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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:glucose intolerance
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Accession:DOID:10603 term browser browse the term
Definition:A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.
Synonyms:exact_synonym: glucose intolerances;   glucose malabsorption;   impaired glucose tolerance;   impaired glucose tolerances;   malabsorption of glucose
 primary_id: MESH:D018149
 xref: ICD10CM:R73.03;   NCI:C34646
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
glucose intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOR2 adiponectin receptor 2 treatment ISO RGD PMID:23797890 RGD:25330096 NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674
JBrowse link
G AGT angiotensinogen EXP CTD Direct Evidence: therapeutic CTD PMID:26704350 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576
JBrowse link
G AGTR1 angiotensin II receptor type 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11564974 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AHR aryl hydrocarbon receptor EXP CTD Direct Evidence: therapeutic CTD PMID:31306034 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G APOC3 apolipoprotein C3 IAGP RGD PMID:11959336 RGD:1578441 NCBI chr11:116,829,907...116,833,072
Ensembl chr11:116,829,706...116,833,072
JBrowse link
G CCL5 C-C motif chemokine ligand 5 IEP protein:increased secretion:serum (human) RGD PMID:16306328 RGD:2307103 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CD36 CD36 molecule (CD36 blood group) EXP CTD Direct Evidence: marker/mechanism CTD PMID:14640889 NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CNR1 cannabinoid receptor 1 EXP CTD Direct Evidence: therapeutic CTD PMID:26563389 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G COQ2 coenzyme Q2, polyprenyltransferase ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 4:83,263,824...83,285,134
Ensembl chr 4:83,261,536...83,284,914
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 EXP CTD Direct Evidence: therapeutic CTD PMID:27036855 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G DUSP1 dual specificity phosphatase 1 resistance ISO RGD PMID:16814733 RGD:2298673 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G ECH1 enoyl-CoA hydratase 1 treatment ISO RGD PMID:31961704 RGD:21408561 NCBI chr19:38,815,422...38,831,794
Ensembl chr19:38,815,422...38,831,841
JBrowse link
G FRK fyn related Src family tyrosine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:17179392 NCBI chr 6:115,931,149...116,100,725
Ensembl chr 6:115,931,149...116,060,891
JBrowse link
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:10611300 RGD:737713 NCBI chr19:45,668,221...45,683,722
Ensembl chr19:45,668,221...45,683,722
JBrowse link
G GLP1R glucagon like peptide 1 receptor susceptibility ISO RGD PMID:8898756 RGD:1624349 NCBI chr 6:39,048,781...39,091,303
Ensembl chr 6:39,048,781...39,091,303
JBrowse link
G GPX4 glutathione peroxidase 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26042203 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791
JBrowse link
G HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 susceptibility IAGP associated with Diabetes Mellitus RGD PMID:15602651 RGD:2301815 NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062
JBrowse link
G HNF1A HNF1 homeobox A susceptibility IAGP DNA:polymorphism: :p.A98V RGD PMID:15277395 RGD:1601481 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 disease_progression IDA associated with Cystic Fibrosis; RGD PMID:11591125 RGD:12910474 NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta EXP CTD Direct Evidence: therapeutic CTD PMID:31095431 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460
JBrowse link
G IL7 interleukin 7 EXP CTD Direct Evidence: therapeutic CTD PMID:20376352 NCBI chr 8:78,675,044...78,805,463
Ensembl chr 8:78,675,743...78,805,523
JBrowse link
G INS insulin EXP CTD Direct Evidence: marker/mechanism CTD PMID:21779873 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221
JBrowse link
G INSR insulin receptor ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:10949030 PMID:10949030 RGD:1302523 NCBI chr19:7,112,265...7,294,414
Ensembl chr19:7,112,255...7,294,414
JBrowse link
G JAK2 Janus kinase 2 treatment ISO associated with Alzheimer Disease RGD PMID:23223021 RGD:10403052 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948
JBrowse link
G LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 EXP CTD Direct Evidence: therapeutic CTD PMID:29259128 NCBI chr 1:110,401,253...110,407,924
Ensembl chr 1:110,401,249...110,407,942
JBrowse link
G LEP leptin ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:21315688 PMID:24150608 PMID:29650965 PMID:22948215 RGD:12904911 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
JBrowse link
G LEPR leptin receptor EXP
ISO
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19452630 PMID:25367288 PMID:28611668 PMID:29988851 PMID:27465994 More... RGD:12911217, RGD:12911216 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G METRNL meteorin like, glial cell differentiation regulator EXP CTD Direct Evidence: therapeutic CTD PMID:30213948 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122
JBrowse link
G MIR125A microRNA 125a ISO RGD PMID:31988048 RGD:21403676 NCBI chr19:51,693,254...51,693,339
Ensembl chr19:51,693,254...51,693,339
JBrowse link
G MIR34A microRNA 34a EXP CTD Direct Evidence: marker/mechanism CTD PMID:23834033 NCBI chr 1:9,151,668...9,151,777
Ensembl chr 1:9,151,668...9,151,777
JBrowse link
G MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:18273840 NCBI chr MT:8,527...9,207
Ensembl chr MT:8,527...9,207
JBrowse link
G MT-TL1 mitochondrially encoded tRNA-Leu (UUA/G) 1 IAGP ClinVar Annotator: match by term: Glucose intolerance ClinVar PMID:1284550 PMID:1315123 PMID:1323207 PMID:1360090 PMID:1454794 More... NCBI chr MT:3,230...3,304
Ensembl chr MT:3,230...3,304
JBrowse link
G NEIL1 nei like DNA glycosylase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21285402 NCBI chr15:75,347,039...75,357,115
Ensembl chr15:75,346,955...75,357,115
JBrowse link
G NEUROD1 neuronal differentiation 1 susceptibility IAGP DNA:polymorphism: :p.A45T (human) RGD PMID:15277395 RGD:1601481 NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,668,295...181,680,827
JBrowse link
G NEUROG3 neurogenin 3 susceptibility IAGP DNA:polymorphism:cds:p.S199F RGD PMID:15277395 RGD:1601481 NCBI chr10:69,571,485...69,573,422
Ensembl chr10:69,571,698...69,573,422
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 EXP CTD Direct Evidence: therapeutic CTD PMID:33933676 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NONO non-POU domain containing octamer binding EXP CTD Direct Evidence: marker/mechanism CTD PMID:29358041 NCBI chr  X:71,283,635...71,301,168
Ensembl chr  X:71,254,814...71,301,522
JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29515023 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420
JBrowse link
G NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit EXP CTD Direct Evidence: therapeutic CTD PMID:33812996 NCBI chr 6:117,675,469...117,710,727
Ensembl chr 6:117,675,469...117,710,727
JBrowse link
G PAX6 paired box 6 IAGP associated with Aniridia;DNA:nonsense mutation:cds:p.R240X (human) RGD PMID:19034419 RGD:2308929 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO associated with Hyperinsulinemia, Aniridia; mRNA, protein:decreased expression:pancreatic islet (mouse) RGD PMID:19034419 RGD:2308929 NCBI chr 5:96,390,333...96,433,248
Ensembl chr 5:96,390,333...96,434,143
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 EXP CTD Direct Evidence: therapeutic CTD PMID:33567340 NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821
JBrowse link
G PLAC8 placenta associated 8 ISO associated with obesity RGD PMID:26296322 RGD:10755343 NCBI chr 4:83,090,048...83,114,729
Ensembl chr 4:83,090,048...83,137,075
JBrowse link
G PLEKHS1 pleckstrin homology domain containing S1 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr10:113,751,682...113,783,429
Ensembl chr10:113,751,262...113,783,429
JBrowse link
G PON1 paraoxonase 1 IAGP DNA:SNP:CDS:amino acid L55M, LL genotype RGD PMID:11889198 RGD:1642628 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha ISO mRNA:decreased expression:quadriceps muscle (mouse) RGD PMID:19158402 RGD:7242049 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PRDX3 peroxiredoxin 3 ISO associated with obesity; RGD PMID:27523322 RGD:11532750 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRDX4 peroxiredoxin 4 EXP CTD Direct Evidence: therapeutic CTD PMID:20446767 NCBI chr  X:23,667,493...23,686,397
Ensembl chr  X:23,664,262...23,686,397
JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:19934007 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374
JBrowse link
G PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:19934007 PMID:12511592 RGD:1302556 NCBI chr 1:56,645,314...56,715,335
Ensembl chr 1:56,645,314...56,715,335
JBrowse link
G RAPGEF3 Rap guanine nucleotide exchange factor 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27381457 NCBI chr12:47,734,363...47,758,880
Ensembl chr12:47,734,363...47,771,040
JBrowse link
G RARRES2 retinoic acid receptor responder 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22355640 NCBI chr 7:150,338,329...150,341,629
Ensembl chr 7:150,338,317...150,341,662
JBrowse link
G SIRT1 sirtuin 1 EXP CTD Direct Evidence: therapeutic CTD PMID:21321189 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC12A2 solute carrier family 12 member 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22872759 NCBI chr 5:128,083,766...128,189,677
Ensembl chr 5:128,083,766...128,189,677
JBrowse link
G SLC27A1 solute carrier family 27 member 1 ISO RGD PMID:15281014 RGD:1642794 NCBI chr19:17,468,767...17,506,168
Ensembl chr19:17,468,769...17,506,168
JBrowse link
G SQSTM1 sequestosome 1 EXP CTD Direct Evidence: therapeutic CTD PMID:33933676 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G WFS1 wolframin ER transmembrane glycoprotein treatment ISO RGD PMID:29976929 RGD:150519890 NCBI chr 4:6,269,850...6,303,265
Ensembl chr 4:6,269,849...6,303,265
JBrowse link
G XBP1 X-box binding protein 1 EXP CTD Direct Evidence: therapeutic CTD PMID:27325692 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 40784
    Nutritional and Metabolic Diseases 10550
      disease of metabolism 10550
        inherited metabolic disorder 7846
          carbohydrate metabolic disorder 3607
            glucose metabolism disease 1988
              hyperglycemia 135
                glucose intolerance 58
Path 2
Term Annotations click to browse term
  disease 40784
    Developmental Disease 36061
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 33199
        genetic disease 32780
          inherited metabolic disorder 7846
            carbohydrate metabolic disorder 3607
              glucose metabolism disease 1988
                hyperglycemia 135
                  glucose intolerance 58
paths to the root