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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:castration-resistant prostate carcinoma
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Accession:DOID:0080909 term browser browse the term
Definition:A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production. (DO)
Synonyms:exact_synonym: Androgen Independent Prostatic Cancer;   Androgen Independent Prostatic Neoplasms;   Androgen Insensitive Prostatic Cancer;   Androgen Insensitive Prostatic Neoplasms;   Androgen Resistant Prostatic Cancer;   Androgen Resistant Prostatic Neoplasms;   Androgen-Independent Prostatic Neoplasm;   Androgen-Insensitive Prostatic Cancers;   Androgen-Insensitive Prostatic Neoplasm;   Androgen-Resistant Prostatic Cancers;   Androgen-Resistant Prostatic Neoplasm;   Castration Resistant Prostatic Cancer;   Castration-Resistant Prostatic Cancers;   Castration-Resistant Prostatic Neoplasm;   Castration-Resistant Prostatic Neoplasms;   Hormone Refractory Prostatic Cancer;   androgen-independent prostatic cancers;   hormone refractory prostatic neoplasms
 primary_id: MESH:D064129
 alt_id: DOID:9004674
 xref: MONDO:0019570;   NCI:C130234



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castration-resistant prostate carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) ISO CTD Direct Evidence: marker/mechanism
mRNA,protein:increased expression:epithelial cell:
CTD
RGD
PMID:23196782 PMID:25555457 RGD:10053626 NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043
JBrowse link
G AR androgen receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:18985049 PMID:24740322 PMID:28500234 PMID:28757136 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912
JBrowse link
G ASF1B anti-silencing function 1B histone chaperone ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr20:48,398,615...48,406,889 JBrowse link
G CCNE2 cyclin E2 treatment ISO RGD PMID:27431942 RGD:13504681 NCBI chr29:39,534,872...39,551,141
Ensembl chr29:39,534,968...39,546,566
JBrowse link
G CENPK centromere protein K ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 2:51,262,475...51,300,016
Ensembl chr 2:51,263,185...51,292,425
JBrowse link
G CHD1 chromodomain helicase DNA binding protein 1 ISO DNA:mutations: : RGD PMID:22722839 RGD:9587749 NCBI chr 3:11,288,873...11,359,972
Ensembl chr 3:11,288,244...11,359,208
JBrowse link
G KDM1A lysine demethylase 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632
JBrowse link
G LOC609365 CD46 molecule, complement regulatory protein-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:30185663 NCBI chr 7:6,602,762...6,646,561 JBrowse link
G NUF2 NUF2 component of NDC80 kinetochore complex treatment ISO RGD PMID:28498618 RGD:28867238 NCBI chr38:19,574,122...19,599,821
Ensembl chr38:19,574,125...19,599,064
JBrowse link
G STAT5A signal transducer and activator of transcription 5A treatment
disease_progression
ISO DNA:CNV: :prostate (human) RGD PMID:23660011 RGD:151667415 NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103
JBrowse link
G TRIM24 tripartite motif containing 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27238081 NCBI chr16:10,033,993...10,133,450
Ensembl chr16:10,034,390...10,133,435
JBrowse link
G ZNF217 zinc finger protein 217 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr24:39,411,531...39,423,614
Ensembl chr24:39,412,277...39,438,204
JBrowse link
G ZNF367 zinc finger protein 367 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29581250 NCBI chr 1:70,461,631...70,485,380
Ensembl chr 1:70,461,776...70,483,053
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17773
    disease of cellular proliferation 7258
      cancer 5271
        cell type cancer 3626
          carcinoma 3098
            prostate carcinoma 152
              castration-resistant prostate carcinoma 13
Path 2
Term Annotations click to browse term
  disease 17773
    disease of anatomical entity 15130
      Urogenital Diseases 4710
        Urogenital Neoplasms 2130
          reproductive system neoplasm 1248
            reproductive organ cancer 1234
              male reproductive organ cancer 821
                prostate cancer 817
                  prostate carcinoma 152
                    castration-resistant prostate carcinoma 13
paths to the root