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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:preterm premature rupture of the membranes
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Accession:DOID:0111144 term browser browse the term
Definition:A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation. (DO)
Synonyms:exact_synonym: PPROM;   Preterm PROM (Pregnancy);   Preterm Premature Rupture of Fetal Membranes
 primary_id: MESH:C563032
 alt_id: OMIM:610504;   RDO:0012486
For additional species annotation, visit the Alliance of Genome Resources.


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preterm premature rupture of the membranes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO protein:increased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Mmp1 matrix metallopeptidase 1 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:9850057 PMID:11741975 PMID:11875051 PMID:18030675 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp8 matrix metallopeptidase 8 ISO ClinVar Annotator: match by term: Preterm premature rupture of the membranes ClinVar PMID:15367487 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520 		JBrowse link
G Serpinh1 serpin family H member 1 susceptibility ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Preterm premature rupture of the membranes		 OMIM
CTD
ClinVar		 PMID:16938879 PMID:25741868 PMID:28492532 NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO protein:decreased expression:plasma RGD PMID:19012190 RGD:11340215 NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18110
    disease of anatomical entity 17482
      reproductive system disease 2847
        female reproductive system disease 1837
          preterm premature rupture of the membranes 5
Path 2
Term Annotations click to browse term
  disease 18110
    disease of anatomical entity 17482
      Urogenital Diseases 4692
        Female Urogenital Diseases and Pregnancy Complications 2218
          Pregnancy Complications 655
            Obstetric Labor Complications 37
              Fetal Membranes, Premature Rupture 15
                preterm premature rupture of the membranes 5
paths to the root