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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   Preterm PROM (Pregnancy);   Preterm Premature Rupture of Fetal Membranes
 primary_id: MESH:C563032
 alt_id: OMIM:610504;   RDO:0012486
For additional species annotation, visit the Alliance of Genome Resources.



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preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III ISO protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:9850057 PMID:11741975 PMID:11875051 PMID:18030675 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr 9:7,558,429...7,568,486
Ensembl chr 9:7,558,456...7,568,485
JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 susceptibility ISO ClinVar Annotator: match by OMIM:610504
ClinVar Annotator: match by term: Preterm premature rupture of the membranes
CTD Direct Evidence: marker/mechanism
ClinVar
OMIM
CTD
PMID:16938879 PMID:25741868 NCBI chr 7:99,345,375...99,353,239
Ensembl chr 7:99,345,376...99,353,239
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:84,432,855...84,476,775
Ensembl chr 2:84,432,855...84,476,775
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14541
    disease of anatomical entity 14141
      reproductive system disease 2735
        female reproductive system disease 1738
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 14541
    disease of anatomical entity 14141
      Urogenital Diseases 4055
        Female Urogenital Diseases and Pregnancy Complications 2043
          Pregnancy Complications 569
            Obstetric Labor Complications 36
              Fetal Membranes, Premature Rupture 15
                preterm premature rupture of the membranes 5
paths to the root