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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   preterm PROM (pregnancy);   preterm premature rupture of fetal membranes
 broad_synonym: SERPINH1-RELATED CONDITION
 primary_id: MESH:C563032
 alt_id: MIM:610504
 xref: MONDO:0012511



show annotations for term's descendants           Sort by:
preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr 8:13,008,873...13,018,729
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Serpinh1 serpin family H member 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Preterm premature rupture of the membranes | ClinVar Annotator: match by term: SERPINH1-related condition
CTD
ClinVar
OMIM
PMID:16938879 PMID:25741868 PMID:28492532 PMID:32161841 PMID:37270749 NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801
JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 3:89,939,862...89,989,253
Ensembl chr 3:69,533,156...69,576,880
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      reproductive system disease 3191
        female reproductive system disease 2188
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 19141
    disease of anatomical entity 18453
      Urogenital Diseases 5391
        Female Urogenital Diseases and Pregnancy Complications 2668
          Pregnancy Complications 806
            Obstetric Labor Complications 50
              Fetal Membranes, Premature Rupture 15
                preterm premature rupture of the membranes 5
paths to the root