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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:sleeping sickness
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Accession:DOID:10112 term browser browse the term
Definition:A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. (DO)
Synonyms:exact_synonym: African sleeping sickness;   African trypanosomiasis;   Nagana;   human African trypanosomiasis
 primary_id: MESH:D014353
 xref: EFO:0005225;   GARD:7826;   ICD10CM:B56;   ICD9CM:086.5;   NCI:C84541;   ORDO:3385
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
sleeping sickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS2 nitric oxide synthase 2 ISO protein:altered activity:brain, peritoneal macrophage RGD PMID:20169057 RGD:4891375 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588 		JBrowse link
G TSLP thymic stromal lymphopoietin susceptibility ISO protein:increased expression:serum (mouse) RGD PMID:28769924 RGD:38549587 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    disease by infectious agent 2127
      parasitic infectious disease 302
        parasitic protozoa infectious disease 155
          trypanosomiasis 26
            sleeping sickness 2
Path 2
Term Annotations click to browse term
  disease 17773
    disease by infectious agent 2127
      parasitic infectious disease 302
        parasitic protozoa infectious disease 155
          Euglenozoa Infections 83
            trypanosomiasis 26
              sleeping sickness 2
paths to the root