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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:multisystem inflammatory syndrome in children
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Accession:DOID:0080711 term browser browse the term
Definition:A Coronavirus infectious disease that is characterized by a patient aged less than 21 years with fever, laboratory evidence of inflammation, and evidence of clinically severe illness requiring hospitalization, with multisystem organ involvement (cardiovascular, dermatologic, gastrointestinal, hematologic, neurologic, renal, or respiratory) who tested positive for SARS-CoV-2 or had exposure to COVID-19. (DO)
Synonyms:exact_synonym: MIS-C;   multisystem inflammatory disorder in children and adolescents;   paediatric inflammatory multisystemic syndrome
 xref: MESH:C000705967;   MONDO:0035375


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multisystem inflammatory syndrome in children term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd163 CD163 molecule ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:158,770,749...158,804,146 		JBrowse link
G Cd84 CD84 molecule ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr13:86,859,979...86,899,984
Ensembl chr13:86,859,990...86,894,318 		JBrowse link
G Ifi44 interferon-induced protein 44 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:243,286,052...243,306,877 		JBrowse link
G Ifi44l interferon-induced protein 44-like ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:243,328,723...243,366,404 		JBrowse link
G Ifih1 interferon induced with helicase C domain 1 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:19264985 PMID:25741868 PMID:28492532 PMID:28716935 PMID:33440462 More... NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:67,637,545...67,683,968 		JBrowse link
G Ifna4 interferon, alpha 4 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 5:103,069,174...103,070,120
Ensembl chr 5:108,115,064...108,116,010 		JBrowse link
G Ifnar2 interferon alpha and beta receptor subunit 2 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:28492532 NCBI chr11:30,613,576...30,645,958
Ensembl chr11:44,099,753...44,131,937 		JBrowse link
G Ifnb1 interferon beta 1 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Il22ra2 interleukin 22 receptor subunit alpha 2 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 1:14,353,736...14,377,844
Ensembl chr 1:16,184,113...16,197,950 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:28492532 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:57,539,557...57,598,706 		JBrowse link
G Irf3 interferon regulatory factor 3 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:104,616,469...104,621,401 		JBrowse link
G Ly9 lymphocyte antigen 9 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr13:84,079,345...84,100,783
Ensembl chr13:86,611,784...86,657,293 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:25741868 PMID:28492532 PMID:33879512 PMID:35639375 NCBI chr 1:74,848,020...74,885,945
Ensembl chr 1:74,848,063...74,876,341 		JBrowse link
G Nlrp2 NLR family pyrin domain containing 2 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 1:69,515,505...69,554,689
Ensembl chr 1:78,557,956...78,597,160 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:10835631 PMID:15163896 PMID:23160464 PMID:25741868 PMID:28492532 NCBI chr 8:82,663,373...82,717,267
Ensembl chr 8:82,663,276...82,717,262 		JBrowse link
G Tlr3 toll-like receptor 3 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:25741868 PMID:26513235 PMID:28368532 PMID:28492532 NCBI chr16:53,554,916...53,572,321
Ensembl chr16:53,555,131...53,568,385 		JBrowse link
G Tlr6 toll-like receptor 6 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,698,751...43,740,462 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar PMID:28492532 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:136,027,157...136,128,363 		JBrowse link
G Trim69 tripartite motif-containing 69 ISO ClinVar Annotator: match by term: Multisystem inflammatory syndrome in children ClinVar NCBI chr 3:109,111,468...109,135,255
Ensembl chr 3:129,564,934...129,585,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19167
    disease by infectious agent 2257
      viral infectious disease 1722
        RNA Virus Infections 1401
          Nidovirales Infections 1029
            Coronaviridae Infections 1029
              Coronavirus infectious disease 1028
                multisystem inflammatory syndrome in children 19
paths to the root