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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   Preterm PROM (Pregnancy);   Preterm Premature Rupture of Fetal Membranes
 primary_id: MESH:C563032
 alt_id: OMIM:610504;   RDO:0012486
For additional species annotation, visit the Alliance of Genome Resources.



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preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor IEP protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G MMP1 matrix metallopeptidase 1 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:9850057 PMID:11741975 PMID:11875051 PMID:18030675 NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
JBrowse link
G MMP8 matrix metallopeptidase 8 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr11:102,711,796...102,724,967
Ensembl chr11:102,711,796...102,727,050
JBrowse link
G SERPINH1 serpin family H member 1 susceptibility IAGP
EXP
ClinVar Annotator: match by term: Preterm premature rupture of the membranes
CTD Direct Evidence: marker/mechanism
ClinVar
CTD
OMIM
PMID:16938879 PMID:25741868 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783
JBrowse link
G TFPI tissue factor pathway inhibitor IEP protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:187,464,230...187,554,501
Ensembl chr 2:187,464,230...187,565,760
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 20297
    disease of anatomical entity 18901
      reproductive system disease 3414
        female reproductive system disease 1907
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 20297
    disease of anatomical entity 18901
      Urogenital Diseases 4873
        Female Urogenital Diseases and Pregnancy Complications 2234
          Pregnancy Complications 593
            Obstetric Labor Complications 36
              Fetal Membranes, Premature Rupture 15
                preterm premature rupture of the membranes 5
paths to the root