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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:pleurisy
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Accession:DOID:10247 term browser browse the term
Definition:A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. (DO)
Synonyms:exact_synonym: pleurisies;   pleuritides;   pleuritis
 primary_id: MESH:D010998
 xref: EFO:1001825;   ICD10CM:R09.1;   ICD9CM:511.8;   NCI:C26860
For additional species annotation, visit the Alliance of Genome Resources.

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show annotations for term's descendants           Sort by:
pleurisy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase ISO RGD PMID:16860713 RGD:5128847 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:9109363 RGD:4890429 NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931 		JBrowse link
G Anxa1 annexin A1 ISO RGD PMID:15784654 RGD:2306907 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:11853231 RGD:5129218 NCBI chrNW_004936604:551,774...567,014 JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:9208140 PMID:15316088 RGD:4891029 RGD:4891041 NCBI chrNW_004936604:548,844...551,031
Ensembl chrNW_004936604:548,847...549,956 		JBrowse link
G C3 complement C3 ISO protein:increased activity:pleural cavity RGD PMID:18256172 RGD:5129520 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Cat catalase ISO RGD PMID:19778612 RGD:5130749 NCBI chrNW_004936533:3,601,270...3,637,128
Ensembl chrNW_004936533:3,600,955...3,637,422 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 ISO protein:increased expression:pleural fluid RGD PMID:18056919 RGD:5130924 NCBI chrNW_004936588:4,973,476...4,998,365 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO protein:increased secretion:lung (mouse) RGD PMID:18672096 RGD:4890016 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 ISO associated with Mycobacterium Infections RGD PMID:17158890 RGD:4145643 NCBI chrNW_004936596:223,660...224,739
Ensembl chrNW_004936596:223,660...224,739 		JBrowse link
G Csf3 colony stimulating factor 3 ISO RGD PMID:8841835 RGD:11039424 NCBI chrNW_004936490:15,142,526...15,146,375
Ensembl chrNW_004936490:15,142,808...15,144,487 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO RGD PMID:14527170 RGD:5135449 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO RGD PMID:14527170 RGD:5135449 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Ednra endothelin receptor type A ISO RGD PMID:15107459 RGD:4892325 NCBI chrNW_004936535:1,950,117...2,005,786
Ensembl chrNW_004936535:1,949,941...2,005,910 		JBrowse link
G Esr1 estrogen receptor 1 ISO RGD PMID:17035596 RGD:4892303 NCBI chrNW_004936489:4,616,839...4,887,179
Ensembl chrNW_004936489:4,614,754...4,887,171 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism
associated with Tuberculosis; protein:increased expression:pleural fluid, natural killer cell (human)
protein:increased expression:bronchial epithelium (mouse)		 CTD
RGD		 PMID:11181422 PMID:19056932 PMID:19714575 RGD:4145510 RGD:4145519 NCBI chrNW_004936659:616,570...627,172
Ensembl chrNW_004936659:616,752...627,174 		JBrowse link
G Il10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chrNW_004936557:5,834,874...5,838,502
Ensembl chrNW_004936557:5,834,874...5,838,502 		JBrowse link
G Il15 interleukin 15 ISO RGD PMID:10823416 RGD:4990464 NCBI chrNW_004936535:6,344,348...6,358,803
Ensembl chrNW_004936535:6,344,395...6,350,197 		JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:21898269 RGD:7175307 NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008 		JBrowse link
G Il1b interleukin 1 beta ISO protein:increased expression:lung
CTD Direct Evidence: marker/mechanism
protein:increased expression:pleural cavity, exudate (rat)		 RGD
CTD		 PMID:11181422 PMID:20141620 PMID:20175894 PMID:21898269 RGD:4142808 RGD:4142826 RGD:7175307 NCBI chrNW_004936783:1,251,678...1,256,807
Ensembl chrNW_004936783:1,252,158...1,257,165 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO RGD PMID:8491511 RGD:4143233 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il6 interleukin 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11181422 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G LOC101961846 neutrophil elastase ISO RGD PMID:20860667 RGD:10450565 NCBI chrNW_004936588:345,678...347,420
Ensembl chrNW_004936588:345,678...347,413 		JBrowse link
G LOC101968920 eotaxin ISO protein:increased expression:pleural fluid RGD PMID:11564646 PMID:11877329 RGD:4145443 RGD:4145479 NCBI chrNW_004936538:835,436...848,907
Ensembl chrNW_004936538:835,859...837,710
Ensembl chrNW_004936538:835,859...837,710 		JBrowse link
G Mpo myeloperoxidase ISO protein:increased activity:lung RGD PMID:11577999 RGD:5130991 NCBI chrNW_004936490:4,809,773...4,819,070
Ensembl chrNW_004936490:4,809,631...4,819,070 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 ISO RGD PMID:14673141 RGD:6893408 NCBI chrNW_004936509:6,589,967...6,621,171
Ensembl chrNW_004936509:6,590,630...6,620,262 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO protein:increased expression:pleural cavity (rat) RGD PMID:20141620 PMID:21898269 RGD:4142808 RGD:7175307 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:15003994 RGD:6482741 NCBI chrNW_004936492:3,011,752...3,060,962
Ensembl chrNW_004936492:3,011,772...3,060,986 		JBrowse link
G Ptafr platelet activating factor receptor treatment ISO RGD PMID:8395390 RGD:10043147 NCBI chrNW_004936474:12,333,905...12,337,140
Ensembl chrNW_004936474:12,336,071...12,337,099 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO RGD PMID:15740981 PMID:20141620 RGD:4142808 RGD:5143929 NCBI chrNW_004936481:3,821,564...3,828,086 JBrowse link
G Selp selectin P ISO CTD Direct Evidence: marker/mechanism
protein:increased expression:lung		 CTD
RGD		 PMID:11181422 PMID:21147071 RGD:6219005 NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963 		JBrowse link
G Serpine1 serpin family E member 1 susceptibility ISO associated with Familial Mediterranean Fever;DNA: DNA:polymorphism:promoter:rs1799768 (human): RGD PMID:23052617 RGD:13207414 NCBI chrNW_004936543:1,032,543...1,040,956
Ensembl chrNW_004936543:1,032,794...1,039,123 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:11161459 PMID:11181422 PMID:15380531 PMID:20141620 RGD:4142808 RGD:4143474 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Tnfsf8 TNF superfamily member 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15380531 NCBI chrNW_004936487:4,057,637...4,081,207
Ensembl chrNW_004936487:4,057,643...4,081,207 		JBrowse link
pleuropneumonia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase ISO RGD PMID:12773506 RGD:4890419 NCBI chrNW_004936554:7,807,914...7,848,691
Ensembl chrNW_004936554:7,808,355...7,867,931 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14116
      respiratory system disease 3166
        Respiratory Tract Infections 473
          pleurisy 34
            pleuropneumonia 1
Path 2
Term Annotations click to browse term
  disease 16465
    disease of anatomical entity 14116
      respiratory system disease 3166
        lower respiratory tract disease 2031
          pleural disease 98
            pleurisy 34
              pleuropneumonia 1
paths to the root