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ONTOLOGY REPORT - ANNOTATIONS


Term:chronic lymphocytic leukemia
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Accession:DOID:1040 term browser browse the term
Definition:A lymphoblastic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. (DO)
Synonyms:exact_synonym: CLL;   chronic lymphatic leukemia;   chronic lymphoid leukemia;   lymphoplasmacytic leukemia
 related_synonym: B-cell chronic lymphoid leukemia
 primary_id: RDO:9001216
 xref: GARD:6104;   NCI:C3163;   ORDO:67038
For additional species annotation, visit the Alliance of Genome Resources.


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chronic lymphocytic leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ak3 adenylate kinase 3 JBrowse link 1 247,144,486 247,169,690 RGD:13842476
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:8554872
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:8554872
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11522717
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354975
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:8554872
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:8554872
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:11354912
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:11526156
RGD:11530031
RGD:11530029
RGD:11530026
RGD:11530021
RGD:11526158
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:8554872
G Lrrc56 leucine rich repeat containing 56 JBrowse link 1 214,182,232 214,197,184 RGD:8554872
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:11340590
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:8554872
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:8554872
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:8554872
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:11073982
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 JBrowse link 12 40,895,515 40,955,999 RGD:8554872
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 JBrowse link 2 206,342,066 206,390,348 RGD:11533998
RGD:11535006
G Sf3b1 splicing factor 3b, subunit 1 JBrowse link 9 61,594,620 61,634,510 RGD:8554872
G Sf3b2 splicing factor 3b, subunit 2 JBrowse link 1 220,645,685 220,665,611 RGD:8554872
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:8554872
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:8554872
B-Cell Chronic Lymphocytic Leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:11080977
G Acoxl acyl-CoA oxidase-like JBrowse link 3 120,414,311 120,724,809 RGD:11554173
G Aicda activation-induced cytidine deaminase JBrowse link 4 155,359,909 155,371,104 RGD:11039455
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:11040549
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:11554173
G Bcl11a BAF chromatin remodeling complex subunit BCL11A JBrowse link 14 108,826,717 108,921,197 RGD:11100004
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:11522735
RGD:11554173
RGD:11526110
RGD:11526105
RGD:11526104
G Bmf Bcl2 modifying factor JBrowse link 3 110,303,515 110,324,125 RGD:11554173
G Braf B-Raf proto-oncogene, serine/threonine kinase JBrowse link 4 67,389,331 67,520,549 RGD:8554872
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:11040699
RGD:8554872
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:11038803
G Ccdc50 coiled-coil domain containing 50 JBrowse link 11 76,742,179 76,804,695 RGD:9685139
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:5490532
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:11352235
G Cd5 Cd5 molecule JBrowse link 1 226,770,912 226,791,861 RGD:11554173
G Cd79b CD79b molecule JBrowse link 10 94,497,445 94,500,591 RGD:11250403
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:11354969
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 JBrowse link 1 143,171,457 143,278,485 RGD:11554173
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:11344923
RGD:11352246
G Dkc1 dyskerin pseudouridine synthase 1 JBrowse link X 155,844,914 155,862,363 RGD:11251735
G Dnmt3b DNA methyltransferase 3 beta JBrowse link 3 149,131,541 149,170,061 RGD:9589146
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:11252203
RGD:11252204
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 JBrowse link 9 100,660,366 100,767,940 RGD:11554173
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:11049461
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:8554872
G Fcgr3a Fc fragment of IgG receptor IIIa JBrowse link 13 89,385,775 89,396,047 RGD:11352260
G Gnas GNAS complex locus JBrowse link 3 172,374,957 172,434,988 RGD:1601379
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:8554872
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:11354983
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:10755703
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:11041895
RGD:11049174
RGD:11049165
G Il19 interleukin 19 JBrowse link 13 47,663,592 47,677,869 RGD:11554173
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:11051968
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:11051967
RGD:11522755
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11522755
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11522755
RGD:11554173
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:11526160
RGD:11554173
RGD:11530024
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:11554173
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:8554872
G Lef1 lymphoid enhancer binding factor 1 JBrowse link 2 236,232,115 236,345,061 RGD:11554173
G Lrrc56 leucine rich repeat containing 56 JBrowse link 1 214,182,232 214,197,184 RGD:8554872
G Mir143 microRNA 143 JBrowse link 18 56,971,273 56,971,377 RGD:11554173
G Mir145 microRNA 145 JBrowse link 18 56,969,907 56,969,994 RGD:11554173
G Ms4a1 membrane spanning 4-domains A1 JBrowse link 1 227,429,241 227,441,492 RGD:2316994
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:11554173
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:8554872
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:11554173
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:11541127
G Plcg2 phospholipase C, gamma 2 JBrowse link 19 50,039,410 50,173,543 RGD:11554173
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:11554173
G Polb DNA polymerase beta JBrowse link 16 74,237,001 74,260,272 RGD:11554173
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:11554173
G Prame preferentially expressed antigen in melanoma JBrowse link X 106,082,984 106,091,256 RGD:11535021
G Prkd2 protein kinase D2 JBrowse link 1 78,767,911 78,796,223 RGD:11554173
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:11554173
G Qpct glutaminyl-peptide cyclotransferase JBrowse link 6 1,657,110 1,689,575 RGD:11554173
G Rbl2 RB transcriptional corepressor like 2 JBrowse link 19 17,300,088 17,346,865 RGD:11554173
G Sf3b1 splicing factor 3b, subunit 1 JBrowse link 9 61,594,620 61,634,510 RGD:11554173
RGD:8554872
G Sf3b2 splicing factor 3b, subunit 2 JBrowse link 1 220,645,685 220,665,611 RGD:8554872
G Sp140 SP140 nuclear body protein JBrowse link 9 92,618,088 92,665,431 RGD:11554173
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:11038662
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:11554173
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:5685033
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10449463
RGD:11041895
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b JBrowse link 15 51,433,853 51,464,215 RGD:11038717
RGD:11038718
G Tnfrsf11a TNF receptor superfamily member 11A JBrowse link 13 25,778,306 25,835,802 RGD:11554173
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:11554173
G Tnfsf13 TNF superfamily member 13 JBrowse link 10 56,286,964 56,290,680 RGD:1549466
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:11554173
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:11075074
RGD:8554872
RGD:11554173
G Vdr vitamin D receptor JBrowse link 7 139,344,452 139,394,138 RGD:11554173
G Xpo1 exportin 1 JBrowse link 14 108,007,421 108,049,088 RGD:8554872
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:11252204
hairy cell leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:11353776
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:11522762
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:11554173
Prolymphocytic Leukemia, T-Cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:8554872
G Jak3 Janus kinase 3 JBrowse link 16 20,107,471 20,120,678 RGD:11531125
G RGD1311251 similar to RIKEN cDNA 4930550C14 JBrowse link 8 57,983,168 58,012,474 RGD:8554872
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:11554173
T-cell large granular lymphocyte leukemia term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15639
    syndrome 5218
      primary immunodeficiency disease 957
        lymphoproliferative syndrome 605
          lymphocytic leukemia 277
            chronic lymphocytic leukemia 85
              B-Cell Chronic Lymphocytic Leukemia 73
              CLL/SLL + 0
              Richter's syndrome 0
              T-cell large granular lymphocyte leukemia 1
              hairy cell leukemia + 3
              prolymphocytic leukemia + 4
Path 2
Term Annotations click to browse term
  disease 15639
    disease of anatomical entity 14969
      Hemic and Lymphatic Diseases 1724
        hematopoietic system disease 1452
          Hematologic Neoplasms 790
            hematologic cancer 789
              leukemia 573
                lymphocytic leukemia 277
                  Lymphoblastic Leukemias 242
                    chronic lymphocytic leukemia 85
                      B-Cell Chronic Lymphocytic Leukemia 73
                      CLL/SLL + 0
                      Richter's syndrome 0
                      T-cell large granular lymphocyte leukemia 1
                      hairy cell leukemia + 3
                      prolymphocytic leukemia + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.