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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pre-eclampsia
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Accession:DOID:10591 term browser browse the term
Definition:A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. (DO)
Synonyms:exact_synonym: EPH Complex;   EPH Gestosis;   PEE;   Preeclampsia;   edema proteinuria hypertension gestosis;   gestational hypertension;   hypertension induced by pregnancy;   preeclampsia/eclampsia;   pregnancy associated hypertension;   proteinuric hypertension of pregnancy
 related_synonym: EPOXIDE HYDROLASE POLYMORPHISM;   HELLP;   HEMOLYSIS, ELEVATED LIVER ENZYMES, AND LOW PLATELET COUNT;   Preeclampsia, susceptibility to
 primary_id: MESH:D011225
 xref: ICD10CM:O14;   ICD10CM:O14.9;   ICD10CM:O14.90;   NCI:C34943;   NCI:C85021;   OMIM:PS189800;   ORDO:275555
For additional species annotation, visit the Alliance of Genome Resources.



show annotations for term's descendants           Sort by:
 
pre-eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 onset ISO CTD Direct Evidence: marker/mechanism
DNA:insertion/deletion:intron 16:
CTD
RGD
PMID:17114810 PMID:20044877 RGD:40400703 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Add1 adducin 1 (alpha) ISO mRNA:increased expression:blood RGD PMID:19731222 RGD:5147993 NCBI chr 5:34,573,664...34,632,308
Ensembl chr 5:34,573,664...34,632,308
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) ISO DNA:polymorphism: :p.M235T (human)
CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Preeclampsia, susceptibility to
CTD
ClinVar
RGD
PMID:7649545 PMID:7883995 PMID:8348146 PMID:8513325 PMID:8518804 More... RGD:1300394, RGD:13432363 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 treatment ISO mRNA:decreased expression:blood: RGD PMID:19681734 PMID:25876805 RGD:10053633, RGD:11541124 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Alb albumin severity ISO RGD PMID:21923989 RGD:11035264 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Anxa5 annexin A5 ISO CTD Direct Evidence: therapeutic CTD PMID:19837457 NCBI chr 3:36,448,923...36,475,887
Ensembl chr 3:36,448,923...36,475,894
JBrowse link
G Apela apelin receptor early endogenous ligand IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 8:65,028,417...65,037,336
Ensembl chr 8:65,028,417...65,037,336
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26095815 NCBI chr10:80,016,672...80,031,471
Ensembl chr10:80,016,653...80,031,472
JBrowse link
G Asb4 ankyrin repeat and SOCS box-containing 4 IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 6:5,383,386...5,433,022
Ensembl chr 6:5,383,386...5,433,022
JBrowse link
G C3 complement component 3 treatment ISO RGD PMID:23685261 RGD:7411624 NCBI chr17:57,203,967...57,228,136
Ensembl chr17:57,203,970...57,228,136
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 ISO protein:increased secretion:serum (rat) RGD PMID:19617880 RGD:2317272 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccn3 cellular communication network factor 3 ISO protein:decreased expression:placenta (human) RGD PMID:16675545 RGD:1580971 NCBI chr15:54,745,910...54,753,762
Ensembl chr15:54,745,702...54,754,039
JBrowse link
G Cd274 CD274 antigen treatment ISO RGD PMID:27277012 RGD:40886269 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cd40 CD40 antigen ISO protein:increased expression:blood, monocyte (human) RGD PMID:19221099 RGD:11520792 NCBI chr 2:165,055,614...165,071,654
Ensembl chr 2:165,055,627...165,072,948
JBrowse link
G Cd40lg CD40 ligand treatment ISO protein:increased expression:blood platelet (human) RGD PMID:26310940 PMID:23241952 RGD:11056772, RGD:11522719 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Cd46 CD46 antigen, complement regulatory protein susceptibility
no_association
ISO DNA:missense mutation:cds:p.A304V (human) RGD PMID:21445332 PMID:25710174 RGD:6483459, RGD:11352807 NCBI chr 1:195,038,971...195,098,784
Ensembl chr 1:195,036,826...195,092,249
JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 7:143,458,339...143,461,059
Ensembl chr 7:143,458,339...143,461,050
JBrowse link
G Chil1 chitinase-like 1 ISO protein:increased secretion:umbilical cord, serum (human) RGD PMID:18054022 RGD:4892664 NCBI chr 1:134,182,156...134,190,031
Ensembl chr 1:134,182,176...134,190,181
JBrowse link
G Clu clusterin ISO DNA:SNP:exon:866C>T (human) RGD PMID:15925890 RGD:1581195 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Comt catechol-O-methyltransferase IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Corin corin, serine peptidase ISO CTD Direct Evidence: marker/mechanism CTD NCBI chr 5:72,299,948...72,504,540
Ensembl chr 5:72,300,025...72,504,473
JBrowse link
G Cp ceruloplasmin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18679377 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Cst3 cystatin C ISO protein:increased expression:plasma (human) RGD PMID:18197549 RGD:2314350 NCBI chr 2:148,871,722...148,875,512
Ensembl chr 2:148,871,722...148,875,692
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 ISO DNA:missense mutation:cds:p.V386A (human) RGD PMID:15569322 RGD:1576428 NCBI chr15:74,850,618...74,856,231
Ensembl chr15:74,851,010...74,856,318
JBrowse link
G Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 ISO mRNA:increased expression:placenta, decidua RGD PMID:23155181 PMID:23155181 RGD:7243127, RGD:7243127 NCBI chr 4:96,516,138...96,564,305
Ensembl chr 4:96,516,138...96,553,661
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 ISO mRNA:increased expression:placenta, decidua RGD PMID:23155181 RGD:7243127 NCBI chr 4:96,568,424...96,592,523
Ensembl chr 4:96,568,429...96,591,578
JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22285683 NCBI chr17:35,059,035...35,062,099
Ensembl chr17:35,059,035...35,062,095
JBrowse link
G Ebag9 estrogen receptor-binding fragment-associated gene 9 ISO protein:increased expression:decidua RGD PMID:17845206 RGD:2289846 NCBI chr15:44,619,227...44,641,538
Ensembl chr15:44,619,175...44,641,515
JBrowse link
G Edn1 endothelin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25230003 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Edn2 endothelin 2 ISO RGD PMID:9015697 RGD:1580919 NCBI chr 4:120,161,206...120,167,360
Ensembl chr 4:120,161,206...120,167,360
JBrowse link
G Eng endoglin severity
treatment
ISO
IDA
IEP
protein:increased expression:serum (human)
protein:increased expression:serum (rat)
protein:increased expression:plasma (mouse)
RGD PMID:23460287 PMID:22763474 PMID:22308016 PMID:20351341 PMID:23357179 RGD:7248767, RGD:7257530, RGD:7257524, RGD:7248777, RGD:7248768 NCBI chr 2:32,646,595...32,682,669
Ensembl chr 2:32,646,595...32,682,669
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO protein:decreased expression:abdominal fascia: RGD PMID:17469012 RGD:9685457 NCBI chr19:40,612,366...40,741,602
Ensembl chr19:40,612,366...40,741,602
JBrowse link
G Epas1 endothelial PAS domain protein 1 ISO RGD PMID:11159352 RGD:1580974 NCBI chr17:86,753,864...86,833,410
Ensembl chr17:86,753,700...86,833,410
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal ISO DNA:polymorphism
CTD Direct Evidence: marker/mechanism
CTD
RGD
PMID:11283205 PMID:12173035 PMID:11283205 RGD:1601064 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO RGD PMID:15894829 RGD:1581016 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G F2 coagulation factor II severity ISO DNA:polymorphism: :20210G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G F2r coagulation factor II (thrombin) receptor ISO RGD PMID:12161502 RGD:1581033 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G F3 coagulation factor III ISO associated with Fetal Death;protein:increased expression:plasma RGD PMID:19736615 RGD:11340220 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G F5 coagulation factor V severity ISO DNA:mutation: :1691G>A(human) RGD PMID:16246971 RGD:6893628 NCBI chr 1:164,151,835...164,220,277
Ensembl chr 1:164,151,838...164,220,277
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) susceptibility ISO DNA:SNP:promoter:-670A>G (human)
DNA:SNP:promoter:-670A>G(rs1800682)(human)
RGD PMID:15695771 PMID:30066360 RGD:12903973, RGD:14700669 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) susceptibility ISO DNA:SNP:intron:124A>G(rs5030772)(human) RGD PMID:30066360 RGD:14700669 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 ISS OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 7:130,162,451...130,266,808
Ensembl chr 7:130,162,451...133,123,350
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:18679377 PMID:28628106 PMID:15472115 RGD:1582493 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 susceptibility ISO DNA:missense mutation:cds:p.I105V (human) RGD PMID:11826024 RGD:737707 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H2-Ab1 histocompatibility 2, class II antigen A, beta 1 susceptibility ISO DNA:polymorphism:cds:HLA-DQB1*04 (human) RGD PMID:10960630 RGD:36174024 NCBI chr17:34,263,227...34,269,418
Ensembl chr17:34,257,689...34,269,419
JBrowse link
G Hmox1 heme oxygenase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22197494 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hp haptoglobin severity ISO protein:increased expression
DNA:polymorphism
RGD PMID:17220952 PMID:16879055 RGD:1626337, RGD:1626343 NCBI chr 8:109,575,128...109,579,172
Ensembl chr 8:109,575,128...109,579,172
JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:21830843 RGD:8547718 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 8:24,584,133...24,596,952
Ensembl chr 8:24,584,136...24,597,009
JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:serum (human) RGD PMID:21126355 RGD:6906962 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Inhba inhibin beta-A ISO CTD Direct Evidence: marker/mechanism CTD PMID:17332518 NCBI chr13:16,004,256...16,031,609
Ensembl chr13:16,011,851...16,031,621
JBrowse link
G Itga4 integrin alpha 4 ISO protein:increased expression:blood, granulocyte (rat) RGD PMID:10694336 RGD:9698441 NCBI chr 2:79,255,426...79,333,114
Ensembl chr 2:79,255,426...79,333,123
JBrowse link
G Kiss1 KiSS-1 metastasis-suppressor ISO RGD PMID:16952198 RGD:2292128 NCBI chr 1:133,321,887...133,329,722
Ensembl chr 1:133,309,827...133,329,722
Ensembl chr 1:133,309,827...133,329,722
JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:serum,urine RGD PMID:23957217 RGD:126781721 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Lep leptin ISO protein:decreased expression:plasma RGD PMID:16021089 RGD:5128718 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor ISO protein:increased expression:placenta RGD PMID:16021089 RGD:5128718 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Mir152 microRNA 152 ISO miRNA:increased expression:placenta RGD PMID:31114978 RGD:21066344 NCBI chr11:96,850,393...96,850,465
Ensembl chr11:96,850,393...96,850,465
JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO mRNA, protein:decreased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IMP
mRNA, protein:decreased expression:placenta RGD PMID:17083831 PMID:23776237 RGD:2290399, RGD:13204787 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD
PMID:29250138 RGD:13504712 NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
G Notch2 notch 2 IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 3:98,013,538...98,150,367
Ensembl chr 3:98,013,527...98,150,361
JBrowse link
G Nsd1 nuclear receptor-binding SET-domain protein 1 ISO ClinVar Annotator: match by term: Preeclampsia ClinVar PMID:12807965 PMID:15942875 PMID:17565729 PMID:18414213 PMID:21196496 More... NCBI chr13:55,209,782...55,318,325
Ensembl chr13:55,209,782...55,318,325
JBrowse link
G Pdcd1 programmed cell death 1 treatment ISO protein:increased expression:Treg cell RGD PMID:27277012 PMID:27277012 RGD:40886269, RGD:40886269 NCBI chr 1:94,038,305...94,052,553
Ensembl chr 1:94,038,305...94,052,553
JBrowse link
G Pde5a phosphodiesterase 5A, cGMP-specific ISO RGD PMID:18538317 RGD:2314465 NCBI chr 3:122,729,158...122,859,374
Ensembl chr 3:122,728,947...122,859,374
JBrowse link
G Pgf placental growth factor ISO RGD PMID:21756887 PMID:20720407 RGD:6483577, RGD:6483779 NCBI chr12:85,166,637...85,177,785
Ensembl chr12:85,166,635...85,177,790
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO protein:increased expression:plasma RGD PMID:21722073 RGD:6484119 NCBI chr 7:24,460,937...24,475,970
Ensembl chr 7:24,462,484...24,475,968
JBrowse link
G Pml promyelocytic leukemia ISO mRNA:decreased expression:placenta (human) RGD PMID:20228380 RGD:41404689 NCBI chr 9:58,217,179...58,249,796
Ensembl chr 9:58,218,076...58,249,786
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO RGD PMID:15562025 RGD:1580687 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Proc protein C ISO RGD PMID:9065198 RGD:11564336 NCBI chr18:32,123,126...32,139,570
Ensembl chr18:32,123,126...32,139,570
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 IEA OMIM:189800 | OMIM:609402 | OMIM:609403 | OMIM:609404 | OMIM:614592 MouseDO NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Scnn1a sodium channel, nonvoltage-gated 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:16555725 NCBI chr 6:125,314,271...125,344,943
Ensembl chr 6:125,320,659...125,344,943
JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:blood:
CTD
RGD
PMID:18679377 PMID:16952198 RGD:2292128 NCBI chr 5:137,061,504...137,072,272
Ensembl chr 5:137,061,504...137,072,268
JBrowse link
G Serpinf2 serine (or cysteine) peptidase inhibitor, clade F, member 2 ISO protein:increased expression:urine RGD PMID:1334334 RGD:1625535 NCBI chr11:75,431,736...75,439,501
Ensembl chr11:75,431,732...75,439,591
JBrowse link
G Stox1 storkhead box 1 no_association ISO DNA:missense mutation:cds:p.Y153H (human)
CTD Direct Evidence: marker/mechanism
human fetally expressed gene in a mouse model
CTD
RGD
PMID:15806103 PMID:23357179 PMID:17617193 RGD:11553888, RGD:7248768, RGD:11553890 NCBI chr10:62,659,043...62,726,094
Ensembl chr10:62,659,043...62,726,128
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:increased expression:plasma: RGD PMID:10078579 RGD:11060132 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 ISO mRNA, protein:increased expression:placenta RGD PMID:17083831 RGD:2290399 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735
JBrowse link
G Tlr3 toll-like receptor 3 ISO protein:increased expression:placenta (rat) RGD PMID:19779466 RGD:5128769 NCBI chr 8:45,395,665...45,411,075
Ensembl chr 8:45,395,665...45,411,080
JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:16157088 RGD:1580682 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284
JBrowse link
G Tnf tumor necrosis factor ISO RGD PMID:15901845 RGD:1580314 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b ISO human protein in rat model RGD PMID:21505354 RGD:5131211 NCBI chr 4:145,212,368...145,246,870
Ensembl chr 4:145,213,463...145,246,870
JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:15866083 RGD:1580806 NCBI chr 4:150,997,097...151,001,810
Ensembl chr 4:150,997,097...151,001,810
JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:16517614 RGD:1580566 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
eclampsia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 treatment ISO RGD PMID:27106269 RGD:11062145 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
HELLP syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13 ISO protein:decreased activity:plasma (human) RGD PMID:12969811 RGD:10449045 NCBI chr 2:26,973,361...27,009,625
Ensembl chr 2:26,973,416...27,009,628
JBrowse link
G Cd40lg CD40 ligand ISO protein:increased expression:blood platelet (human) RGD PMID:23241952 RGD:11522719 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:9158311 RGD:1580990 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) susceptibility ISO DNA:SNP:promoter:-670A>G(rs1800682)(human)
protein,mRNA:altered expression:placenta, liver:
RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) susceptibility ISO DNA:SNP:intron:124A>G(rs5030772)(human)
protein:altered expression:blood, placenta, liver:
RGD PMID:30066360 PMID:28501275 RGD:14700669, RGD:14700673 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
Preeclampsia/Eclampsia 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos3 nitric oxide synthase 3, endothelial cell ISO OMIM NCBI chr 5:24,364,816...24,384,474
Ensembl chr 5:24,364,810...24,384,474
JBrowse link
Preeclampsia/Eclampsia 4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stox1 storkhead box 1 ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 4 ClinVar
OMIM
PMID:15806103 PMID:17325670 NCBI chr10:62,659,043...62,726,094
Ensembl chr10:62,659,043...62,726,128
JBrowse link
Preeclampsia/Eclampsia 5 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Corin corin, serine peptidase ISO ClinVar Annotator: match by term: Preeclampsia/eclampsia 5 OMIM
ClinVar
PMID:22437503 PMID:24828501 PMID:25741868 PMID:28492532 NCBI chr 5:72,299,948...72,504,540
Ensembl chr 5:72,300,025...72,504,473
JBrowse link
Preeclamptic Toxemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pecam1 platelet/endothelial cell adhesion molecule 1 ISO RGD PMID:22534418 RGD:6771230 NCBI chr11:106,654,213...106,715,281
Ensembl chr11:106,654,217...106,750,628
JBrowse link
G Ren1 renin 1 structural ISO protein:increased activity:blood plasma (human) RGD PMID:683663 RGD:125097480 NCBI chr 1:133,350,674...133,360,320
Ensembl chr 1:133,350,510...133,360,325
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14544
    disease of anatomical entity 14144
      cardiovascular system disease 3696
        vascular disease 2692
          hypertension 861
            Pregnancy-Induced Hypertension 88
              pre-eclampsia 87
                Preeclampsia/Eclampsia 1 1
                Preeclampsia/Eclampsia 2 0
                Preeclampsia/Eclampsia 3 0
                Preeclampsia/Eclampsia 4 1
                Preeclampsia/Eclampsia 5 1
                Preeclamptic Toxemia 2
                eclampsia 1
                mild pre-eclampsia 0
                severe pre-eclampsia + 5
Path 2
Term Annotations click to browse term
  disease 14544
    disease of anatomical entity 14144
      cardiovascular system disease 3696
        vascular disease 2692
          artery disease 1708
            hypertension 861
              Pregnancy-Induced Hypertension 88
                pre-eclampsia 87
                  Preeclampsia/Eclampsia 1 1
                  Preeclampsia/Eclampsia 2 0
                  Preeclampsia/Eclampsia 3 0
                  Preeclampsia/Eclampsia 4 1
                  Preeclampsia/Eclampsia 5 1
                  Preeclamptic Toxemia 2
                  eclampsia 1
                  mild pre-eclampsia 0
                  severe pre-eclampsia + 5
paths to the root