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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:urinary tract infection
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Accession:DOID:0080784 term browser browse the term
Definition:An urinary system disease that is characterized by an infection in any part of the urinary system, including the kidneys, ureters, bladder or urethra. (DO)
Synonyms:exact_synonym: UTI;   urinary tract infections
 primary_id: MESH:D014552
 alt_id: MIM:603806
 xref: EFO:0003103;   ICD10CM:N39.0


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urinary tract infection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl15 C-X-C motif chemokine ligand 15 treatment ISO human recombinant protein in a mouse model RGD PMID:28011398 RGD:150520199 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 ISO RGD PMID:21151974 RGD:7207862 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 IMP RGD PMID:18401338 RGD:7257688 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Hspa1b heat shock protein 1B ISO DNA: SNP: :g.1267A>G RGD PMID:20379347 RGD:7242733 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:urine RGD PMID:19171043 RGD:2311084 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha ISO
IEP 		protein:increased expression:urine RGD PMID:19171043 PMID:21690238 RGD:2311084, RGD:6907113 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta ISO
IMP 		protein:increased expression:urine RGD PMID:19171043 PMID:20886104 RGD:2311084, RGD:7175340 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Lcn2 lipocalin 2 disease_progression
ameliorates
treatment 		IEP
IMP
ISO 		protein:increased expression:urine: RGD PMID:25398327 PMID:24937428 PMID:24937428 PMID:24937428 RGD:126779559, RGD:126779579, RGD:126779579, RGD:126779579 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible ISO CTD Direct Evidence: marker/mechanism CTD PMID:9011564 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pomc pro-opiomelanocortin-alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:6254450 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Tlr2 toll-like receptor 2 susceptibility ISO DNA:polymorphism: :p.R753Q (human) RGD PMID:18001294 RGD:7240561 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
G Tlr4 toll-like receptor 4 susceptibility ISO DNA:snp:cds:p.D299G (human) RGD PMID:19543401 RGD:7246906 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
bacteriuria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd209b CD209b antigen IMP associated with Escherichia Coli Infections RGD PMID:31998663 RGD:41410804 NCBI chr 8:3,967,655...3,976,841
Ensembl chr 8:3,967,655...3,976,844 		JBrowse link
urinary schistosomiasis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 antigen ISO protein:increased expression:B cell (human) RGD PMID:22347409 RGD:127345101 NCBI chr 3:86,903,141...86,919,665
Ensembl chr 3:86,903,141...86,906,748 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 susceptibility ISO DNA:SNPs:multiple:Gabonese(human) RGD PMID:22288822 RGD:7204674 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Il5 interleukin 5 resistance ISO RGD PMID:9697734 RGD:7241010 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 severity ISO DNA:SNP:enhancer: (rs324013) RGD PMID:18273035 RGD:7243977 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16271
    disease of anatomical entity 15863
      Urogenital Diseases 5076
        urinary system disease 2512
          urinary tract infection 17
            acute gonococcal cystitis 0
            bacteriuria 1
            pyuria 0
            sparganosis 0
            urinary schistosomiasis 4
paths to the root