID:12160938 RGD:2301429, RGD:2301427 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Gnas GNAS complex locus ISO RGD PMID:8012802 RGD:10401266 NCBI chr 2:174,126,113...174,188,537
Ensembl chr 2:174,126,113...174,188,537 		JBrowse link
G Grid2ip glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chr 5:143,343,085...143,377,534
Ensembl chr 5:143,343,093...143,377,907 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) ISO RGD PMID:24156266 RGD:13792688 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ISO RGD PMID:24156266 RGD:13792688 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) no_association ISO DNA:SNP, haplotype: :rs1806201 (human)
DNA:SNP: :2664C>T (rs1806201) (human)
DNA:SNP:promoter:-421C>A (rs3764028) (human)
DNA:SNPs:promoter:-200T>G (rs1019385), -1447T>C, -1497G>A (rs12368476) (human)
DNA:SNPs:promoter, exon, 3' utr:-200T>G (rs1019385), 2664C>T (rs1806201), 5072G>T (rs890) (human)		 RGD PMID:24156266 PMID:24292895 PMID:24292895 PMID:18983893 PMID:18983893 More... RGD:13792688, RGD:13792709, RGD:13792709, RGD:13792713, RGD:13792713, RGD:13792714 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 IAGP DNA: deletion: exons 7,8: heterozygote RGD PMID:18522748 RGD:5688375 NCBI chr19:60,877,995...61,084,406
Ensembl chr19:60,878,187...61,084,406 		JBrowse link
G Grn granulin severity
onset		 ISO
IEP		 DNA:SNP:3'UTR:rs5848(human)
ClinVar Annotator: match by term: Alzheimer disease
DNA:SNPs: :rs5848, rs850713, rs4792939 (human)
DNA:mutations: :
mRNA, protein:increased expression:microglia, neuron:
DNA:deletion:exon:c.154delA(human)		 ClinVar
RGD		 PMID:16199547 PMID:16862116 PMID:16950801 PMID:22608501 PMID:28492532 More... RGD:5509600, RGD:10401636, RGD:5509616, RGD:5509606, RGD:5509601 NCBI chr11:102,321,333...102,327,635
Ensembl chr11:102,321,141...102,327,874 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha treatment IDA
IMP		 RGD PMID:18410522 PMID:22623685 RGD:10401797, RGD:10401801 NCBI chr 7:24,927,683...24,937,276
Ensembl chr 7:24,927,683...24,937,276 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta treatment IMP
ISO
IEP		 DNA:SNP:promoter:rs334558 (human)
CTD Direct Evidence: marker/mechanism
protein:decreased phosphorylation:hippocampus:
DNA:altered methylation:CpG island:		 CTD
RGD		 PMID:17409235 PMID:22944069 PMID:11226152 PMID:29257340 PMID:27893738 More... RGD:1302533, RGD:13792777, RGD:13792736, RGD:13782364, RGD:10401801, RGD:10045670, RGD:10045669, RGD:10045668 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446 		JBrowse link
G Gsr glutathione reductase treatment ISO
IEP		 protein:decreased expression:blood
mRNA:increased expression:hippocampus		 RGD PMID:17721818 PMID:21376020 PMID:19374888 PMID:10096042 RGD:10401827, RGD:10401857, RGD:10401849, RGD:10401847 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gss glutathione synthetase ISO RGD PMID:15693022 RGD:5508441 NCBI chr 2:155,405,101...155,434,730
Ensembl chr 2:155,405,101...155,434,730 		JBrowse link
G Gstm3 glutathione S-transferase, mu 3 ISO RGD PMID:15621212 RGD:5688745 NCBI chr 3:107,871,019...107,876,484
Ensembl chr 3:107,871,012...107,876,599 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 ISO DNA:SNP:cds: rs7483 (human) RGD PMID:18423940 RGD:5688729 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gsto1 glutathione S-transferase omega 1 onset
susceptibility
no_association		 ISO DNA:polymorphism:exon:p. A140D (rs4925) (human) RGD PMID:14570706 PMID:20818931 PMID:15917099 RGD:1358651, RGD:5490521, RGD:5490514 NCBI chr19:47,843,412...47,853,229
Ensembl chr19:47,843,409...47,853,229 		JBrowse link
G Gsto2 glutathione S-transferase omega 2 onset
no_association		 ISO DDNA:polymorphism: : -183 A>G (rs2297235)(human)
DNA:polymorphism:promoter: -183 A>G (rs2297235)(human)		 RGD PMID:14570706 PMID:15917099 RGD:1358651, RGD:5490514 NCBI chr19:47,853,879...47,874,747
Ensembl chr19:47,853,973...47,874,763 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 susceptibility
onset		 ISO
IEP		 mRNA:decreased expression:cerebral cortex
DNA:polymorphisms
DNA:polymorphism:exon:		 RGD PMID:15805147 PMID:23211594 PMID:24584466 PMID:17911365 RGD:5490123, RGD:10401913, RGD:10401912, RGD:5490271 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G Gstt1 glutathione S-transferase, theta 1 susceptibility
onset		 ISO DNA:deletion: : RGD PMID:10215103 PMID:17911365 RGD:5490213, RGD:5490271 NCBI chr10:75,619,647...75,634,418
Ensembl chr10:75,619,647...75,634,418 		JBrowse link
G Gucy1b1 guanylate cyclase 1, soluble, beta 1 ISO RGD PMID:15571982 RGD:10401946 NCBI chr 3:81,939,311...81,982,018
Ensembl chr 3:81,939,313...81,981,996 		JBrowse link
G H2-Eb1 histocompatibility 2, class II antigen E beta ISO RGD PMID:21473952 RGD:5147563 NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha ISO protein:decreased expression:brain RGD PMID:25260493 RGD:10047114 NCBI chr 5:30,324,421...30,359,978
Ensembl chr 5:30,323,302...30,360,160 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta ISO RGD PMID:11430884 RGD:1600786 NCBI chr 5:30,360,251...30,389,591
Ensembl chr 5:30,360,246...30,389,591 		JBrowse link
G Hba-a1 hemoglobin alpha, adult chain 1 ISO RGD PMID:21428213 RGD:10450508 NCBI chr11:32,233,672...32,234,486
Ensembl chr11:32,233,511...32,234,465 		JBrowse link
G Hdac2 histone deacetylase 2 IEP protein:increased expression:hippocampus: RGD PMID:22388814 RGD:9590324 NCBI chr10:36,850,293...36,877,885
Ensembl chr10:36,850,540...36,877,885 		JBrowse link
G Hfe homeostatic iron regulator ISO with Tf C2 variant;DNA:missense mutation:cds:p.C282Y (human)
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer's disease
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:8696333 PMID:8896550 PMID:9162021 PMID:9356458 PMID:9462220 More... RGD:1358657 NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO
IEP		 mRNA, protein:increased expression:cerebral cortex, microvessel (human)
protein:increased expression:brain, microvessel (mouse)		 RGD PMID:16627934 PMID:21904637 RGD:9068875, RGD:9068888 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgb1 high mobility group box 1 IEP RGD PMID:23905994 RGD:10402058 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase ISO RGD PMID:17724290 RGD:5508460 NCBI chr13:96,785,470...96,807,444
Ensembl chr13:96,785,475...96,807,444 		JBrowse link
G Hmox1 heme oxygenase 1 ISO protein:increased expression:hippocampus, temporal cortex (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11144356 PMID:7778849 RGD:1358658 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chr15:103,148,840...103,155,119
Ensembl chr15:103,148,859...103,155,119 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 ISO protein:decreased expression:entorhinal cortex (human) RGD PMID:22628224 RGD:9999191 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874 		JBrowse link
G Hras Harvey rat sarcoma virus oncogene ISO protein:increased expression:brain, neuron (human) RGD PMID:10661494 RGD:10412306 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 treatment ISO
IEP
IMP		 protein:increased expression:brain (human)
protein:increased expression:hippocampus, neuron, mitochondria		 RGD PMID:9338779 PMID:11869808 PMID:21307267 RGD:1358426, RGD:632866, RGD:13792781 NCBI chr  X:150,784,892...150,787,438
Ensembl chr  X:150,784,841...150,787,438 		JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chr13:64,206,088...64,237,076
Ensembl chr13:64,206,080...64,237,044 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ISO mRNA:altered expression:cerebellum, hippocampus (human) RGD PMID:18180323 RGD:4889108 NCBI chr 3:98,618,423...98,631,859
Ensembl chr 3:98,616,571...98,631,859 		JBrowse link
G Hsf1 heat shock factor 1 IEP
ISO		 protein:altered localization:promoter (mouse)
protein:decreased expression:cerebellum (rat)		 RGD PMID:24849358 PMID:23665061 RGD:10402385, RGD:10402771 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 ISO protein:decreased expression:serum (human) RGD PMID:23948885 RGD:10413860 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Hspa13 heat shock protein 70 family, member 13 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:75,552,078...75,564,575
Ensembl chr16:75,542,319...75,563,992 		JBrowse link
G Hspa1a heat shock protein 1A ISO DNA:polymorphism: :-110A>C(human) RGD PMID:15832029 RGD:10402403 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B disease_progression ISO DNA:polymorphism: : RGD PMID:12967056 RGD:10402401 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Hspa9 heat shock protein 9 IEP
ISO		 RGD PMID:17050040 PMID:17050040 RGD:10402560, RGD:10402560 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Hspb1 heat shock protein 1 ISO mRNA,protein:increased expression:brainstem, astrocyte: RGD PMID:25772164 RGD:10402580 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) ISO
IEP		 protein:increased modification:brain
protein:increased expression:mitochondrion:
protein:increased expression:cytosol, mitochondrion:		 RGD PMID:15802185 PMID:22753410 PMID:22753410 RGD:1624243, RGD:10402831, RGD:10402831 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402 		JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A ISO RGD PMID:20508993 RGD:5683632 NCBI chr13:105,580,040...105,584,630
Ensembl chr13:105,580,147...105,584,630 		JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A treatment ISO RGD PMID:26889223 RGD:401901085 NCBI chr14:74,878,314...74,944,299
Ensembl chr14:74,878,280...74,946,934 		JBrowse link
G Htr6 5-hydroxytryptamine (serotonin) receptor 6 susceptibility ISO DNA:silent mutation:cds: 267C>T (human) RGD PMID:10624811 RGD:1358662 NCBI chr 4:138,787,017...138,802,881
Ensembl chr 4:138,788,419...138,802,881 		JBrowse link
G Htra2 HtrA serine peptidase 2 ISO protein:increased activity:frontal cortex (human) RGD PMID:21163861 RGD:5688722 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO DNA:missense mutation:cds:p.K469E (human) RGD PMID:12498973 RGD:1358664 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ide insulin degrading enzyme treatment IMP
ISO
IDA		 protein:decreased expression:cerebrospinal fluid
associated with Insulin Resistance
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:17192785 PMID:12634421 PMID:28157092 PMID:28164769 PMID:29948724 More... RGD:737718, RGD:13792829, RGD:13792824, RGD:13792800, RGD:13792798, RGD:13792793, RGD:13792792, RGD:13792790 NCBI chr19:37,246,140...37,341,664
Ensembl chr19:37,246,142...37,340,010 		JBrowse link
G Igf1 insulin-like growth factor 1 onset
susceptibility
treatment		 IEP
ISO		 protein:decreased expression:hippocampus:
protein:altered expression:plasma,cerebral spinal fluid:
DNA:polymorphism:intron: rs972936(human)
protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15750215 PMID:23740209 PMID:24301648 PMID:24301648 PMID:23089282 More... RGD:10045852, RGD:10045853, RGD:10045853, RGD:10045854, RGD:10045860, RGD:10402576 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igf1r insulin-like growth factor I receptor severity
treatment		 IAGP
IMP
ISO
IEP		 DNA: haploinsufficiency:: full knockout dies at birth
protein:increased expression:temporal cortex:
protein:increased expression: cerebral cortex:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15750215 PMID:20409077 PMID:19487308 PMID:16274856 PMID:16274856 More... RGD:5686420, RGD:10045878, RGD:10045879, RGD:10045879, RGD:10045894, RGD:10045894, RGD:12904921 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Igf2 insulin-like growth factor 2 treatment ISO
IEP
IDA		 mRNA:decreased expression:brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15750215 PMID:16627931 PMID:24887203 PMID:21040071 PMID:24685003 RGD:5509963, RGD:10045934, RGD:10402558, RGD:10402559 NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15750215 NCBI chr17:12,901,293...12,988,593
Ensembl chr17:12,901,293...12,988,551 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO protein:decreased expression:temporal cortex: RGD PMID:18479783 RGD:10045894 NCBI chr 1:72,863,650...72,891,633
Ensembl chr 1:72,863,662...72,891,633 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 treatment ISO
IEP		 protein:increased expression:serum
mRNA:decreased expression:hippocampus		 RGD PMID:23473966 PMID:24964199 PMID:10399774 RGD:10402570, RGD:10402572, RGD:10402576 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta treatment ISO protein:increased expression:hippocampus: RGD PMID:24380241 RGD:10045941 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 susceptibility
treatment		 ISO
IMP		 DNA:SNPs,haplotype: -1082G>A, -819T>C, -592C>A (human) RGD PMID:14746878 PMID:21803105 RGD:1358665, RGD:7364841 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1a interleukin 1 alpha susceptibility
no_association
disease_progression		 ISO DNA:SNP:5'UTR:rs1800587(human)
protein:increased expression:microglial cell, cortical layer:		 RGD PMID:10716257 PMID:19158434 PMID:11402127 PMID:9775393 RGD:1358667, RGD:10045945, RGD:10045947, RGD:10046059 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta onset
no_association
treatment		 ISO
IEP		 protein:increased expression:plasma
DNA:SNP: :rs1143634 (human)
DNA:SNP:promoter:-31T>C (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:18675847 PMID:16600299 PMID:20413850 PMID:18830724 PMID:18830724 More... RGD:1626633, RGD:13793381, RGD:13792820, RGD:13792820, RGD:13792819, RGD:11522340, RGD:13792818, RGD:13792817, RGD:13792816, RGD:7204700 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il2 interleukin 2 severity ISO protein:increased secretion:mononuclear cell: RGD PMID:8915041 PMID:8586980 RGD:10047080, RGD:10047081 NCBI chr 3:37,174,862...37,180,103
Ensembl chr 3:37,174,672...37,180,108 		JBrowse link
G Il3 interleukin 3 ISO protein:decreased expression:plasma RGD PMID:17934472 PMID:18769539 RGD:5686815, RGD:5686817 NCBI chr11:54,155,911...54,158,105
Ensembl chr11:54,156,129...54,158,103 		JBrowse link
G Il33 interleukin 33 IAGP OMIM:608907 MouseDO NCBI chr19:29,902,513...29,938,118
Ensembl chr19:29,902,514...29,938,118 		JBrowse link
G Il4 interleukin 4 ISO DNA:polymorphisms:promoter RGD PMID:20213229 RGD:10402788 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 treatment ISO RGD PMID:27088818 RGD:11062148 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il6ra interleukin 6 receptor, alpha no_association ISO protein:increased expression:cerebrospinal fluid, plasma
DNA:SNPs:promoter:-208G>A (rs4845617) (human)
DNA:SNPs:promoter, exon:-530G>T, 48867A/>C (p.D358A, rs8192284) (human)		 RGD PMID:12664314 PMID:20197062 PMID:20197062 RGD:10402808, RGD:10402810, RGD:10402810 NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503 		JBrowse link
G Il6st interleukin 6 signal transducer ISO protein:decreased expression:cerebrospinal fluid RGD PMID:10095017 RGD:10402847 NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620 		JBrowse link
G Il7 interleukin 7 ISO RGD PMID:22571981 RGD:10402933 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO CTD Direct Evidence: marker/mechanism CTD PMID:30320580 NCBI chr 1:87,548,034...87,648,232
Ensembl chr 1:87,548,034...87,648,229 		JBrowse link
G Ins1 insulin I ISO mRNA:decreased expression:hippocampus RGD PMID:17448147 RGD:2298713 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Ins2 insulin II ISO mRNA:decreased expression:cerebral cortex
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:9443474 PMID:15750215 PMID:17448147 RGD:2298713 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118 		JBrowse link
G Insr insulin receptor treatment IDA
ISO		 CTD Direct Evidence: marker/mechanism
mRNA:decreased expression:brain
protein:altered localization:brain, neuron		 CTD
RGD		 PMID:24055495 PMID:23011726 PMID:16627931 PMID:18479783 RGD:10403036, RGD:5509963, RGD:10045894 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617 		JBrowse link
G Iqck IQ motif containing K ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chr 7:118,454,975...118,571,343
Ensembl chr 7:118,454,975...118,571,875 		JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO DNA:SNPs: :rs2656070, rs13180(human) RGD PMID:16914832 RGD:6893299 NCBI chr 9:54,769,942...54,819,812
Ensembl chr 9:54,771,073...54,819,814 		JBrowse link
G Irs1 insulin receptor substrate 1 treatment
severity		 ISO
IEP
IDA		 protein:increased expression, increased serine phosphorylation, increased tyrosine phosphorylation:hippocampus CA1
protein:decreased expression:hippocampus:
DNA:SNP:cds:rs1801278(human)
protein:altered expression:temporal cortex:
protein:increased serine phosphorylation:hippocampus		 RGD PMID:22476197 PMID:23011726 PMID:22527777 PMID:23660953 PMID:24589556 More... RGD:6482860, RGD:10403036, RGD:10045939, RGD:10045935, RGD:10045932, RGD:10045894, RGD:6482861 NCBI chr 1:82,210,826...82,269,160
Ensembl chr 1:82,210,822...82,269,137 		JBrowse link
G Irs2 insulin receptor substrate 2 severity IMP
IEP
ISO		 mRNA:decreased expression:hippocampus:
protein:decreased expression:temporal cortex:		 RGD PMID:19487308 PMID:24887203 PMID:18479783 RGD:10045878, RGD:10045934, RGD:10045894 NCBI chr 8:11,034,681...11,058,929
Ensembl chr 8:11,034,681...11,058,458 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 ISO protein:decreased expression:temporal cortex, frontal cortex (human) RGD PMID:8819138 RGD:6482821 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Jak2 Janus kinase 2 treatment IMP RGD PMID:18813209 RGD:10403051 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Jam2 junction adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:84,571,011...84,623,268
Ensembl chr16:84,571,011...84,622,816 		JBrowse link
G Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 IEP mRNA, protein:decreased expression:neocortex (mouse) RGD PMID:21912965 RGD:9686062 NCBI chr 7:46,045,643...46,088,130
Ensembl chr 7:46,045,921...46,088,128 		JBrowse link
G Kcnc4 potassium voltage gated channel, Shaw-related subfamily, member 4 IEP
ISO		 mRNA:decreased expression:neocortex (mouse)
mRNA, protein:increased expression: frontal cortex 		RGD PMID:21912965 PMID:15485486 RGD:9686062, RGD:10411900 NCBI chr 3:107,345,614...107,367,617
Ensembl chr 3:107,345,619...107,366,868 		JBrowse link
G Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 onset ISO DNA:SNP: :rs16934131 (human) RGD PMID:21480501 RGD:10412025 NCBI chr14:23,342,356...24,055,173
Ensembl chr14:23,339,499...24,064,559 		JBrowse link
G Kl klotho treatment IEP mRNA,protein:decreased expression:cerebral choroid,serum: RGD PMID:23973442 RGD:10403049 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282 		JBrowse link
G Klc1 kinesin light chain 1 susceptibility ISO DNA:SNPs: :rs8007903, rs3212079 (human)
DNA:SNP:intron:56836G>C (human)		 RGD PMID:19911314 PMID:15364413 RGD:5683908, RGD:5684007 NCBI chr12:111,724,869...111,774,278
Ensembl chr12:111,725,283...111,774,278 		JBrowse link
G Klk6 kallikrein related-peptidase 6 ISO RGD PMID:12480753 PMID:12074831 RGD:1358604, RGD:1358599 NCBI chr 7:43,473,967...43,481,219
Ensembl chr 7:43,473,923...43,481,454 		JBrowse link
G Klrg1 killer cell lectin-like receptor subfamily G, member 1 ISO ClinVar Annotator: match by term: ALPHA-2-MACROGLOBULIN POLYMORPHISM ClinVar PMID:1370808 PMID:1717945 PMID:9697696 PMID:9811940 PMID:15023809 More... NCBI chr 6:122,247,555...122,259,792
Ensembl chr 6:122,247,555...122,259,841 		JBrowse link
G L1cam L1 cell adhesion molecule ISO protein:increased expression:cerebrospinal fluid (human) RGD PMID:16298234 RGD:6483456 NCBI chr  X:72,897,384...72,924,843
Ensembl chr  X:72,897,384...72,939,711 		JBrowse link
G Ldlr low density lipoprotein receptor no_association IMP
ISO		 DNA:SNPs:exon:rs5925, rs5927, rs5930 (human)
DNA:SNPs:exon (human)
DNA:SNPs:exon:rs5925, rs5930, rs11669576 (human)
DNA:SNPs: :rs5925, rs2738444, rs11669576 (human)		 RGD PMID:21755005 PMID:15585340 PMID:16378661 PMID:15689450 PMID:16741934 More... RGD:5490231, RGD:5490244, RGD:5490243, RGD:5490242, RGD:5490241, RGD:5490239 NCBI chr 9:21,634,872...21,661,215
Ensembl chr 9:21,634,779...21,661,215 		JBrowse link
G Lep leptin treatment ISO associated with Obesity
CTD Direct Evidence: therapeutic
compared to cortisol;protein:altered expression:plasma (human)		 CTD
RGD		 PMID:20157255 PMID:25296496 PMID:9755363 RGD:10053617, RGD:10053632 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lipc lipase, hepatic no_association ISO DNA:SNPs: :rs6074, rs6083, rs6084 (human)
DNA:SNPs: :rs6084 (human)		 RGD PMID:17175070 PMID:17175070 RGD:1600644, RGD:1600644 NCBI chr 9:70,705,410...70,859,503
Ensembl chr 9:70,705,410...70,859,508 		JBrowse link
G Lipi lipase, member I ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:75,337,431...75,382,960
Ensembl chr16:75,337,402...75,382,949 		JBrowse link
G LOC106677018 Mpo proximal enhancer and promoter region ISO ClinVar Annotator: match by term: Alzheimer disease, susceptibility to ClinVar PMID:11087769 PMID:12915675 PMID:15023809 PMID:17304047 NCBI chr11:87,683,311...87,685,373 JBrowse link
G Lpl lipoprotein lipase no_association
severity		 ISO DNA:point mutations: :p.N291S, p.S447X (human)
DNA:polymorphism:intron
DNA:SNPs: :rs268, rs328 (human)
DNA:SNPs: :multiple
DNA, mRNA:SNP, decreased expression: :rs285 (human)		 RGD PMID:24004859 PMID:10206232 PMID:12133567 PMID:15331147 PMID:16013913 More... RGD:13793392, RGD:13799353, RGD:13793397, RGD:13793396, RGD:5685661, RGD:13793395, RGD:13793393 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Lrp1 low density lipoprotein receptor-related protein 1 treatment ISO
IEP
IAGP		 DNA:SNP:exon 3:C>T (human)
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907		 MouseDO
RGD		 PMID:9635959 PMID:19150622 PMID:29115637 RGD:1358747, RGD:13800553, RGD:13799352 NCBI chr10:127,374,026...127,457,158
Ensembl chr10:127,374,030...127,457,017 		JBrowse link
G Lrp1b low density lipoprotein-related protein 1B onset IEP mRNA:increased expression:hippocampus (mouse) RGD PMID:23150673 RGD:151665140 NCBI chr 2:40,485,302...42,543,747
Ensembl chr 2:40,485,258...42,543,636 		JBrowse link
G Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor no_association ISO DNA:polymorphism:exon:2622T>C (human)
DNA:polymorphisms: :multiple		 RGD PMID:12399018 PMID:20208369 RGD:6483064, RGD:6483065 NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037 		JBrowse link
G Lrpap1 low density lipoprotein receptor-related protein associated protein 1 onset ISO RGD PMID:11425005 RGD:1358749 NCBI chr 5:35,248,834...35,263,043
Ensembl chr 5:35,248,845...35,263,110 		JBrowse link
G Maoa monoamine oxidase A ISO RGD PMID:1627256 RGD:10046060 NCBI chr  X:16,485,937...16,554,051
Ensembl chr  X:16,485,937...16,554,057 		JBrowse link
G Maob monoamine oxidase B ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:7816197 PMID:21075085 PMID:1627256 RGD:10046060 NCBI chr  X:16,575,520...16,683,605
Ensembl chr  X:16,575,521...16,683,605 		JBrowse link
G Map2 microtubule-associated protein 2 ISO RGD PMID:22083255 RGD:6483322 NCBI chr 1:66,214,337...66,481,742
Ensembl chr 1:66,214,432...66,481,742 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 treatment
onset		 IDA
ISO		 mRNA:increased expression: CA2 field of hippocampus, pyramidal neuron RGD PMID:28079060 PMID:24334724 RGD:13800563, RGD:13800868 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk10 mitogen-activated protein kinase 10 ISO protein:increased expression:CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr 5:103,056,413...103,359,200
Ensembl chr 5:103,055,814...103,359,200 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 treatment ISO
IMP		 mRNA:increased expression:frontal lobe cortex, hippocampus CA2 (rat) RGD PMID:20529587 PMID:17784957 RGD:10047076, RGD:10047104 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 treatment IDA RGD PMID:28079060 RGD:13800563 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 disease_progression ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO protein:increased expression:brain,CA1 field of hippocampus: RGD PMID:11208906 RGD:10412676 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mapt microtubule-associated protein tau treatment
onset
no_association		 ISO protein:increased expression:CSF (human)
ClinVar Annotator: match by term: Alzheimer disease
CTD Direct Evidence: marker/mechanism
protein:hyperphosphorylation:brain:
DNA:mutation:cds:p.R406W(human)
DNA:SNP, haplotypes:promoter:rs242557 (human)
DNA:SNPs, haplotypes:promoter:rs242557 (human)		 ClinVar
CTD
RGD		 PMID:12852432 PMID:14517953 PMID:15750215 PMID:20157255 PMID:21715663 More... RGD:1302530, RGD:127284889, RGD:13800908, RGD:13800904, RGD:13782165, RGD:10412709, RGD:10412704, RGD:10412701, RGD:8158105, RGD:8158097 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 susceptibility ISO protein:decreased expression:cerebrospinal fluid (human)
DNA:haplotype:promoter:		 RGD PMID:9631454 PMID:23348713 RGD:4889155, RGD:12910848 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Mcm2 minichromosome maintenance complex component 2 ISO
IEP		 RGD PMID:19946466 PMID:17070803 RGD:10412048, RGD:10412050 NCBI chr 6:88,860,456...88,875,762
Ensembl chr 6:88,860,456...88,875,762 		JBrowse link
G Mdm4 transformed mouse 3T3 cell double minute 4 disease_progression ISO RGD PMID:23861893 RGD:10047419 NCBI chr 1:132,913,843...132,958,325
Ensembl chr 1:132,887,222...132,958,299 		JBrowse link
G Mfn1 mitofusin 1 ISO protein:decreased expression:hippocampus (human) RGD PMID:19605646 RGD:7800727 NCBI chr 3:32,583,594...32,633,384
Ensembl chr 3:32,583,614...32,633,388 		JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:hippocampus (human)
protein:increased expression:hippocampus (rat)		 RGD PMID:19605646 PMID:28302704 RGD:7800727, RGD:12910737 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir100 microRNA 100 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 9:41,442,721...41,442,800
Ensembl chr 9:41,442,721...41,442,800 		JBrowse link
G Mir124a-3 microRNA 124a-3 EXP CTD Direct Evidence: therapeutic CTD PMID:28867212 NCBI chr 2:180,535,833...180,535,900
Ensembl chr 2:180,535,833...180,535,900 		JBrowse link
G Mir125b-2 microRNA 125b-2 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:77,443,161...77,443,231
Ensembl chr16:77,443,161...77,443,231 		JBrowse link
G Mir132 microRNA 132 ISO RNA:decreased expression:brain RGD PMID:23585551 RGD:7327146 NCBI chr11:75,064,508...75,064,573
Ensembl chr11:75,064,508...75,064,573 		JBrowse link
G Mir146 microRNA 146 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22099153 PMID:25992776 NCBI chr11:43,265,224...43,265,288
Ensembl chr11:43,265,224...43,265,288 		JBrowse link
G Mir155 microRNA 155 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir212 microRNA 212 ISO RNA:decreased expression:brain RGD PMID:23585551 RGD:7327146 NCBI chr11:75,064,214...75,064,304
Ensembl chr11:75,064,214...75,064,304 		JBrowse link
G Mir296 microRNA 296 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 2:174,108,840...174,108,918
Ensembl chr 2:174,108,840...174,108,918 		JBrowse link
G Mir375 microRNA 375 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 1:74,939,817...74,939,880
Ensembl chr 1:74,939,817...74,939,880 		JBrowse link
G Mir505 microRNA 505 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr  X:59,439,649...59,439,738
Ensembl chr  X:59,439,649...59,439,738 		JBrowse link
G Mir708 microRNA 708 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25992776 NCBI chr 7:95,898,631...95,898,739
Ensembl chr 7:95,898,631...95,898,739 		JBrowse link
G Mir99a microRNA 99a ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:77,395,824...77,395,888
Ensembl chr16:77,395,824...77,395,888 		JBrowse link
G Mirlet7c-1 microRNA let7c-1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:77,396,545...77,396,638
Ensembl chr16:77,396,545...77,396,638 		JBrowse link
G Mme membrane metallo endopeptidase treatment
no_association
severity
onset		 IAGP
IEP
ISO
IMP		 OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907
associated with Endotoxemia
DNA:SNPs, repeat:multiple:multiple
DNA:SNPs:introns:rs1836915, rs6776185, rs6801319 (human)
DNA:SNPs, haplotypes:promoter, introns:-204G>C, IVS17-294C>T, IVS22+36C>A (human)
DNA:SNPs, repeats, deletion:promoter:multiple
DNA:repeats
DNA:SNPs:5' utr, 3' utr:rs3736187, rs989692, rs701109 (human)
DNA:SNPs: :multiple
DNA:SNP: :rs6797911 (human)
DNA:SNP:3' utr:rs6665 (human)		 MouseDO
RGD		 PMID:25416980 PMID:25884928 PMID:20141738 PMID:17928142 PMID:17928142 More... RGD:13801033, RGD:13801034, RGD:13801024, RGD:13801023, RGD:13801023, RGD:13801022, RGD:13801021, RGD:13801020, RGD:1600813, RGD:13801019, RGD:13801012, RGD:13801011, RGD:13801011, RGD:13801010, RGD:13801009 NCBI chr 3:63,202,632...63,291,134
Ensembl chr 3:63,148,958...63,293,451 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO protein:decreased expression:platelet RGD PMID:21875409 RGD:10059680 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression:plasma (human) RGD PMID:17697439 RGD:7207052 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, susceptibility to		 CTD
ClinVar		 PMID:11087769 PMID:12915675 PMID:15023809 PMID:17304047 PMID:25741868 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mre11a MRE11A homolog A, double strand break repair nuclease ISO protein:decreased expression:cerebral cortex (human) RGD PMID:15337312 RGD:2317734 NCBI chr 9:14,695,971...14,748,421
Ensembl chr 9:14,695,950...14,748,419 		JBrowse link
G Mrpl39 mitochondrial ribosomal protein L39 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 PMID:25741868 NCBI chr16:84,515,068...84,532,261
Ensembl chr16:84,514,464...84,532,630 		JBrowse link
G Ms4a4a membrane-spanning 4-domains, subfamily A, member 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21460841 NCBI chr19:11,352,827...11,370,682
Ensembl chr19:11,352,887...11,370,154 		JBrowse link
G mt-Nd1 NADH dehydrogenase 1, mitochondrial ISO mRNA:decreased expression:frontal cortex, Brodmann area 9 (human)
ClinVar Annotator: match by term: Alzheimer disease		 ClinVar
RGD		 PMID:8104867 PMID:15972314 PMID:15075441 RGD:5490287 NCBI chr MT:2,751...3,707
Ensembl chr MT:2,751...3,707 		JBrowse link
G mt-Nd2 NADH dehydrogenase 2, mitochondrial no_association ISO DNA:mutation::m.5460G>A (human) RGD PMID:1352971 PMID:1370613 RGD:5507833, RGD:5507834 NCBI chr MT:3,914...4,951
Ensembl chr MT:3,914...4,951 		JBrowse link
G mt-Nd4 NADH dehydrogenase 4, mitochondrial ISO mRNA:decreased expression:brain RGD PMID:10447460 RGD:5508713 NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544 		JBrowse link
G Mt1 metallothionein 1 IMP RGD PMID:22766972 RGD:10412319 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 IMP
ISO		 mRNA:decreased expression:cerebral cortex (rat) RGD PMID:22766972 PMID:16914836 RGD:10412319, RGD:10412320 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mt3 metallothionein 3 ISO
IEP		 mRNA:decreased expression:brain
mRNA:increased expression:brain		 RGD PMID:1464312 PMID:10595827 PMID:16444595 PMID:19619132 RGD:6480485, RGD:9685805, RGD:6480619, RGD:6480534 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17192785 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 ISO RGD PMID:14557245 RGD:2302388 NCBI chr 8:105,237,660...105,261,269
Ensembl chr 8:105,237,660...105,261,269 		JBrowse link
G Napb N-ethylmaleimide sensitive fusion protein attachment protein beta ISO protein:decreased expression:temporal cortex RGD PMID:11244216 RGD:10412652 NCBI chr 2:148,535,905...148,574,396
Ensembl chr 2:148,535,905...148,574,387 		JBrowse link
G Nbn nibrin ISO RGD PMID:15337312 RGD:2317734 NCBI chr 4:15,955,388...15,992,589
Ensembl chr 4:15,957,925...15,992,589 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO RGD PMID:31028587 RGD:40925918 NCBI chr 9:49,413,434...49,710,909
Ensembl chr 9:49,413,436...49,710,225 		JBrowse link
G Ncam2 neural cell adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:80,997,501...81,425,549
Ensembl chr16:80,997,585...81,423,716 		JBrowse link
G Ncf2 neutrophil cytosolic factor 2 ISO protein:altered localization RGD PMID:10873554 RGD:2314452 NCBI chr 1:152,675,904...152,712,743
Ensembl chr 1:152,675,945...152,712,742 		JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr 1:43,484,643...43,609,678
Ensembl chr 1:43,483,739...43,609,675 		JBrowse link
G Ncstn nicastrin no_association
onset		 ISO CTD Direct Evidence: marker/mechanism
DNA:missense mutation, SNPs:exon, intron, 3' utr:multiple
DNA:missense mutation: :417N>Y (human)
DNA:SNPs, haplotype:introns:multiple
protein:increased modification:brain
DNA:SNP:promoter:-436C>T (human)
DNA:SNPs:promoter:-796T>G, -1216C>A (human)
DNA:SNP:promoter:-922G>T (rs10752637) (human)		 CTD
RGD		 PMID:17192785 PMID:14642438 PMID:23595812 PMID:11992262 PMID:11992262 More... RGD:13801188, RGD:13801187, RGD:13801052, RGD:13801052, RGD:13801051, RGD:13801050, RGD:13801050, RGD:13801049, RGD:13801048 NCBI chr 1:171,893,580...171,910,356
Ensembl chr 1:171,893,580...171,910,362 		JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 ISO RGD PMID:28474567 RGD:13792588 NCBI chr18:36,875,385...36,877,640
Ensembl chr18:36,875,385...36,877,610 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 IEP RGD PMID:19760337 RGD:13801191 NCBI chr 6:24,518,661...24,527,689
Ensembl chr 6:24,518,665...24,528,012 		JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 ISO mRNA:increased expression:blood RGD PMID:26943237 RGD:11572212 NCBI chr15:82,234,342...82,238,438
Ensembl chr15:82,234,341...82,238,523 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 ISO RGD PMID:28474567 RGD:13792588 NCBI chr 1:58,625,556...58,635,123
Ensembl chr 1:58,625,543...58,635,123 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 ISO RGD PMID:14570706 RGD:1358651 NCBI chr19:44,537,010...44,543,881
Ensembl chr19:44,537,011...44,543,879 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 onset ISO RGD PMID:28242297 RGD:13824970 NCBI chr 2:90,724,971...90,735,065
Ensembl chr 2:90,724,978...90,735,171 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO DNA:SNP: :rs6859 (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:29107063 PMID:30319691 PMID:30320580 PMID:22159054 RGD:6484658 NCBI chr 7:19,450,569...19,483,498
Ensembl chr 7:19,450,569...19,484,408 		JBrowse link
G Nefl neurofilament, light polypeptide ISO protein:increased expression:CSF (human) RGD PMID:29368621 PMID:29391125 RGD:127284889, RGD:127285384 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nefm neurofilament, medium polypeptide ISO protein:decreased glycosylation:cerebral cortex RGD PMID:17687114 RGD:9743945 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 onset
treatment		 ISO
IEP		 DNA:snps, haplotype:5' utr, intron:multiple (human)
protein:increased expression:brain, nucleus		 RGD PMID:20064547 PMID:19805328 PMID:22913737 PMID:23771816 RGD:6893326, RGD:10412689, RGD:10412685, RGD:10412683 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Ngb neuroglobin treatment ISO RGD PMID:23428737 RGD:9743955 NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313 		JBrowse link
G Ngf nerve growth factor ISO RGD PMID:21368378 RGD:5144128 NCBI chr 3:102,377,235...102,428,329
Ensembl chr 3:102,377,235...102,428,329 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) treatment
no_association		 IEP
ISO
IDA		 protein:altered localization:brain
protein:altered expression:urine
protein:decreased expression:basal nucleus of telencephalon, neuron
DNA:SNPs, haplotypes: :multiple
DNA:SNP:CDS:rs2072446 (human)		 RGD PMID:19334058 PMID:2557638 PMID:23545424 PMID:19070649 PMID:8215963 More... RGD:5508225, RGD:10414073, RGD:10413895, RGD:10413894, RGD:10413893, RGD:10413892, RGD:10413891, RGD:5508228 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nog noggin IEP RGD PMID:19463786 RGD:10414082 NCBI chr11:89,191,464...89,193,385
Ensembl chr11:89,191,464...89,193,158 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal susceptibility
no_association		 ISO DNA:repeat:promoter
DNA:repeat:exon
DNA:SNP:exon:-84G>A (human)		 RGD PMID:21098972 PMID:12384247 PMID:10964481 PMID:17418914 PMID:17418914 RGD:13824974, RGD:13824978, RGD:13824976, RGD:13824975, RGD:13824975 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO
IMP		 RGD PMID:21163295 PMID:12384247 PMID:16908860 RGD:4891161, RGD:13824978, RGD:5508721 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell onset ISO human gene in rat model
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to
CTD Direct Evidence: marker/mechanism
DNA:snp:cds:p.E298D (human)		 ClinVar
CTD
RGD		 PMID:9737779 PMID:9894802 PMID:10475066 PMID:10510054 PMID:10514107 More... RGD:2292144, RGD:13824978, RGD:1358752 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Npy neuropeptide Y treatment ISO CTD Direct Evidence: marker/mechanism
protein:decreased expression:plasma		 CTD
RGD		 PMID:11709213 PMID:22266216 PMID:8592643 RGD:10431479, RGD:10432246 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nrg1 neuregulin 1 disease_progression IEP
ISO		 protein:decreased expression:hippocampus RGD PMID:12528817 PMID:29914798 PMID:27558862 PMID:29295823 RGD:10449002, RGD:13703135, RGD:405650194, RGD:41404730 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nrgn neurogranin ISO RGD PMID:9329454 RGD:9835394 NCBI chr 9:37,455,789...37,464,041
Ensembl chr 9:37,455,788...37,464,200 		JBrowse link
G Nrip1 nuclear receptor interacting protein 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715 		JBrowse link
G Nrp1 neuropilin 1 severity IEP
ISO		 mRNA,protein:increased expression:brain RGD PMID:34745215 PMID:34745215 RGD:401901163, RGD:401901163 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844 		JBrowse link
G Ntf3 neurotrophin 3 ISO DNA:missense mutation:cds:p.G63E (human) RGD PMID:9502217 RGD:1358754 NCBI chr 6:126,078,375...126,143,703
Ensembl chr 6:126,078,375...126,143,873 		JBrowse link
G Ntn1 netrin 1 treatment IDA RGD PMID:30066400 RGD:13782183 NCBI chr11:68,100,190...68,277,652
Ensembl chr11:68,100,190...68,291,649 		JBrowse link
G Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 disease_progression ISO early onset sporadic AD; DNA:SNP:CDS:rs6336 (human)
mRNA:decreased expression:brain		 RGD PMID:18780967 PMID:21397006 RGD:5508228, RGD:5684531 NCBI chr 3:87,685,551...87,702,549
Ensembl chr 3:87,685,551...87,702,469 		JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 treatment ISO
IDA		 sporadic AD; DNA:SNP:intron:rs2289656 (human) RGD PMID:18780967 PMID:24877042 PMID:21900882 RGD:5508228, RGD:10059402, RGD:5684548 NCBI chr13:58,954,363...59,281,782
Ensembl chr13:58,954,383...59,281,784 		JBrowse link
G Nudt1 nudix hydrolase 1 ISO protein:decreased expression:hippocampus RGD PMID:21538080 RGD:10449033 NCBI chr 5:140,307,375...140,323,892
Ensembl chr 5:140,307,411...140,323,892 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase ISO protein:decreased expression:brain RGD PMID:19605646 RGD:7800727 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO protein:altered localization RGD PMID:18347024 RGD:2299169 NCBI chr 7:97,437,748...97,561,588
Ensembl chr 7:97,437,748...97,561,588 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 susceptibility IMP
IEP
ISO		 protein:increased activity:brain:
DNA:haplotypes:cds:rs1136410,rs1805404 (human)
DNA:haplotypes: :		 RGD PMID:22051244 PMID:21616968 PMID:20486200 PMID:17290104 RGD:5510011, RGD:10413888, RGD:10413887, RGD:10413885 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator ISO mRNA,protein:increased expression:brain: RGD PMID:9701251 RGD:9835364 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pcdh11x protocadherin 11 X-linked ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease		 CTD
ClinVar		 PMID:19136949 PMID:29476165 NCBI chr  X:119,199,954...119,820,319
Ensembl chr  X:119,199,956...119,820,316 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic disease_progression ISO DNA:SNPs
DNA:SNP: :rs8192708(human)		 RGD PMID:17440948 PMID:20574532 RGD:2311642, RGD:10427727 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcmt1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 ISO mRNA:increased expression:cerebral cortex: RGD PMID:8736634 RGD:10448277 NCBI chr10:7,503,608...7,556,922
Ensembl chr10:7,505,137...7,556,900 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor ISO RGD PMID:14746899 RGD:1642360 NCBI chr  X:7,786,061...7,790,649
Ensembl chr  X:7,786,061...7,790,649 		JBrowse link
G Pde2a phosphodiesterase 2A, cGMP-stimulated treatment IMP RGD PMID:22771768 RGD:10449025 NCBI chr 7:101,070,905...101,162,026
Ensembl chr 7:101,060,093...101,162,026
Ensembl chr 7:101,060,093...101,162,026 		JBrowse link
G Pdgfb platelet derived growth factor, B polypeptide ISO protein:increased expression:plasma: RGD PMID:22279551 RGD:10449445 NCBI chr15:79,880,066...79,899,178
Ensembl chr15:79,880,075...79,899,178 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 onset ISO
IEP		 mRNA:decreased expression:hippocampus RGD PMID:10210891 PMID:11853019 PMID:7770119 PMID:15941609 RGD:2302864, RGD:2302863, RGD:2302735, RGD:2302869 NCBI chr 5:117,420,716...117,425,629
Ensembl chr 5:117,420,719...117,425,690 		JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25390692 NCBI chr  X:35,861,846...35,869,732
Ensembl chr  X:35,861,859...35,869,732 		JBrowse link
G Phactr2 phosphatase and actin regulator 2 ISO mRNA: splice variants RGD PMID:20590401 RGD:6483097 NCBI chr10:13,083,461...13,350,266
Ensembl chr10:13,083,461...13,350,156 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:19734902 PMID:21460841 NCBI chr 7:89,778,711...89,858,655
Ensembl chr 7:89,779,421...89,862,673 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma IMP RGD PMID:20025958 RGD:6482689 NCBI chr12:32,223,128...32,258,675
Ensembl chr12:32,223,472...32,258,658 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 onset ISO DNA:polymorphism: :p.M326I (human) RGD PMID:12185156 RGD:1625215 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725 		JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr 5:137,820,214...137,834,540
Ensembl chr 5:137,820,214...137,834,543 		JBrowse link
G Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 IAGP OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO NCBI chr 9:20,563,335...20,575,008
Ensembl chr 9:20,563,391...20,577,880 		JBrowse link
G Plau plasminogen activator, urokinase no_association IDA
ISO
IAGP		 ClinVar Annotator: match by term: Alzheimer disease, late-onset, susceptibility to
CTD Direct Evidence: marker/mechanism
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907
DNA:SNPs: :multiple
mRNA:increased expression:brain		 ClinVar
CTD
MouseDO
RGD		 PMID:12898287 PMID:15615772 PMID:15616835 PMID:16341549 PMID:28492532 More... RGD:6483793, RGD:6484115, RGD:6483807, RGD:6483794 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plcb1 phospholipase C, beta 1 IAGP
ISO		 OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907 MouseDO
RGD		 PMID:8534418 RGD:13825140 NCBI chr 2:134,628,084...135,317,178
Ensembl chr 2:134,627,987...135,317,178 		JBrowse link
G Plcd1 phospholipase C, delta 1 ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar
RGD		 PMID:25741868 PMID:8534418 RGD:13825140 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570 		JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO RGD PMID:8534418 RGD:13825140 NCBI chr 2:160,573,230...160,617,680
Ensembl chr 2:160,573,220...160,617,680 		JBrowse link
G Plcg2 phospholipase C, gamma 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28714976 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881 		JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase onset ISO DNA:snps:5' utr:g.-390G>A, g.-184G>A rs876493 (human) RGD PMID:11378842 RGD:5130171 NCBI chr11:98,277,449...98,279,006
Ensembl chr11:98,277,276...98,279,007 		JBrowse link
G Pon1 paraoxonase 1 ISO DNA:polymorphisms:multiple SNPs (human) RGD PMID:16319130 RGD:5509926 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Pon2 paraoxonase 2 ISO DNA:missense mutation:cds:p.C311S (human)
DNA:SNPs:multiple		 RGD PMID:11803456 PMID:16319130 RGD:1580219, RGD:5509926 NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455 		JBrowse link
G Pon3 paraoxonase 3 ISO DNA:polymorphisms:multiple SNPs (human) RGD PMID:16319130 RGD:5509926 NCBI chr 6:5,216,253...5,256,236
Ensembl chr 6:5,220,852...5,256,286 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha no_association ISO DNA:SNP:CDS:rs1800206, p.L162V (human)
No association found for any polymorphisms of PPARA, including rs1800206 (human)		 RGD PMID:12938026 PMID:17850927 RGD:5561899, RGD:5561928 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma no_association
susceptibility		 ISO DNA:SNPs: :multiple (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:cds:p.P12A(human)		 CTD
RGD		 PMID:15993441 PMID:16407166 PMID:30328325 PMID:18573313 PMID:17440948 RGD:2301852, RGD:2311642 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha disease_progression IDA
ISO		 mRNA, protein:decreased expression:hippocampal formation (human) RGD PMID:22540007 PMID:22510382 PMID:19273754 RGD:6484260, RGD:7242180, RGD:7242017 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Ppp1r9b protein phosphatase 1, regulatory subunit 9B severity IEP
ISO		 protein:decreased expression:cerebral cortex (mouse)
protein:decreased expression:brain, synaptosome (human)		 RGD PMID:23764848 PMID:23764848 RGD:10043802, RGD:10043802 NCBI chr11:94,882,038...94,897,724
Ensembl chr11:94,881,861...94,897,725 		JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta ISO DNA:repeat RGD PMID:21029765 RGD:5686295 NCBI chr18:42,777,811...43,192,827
Ensembl chr18:42,770,497...43,216,192 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) disease_progression ISO
IEP		 DNA:SNP: :rs1868402 (human) RGD PMID:23727081 PMID:21223993 RGD:13830878, RGD:13830879 NCBI chr11:17,109,298...17,150,380
Ensembl chr11:17,109,263...17,150,375 		JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:8534418 RGD:13825140 NCBI chr 7:121,888,327...122,233,625
Ensembl chr 7:121,887,974...122,233,625 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase treatment IMP
ISO		 protein:increased expression:vessel,astrocyte: RGD PMID:24105468 PMID:19716418 RGD:10412735, RGD:10412736 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Prnp prion protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, early-onset, susceptibility to		 CTD
ClinVar		 PMID:1353341 PMID:1677164 PMID:1682813 PMID:1684089 PMID:1971924 More... NCBI chr 2:131,751,848...131,780,356
Ensembl chr 2:131,751,848...131,780,349 		JBrowse link
G Psen1 presenilin 1 ISO
IAGP		 DNA:missense mutations:cds:multiple (human)
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease | ClinVar Annotator: match by term: Familial Alzheimer disease
CTD Direct Evidence: marker/mechanism
OMIM:104300 | OMIM:502500 | OMIM:604154 | OMIM:608907		 ClinVar
CTD
MouseDO
RGD		 PMID:7596406 PMID:8773614 PMID:9384602 PMID:9452052 PMID:9851443 More... RGD:1302519, RGD:13782044 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Psen2 presenilin 2 severity ISO DNA:missense mutations:cds:p.N141I, p.M239V (human)
ClinVar Annotator: match by term: Alzheimer disease | ClinVar Annotator: match by term: Alzheimer's disease | ClinVar Annotator: match by term: Early-Onset Familial Alzheimer Disease
DNA:missense mutation:cds:p.N141I (human)
CTD Direct Evidence: marker/mechanism		 ClinVar
RGD
CTD		 PMID:9050898 PMID:9384602 PMID:10976645 PMID:11723295 PMID:12925374 More... RGD:9743900, RGD:1302522, RGD:9743900 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) IMP RGD PMID:22044482 RGD:6483525 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 ISO
IMP		 protein:increased expression:cerebral cortex RGD PMID:21701788 PMID:10560656 PMID:20157512 RGD:5688147, RGD:5688249, RGD:5688156 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO mRNA:decreased expression:neocortex, hippocampus RGD PMID:21701788 PMID:8892355 PMID:9740394 RGD:5688147, RGD:5688254, RGD:5688252 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 severity ISO
IEP
IMP		 protein:increased expression:prefrontal cortex (human)
protein:increased expression:dentate gyrus (mouse)		 RGD PMID:20427654 PMID:16237174 PMID:20956308 RGD:9835008, RGD:10044037, RGD:9835007 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Pyy peptide YY ISO CTD Direct Evidence: marker/mechanism CTD PMID:11709213 NCBI chr11:101,997,502...101,998,658
Ensembl chr11:101,997,502...101,998,658 		JBrowse link
G Rbm11 RNA binding motif protein 11 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:75,389,796...75,399,706
Ensembl chr16:75,389,732...75,399,717 		JBrowse link
G Rcan1 regulator of calcineurin 1 ISO RGD PMID:11483593 RGD:1580889 NCBI chr16:92,188,839...92,263,057
Ensembl chr16:92,188,841...92,267,755 		JBrowse link
G Reg1 regenerating islet-derived 1 ISO mRNA:increased expression:brain (human) RGD PMID:2394826 RGD:9850119 NCBI chr 6:78,402,966...78,405,651
Ensembl chr 6:78,399,694...78,405,650 		JBrowse link
G Reln reelin ISO protein:increased expression:cerebrospinal fluid (human)
protein: increased expression: brain
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20610758 PMID:12645087 PMID:20025970 RGD:729771, RGD:13207521 NCBI chr 5:22,089,452...22,549,703
Ensembl chr 5:22,089,452...22,549,700 		JBrowse link
G Runx1 runt related transcription factor 1 ISO associated with Down Syndrome RGD PMID:20946940 RGD:6482829 NCBI chr16:92,398,354...92,622,962
Ensembl chr16:92,398,354...92,623,037 		JBrowse link
G S100b S100 protein, beta polypeptide, neural severity IMP
ISO		 protein:decreased expression:cerebrospinal fluid RGD PMID:21080947 PMID:19705461 PMID:20105309 PMID:20953641 RGD:5508775, RGD:5508798, RGD:5508787, RGD:5508780 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Samsn1 SAM domain, SH3 domain and nuclear localization signals, 1 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:75,655,682...75,706,154
Ensembl chr16:75,655,681...75,819,169 		JBrowse link
G Sell selectin, lymphocyte severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chr 1:163,889,556...163,908,354
Ensembl chr 1:163,889,551...163,911,750 		JBrowse link
G Selp selectin, platelet severity ISO protein:decreased expression:plasma RGD PMID:21484243 RGD:5685677 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 ISO RGD PMID:2813392 RGD:2317937 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:increased expression:cerebrospinal fluid, serum (human) RGD PMID:17073149 PMID:28320113 RGD:2312353, RGD:27226702 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Shc1 src homology 2 domain-containing transforming protein C1 IEP protein:increased phosphorylation:neuron RGD PMID:15837797 RGD:1643185 NCBI chr 3:89,325,858...89,337,336
Ensembl chr 3:89,325,750...89,337,334 		JBrowse link
G Sirt1 sirtuin 1 treatment IEP
IDA		 protein:increased expression:forebrain (mouse) RGD PMID:17581637 PMID:16751189 RGD:2290573, RGD:10047116 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Sirt3 sirtuin 3 IEP mRNA:increased expression:brain RGD PMID:23139766 RGD:9586045 NCBI chr 7:140,443,576...140,462,222
Ensembl chr 7:140,443,579...140,462,222 		JBrowse link
G Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 ISO
IEP		 mRNA, protein:decreased expression:frontal association cortex
mRNA:decreased expression:cerebral cortex		 RGD PMID:21743130 PMID:21333939 RGD:5686430, RGD:5686673 NCBI chr14:32,184,394...32,186,807
Ensembl chr14:32,184,395...32,186,807 		JBrowse link
G Slc25a4 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 ISO RGD PMID:21958963 RGD:9681463 NCBI chr 8:46,660,205...46,664,099
Ensembl chr 8:46,659,834...46,664,321 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 ISO RGD PMID:8179300 RGD:2313620 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 ISO RGD PMID:8179300 RGD:2313620 NCBI chr 6:122,704,783...122,779,149
Ensembl chr 6:122,704,768...122,778,599 		JBrowse link
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24055495 NCBI chr11:69,833,112...69,839,040
Ensembl chr11:69,833,365...69,839,014 		JBrowse link
G Slc30a4 solute carrier family 30 (zinc transporter), member 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chr 2:122,523,153...122,544,583
Ensembl chr 2:122,523,153...122,544,583 		JBrowse link
G Slc30a6 solute carrier family 30 (zinc transporter), member 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16580781 NCBI chr17:74,702,573...74,731,225
Ensembl chr17:74,702,603...74,731,216 		JBrowse link
G Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr17:81,680,534...82,045,816
Ensembl chr17:81,680,534...82,045,806 		JBrowse link
G Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 ISO protein:altered expression:synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr 7:15,861,540...15,894,988
Ensembl chr 7:15,863,751...15,894,988 		JBrowse link
G Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 ISO protein:altered expression:parietal cortex, synaptosome: RGD PMID:21382638 RGD:13628395 NCBI chr12:81,244,686...81,380,506
Ensembl chr12:81,244,689...81,379,954 		JBrowse link
G Snap91 synaptosomal-associated protein 91 ISO
IEP		 protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
denntate gyrus, hippocampus, entorhinal cortex		 RGD PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238 NCBI chr 9:86,647,976...86,762,766
Ensembl chr 9:86,647,976...86,762,707 		JBrowse link
G Snca synuclein, alpha ISO human gene in a mouse model
protein:increased expression:cerebrospinal fluid		 RGD PMID:11572944 PMID:18577885 RGD:1302528, RGD:6478792 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sncb synuclein, beta ISO mRNA:decreased expression:brain RGD PMID:11578596 RGD:6480194 NCBI chr13:54,906,673...54,914,435
Ensembl chr13:54,906,673...54,914,408 		JBrowse link
G Sncg synuclein, gamma ISO protein:increased expression:cerebrospinal fluid RGD PMID:18577885 RGD:6478792 NCBI chr14:34,092,231...34,096,626
Ensembl chr14:34,092,231...34,096,746 		JBrowse link
G Snrnp70 small nuclear ribonucleoprotein 70 (U1) ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chr 7:45,025,878...45,045,177
Ensembl chr 7:45,025,877...45,045,166 		JBrowse link
G Snrpa small nuclear ribonucleoprotein polypeptide A ISO protein:increased expression:cerebral cortex (human) RGD PMID:24023061 RGD:10448959 NCBI chr 7:26,886,431...26,895,696
Ensembl chr 7:26,886,430...26,895,696 		JBrowse link
G Sod1 superoxide dismutase 1, soluble IMP
ISO		 mRNA:altered expression:hippocampus, hypothalamus (rat)
protein:decreased expression:frontal lobe (human)		 RGD PMID:22072713 PMID:20027333 PMID:22072713 RGD:8655610, RGD:8657017, RGD:8655610 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19374891 PMID:16369462 RGD:1579972 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing ISO RGD PMID:15313836 RGD:1581303 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593 		JBrowse link
G Spint1 serine protease inhibitor, Kunitz type 1 ISO protein:decreased expression:parietal cortex (human) RGD PMID:9743567 RGD:1581317 NCBI chr 2:119,067,841...119,079,995
Ensembl chr 2:119,067,843...119,080,008 		JBrowse link
G Spred2 sprouty-related EVH1 domain containing 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr11:19,874,442...19,974,026
Ensembl chr11:19,874,375...19,974,026 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
IDA		 protein:decreased tyrosine phosphorylation:dentate gyrus
protein:decreased tyrosine phosphorylation:dentate gyrus, CA1 field of hippocampus 		RGD PMID:18813209 PMID:18813209 RGD:10403051, RGD:10403051 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Stox1 storkhead box 1 severity ISO protein:increased expression:CA4 field of hippocampus (human) RGD PMID:20110611 RGD:11554028 NCBI chr10:62,494,822...62,561,907
Ensembl chr10:62,494,822...62,561,907 		JBrowse link
G Syp synaptophysin ISO
IEP		 protein:decreased expression:dentate gyrus molecular layer,hippocampus,entorhinal, tempocampal corteces:
mRNA,protein:decreased expression:hippocampus, temporal cortex
denntate gyrus, hippocampus, entorhinal cortex		 RGD PMID:20847448 PMID:20847448 PMID:20847448 RGD:13506238, RGD:13506238, RGD:13506238 NCBI chr  X:7,504,819...7,519,495
Ensembl chr  X:7,504,710...7,519,495 		JBrowse link
G Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) susceptibility ISO DNA:SNP: :(rs241448)(human) RGD PMID:16595160 RGD:6482265 NCBI chr17:34,423,453...34,435,295
Ensembl chr17:34,422,501...34,435,295 		JBrowse link
G Tardbp TAR DNA binding protein ISO
IEP		 protein:increased expression, phosphorylation:motor cortex
protein:increased expression:brain		 RGD PMID:21376022 PMID:21070634 RGD:5687139, RGD:5687178 NCBI chr 4:148,696,839...148,711,672
Ensembl chr 4:148,696,839...148,711,476 		JBrowse link
G Tbp TATA box binding protein ISO protein:increased expression:hippocampus, entorhinal cortex (human) RGD PMID:15193429 RGD:5684338 NCBI chr17:15,720,150...15,737,689
Ensembl chr17:15,720,150...15,748,641 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase treatment IDA RGD PMID:27190010 RGD:13601984 NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509 		JBrowse link
G Tfam transcription factor A, mitochondrial susceptibility ISO DNA:SNP: :rs1937 (human)
CTD Direct Evidence: marker/mechanism
DNA:SNP:intron:IVS4+113A>G (rs2306604) (human)		 CTD
RGD		 PMID:17192785 PMID:21799244 PMID:17537576 RGD:6767575, RGD:6771185 NCBI chr10:71,061,298...71,074,157
Ensembl chr10:71,061,294...71,074,110 		JBrowse link
G Thbd thrombomodulin ISO RGD PMID:15760641 RGD:5685018 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 ISO RGD PMID:12614934 RGD:1580169 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:16157451 RGD:1580680 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 ISO protein:decreased expression:brain cortex (human) RGD PMID:18652896 RGD:2317276 NCBI chr12:85,387,388...85,421,491
Ensembl chr12:85,387,388...85,421,621 		JBrowse link
G Tmprss15 transmembrane protease, serine 15 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:78,749,896...78,887,988
Ensembl chr16:78,749,896...78,887,985 		JBrowse link
G Tnf tumor necrosis factor no_association
onset
susceptibility		 ISO DNA:polymorphism:promoter:multiple(human)
DNA:polymorphism:promoter:-308G>A(human)
protein:decreased expression:brain:
DNA:haploltype:promoter:-863A>C,-308G>A(human)
protein:increased secretion:serum:
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, protection against		 CTD
ClinVar
RGD		 PMID:10400991 PMID:16908746 PMID:17192785 PMID:12962917 PMID:18834925 More... RGD:1580320, RGD:13825257, RGD:13825256, RGD:13825255, RGD:13825253, RGD:13825250, RGD:13825248, RGD:13825248 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a no_association ISO
IMP		 protein:increased expression:brain:
protein:increased expression:cerebrospinal fluid:		 RGD PMID:20110607 PMID:21978728 PMID:17724122 PMID:17267158 RGD:13825249, RGD:13825268, RGD:13825267, RGD:13825266 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b ISO protein:decreased expression:brain:
protein:increased expression:cerebrospinal fluid:		 RGD PMID:20110607 PMID:21978728 RGD:13825249, RGD:13825268 NCBI chr 4:144,938,938...144,973,453
Ensembl chr 4:144,940,033...144,973,440 		JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 homolog (yeast) ISO CTD Direct Evidence: marker/mechanism CTD PMID:27023435 PMID:29107063 PMID:30319691 PMID:30320580 NCBI chr 7:19,435,238...19,449,370
Ensembl chr 7:19,435,238...19,449,363 		JBrowse link
G Tph1 tryptophan hydroxylase 1 ISO RGD PMID:15182943 RGD:1580467 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961 		JBrowse link
G Tpi1 triosephosphate isomerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19374891 NCBI chr 6:124,787,549...124,791,121
Ensembl chr 6:124,787,549...124,791,259 		JBrowse link
G Tpp1 tripeptidyl peptidase I ISO CTD Direct Evidence: marker/mechanism CTD PMID:10320038 NCBI chr 7:105,394,018...105,401,489
Ensembl chr 7:105,394,018...105,401,442 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24663666 PMID:28714976 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
G Trf transferrin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Transferrin variant C1/C2		 CTD
ClinVar		 PMID:9272172 PMID:15060098 PMID:17192785 PMID:20029940 PMID:25741868 More... NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Trp53 transformation related protein 53 IEP RGD PMID:17581637 RGD:2290573 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:16341938 RGD:1580518 NCBI chr17:24,814,788...24,851,607
Ensembl chr17:24,814,790...24,851,604 		JBrowse link
G Tspan14 tetraspanin 14 ISO CTD Direct Evidence: marker/mechanism CTD PMID:33589840 NCBI chr14:40,628,384...40,688,835
Ensembl chr14:40,628,402...40,688,764 		JBrowse link
G Ttr transthyretin ISO RGD PMID:16552785 RGD:1580525 NCBI chr18:20,797,266...20,807,383
Ensembl chr18:20,798,337...20,807,378 		JBrowse link
G Uchl1 ubiquitin carboxy-terminal hydrolase L1 ISO RGD PMID:14722078 RGD:1580538 NCBI chr 5:66,833,464...66,844,577
Ensembl chr 5:66,833,434...66,844,577 		JBrowse link
G Ucp1 uncoupling protein 1 (mitochondrial, proton carrier) ISO protein:decreased expression:plasma (human) RGD PMID:24498895 RGD:10045648 NCBI chr 8:84,016,977...84,025,085
Ensembl chr 8:84,016,981...84,025,081 		JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 ISO DNA:hypermethylation:promoter:
protein:decreased expression:temporal cortex		 RGD PMID:26943237 PMID:11130185 RGD:11572212, RGD:13831335 NCBI chr 9:108,765,716...108,778,709
Ensembl chr 9:108,765,701...108,778,691 		JBrowse link
G Usp25 ubiquitin specific peptidase 25 ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:16369530 PMID:16921174 PMID:24691562 NCBI chr16:76,810,573...76,913,671
Ensembl chr16:76,810,594...76,913,668 		JBrowse link
G Vcp valosin containing protein ISO ClinVar Annotator: match by term: Alzheimer disease ClinVar PMID:30279455 NCBI chr 4:42,979,964...43,000,507
Ensembl chr 4:42,979,963...43,000,507 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15732116 PMID:15732116 RGD:1580571 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin ISO
IEP		 protein:increased expression:brain RGD PMID:19728994 PMID:19728994 RGD:6480519, RGD:6480519 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Vldlr very low density lipoprotein receptor ISO DNA:repeat RGD PMID:7550352 RGD:737739 NCBI chr19:27,190,070...27,231,631
Ensembl chr19:27,193,884...27,231,631 		JBrowse link
G Vps13c vacuolar protein sorting 13C ISO ClinVar Annotator: match by term: Alzheimer disease, early onset ClinVar PMID:25741868 NCBI chr 9:67,747,594...67,905,026
Ensembl chr 9:67,747,678...67,902,920 		JBrowse link
G Vsnl1 visinin-like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25806004 NCBI chr12:11,375,258...11,486,579
Ensembl chr12:11,375,243...11,486,614 		JBrowse link
G Wt1 WT1 transcription factor ISO RGD PMID:12914969 RGD:1580623 NCBI chr 2:104,956,874...105,003,959
Ensembl chr 2:104,956,874...105,003,961 		JBrowse link
G Wwox WW domain-containing oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:30820047 NCBI chr 8:115,166,377...116,079,451
Ensembl chr 8:115,166,395...116,079,447 		JBrowse link
G Xrn1 5'-3' exoribonuclease 1 susceptibility ISO DNA:snp:intron:c.1883+365T>C (rs1351965) (human) RGD PMID:22984654 RGD:11528589 NCBI chr 9:95,836,803...95,939,859
Ensembl chr 9:95,836,813...95,939,856 		JBrowse link
Alzheimer's disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: APP POLYMORPHISM | ClinVar Annotator: match by term: APP-related condition | ClinVar Annotator: match by term: Alzheimer disease type 1 OMIM
ClinVar		 PMID:1303172 PMID:1303239 PMID:1303275 PMID:1415269 PMID:1520398 More... NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Alzheimer disease type 1 ClinVar PMID:678784 PMID:8696333 PMID:8896549 PMID:8896550 PMID:8931958 More... NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Mpo myeloperoxidase ISO ClinVar Annotator: match by term: Alzheimer disease type 1 ClinVar
OMIM		 PMID:6260268 PMID:7904599 PMID:8142659 PMID:8621627 PMID:9468285 More... NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell ISO ClinVar Annotator: match by term: Alzheimer disease type 1 ClinVar PMID:25741868 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Plau plasminogen activator, urokinase susceptibility ISO OMIM NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
Alzheimer's disease 18 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 a disintegrin and metallopeptidase domain 10 ISO ClinVar Annotator: match by term: Alzheimer disease 18 ClinVar
OMIM		 PMID:19608551 PMID:24055016 NCBI chr 9:70,586,133...70,687,511
Ensembl chr 9:70,586,279...70,687,511 		JBrowse link
Alzheimer's disease 19 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pld3 phospholipase D family member 3 ISO ClinVar Annotator: match by term: Alzheimer disease 19 ClinVar PMID:24336208 PMID:25832408 PMID:25832410 PMID:25832411 PMID:25832412 More... NCBI chr 7:27,231,090...27,252,511
Ensembl chr 7:27,231,425...27,252,643 		JBrowse link
Alzheimer's disease 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease 2 | ClinVar Annotator: match by term: Alzheimer disease associated with APOE E4 | ClinVar Annotator: match by term: Late-onset familial alzheimer disease		 CTD
OMIM
ClinVar		 PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
Alzheimer's disease 3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE, FAMILIAL, 3 | ClinVar Annotator: match by term: Alzheimer disease 3 ClinVar
OMIM		 PMID:8488843 PMID:9279208 PMID:9360638 PMID:10432380 PMID:10529625 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Kif5c kinesin family member 5C ISO protein:decreased expression:cerebellum (human) RGD PMID:24569455 RGD:12859086 NCBI chr 2:49,509,298...49,664,790
Ensembl chr 2:49,509,310...49,664,790 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance ClinVar PMID:18412265 PMID:18688798 PMID:18716801 PMID:18781329 PMID:19699188 More... NCBI chr15:91,556,994...91,700,327
Ensembl chr15:91,557,378...91,700,323 		JBrowse link
G Psen1 presenilin 1 ISO
IAGP		 ClinVar Annotator: match by term: ALZHEIMER DISEASE, FAMILIAL, 3 | ClinVar Annotator: match by term: Alzheimer disease 3 | ClinVar Annotator: match by term: Early onset Alzheimer disease with behavioral disturbance
OMIM:607822		 OMIM
ClinVar
MouseDO		 PMID:1985297 PMID:2025423 PMID:2793034 PMID:7550356 PMID:7581374 More... NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Alzheimer's disease 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease 4 | ClinVar Annotator: match by term: Alzheimer disease familial type 4		 CTD
ClinVar		 PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease 4 ClinVar PMID:8910898 PMID:9189043 PMID:9437013 PMID:9804121 PMID:10468510 More... NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Psen2 presenilin 2 ISO ClinVar Annotator: match by term: Alzheimer disease 4 | ClinVar Annotator: match by term: Alzheimer disease familial type 4
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:7638622 PMID:7651536 PMID:8661049 PMID:8939861 PMID:8986743 More... NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
Alzheimer's disease 6 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sorcs1 sortilin-related VPS10 domain containing receptor 1 ISO ClinVar Annotator: match by term: Alzheimer disease 6 ClinVar PMID:19241460 PMID:21280075 PMID:25741868 NCBI chr19:50,131,733...50,668,030
Ensembl chr19:50,131,737...50,667,084 		JBrowse link
Alzheimer's disease 9 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca7 ATP-binding cassette, sub-family A member 7 susceptibility ISO ClinVar Annotator: match by term: ALZHEIMER DISEASE 9, LATE-ONSET | ClinVar Annotator: match by term: Alzheimer disease 9
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:25741868 PMID:25807283 PMID:26141617 PMID:27066581 PMID:28492532 More... NCBI chr10:79,832,328...79,851,406
Ensembl chr10:79,832,328...79,851,406 		JBrowse link
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing ISO ClinVar Annotator: match by term: Alzheimer disease 9 ClinVar PMID:28789839 NCBI chr 9:41,876,005...42,035,593
Ensembl chr 9:41,876,016...42,035,593 		JBrowse link
Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,624,754...84,632,495
Ensembl chr16:84,624,754...84,632,513 		JBrowse link
G Cyyr1 cysteine and tyrosine-rich protein 1 ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:85,247,245...85,347,793
Ensembl chr16:85,218,421...85,350,285 		JBrowse link
G Gabpa GA repeat binding protein, alpha ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,631,795...84,660,671
Ensembl chr16:84,631,813...84,660,667 		JBrowse link
G Jam2 junction adhesion molecule 2 ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,571,011...84,623,268
Ensembl chr16:84,571,011...84,622,816 		JBrowse link
G Mir155 microRNA 155 ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir155hg Mir155 host gene (non-protein coding) ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,509,911...84,512,133
Ensembl chr16:84,500,055...84,512,133 		JBrowse link
G Mrpl39 mitochondrial ribosomal protein L39 ISO ClinVar Annotator: match by term: Alzheimer disease, early-onset, with cerebral amyloid angiopathy ClinVar PMID:16369530 PMID:19047566 NCBI chr16:84,515,068...84,532,261
Ensembl chr16:84,514,464...84,532,630 		JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease familial 3, with spastic paraparesis ClinVar PMID:24121961 PMID:25741868 PMID:27930341 PMID:28492532 PMID:34776449 More... NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Apraxia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Psen1 presenilin 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and apraxia		 CTD
ClinVar		 PMID:11920851 PMID:15534188 PMID:25741868 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Alzheimer's Disease, Familial, 3, with Spastic Paraparesis and Unusual Plaques term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Psen1 presenilin 1 ISO ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with spastic paraparesis and unusual plaques | ClinVar Annotator: match by term: Alzheimer disease, familial, 3, with unusual plaques | ClinVar Annotator: match by term: Alzheimer disease, familial, with spastic paraparesis and unusual plaques ClinVar PMID:7550356 PMID:8733749 PMID:8755489 PMID:9172170 PMID:9546792 More... NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trem2 triggering receptor expressed on myeloid cells 2 ISO ClinVar Annotator: match by term: Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 OMIM
ClinVar		 PMID:6681564 PMID:12080485 PMID:12754369 PMID:12883936 PMID:12925681 More... NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
Presenile and Senile Dementia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:2987927 PMID:3353383 PMID:3922972 PMID:7263700 PMID:8294487 More... NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G App amyloid beta precursor protein ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:1303239 PMID:1303275 PMID:1415269 PMID:1679289 PMID:2111584 More... NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Hfe homeostatic iron regulator ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:10194428 PMID:10660483 PMID:11336458 PMID:12377814 PMID:19159930 More... NCBI chr13:23,886,017...23,894,837
Ensembl chr13:23,886,017...23,894,837 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:23126199 RGD:7193138 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Psen2 presenilin 2 ISO ClinVar Annotator: match by term: Presenile and senile dementia ClinVar PMID:14623725 PMID:15663477 PMID:17186461 PMID:17345043 PMID:22503161 More... NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16193
    Diseases of the Aged 1287
      dementia 868
        Alzheimer's disease 495
          Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy 8
          Alzheimer's Disease, Familial Early-Onset, with Coexisting Amyloid and Prion Pathology 0
          Alzheimer's disease 1 5
          Alzheimer's disease 10 0
          Alzheimer's disease 11 0
          Alzheimer's disease 12 0
          Alzheimer's disease 13 0
          Alzheimer's disease 14 0
          Alzheimer's disease 15 0
          Alzheimer's disease 16 0
          Alzheimer's disease 17 0
          Alzheimer's disease 18 1
          Alzheimer's disease 19 1
          Alzheimer's disease 2 1
          Alzheimer's disease 3 + 4
          Alzheimer's disease 4 3
          Alzheimer's disease 5 0
          Alzheimer's disease 6 1
          Alzheimer's disease 7 0
          Alzheimer's disease 8 0
          Alzheimer's disease 9 2
          Lewy Body Variant of Alzheimer's Disease 0
          Presenile and Senile Dementia + 6
Path 2
Term Annotations click to browse term
  disease 16193
    disease of anatomical entity 15759
      nervous system disease 13651
        central nervous system disease 12235
          brain disease 11478
            disease of mental health 8259
              cognitive disorder 2194
                dementia 868
                  Alzheimer's disease 495
                    Alzheimer's Disease, Early-Onset, with Cerebral Amyloid Angiopathy 8
                    Alzheimer's Disease, Familial Early-Onset, with Coexisting Amyloid and Prion Pathology 0
                    Alzheimer's disease 1 5
                    Alzheimer's disease 10 0
                    Alzheimer's disease 11 0
                    Alzheimer's disease 12 0
                    Alzheimer's disease 13 0
                    Alzheimer's disease 14 0
                    Alzheimer's disease 15 0
                    Alzheimer's disease 16 0
                    Alzheimer's disease 17 0
                    Alzheimer's disease 18 1
                    Alzheimer's disease 19 1
                    Alzheimer's disease 2 1
                    Alzheimer's disease 3 + 4
                    Alzheimer's disease 4 3
                    Alzheimer's disease 5 0
                    Alzheimer's disease 6 1
                    Alzheimer's disease 7 0
                    Alzheimer's disease 8 0
                    Alzheimer's disease 9 2
                    Lewy Body Variant of Alzheimer's Disease 0
                    Presenile and Senile Dementia + 6
paths to the root