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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:glucose intolerance
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Accession:DOID:10603 term browser browse the term
Definition:A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
Synonyms:exact_synonym: glucose intolerances;   glucose malabsorption;   impaired glucose tolerance;   impaired glucose tolerances;   malabsorption of glucose
 primary_id: MESH:D018149
 xref: ICD10CM:R73.03;   NCI:C34646
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
glucose intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor2 adiponectin receptor 2 treatment ISO RGD PMID:23797890 RGD:25330096 NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665
JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: therapeutic CTD PMID:26704350 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445
JBrowse link
G Agtr1a angiotensin II receptor, type 1a EXP CTD Direct Evidence: marker/mechanism CTD PMID:11564974 NCBI chr13:30,520,339...30,566,850
Ensembl chr13:30,520,424...30,566,850
JBrowse link
G Ahr aryl-hydrocarbon receptor ISO CTD Direct Evidence: therapeutic CTD PMID:31306034 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037
JBrowse link
G Apoc3 apolipoprotein C-III ISO RGD PMID:11959336 RGD:1578441 NCBI chr 9:46,144,348...46,146,934
Ensembl chr 9:46,144,231...46,146,934
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:serum (human) RGD PMID:16306328 RGD:2307103 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344
JBrowse link
G Cd36 CD36 molecule ISO CTD Direct Evidence: marker/mechanism CTD PMID:14640889 NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799
JBrowse link
G Cnr1 cannabinoid receptor 1 ISO CTD Direct Evidence: therapeutic CTD PMID:26563389 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Coq2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 5:100,802,589...100,822,154
Ensembl chr 5:100,802,589...100,823,006
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27036855 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490
JBrowse link
G Dusp1 dual specificity phosphatase 1 resistance IAGP RGD PMID:16814733 RGD:2298673 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102
JBrowse link
G Ech1 enoyl coenzyme A hydratase 1, peroxisomal treatment IDA RGD PMID:31961704 RGD:21408561 NCBI chr 7:28,524,763...28,531,664
Ensembl chr 7:28,524,642...28,531,672
JBrowse link
G Frk fyn-related kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:17179392 NCBI chr10:34,359,396...34,487,530
Ensembl chr10:34,359,395...34,487,274
JBrowse link
G Gipr gastric inhibitory polypeptide receptor IMP RGD PMID:10611300 RGD:737713 NCBI chr 7:18,889,988...18,904,173
Ensembl chr 7:18,889,986...18,900,052
JBrowse link
G Glp1r glucagon-like peptide 1 receptor susceptibility IAGP RGD PMID:8898756 RGD:1624349 NCBI chr17:31,120,841...31,155,484
Ensembl chr17:31,120,791...31,159,765
JBrowse link
G Gpx4 glutathione peroxidase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26042203 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273
JBrowse link
G H2-Aa histocompatibility 2, class II antigen A, alpha susceptibility ISO associated with Diabetes Mellitus RGD PMID:15602651 RGD:2301815 NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797
JBrowse link
G Hnf1a HNF1 homeobox A susceptibility ISO DNA:polymorphism: :p.A98V RGD PMID:15277395 RGD:1601481 NCBI chr 5:115,087,039...115,109,121
Ensembl chr 5:115,087,039...115,109,153
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) disease_progression ISO associated with Cystic Fibrosis; RGD PMID:11591125 RGD:12910474 NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta ISO CTD Direct Evidence: therapeutic CTD PMID:31095431 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605
JBrowse link
G Il7 interleukin 7 ISO CTD Direct Evidence: therapeutic CTD PMID:20376352 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Ins2 insulin II ISO CTD Direct Evidence: marker/mechanism CTD PMID:21779873 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Insr insulin receptor IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10949030 PMID:10949030 RGD:1302523 NCBI chr 8:3,200,922...3,329,649
Ensembl chr 8:3,172,061...3,329,617
JBrowse link
G Jak2 Janus kinase 2 treatment IMP associated with Alzheimer Disease RGD PMID:23223021 RGD:10403052 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480
JBrowse link
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 ISO CTD Direct Evidence: therapeutic CTD PMID:29259128 NCBI chr 3:107,186,174...107,191,398
Ensembl chr 3:107,186,174...107,191,398
JBrowse link
G Lep leptin ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21315688 PMID:24150608 PMID:29650965 PMID:22948215 RGD:12904911 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
JBrowse link
G Lepr leptin receptor ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19452630 PMID:25367288 PMID:28611668 PMID:29988851 PMID:26537785 More... RGD:12911216, RGD:12911217 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549
JBrowse link
G Metrnl meteorin, glial cell differentiation regulator-like ISO CTD Direct Evidence: therapeutic CTD PMID:30213948 NCBI chr11:121,593,253...121,608,215
Ensembl chr11:121,592,370...121,607,132
JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:31988048 RGD:21403676 NCBI chr17:18,051,074...18,051,141
Ensembl chr17:18,051,074...18,051,141
JBrowse link
G Mir34a microRNA 34a ISO CTD Direct Evidence: marker/mechanism CTD PMID:23834033 NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012
JBrowse link
G mt-Atp6 ATP synthase 6, mitochondrial ISO CTD Direct Evidence: marker/mechanism CTD PMID:18273840 NCBI chr MT:7,927...8,607
Ensembl chr MT:7,927...8,607
JBrowse link
G mt-Tl1 tRNA leucine 1, mitochondrial ISO ClinVar Annotator: match by term: Glucose intolerance ClinVar PMID:1284550 PMID:1315123 PMID:1323207 PMID:1360090 PMID:1454794 More... NCBI chr MT:2,676...2,750
Ensembl chr MT:2,676...2,750
JBrowse link
G Neil1 nei endonuclease VIII-like 1 (E. coli) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21285402 NCBI chr 9:57,050,072...57,055,973
Ensembl chr 9:57,050,084...57,055,589
JBrowse link
G Neurod1 neurogenic differentiation 1 susceptibility ISO DNA:polymorphism: :p.A45T (human) RGD PMID:15277395 RGD:1601481 NCBI chr 2:79,282,981...79,286,980
Ensembl chr 2:79,282,865...79,287,095
JBrowse link
G Neurog3 neurogenin 3 susceptibility ISO DNA:polymorphism:cds:p.S199F RGD PMID:15277395 RGD:1601481 NCBI chr10:61,968,869...61,970,542
Ensembl chr10:61,968,869...61,970,542
JBrowse link
G Nono non-POU-domain-containing, octamer binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:29358041 NCBI chr  X:100,473,295...100,492,193
Ensembl chr  X:100,472,924...100,492,197
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29515023 NCBI chr 1:136,770,300...136,888,186
Ensembl chr 1:136,770,309...136,888,186
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit ISO CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chr10:52,293,643...52,316,288
Ensembl chr10:52,293,643...52,316,279
JBrowse link
G Pax6 paired box 6 ISO associated with Aniridia;DNA:nonsense mutation:cds:p.R240X (human) RGD PMID:19034419 RGD:2308929 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 IAGP associated with Hyperinsulinemia, Aniridia; mRNA, protein:decreased expression:pancreatic islet (mouse) RGD PMID:19034419 RGD:2308929 NCBI chr13:75,237,407...75,282,980
Ensembl chr13:75,237,945...75,282,980
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO CTD Direct Evidence: therapeutic CTD PMID:33567340 NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725
JBrowse link
G Plac8 placenta-specific 8 ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 5:100,699,455...100,720,119
Ensembl chr 5:100,701,591...100,720,111
JBrowse link
G Plekhs1 pleckstrin homology domain containing, family S member 1 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr19:56,445,705...56,475,161
Ensembl chr19:56,450,072...56,475,184
JBrowse link
G Pon1 paraoxonase 1 ISO RGD PMID:11889198 RGD:1642628 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha IEP mRNA:decreased expression:quadriceps muscle (mouse) RGD PMID:19158402 RGD:7242049 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Prdx3 peroxiredoxin 3 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994
JBrowse link
G Prdx4 peroxiredoxin 4 ISO CTD Direct Evidence: therapeutic CTD PMID:20446767 NCBI chr  X:154,106,914...154,125,268
Ensembl chr  X:154,106,914...154,123,750
JBrowse link
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:19934007 NCBI chr15:5,172,641...5,211,380
Ensembl chr15:5,173,343...5,211,380
JBrowse link
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit IMP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19934007 PMID:12511592 RGD:1302556 NCBI chr 4:104,886,846...104,967,095
Ensembl chr 4:104,887,071...104,967,087
JBrowse link
G Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27381457 NCBI chr15:97,637,886...97,666,300
Ensembl chr15:97,642,651...97,665,853
JBrowse link
G Rarres2 retinoic acid receptor responder (tazarotene induced) 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22355640 NCBI chr 6:48,546,630...48,549,778
Ensembl chr 6:48,546,630...48,549,723
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21661758 NCBI chr19:44,382,889...44,396,148
Ensembl chr19:44,382,894...44,396,318
JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:21321189 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483
JBrowse link
G Slc12a2 solute carrier family 12, member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22872759 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893
JBrowse link
G Slc27a1 solute carrier family 27 (fatty acid transporter), member 1 ISO RGD PMID:15281014 RGD:1642794 NCBI chr 8:72,021,372...72,039,951
Ensembl chr 8:72,021,526...72,039,946
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:29976929 RGD:150519890 NCBI chr 5:37,123,448...37,146,326
Ensembl chr 5:37,123,448...37,146,549
JBrowse link
G Xbp1 X-box binding protein 1 ISO CTD Direct Evidence: therapeutic CTD PMID:27325692 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18295
    Nutritional and Metabolic Diseases 7383
      disease of metabolism 7383
        inherited metabolic disorder 5657
          carbohydrate metabolic disorder 2809
            glucose metabolism disease 1592
              hyperglycemia 134
                glucose intolerance 57
Path 2
Term Annotations click to browse term
  disease 18295
    Developmental Disease 17901
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 17772
        genetic disease 17746
          inherited metabolic disorder 5657
            carbohydrate metabolic disorder 2809
              glucose metabolism disease 1592
                hyperglycemia 134
                  glucose intolerance 57
paths to the root