RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: castration-resistant prostate carcinoma
Accession: DOID:0080909
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Definition: A prostate carcinoma that is characterized by continued growth and spread despite the surgical removal of the testes or medical intervention to block androgen production. (DO)
Synonyms: exact_synonym: Androgen Independent Prostatic Cancer; Androgen Independent Prostatic Neoplasms; Androgen Insensitive Prostatic Cancer; Androgen Insensitive Prostatic Neoplasms; Androgen Resistant Prostatic Cancer; Androgen Resistant Prostatic Neoplasms; Androgen-Independent Prostatic Neoplasm; Androgen-Insensitive Prostatic Cancers; Androgen-Insensitive Prostatic Neoplasm; Androgen-Resistant Prostatic Cancers; Androgen-Resistant Prostatic Neoplasm; Castration Resistant Prostatic Cancer; Castration-Resistant Prostatic Cancers; Castration-Resistant Prostatic Neoplasm; Castration-Resistant Prostatic Neoplasms; Hormone Refractory Prostatic Cancer; androgen-independent prostatic cancers; hormone refractory prostatic neoplasms
primary_id: MESH:D064129
alt_id: DOID:9004674
xref: MONDO:0019570 ; NCI:C130234
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AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
ISO
CTD Direct Evidence: marker/mechanism mRNA,protein:increased expression:epithelial cell:
CTD RGD
PMID:23196782 PMID:25555457
RGD:10053626
NCBI chr 2:30,661,333...30,691,283
Ensembl chr 2:30,674,558...30,690,043
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AR
androgen receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18985049 PMID:24740322 PMID:28500234 PMID:28757136
NCBI chr24:34,713,390...34,731,461 NCBI chr X:51,969,785...52,167,450
Ensembl chr X:51,969,785...52,151,912
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ASF1B
anti-silencing function 1B histone chaperone
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29581250
NCBI chr20:48,398,615...48,406,889
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CCNE2
cyclin E2
treatment
ISO
RGD
PMID:27431942
RGD:13504681
NCBI chr29:39,534,872...39,551,141
Ensembl chr29:39,534,968...39,546,566
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CENPK
centromere protein K
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29581250
NCBI chr 2:51,262,475...51,300,016
Ensembl chr 2:51,263,185...51,292,425
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CHD1
chromodomain helicase DNA binding protein 1
ISO
DNA:mutations: :
RGD
PMID:22722839
RGD:9587749
NCBI chr 3:11,288,873...11,359,972
Ensembl chr 3:11,288,244...11,359,208
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KDM1A
lysine demethylase 1A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29581250
NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632
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LOC609365
CD46 molecule, complement regulatory protein-like
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30185663
NCBI chr 7:6,602,762...6,646,561
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NUF2
NUF2 component of NDC80 kinetochore complex
treatment
ISO
RGD
PMID:28498618
RGD:28867238
NCBI chr38:19,574,122...19,599,821
Ensembl chr38:19,574,125...19,599,064
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STAT5A
signal transducer and activator of transcription 5A
treatment disease_progression
ISO
DNA:CNV: :prostate (human)
RGD
PMID:23660011
RGD:151667415
NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103
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TRIM24
tripartite motif containing 24
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27238081
NCBI chr16:10,033,993...10,133,450
Ensembl chr16:10,034,390...10,133,435
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ZNF217
zinc finger protein 217
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29581250
NCBI chr24:39,411,531...39,423,614
Ensembl chr24:39,412,277...39,438,204
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ZNF367
zinc finger protein 367
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29581250
NCBI chr 1:70,461,631...70,485,380
Ensembl chr 1:70,461,776...70,483,053
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