RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: transverse myelitis
Accession: DOID:0080743
browse the term
Definition: A myelitis that is characterized by a band-like sensation across the trunk of the body, with sensory changes below. (DO)
Synonyms: exact_synonym: Demyelinative Myelitis; Necrotizing Myelitis; Paraneoplastic Myelitis; Postinfectious Myelitis; Postvaccinal Myelitis; Subacute Transverse Myelitis; acute transverse myelitis; subacute transverse myelitides; transverse myelopathy syndrome; transverse myelopathy syndromes
narrow_synonym: IDIOPATHIC TRANSVERSE MYELITIS
primary_id: MESH:D009188
G
AQP4
aquaporin 4
ISO
RGD
PMID:21771203 PMID:23999580
RGD:5148008 RGD:8696028
NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919
G
IL6
interleukin 6
ISO
protein:increased expression:serum, cerebral spinal fluid:
RGD
PMID:20128675
RGD:7829722
NCBI chr 7:23,415,922...23,420,767
G
VPS37A
VPS37A subunit of ESCRT-I
ISO
ClinVar Annotator: match by term: Idiopathic transverse myelitis
ClinVar
PMID:25741868 PMID:28492532 PMID:29473047
NCBI chr 8:16,459,660...16,508,333
Ensembl chr 8:13,404,889...13,456,046
G
AQP4
aquaporin 4
disease_progression
ISO
DNA:polymorphism:promoter:-1003A>G(human) associated withHiccup; CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16087714 PMID:18420727 PMID:18509235 PMID:20047900 PMID:22271321 PMID:23116879 PMID:23890015 PMID:23995423 PMID:24070676 More...
RGD:5148024 RGD:5148032 RGD:8695993 RGD:8696026 RGD:8696032 RGD:8696033 RGD:8696034
NCBI chr18:20,108,607...20,122,381
Ensembl chr18:23,713,146...23,726,919
G
CD59
CD59 molecule (CD59 blood group)
severity
ISO
RGD
PMID:28212662
RGD:13792592
NCBI chr11:33,680,580...33,708,479
Ensembl chr11:33,552,164...33,590,157
G
GFAP
glial fibrillary acidic protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18509235
NCBI chr17:12,407,211...12,417,072
Ensembl chr17:12,579,754...12,591,961
G
IL21
interleukin 21
ISO
protein:increased expression:cerebrospinal fluid (human)
RGD
PMID:23041403
RGD:127285589
NCBI chr 4:114,795,979...114,806,936
Ensembl chr 4:125,943,495...125,951,915
G
IL32
interleukin 32
exacerbates
ISO
protein:increased expression:blood plasma (human)
RGD
PMID:23180362
RGD:150340728
NCBI chr16:2,007,018...2,023,757
Ensembl chr16:3,179,637...3,203,929
G
IL6
interleukin 6
severity
ISO
protein:increased expression:serum, cerebral spinal fluid:
RGD
PMID:20128675
RGD:7829722
NCBI chr 7:23,415,922...23,420,767
G
LOC100972994
HLA class II histocompatibility antigen, DQ beta 1 chain
susceptibility
ISO
DNA:polymorphism:cds:HLA-DQB1*0402 (human) DNA:polymorphism:: HLA-DQB1*02:02 (human)
RGD
PMID:21908482 PMID:27049564
RGD:11530523 RGD:7421588
NCBI chr 6:32,237,395...32,244,201
Ensembl chr 6:33,353,599...33,360,272
G
MBP
myelin basic protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18509235
NCBI chr18:70,369,882...70,526,693
Ensembl chr18:73,629,522...73,755,351
G
MMP9
matrix metallopeptidase 9
ISO
protein:increased expression:serum
RGD
PMID:21621856
RGD:8547883
NCBI chr20:42,346,305...42,354,018
Ensembl chr20:43,432,389...43,440,129
G
NEFH
neurofilament heavy chain
ISO
protein:increased expression:serum:
RGD
PMID:23316360
RGD:27226805
NCBI chr22:10,525,738...10,536,788
G
NEFL
neurofilament light chain
ISO
protein:increased expression:serum (human)
RGD
PMID:33317883
RGD:127285024
NCBI chr 8:24,218,510...24,224,627
Ensembl chr 8:21,134,533...21,140,694
G
S100B
S100 calcium binding protein B
ISO
RGD
PMID:21371524
RGD:5508767
NCBI chr21:33,063,845...33,070,073
Ensembl chr21:46,197,750...46,203,953
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all