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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   preterm PROM (pregnancy);   preterm premature rupture of fetal membranes
 primary_id: MESH:C563032
 alt_id: OMIM:610504
 xref: MONDO:0012511


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preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor IEP protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G MMP1 matrix metallopeptidase 1 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160 		JBrowse link
G MMP8 matrix metallopeptidase 8 IAGP ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050 		JBrowse link
G SERPINH1 serpin family H member 1 susceptibility IAGP
EXP		 ClinVar Annotator: match by term: Preterm premature rupture of the membranes
CTD Direct Evidence: marker/mechanism		 ClinVar
OMIM
CTD		 PMID:16938879 PMID:25741868 PMID:28492532 PMID:32161841 NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783 		JBrowse link
G TFPI tissue factor pathway inhibitor IEP protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:187,464,230...187,554,435
Ensembl chr 2:187,464,230...187,565,760 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      reproductive system disease 4002
        female reproductive system disease 2461
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 41189
    disease of anatomical entity 32344
      Urogenital Diseases 6456
        Female Urogenital Diseases and Pregnancy Complications 2996
          Pregnancy Complications 862
            Obstetric Labor Complications 65
              Fetal Membranes, Premature Rupture 15
                preterm premature rupture of the membranes 5
paths to the root