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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:pneumoconiosis
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Accession:DOID:10316 term browser browse the term
Definition:An interstitial lung disease that is caused by the inhalation of dust. (DO)
Synonyms:exact_synonym: pneumoconioses
 primary_id: MESH:D011009
 xref: ICD10CM:J64;   ICD9CM:505;   NCI:C26861
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
 
pneumoconiosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAN aggrecan EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,354
Ensembl chr15:88,803,436...88,875,354
JBrowse link
G ATR ATR serine/threonine kinase EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 3:142,449,235...142,578,793
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G CA1 carbonic anhydrase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014
JBrowse link
G CA3 carbonic anhydrase 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CAT catalase IEP protein:increased expression:respiratory system fluid/secretion RGD PMID:19273541 RGD:5130756 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CDH23 cadherin related 23 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr10:71,396,920...71,815,947
Ensembl chr10:71,396,920...71,815,947
JBrowse link
G H3-4 H3.4 histone EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 1:228,424,845...228,425,360
Ensembl chr 1:228,424,845...228,425,325
Ensembl chr 1:228,424,845...228,425,325
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 susceptibility IAGP DNA:polymorphisms:cds:HLA-DQB1*06, HLA-DQB1*08, HLA-DQB1*09 (human) RGD PMID:16188098 RGD:7421557 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HS3ST6 heparan sulfate-glucosamine 3-sulfotransferase 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr16:1,911,475...1,921,428
Ensembl chr16:1,911,475...1,918,415
JBrowse link
G IL27RA interleukin 27 receptor subunit alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr19:14,031,762...14,053,218
Ensembl chr19:14,031,762...14,053,218
JBrowse link
G IL4 interleukin 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21857939 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G MDM4 MDM4 regulator of p53 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 1:204,516,377...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G OVGP1 oviductal glycoprotein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 1:111,414,319...111,427,735
Ensembl chr 1:111,414,319...111,427,735
JBrowse link
G PTPRZ1 protein tyrosine phosphatase receptor type Z1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr 7:121,873,161...122,062,036
Ensembl chr 7:121,873,089...122,062,036
JBrowse link
G TICAM1 toll like receptor adaptor molecule 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712
JBrowse link
G TMPRSS3 transmembrane serine protease 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25445010 NCBI chr21:42,371,890...42,396,052
Ensembl chr21:42,371,887...42,396,091
Ensembl chr21:42,371,887...42,396,091
JBrowse link
anthracosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29394417 NCBI chr 1:160,151,603...160,186,980
Ensembl chr 1:160,151,586...160,186,980
Ensembl chr 1:160,151,586...160,186,980
JBrowse link
G FLACC1 flagellum associated containing coiled-coil domains 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29394417 NCBI chr 2:201,288,271...201,364,285
Ensembl chr 2:201,288,271...201,357,398
JBrowse link
G FNBP1P1 formin binding protein 1 pseudogene 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29394417 NCBI chr 2:74,120,519...74,121,816
Ensembl chr 2:74,120,680...74,123,218
JBrowse link
G IL1A interleukin 1 alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:20005085 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
JBrowse link
G IL1B interleukin 1 beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:20005085 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist EXP CTD Direct Evidence: marker/mechanism CTD PMID:20005085 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G RBM26 RNA binding motif protein 26 EXP CTD Direct Evidence: marker/mechanism CTD PMID:29394417 NCBI chr13:79,311,827...79,406,255
Ensembl chr13:79,311,824...79,406,477
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20005085 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
asbestosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG1 arginase 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26699812 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ATF6 activating transcription factor 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25324550 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G CFD complement factor D EXP CTD Direct Evidence: marker/mechanism CTD PMID:22832039 NCBI chr19:859,664...863,641
Ensembl chr19:859,664...863,641
JBrowse link
G CLCA1 chloride channel accessory 1 ISO mRNA, protein:increased expression:lung RGD PMID:17637221 RGD:4145655 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259
Ensembl chr 1:86,468,368...86,500,259
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 IEP mRNA:decreased expression:leukocyte RGD PMID:20514434 RGD:4892076 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G DDIT3 DNA damage inducible transcript 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25324550 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G EPHX1 epoxide hydrolase 1 susceptibility IAGP DNA:SNP:exon:p.Y113H (rs1051740) (human) RGD PMID:17159790 RGD:4889408 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G GSTM1 glutathione S-transferase mu 1 susceptibility IAGP DNA:deletion: : RGD PMID:9055949 RGD:5490588 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTT1 glutathione S-transferase theta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:17563610
G HSPA5 heat shock protein family A (Hsp70) member 5 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25324550 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24142982 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOS2 nitric oxide synthase 2 ISO
EXP
CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression:lung
CTD PMID:12160931, PMID:12160931, PMID:12051993 RGD:4891441, RGD:4891438 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PRDX1 peroxiredoxin 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22537621 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PRDX2 peroxiredoxin 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22537621 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G SERPINA1 serpin family A member 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:12368052 NCBI chr14:94,376,747...94,390,654
Ensembl chr14:94,376,747...94,390,693
JBrowse link
G SPP1 secreted phosphoprotein 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16221779, PMID:21514415 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,650...87,983,426
JBrowse link
G TNC tenascin C IEP protein:increased expression:pleura RGD PMID:10950882 RGD:4889594 NCBI chr 9:115,019,575...115,118,244
Ensembl chr 9:115,019,575...115,118,257
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:20486865 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TPM4 tropomyosin 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:22537621 NCBI chr19:16,067,507...16,103,005
Ensembl chr19:16,067,021...16,103,002
JBrowse link
berylliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme EXP CTD Direct Evidence: marker/mechanism CTD PMID:10194187 NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
JBrowse link
G BTNL2 butyrophilin like 2 susceptibility IAGP
EXP
DNA:SNP: :rs3117099(human)
CTD Direct Evidence: marker/mechanism
CTD PMID:17927685, PMID:17927685 RGD:9685029 NCBI chr 6:32,393,339...32,408,879
Ensembl chr 6:32,393,963...32,407,128
JBrowse link
G CCR5 C-C motif chemokine receptor 5 disease_progression IAGP DNA:polymorphisms:5' utr:multiple (human) RGD PMID:20075058 RGD:4892065 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G CD28 CD28 molecule EXP CTD Direct Evidence: marker/mechanism CTD PMID:12952926 NCBI chr 2:203,706,509...203,739,756
Ensembl chr 2:203,706,475...203,738,912
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:16766924 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G HLA-DPB1 major histocompatibility complex, class II, DP beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:8105536, PMID:11551429, PMID:14662898, PMID:15273960, PMID:17927685, PMID:17956852 NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,990...33,089,696
JBrowse link
G HLA-DPB2 major histocompatibility complex, class II, DP beta 2 (pseudogene) EXP CTD Direct Evidence: marker/mechanism CTD PMID:16272364 NCBI chr 6:33,112,516...33,129,113
Ensembl chr 6:33,112,451...33,129,084
JBrowse link
G HLA-DRB1 major histocompatibility complex, class II, DR beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:16272364, PMID:17927685 NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,578,769...32,589,848
JBrowse link
G HMOX1 heme oxygenase 1 IEP protein:increased activity:sputum RGD PMID:19453654 RGD:4145349 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha EXP CTD Direct Evidence: marker/mechanism CTD PMID:8977230 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL6 interleukin 6 EXP CTD Direct Evidence: marker/mechanism CTD PMID:8428540 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G TGFB1 transforming growth factor beta 1 severity IAGP
EXP
DNA:polymorphisms: :-509C>T (human)
CTD Direct Evidence: marker/mechanism
CTD PMID:15750822, PMID:17785866, PMID:17785866 RGD:4145294 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TNF tumor necrosis factor EXP CTD Direct Evidence: marker/mechanism CTD PMID:8428540, PMID:12449171, PMID:15127972, PMID:16980557 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
silicosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor EXP CTD Direct Evidence: marker/mechanism CTD PMID:22273745 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ARG1 arginase 1 ISO
EXP
mRNA:increased expression:lung (rat)
CTD Direct Evidence: marker/mechanism
CTD PMID:15292275, PMID:17365572 RGD:4143368 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ARPC2 actin related protein 2/3 complex subunit 2 ISO mRNA:altered expression:lung (rat) RGD PMID:18685790 RGD:4893904 NCBI chr 2:218,217,138...218,254,348
Ensembl chr 2:218,217,141...218,254,356
JBrowse link
G C3 complement C3 IAGP DNA:polymorphism (human) RGD PMID:12096683 RGD:5129516 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
JBrowse link
G CCL2 C-C motif chemokine ligand 2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:26163174 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL7 C-C motif chemokine ligand 7 ISO RGD PMID:21830856 RGD:6483764 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CD36 CD36 molecule treatment ISO RGD PMID:24053919 RGD:11041147 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CHIA chitinase acidic ISO mRNA:increased expression:lung (rat) RGD PMID:18685790 RGD:4893904 NCBI chr 1:111,290,851...111,320,566
Ensembl chr 1:111,290,851...111,320,566
JBrowse link
G CPM carboxypeptidase M EXP CTD Direct Evidence: marker/mechanism CTD PMID:24986923 NCBI chr12:68,842,193...68,963,469
Ensembl chr12:68,842,197...68,971,570
JBrowse link
G CSF2 colony stimulating factor 2 ISO protein:increased expression:serum: RGD PMID:21505002 RGD:10450467 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
JBrowse link
G CTLA4 cytotoxic T-lymphocyte associated protein 4 IEP RGD PMID:16831302 RGD:4891515 NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,867,771...203,873,965
JBrowse link
G EGR1 early growth response 1 ISO protein:increased expression:lung, epithelial cell, macrophage (rat) RGD PMID:15033019 RGD:5131937 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ELN elastin ISO protein:increased expression:lung connective tissue: RGD PMID:7573374 RGD:9585691 NCBI chr 7:74,027,772...74,069,907
Ensembl chr 7:74,027,789...74,069,907
JBrowse link
G HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 IAGP DNA:polymorphism: :HLA-DQB1*0402(human) RGD PMID:11776400 RGD:36049758 NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
JBrowse link
G HMOX1 heme oxygenase 1 ISO
IEP
protein:increased expression:serum, lung RGD PMID:16858012, PMID:16858012 RGD:4145384, RGD:4145384 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 ISO protein:increased expression:lung RGD PMID:19534998 RGD:10059658 NCBI chr 2:177,212,694...177,223,959
Ensembl chr 2:177,212,563...177,223,958
JBrowse link
G IL17A interleukin 17A ISO mRNA, protein:increased expression:lung RGD PMID:20421647 RGD:4888525 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL1B interleukin 1 beta EXP CTD Direct Evidence: marker/mechanism CTD PMID:23640035 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility
treatment
IAGP
ISO
DNA:SNP (human) RGD PMID:11264025, PMID:23842733 RGD:4142816, RGD:8551847 NCBI chr 2:113,099,365...113,134,016
Ensembl chr 2:113,107,214...113,134,016
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha ISO RGD PMID:21072213 RGD:4891500 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit EXP CTD Direct Evidence: marker/mechanism CTD PMID:27621875 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G MMP13 matrix metallopeptidase 13 ISO mRNA:increased expression:lung, fibroblast RGD PMID:9614183 RGD:10043156 NCBI chr11:102,942,995...102,955,732
Ensembl chr11:102,942,995...102,955,732
JBrowse link
G NOS2 nitric oxide synthase 2 ISO
EXP
CTD Direct Evidence: marker/mechanism CTD PMID:15292275, PMID:15205031 RGD:4891445 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G PDZRN4 PDZ domain containing ring finger 4 EXP CTD Direct Evidence: marker/mechanism CTD PMID:24986923 NCBI chr12:41,188,320...41,574,745
Ensembl chr12:41,188,320...41,574,745
JBrowse link
G PRKCB protein kinase C beta ISO protein:increased activation:alveolar macrophage RGD PMID:14680365 RGD:1625527 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PTEN phosphatase and tensin homolog EXP CTD Direct Evidence: marker/mechanism CTD PMID:27621875 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,863,625...87,971,930
JBrowse link
G TNF tumor necrosis factor treatment IAGP
ISO
DNA:polymorphisms: : RGD PMID:11264025, PMID:25199287 RGD:4142816, RGD:10450591 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A ISO RGD PMID:11208652 RGD:5131150 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B ISO RGD PMID:11208652 RGD:5131150 NCBI chr 1:12,166,948...12,209,222
Ensembl chr 1:12,166,991...12,209,228
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17777
    Occupational Diseases 116
      pneumoconiosis 75
        Byssinosis + 0
        Caplan's syndrome 0
        anthracosilicosis 0
        anthracosis + 8
        asbestosis 19
        bagassosis 0
        baritosis 0
        berylliosis 13
        kaolin pneumoconiosis 0
        mixed mineral dust pneumoconiosis 0
        pneumoconiosis due to talc 0
        siderosis + 0
        silicosis + 29
        slate pneumoconiosis 0
Path 2
Term Annotations click to browse term
  disease 17777
    disease of anatomical entity 16339
      respiratory system disease 2898
        lower respiratory tract disease 1798
          lung disease 1757
            Lung Injury 245
              pneumoconiosis 75
                Byssinosis + 0
                Caplan's syndrome 0
                anthracosilicosis 0
                anthracosis + 8
                asbestosis 19
                bagassosis 0
                baritosis 0
                berylliosis 13
                kaolin pneumoconiosis 0
                mixed mineral dust pneumoconiosis 0
                pneumoconiosis due to talc 0
                siderosis + 0
                silicosis + 29
                slate pneumoconiosis 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.