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Term:aminoglycoside-induced deafness
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Accession:DOID:0111734 term browser browse the term
Definition:A drug-induced hearing loss characterized by hearing loss induced by therapeutic doses of aminoglycoside antibiotics that has_material_basis_in mutation in the mitochondrial genes MTRNR1 or MTCO1 in combination with homozygous mutation in TRMU on chromosome 22q13.31. (DO)
Synonyms:exact_synonym: streptomycin ototoxicity;   streptomycin-induced deafness
 related_synonym: Deafness, mitochondrial, modifier of
 primary_id: MESH:C564013
 alt_id: OMIM:580000
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aminoglycoside-induced deafness term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mt-co1 mitochondrially encoded cytochrome c oxidase I JBrowse link MT 5,323 6,867 RGD:8554872
G Trmu tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase JBrowse link 7 126,756,140 126,772,749 RGD:7240710

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15992
    sensory system disease 4969
      auditory system disease 713
        inner ear disease 506
          sensorineural hearing loss 468
            aminoglycoside-induced deafness 2
Path 2
Term Annotations click to browse term
  disease 15992
    disease of anatomical entity 15263
      nervous system disease 10756
        sensory system disease 4969
          Otorhinolaryngologic Diseases 1119
            auditory system disease 713
              Hearing Disorders 577
                Hearing Loss 573
                  Deafness 263
                    nonsyndromic deafness 163
                      drug-induced hearing loss 9
                        aminoglycoside-induced deafness 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.