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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thrombosis
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Accession:DOID:0060903 term browser browse the term
Definition:A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. (DO)
Synonyms:exact_synonym: Blood Clot;   Blood Clots;   Thromboses;   Thrombus
 primary_id: MESH:D013927


show annotations for term's descendants           Sort by:
thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin converting enzyme 2 treatment ISO RGD PMID:20111697 RGD:9685451 NCBI chr  X:162,922,338...162,971,414
Ensembl chr  X:162,922,328...162,971,416 		JBrowse link
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 PMID:28492532 NCBI chr 2:26,863,363...26,899,638
Ensembl chr 2:26,863,428...26,899,640 		JBrowse link
G Agt angiotensinogen ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:11881036 PMID:21501650 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Apoh apolipoprotein H ISO RGD PMID:24642748 RGD:10054118 NCBI chr11:108,286,123...108,305,222
Ensembl chr11:108,234,180...108,305,222 		JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16514058 NCBI chr12:105,529,431...105,561,503
Ensembl chr12:105,529,485...105,561,496 		JBrowse link
G C5ar1 complement component 5a receptor 1 ISO associated with Anti-Glomerular Basement Membrane Disease RGD PMID:11422211 RGD:1600652 NCBI chr 7:15,980,668...15,993,465
Ensembl chr 7:15,980,668...15,993,465 		JBrowse link
G Cd2 CD2 antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:16932337 NCBI chr 3:101,183,224...101,195,255
Ensembl chr 3:101,183,215...101,195,255 		JBrowse link
G Cd40 CD40 antigen IMP RGD PMID:21914625 RGD:5490522 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand susceptibility
treatment		 IMP
ISO		 associated with Endotoxemia
protein:increased expression:plasma (human)		 RGD PMID:21914625 PMID:15306157 PMID:27085896 RGD:5490522, RGD:11352250, RGD:11344959 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:16931792 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20978260 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16754899 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:14979412 PMID:25013951 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G F10 coagulation factor X ISO CTD Direct Evidence: marker/mechanism CTD PMID:1279834 NCBI chr 8:13,087,308...13,106,676
Ensembl chr 8:13,087,308...13,106,676 		JBrowse link
G F11 coagulation factor XI susceptibility ISO DNA:SNPs:intron: rs2289252,rs2036914(human) RGD PMID:22633531 PMID:19583818 RGD:11041774, RGD:11041778 NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068 		JBrowse link
G F12 coagulation factor XII (Hageman factor) ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606 		JBrowse link
G F13b coagulation factor XIII, beta subunit ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 NCBI chr 1:139,429,285...139,451,496
Ensembl chr 1:139,429,440...139,451,490 		JBrowse link
G F2 coagulation factor II treatment
no_association		 ISO
IMP		 DNA:mutation: :20210G>A (human)
CTD Direct Evidence: marker/mechanism
associated with Carotid Artery Injuries
associated with Behcet Syndrome;DNA:mutation: :20210G>A (human)		 CTD
RGD		 PMID:1279834 PMID:10064001 PMID:11132655 PMID:17245631 PMID:21070754 More... RGD:6893603, RGD:11035267, RGD:10449423, RGD:7394765, RGD:7387314, RGD:7387259 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F2r coagulation factor II thrombin receptor TAS RGD PMID:14529396 RGD:1581036 NCBI chr13:95,738,288...95,754,974
Ensembl chr13:95,738,311...95,754,995 		JBrowse link
G F3 coagulation factor III, tissue factor ISO associated with Antiphospholipid Syndrome
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11858183 PMID:25339356 PMID:9153543 RGD:11340222 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G F5 coagulation factor V ISO
IMP		 associated with kidney failure, chronic;DNA:mutation: :1691G>A(human)
ClinVar Annotator: match by term: Thrombus
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:9164807 PMID:11132655 PMID:25741868 PMID:16549134 PMID:11110695 RGD:6893627, RGD:11564340 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F9 coagulation factor IX ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Thrombus		 CTD
ClinVar		 PMID:1279834 PMID:7937052 PMID:19846852 PMID:25741868 NCBI chr  X:59,044,675...59,076,120
Ensembl chr  X:59,044,824...59,076,119 		JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III ISO RGD PMID:18983497 RGD:11040996 NCBI chr 1:170,878,738...170,893,477
Ensembl chr 1:170,878,743...170,892,504 		JBrowse link
G Fga fibrinogen alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:8473507 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Fgb fibrinogen beta chain susceptibility ISO associated with Lupus Nephritis;;DNA:polymorphism: :-455G>A (human)
ClinVar Annotator: match by term: Thrombus		 ClinVar
RGD		 PMID:10688828 PMID:19420351 PMID:20978265 PMID:24033266 PMID:25741868 More... RGD:7175506 NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170 		JBrowse link
G Fgg fibrinogen gamma chain ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:10688828 PMID:15795540 PMID:17938819 PMID:19300242 PMID:21228398 More... NCBI chr 3:82,915,031...82,922,363
Ensembl chr 3:82,915,031...82,922,356 		JBrowse link
G Flt3 FMS-like tyrosine kinase 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16932337 NCBI chr 5:147,267,551...147,337,299
Ensembl chr 5:147,267,551...147,337,299 		JBrowse link
G Fut4 fucosyltransferase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16932337 NCBI chr 9:14,659,755...14,663,418
Ensembl chr 9:14,659,616...14,663,689 		JBrowse link
G Gas6 growth arrest specific 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11175853 PMID:15130911 PMID:15733062 PMID:16564713 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490 		JBrowse link
G Gp1ba glycoprotein 1b, alpha polypeptide ISO CTD Direct Evidence: marker/mechanism CTD PMID:17334511 NCBI chr11:70,529,928...70,534,812
Ensembl chr11:70,529,948...70,532,862 		JBrowse link
G Gucy1a1 guanylate cyclase 1, soluble, alpha 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24213632 NCBI chr 3:81,999,734...82,053,253
Ensembl chr 3:81,999,734...82,053,096 		JBrowse link
G Hgf hepatocyte growth factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:15367830 NCBI chr 5:16,758,493...16,827,448
Ensembl chr 5:16,758,493...16,825,150 		JBrowse link
G Hmox1 heme oxygenase 1 IDA
ISO		 CTD Direct Evidence: therapeutic CTD
RGD		 PMID:19168058 PMID:15242554 RGD:1598405 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hrg histidine-rich glycoprotein ISO DNA, protein:missense mutation, decreased expression:exon, plasma:p.G85E (429G>A) (human)
ClinVar Annotator: match by term: Thrombus		 ClinVar
RGD		 PMID:25741868 PMID:34355501 PMID:9414276 RGD:1599656 NCBI chr16:22,769,822...22,780,409
Ensembl chr16:22,769,822...22,780,406 		JBrowse link
G Il10 interleukin 10 IAGP RGD PMID:12765335 RGD:1598469 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Itga2 integrin alpha 2 susceptibility ISO associated with Behcet Syndrome;DNA:snp:cds:c.807C>T (human) RGD PMID:14563646 PMID:12412731 RGD:1582298, RGD:1582300 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Itgam integrin alpha M ISO associated with atrial fibrillation;protein:increased expression:monocyte, granulocyte (human) RGD PMID:26411420 RGD:329901838 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Jak2 Janus kinase 2 IAGP associated with Budd-Chiari syndrome;DNA:missense mutation:cds:p.V617F (human) RGD PMID:22467227 RGD:15039391 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Klf4 Kruppel-like transcription factor 4 (gut) ISO CTD Direct Evidence: therapeutic CTD PMID:25339356 NCBI chr 4:55,527,137...55,536,984
Ensembl chr 4:55,527,143...55,532,466 		JBrowse link
G Klkb1 kallikrein B, plasma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25339356 NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896 		JBrowse link
G Kng1 kininogen 1 ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 NCBI chr16:22,876,970...22,900,828
Ensembl chr16:22,876,615...22,900,828 		JBrowse link
G Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor IMP associated with Antiphospholipid Syndrome RGD PMID:21119114 RGD:6483062 NCBI chr 4:107,659,337...107,734,037
Ensembl chr 4:107,659,066...107,734,037 		JBrowse link
G Mas1 MAS1 oncogene ISO CTD Direct Evidence: therapeutic CTD PMID:25339356 NCBI chr17:13,056,981...13,087,037
Ensembl chr17:13,059,966...13,087,030 		JBrowse link
G Mertk MER proto-oncogene tyrosine kinase IAGP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15130911 PMID:15130911 RGD:1582496 NCBI chr 2:128,540,836...128,645,082
Ensembl chr 2:128,540,876...128,644,814 		JBrowse link
G Mmp1a matrix metallopeptidase 1a (interstitial collagenase) ISO associated with Arteriovenous Fistula;DNA:insertion:promoter:g.-1607insG (rs11292517) (human) RGD PMID:20616161 RGD:7207048 NCBI chr 9:7,464,141...7,476,870
Ensembl chr 9:7,464,141...7,476,857 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) ISO associated with Arteriovenous Fistula;DNA:insertion:promoter:g.-1607insG (rs11292517) (human) RGD PMID:20616161 RGD:7207048 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO associated with Arteriovenous Fistula;DNA:insertion:promoter:g.-1612insA (rs35068180) (human) RGD PMID:20616161 RGD:7207048 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO associated with Arteriovenous Fistula;DNA:snp:promoter:g.-1562C>A (rs34016235) (human) RGD PMID:20616161 RGD:7207048 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase no_association ISO DNA:SNP: :677C>T (human) RGD PMID:10780318 RGD:10449414 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G P2ry1 purinergic receptor P2Y, G-protein coupled 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17334511 NCBI chr 3:60,910,206...60,916,403
Ensembl chr 3:60,910,216...60,916,403 		JBrowse link
G P2ry12 purinergic receptor P2Y, G-protein coupled 12 IMP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17334511 PMID:12897207 PMID:19692114 RGD:1580187, RGD:6480647 NCBI chr 3:59,123,692...59,170,408
Ensembl chr 3:59,123,693...59,170,292 		JBrowse link
G Pde3a phosphodiesterase 3A, cGMP inhibited ISO CTD Direct Evidence: marker/mechanism CTD PMID:17482796 NCBI chr 6:141,194,995...141,452,588
Ensembl chr 6:141,194,995...141,453,174 		JBrowse link
G Pf4 platelet factor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8282825 PMID:9446652 PMID:11588041 PMID:15795722 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 NCBI chr16:17,098,215...17,224,178
Ensembl chr16:17,098,215...17,224,178 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO RGD PMID:15834429 RGD:1580861 NCBI chr 9:98,920,455...99,022,264
Ensembl chr 9:98,918,707...99,022,674 		JBrowse link
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:2123154 PMID:12677255 PMID:19348381 PMID:22352330 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased activity:extracellular region (rat)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:2106299 PMID:2133253 PMID:2795766 PMID:4884574 PMID:8657906 More... RGD:2325698 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plg plasminogen ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 PMID:28492532 PMID:34355501 NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272 		JBrowse link
G Podxl podocalyxin-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:22016802 NCBI chr 6:31,496,428...31,540,872
Ensembl chr 6:31,496,423...31,540,916 		JBrowse link
G Proc protein C treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8967151 PMID:9164807 PMID:11132655 PMID:18376272 PMID:8073406 RGD:11250413 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Pros1 protein S (alpha) ISO CTD Direct Evidence: marker/mechanism CTD PMID:10706858 PMID:11132655 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709 		JBrowse link
G Ptger3 prostaglandin E receptor 3 (subtype EP3) ISO CTD Direct Evidence: marker/mechanism CTD PMID:17242161 NCBI chr 3:157,272,459...157,350,392
Ensembl chr 3:157,272,529...157,351,525 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20350286 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Selp selectin, platelet ISO CTD Direct Evidence: marker/mechanism CTD PMID:10544909 NCBI chr 1:163,942,833...163,977,595
Ensembl chr 1:163,942,833...163,977,595 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 treatment ISO DNA:missense mutation:cds:p.F229L (human)
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:2133253 PMID:6889048 PMID:8967151 PMID:11132655 PMID:12595305 More... RGD:1580119, RGD:11035267 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 ISO ClinVar Annotator: match by term: Thrombus ClinVar PMID:25741868 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 susceptibility
no_association		 ISO associated with Lupus Nephritis;;DNA:insertion/deletion: :
ClinVar Annotator: match by term: Thrombus
CTD Direct Evidence: marker/mechanism
associated with Behcet Syndrome;DNA:deletion:promoter:g.-676_-674delG (human)
associated with Behcet Syndrome;protein:increased expression:plasma (human)		 ClinVar
CTD
RGD		 PMID:12677255 PMID:22352330 PMID:25741868 PMID:17469143 PMID:12632020 More... RGD:7175506, RGD:7394765, RGD:8547802 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Sirt1 sirtuin 1 ISO CTD Direct Evidence: therapeutic CTD PMID:25339356 NCBI chr10:63,154,784...63,174,814
Ensembl chr10:63,154,784...63,217,483 		JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 IMP RGD PMID:9845553 RGD:11059524 NCBI chr 1:174,000,305...174,076,015
Ensembl chr 1:174,000,342...174,076,016 		JBrowse link
G Tbxas1 thromboxane A synthase 1, platelet ISO RGD PMID:12384182 RGD:1601457 NCBI chr 6:38,817,897...39,061,524
Ensembl chr 6:38,852,338...39,061,519 		JBrowse link
G Thbd thrombomodulin ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Thrombus		 CTD
ClinVar		 PMID:11132655 PMID:11518727 PMID:25741868 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tnf tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19691487 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tyro3 TYRO3 protein tyrosine kinase 3 IDA
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15733062 PMID:15733062 RGD:1580531 NCBI chr 2:119,628,123...119,648,585
Ensembl chr 2:119,628,214...119,648,585 		JBrowse link
G Vkorc1 vitamin K epoxide reductase complex, subunit 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Thrombus		 CTD
ClinVar		 PMID:15883587 PMID:15888487 PMID:15930419 PMID:15947090 PMID:16580898 More... NCBI chr 7:127,492,235...127,494,833
Ensembl chr 7:127,485,399...127,494,626
Ensembl chr 7:127,485,399...127,494,626 		JBrowse link
G Vtn vitronectin ISO RGD PMID:15069014 RGD:1580815 NCBI chr11:78,389,946...78,393,151
Ensembl chr11:78,389,917...78,393,150 		JBrowse link
G Vwf Von Willebrand factor ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Thrombus		 CTD
ClinVar		 PMID:3875694 PMID:12649144 PMID:14525793 PMID:15755288 PMID:15842375 More... NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
Arterial Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F7 coagulation factor VII treatment ISO human protein in a rat model RGD PMID:12714830 PMID:11167855 RGD:11041657, RGD:11049507 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G Flna filamin, alpha ISO ClinVar Annotator: match by term: Arterial thrombosis ClinVar PMID:25741868 NCBI chr  X:73,267,067...73,293,787
Ensembl chr  X:73,267,067...73,293,426 		JBrowse link
G Gp6 glycoprotein 6 platelet ameliorates
treatment		 IMP
ISO		 RGD PMID:25051961 PMID:17322098 PMID:16254207 PMID:23448972 PMID:15507524 RGD:401794404, RGD:401824682, RGD:401824681, RGD:401824648, RGD:401824646 NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743 		JBrowse link
G Gsn gelsolin ameliorates ISO human gene in mouse model RGD PMID:31002695 RGD:329333020 NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO protein:increased expression:plantar, foot muscle (rat) RGD PMID:22351094 RGD:8695963 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Il17a interleukin 17A IDA mouse protein in a rat model RGD PMID:24940514 RGD:9068933 NCBI chr 1:20,801,129...20,804,720
Ensembl chr 1:20,801,129...20,804,720 		JBrowse link
G Mbl2 mannose-binding lectin (protein C) 2 treatment ISO RGD PMID:25482922 RGD:11530049 NCBI chr19:30,210,306...30,217,087
Ensembl chr19:30,210,342...30,217,087 		JBrowse link
G Plat plasminogen activator, tissue treatment ISO associated with Antiphospholipid Syndrome RGD PMID:14630788 PMID:24806322 RGD:11541057, RGD:11541078 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO protein:increased expression:plasma (rat) RGD PMID:26857113 RGD:11073687 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment ISO human protein in a rat model RGD PMID:17850801 RGD:8655540 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Xdh xanthine dehydrogenase treatment ISO RGD PMID:26374946 RGD:13208952 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
Budd-Chiari syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A-I ISO protein: decreased expression: plasma (human) RGD PMID:21145806 RGD:25671435 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G F5 coagulation factor V severity
disease_progression
susceptibility		 ISO ClinVar Annotator: match by term: Budd-Chiari syndrome
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:R506Q (human)
associated with hyperhomocysteinemia:DNA:missense mutation:cds: (R506Q) (human)		 OMIM
ClinVar
CTD
RGD		 PMID:7586244 PMID:7803250 PMID:7877648 PMID:7910348 PMID:7911872 More... RGD:14700660, RGD:11537993, RGD:15036813, RGD:14700661 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G Insl6 insulin-like 6 ISO ClinVar Annotator: match by term: Budd-Chiari syndrome ClinVar PMID:15781101 PMID:15793561 PMID:15837627 PMID:15858187 PMID:15920007 More... NCBI chr19:29,298,754...29,302,718
Ensembl chr19:29,298,744...29,302,756 		JBrowse link
G Jak2 Janus kinase 2 ISO ClinVar Annotator: match by term: Budd-Chiari syndrome
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:15781101 PMID:15793561 PMID:15837627 PMID:15858187 PMID:15920007 More... NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:transition: :677C>T (human)
DNA:SNPs: :DNA:SNPs: :677C>T, 1298A>C(human)		 RGD PMID:12221667 PMID:26238013 RGD:10449395, RGD:11537993 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
carotid artery thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F3 coagulation factor III, tissue factor ISO associated with Diabetes Mellitus, Non-Insulin-Dependent RGD PMID:17969370 RGD:2313859 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G Gp1bb glycoprotein Ib, beta polypeptide IMP RGD PMID:17095718 RGD:11040529 NCBI chr16:18,439,069...18,441,153
Ensembl chr16:18,439,067...18,441,153 		JBrowse link
G Hmox1 heme oxygenase 1 treatment IMP associated with Anemia, Sickle Cell RGD PMID:23590132 RGD:10755698 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Itga2b integrin alpha 2b ISO CTD Direct Evidence: marker/mechanism CTD PMID:1605806 NCBI chr11:102,344,134...102,360,570
Ensembl chr11:102,344,123...102,360,948 		JBrowse link
G Itgb3 integrin beta 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1605806 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Klkb1 kallikrein B, plasma 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25339356 NCBI chr 8:45,719,725...45,747,872
Ensembl chr 8:45,719,726...45,747,896 		JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 ISO CTD Direct Evidence: therapeutic CTD PMID:11805133 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439 		JBrowse link
G Stxbp2 syntaxin binding protein 2 ISO CTD Direct Evidence: therapeutic CTD PMID:30696774 NCBI chr 8:3,680,960...3,693,998
Ensembl chr 8:3,680,955...3,693,644 		JBrowse link
G Thbd thrombomodulin ISO RGD PMID:21885846 RGD:5684980 NCBI chr 2:148,246,391...148,250,108
Ensembl chr 2:148,246,386...148,250,108 		JBrowse link
G Tlr2 toll-like receptor 2 IMP RGD PMID:28572286 RGD:15090824 NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074 		JBrowse link
central retinal vein occlusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Proc protein C treatment ISO RGD PMID:20688738 RGD:11100028 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:increased expression:neuroretina (rat) RGD PMID:21487926 RGD:5490120 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
cerebral venous thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit ISO ClinVar Annotator: match by term: Cerebral venous thrombosis ClinVar PMID:25741868 PMID:26467025 PMID:28492532 NCBI chr 8:85,065,257...85,366,880
Ensembl chr 8:85,065,268...85,366,875 		JBrowse link
G Gpx3 glutathione peroxidase 3 no_association ISO DNA:SNPs, haplotype:promoter:-942 A>C, -927 T>C, -861 A>T, -302 A>T, -284 T>A, -568 T>C, -518 T>C, -65 T>C (human) RGD PMID:18096833 PMID:19095977 RGD:401827161, RGD:401827164 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
coronary thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gp6 glycoprotein 6 platelet ISO DNA:missense mutation:CDS:c.13254T>C (human) RGD PMID:15306180 RGD:401793750 NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743 		JBrowse link
G Itgb3 integrin beta 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8598867 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: therapeutic CTD PMID:1452937 PMID:8172379 PMID:15301905 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
heparin cofactor II deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pi4ka phosphatidylinositol 4-kinase alpha ISO ClinVar Annotator: match by term: Heparin cofactor II deficiency | ClinVar Annotator: match by term: SERPIND1-related condition | ClinVar Annotator: match by term: Thrombotic stroke ClinVar PMID:2647747 PMID:8562924 PMID:8902986 PMID:11204559 PMID:25741868 More... NCBI chr16:17,098,215...17,224,178
Ensembl chr16:17,098,215...17,224,178 		JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Heparin cofactor II deficiency | ClinVar Annotator: match by term: SERPIND1-related condition | ClinVar Annotator: match by term: Thrombotic stroke		 OMIM
CTD
ClinVar		 PMID:2647747 PMID:8562924 PMID:8902986 PMID:11204559 PMID:25741868 More... NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439 		JBrowse link
intracranial sinus thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD PMID:12269725 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Gpx3 glutathione peroxidase 3 no_association ISO DNA:SNPs, haplotypes:promoter:rs8177412, rs870407, rs870406 (human) RGD PMID:20946167 RGD:401827165 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18941937 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
intracranial thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: therapeutic CTD PMID:8678742 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:6636041 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Vwf Von Willebrand factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:3111251 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
Lower Extremity Deep Vein Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 ISO associated with Behcet Syndrome;protein:increased expression:serum (human) RGD PMID:16273763 RGD:8548850 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
portal vein thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II severity ISO associated with liver cirrhosis;protein:increased expression:plasma (human) RGD PMID:28465646 RGD:14985237 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G Igf1r insulin-like growth factor I receptor susceptibility ISO associated with hepatocellular carcinoma;DNA:SNP:3'UTR:rs3743251(human) RGD PMID:24758241 RGD:14985227 NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO DNA:SNP: :677C>T(human) RGD PMID:27221722 PMID:25987440 RGD:14696705, RGD:14696749 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 susceptibility ISO DNA:polymorphism:promoter: RGD PMID:25987440 RGD:14696749 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
retinal vein occlusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp1 aquaporin 1 ISO RGD PMID:21487926 RGD:5490120 NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Aqp4 aquaporin 4 ISO mRNA:decreased expression:retina RGD PMID:21487926 RGD:5490120 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Crp C-reactive protein, pentraxin-related ISO protein:increased expression:serum: RGD PMID:6720266 RGD:9491754 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G F2 coagulation factor II no_association ISO DNA:SNP: :20210G>A (human) RGD PMID:22800650 PMID:14994919 RGD:7387258, RGD:7394774 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F5 coagulation factor V onset
no_association		 ISO associated with Behcet Syndrome;DNA:missense mutation:cds:p.R506Q (human)
CTD Direct Evidence: marker/mechanism
DNA:missense mutation:cds:1691G>A (human)
DNA:SNP:cds:1691G>A (human)		 CTD
RGD		 PMID:12022286 PMID:10511031 PMID:16113792 PMID:10634550 RGD:7394767, RGD:7394778, RGD:7394773 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G Fgf2 fibroblast growth factor 2 ISO RGD PMID:10342378 RGD:8655593 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Il1b interleukin 1 beta ISO mRNA:increased expression:neuroretina, retinal pigment epithelium (rat) RGD PMID:21487926 RGD:5490120 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:21487926 RGD:5490120 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Itga2 integrin alpha 2 susceptibility ISO DNA:snp, haplotype:cds:g.807C>T (human)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:12928694 PMID:12928694 RGD:8686430 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 ISO RGD PMID:21487926 RGD:5490120 NCBI chr 1:172,168,777...172,201,652
Ensembl chr 1:172,168,777...172,201,652 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO DNA:SNP:promoter:-1306C>T (rs243865) (human) RGD PMID:23791966 RGD:8657048 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility
no_association		 ISO DNA:SNP: :677C>T(human)
DNA:missense mutation:cds:677C>T (human)
DNA:SNP: :1298A>C(human)		 RGD PMID:10485556 PMID:24250697 PMID:23289804 RGD:7387256, RGD:10449421, RGD:10449405 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Nrp1 neuropilin 1 IAGP MouseDO NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844 		JBrowse link
G Pon1 paraoxonase 1 susceptibility ISO DNA:missense mutation:cds:p.L55M (human)
protein:decreased activity:serum (human)		 RGD PMID:23441121 PMID:18084236 RGD:8547547, RGD:8547555 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 susceptibility ISO DNA:deletion:promoter:g.-676_-674delG (human)
protein:increased activity:plasma (human)		 RGD PMID:16244763 PMID:15213845 RGD:8547742, RGD:8547805 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:decreased expression:vitreous humor (human) RGD PMID:21275514 RGD:8554901 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16680105 PMID:21487926 RGD:5490120 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vegfb vascular endothelial growth factor B ISO RGD PMID:21487926 RGD:5490120 NCBI chr19:6,959,840...6,965,019
Ensembl chr19:6,959,841...6,965,019 		JBrowse link
sagittal sinus thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F5 coagulation factor V ISO CTD Direct Evidence: marker/mechanism CTD PMID:18382986 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:10668740 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Pros1 protein S (alpha) ISO CTD Direct Evidence: marker/mechanism CTD PMID:18382986 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709 		JBrowse link
thrombophlebitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H2-M2 histocompatibility 2, M region locus 2 ISO associated with Behcet Syndrome; DNA:polymorphisms:cds:HLA-B35, HLA-B51 (human, Turkish) RGD PMID:12372094 RGD:7364924 NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443 		JBrowse link
G H2-Q4 histocompatibility 2, Q region locus 4 ISO associated with Behcet Syndrome; DNA:polymorphisms:cds:HLA-B35, HLA-B51 (human, Turkish) RGD PMID:12372094 RGD:7364924 NCBI chr17:35,598,593...35,603,650
Ensembl chr17:35,598,593...35,604,266 		JBrowse link
G Mir223 microRNA 223 ISO RGD PMID:32141571 RGD:26884338 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Pros1 protein S (alpha) ISO RGD PMID:12907438 RGD:1578677 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709 		JBrowse link
Venous Thrombosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts13 ADAM metallopeptidase with thrombospondin type 1 motif 13 treatment ISO RGD PMID:21095090 RGD:10449099 NCBI chr 2:26,863,363...26,899,638
Ensembl chr 2:26,863,428...26,899,640 		JBrowse link
G Apoe apolipoprotein E IMP RGD PMID:22119245 RGD:6903200 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Arvcf armadillo repeat gene deleted in velocardiofacial syndrome ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,166,046...18,225,826
Ensembl chr16:18,166,046...18,225,826 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO mRNA, protein:increased expression:vein RGD PMID:18167211 RGD:2307053 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Comt catechol-O-methyltransferase susceptibility ISO DNA:polymorphism: :324G>A
ClinVar Annotator: match by term: Deep venous thrombosis		 ClinVar
RGD		 PMID:25741868 PMID:31064749 PMID:18064318 RGD:2289709 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Csf2 colony stimulating factor 2 (granulocyte-macrophage) ISO CTD Direct Evidence: marker/mechanism CTD PMID:8120554 NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 ISO RGD PMID:7749835 RGD:5135275 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Dgcr8 DGCR8, microprocessor complex subunit ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,071,812...18,107,115
Ensembl chr16:18,071,812...18,107,110 		JBrowse link
G Epo erythropoietin ISO CTD Direct Evidence: marker/mechanism CTD PMID:12670338 PMID:17547733 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G F11 coagulation factor XI susceptibility ISO protein:increased activity:blood: RGD PMID:10706899 RGD:11041768 NCBI chr 8:45,693,696...45,715,092
Ensembl chr 8:45,694,211...45,715,068 		JBrowse link
G F12 coagulation factor XII (Hageman factor) susceptibility ISO DNA:polymorphism::46C>T(human)
associated with Pregnancy Complications; DNA:polymorphism::46C>T(human)		 RGD PMID:15116249 PMID:20141580 RGD:11041808, RGD:11041858 NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606 		JBrowse link
G F13a1 coagulation factor XIII, A1 subunit susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphism:cds:p.V34L(human)		 CTD
RGD		 PMID:10365735 PMID:9920839 PMID:12358922 RGD:1581032, RGD:10450745 NCBI chr13:37,051,150...37,234,220
Ensembl chr13:37,051,152...37,234,220 		JBrowse link
G F13b coagulation factor XIII, beta subunit ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Venous thrombosis, susceptibility to		 CTD
ClinVar		 PMID:12456499 PMID:16241947 PMID:25741868 NCBI chr 1:139,429,285...139,451,496
Ensembl chr 1:139,429,440...139,451,490 		JBrowse link
G F2 coagulation factor II ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9869612 PMID:12296757 PMID:19920886 PMID:9409269 PMID:23535565 RGD:1580342, RGD:10449430 NCBI chr 2:91,442,742...91,466,799
Ensembl chr 2:91,455,665...91,466,759 		JBrowse link
G F3 coagulation factor III, tissue factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:14967414 NCBI chr 3:121,517,186...121,528,701
Ensembl chr 3:121,517,186...121,528,697 		JBrowse link
G F5 coagulation factor V ISO DNA:missense mutation:cds:p.R506Q (human)
ClinVar Annotator: match by term: Deep venous thrombosis
CTD Direct Evidence: marker/mechanism
DNA:mutation: :1691G>A (human)
associated with Behcet Syndrome;DNA:SNP: :1691G>A (human)
associated with lupus erythematosus, systemic; DNA:polymorphism:cds:rs6025(human)		 ClinVar
CTD
RGD		 PMID:12296757 PMID:12827938 PMID:12865888 PMID:15033664 PMID:16875063 More... RGD:6893601, RGD:7394779, RGD:7394762, RGD:6893602 NCBI chr 1:163,979,396...164,048,539
Ensembl chr 1:163,979,407...164,047,846 		JBrowse link
G F7 coagulation factor VII treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14967414 PMID:16378835 RGD:11041650 NCBI chr 8:13,075,499...13,085,809
Ensembl chr 8:13,076,034...13,085,809 		JBrowse link
G F8 coagulation factor VIII ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16875063 PMID:15634269 RGD:1582359 NCBI chr  X:74,213,950...74,426,342
Ensembl chr  X:74,216,321...74,426,221 		JBrowse link
G Fga fibrinogen alpha chain ISO DNA:SNP: :rs6050 (human)
ClinVar Annotator: match by term: Deep vein thrombosis
protein:increased expression:peripheral blood (rat)		 ClinVar
RGD		 PMID:8473507 PMID:8636415 PMID:25741868 PMID:34355501 PMID:22353194 More... RGD:5688756, RGD:7207783 NCBI chr 3:82,933,460...82,940,934
Ensembl chr 3:82,933,383...82,940,934 		JBrowse link
G Fgb fibrinogen beta chain ISO ClinVar Annotator: match by term: Deep vein thrombosis | ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:12573244 PMID:15795540 PMID:25741868 PMID:28492532 PMID:31064749 NCBI chr 3:82,949,553...82,957,170
Ensembl chr 3:82,947,448...82,957,170 		JBrowse link
G Gm14305 predicted gene 14305 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr 2:176,400,146...176,413,606
Ensembl chr 2:176,400,121...176,413,606 		JBrowse link
G Gnb1l guanine nucleotide binding protein (G protein), beta polypeptide 1-like ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,316,029...18,385,430
Ensembl chr16:18,317,463...18,385,429 		JBrowse link
G Gp1bb glycoprotein Ib, beta polypeptide ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,439,069...18,441,153
Ensembl chr16:18,439,067...18,441,153 		JBrowse link
G Gp6 glycoprotein 6 platelet treatment ISO
IMP		 protein:increased expression:plasma (human) RGD PMID:25253166 PMID:16254207 RGD:401794452, RGD:401824681 NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743 		JBrowse link
G Gpx1 glutathione peroxidase 1 IMP RGD PMID:23426106 RGD:11352755 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Habp2 hyaluronic acid binding protein 2 ISO DNA:SNP: :p.G534E (rs7080536) (human) RGD PMID:22421107 RGD:11353820 NCBI chr19:56,275,541...56,309,252
Ensembl chr19:56,275,569...56,309,254 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:36162953 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hp haptoglobin ISO associated with Pulmonary Embolism;protein:increased expression:serum RGD PMID:17203959 RGD:1626365 NCBI chr 8:110,301,760...110,305,804
Ensembl chr 8:110,301,760...110,305,804 		JBrowse link
G Il10 interleukin 10 susceptibility ISO RGD PMID:16807647 RGD:1598472 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il18 interleukin 18 ISO protein:increased expression:serum RGD PMID:22318348 RGD:8655957 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1a interleukin 1 alpha ISO RGD PMID:17651586 RGD:2311092 NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:17651586 RGD:2311092 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist susceptibility ISO DNA:haplotype::rs2232354(human) RGD PMID:17413037 RGD:11528540 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Itga2 integrin alpha 2 no_association ISO RGD PMID:16380674 RGD:1582295 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Itgb3 integrin beta 3 susceptibility ISO associated with Behcet Syndrome; DNA:polymorphism: : RGD PMID:21813062 RGD:8693342 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Jak2 Janus kinase 2 no_association ISO DNA:SNPs, haplotype: :rs12342421, rs12343867 (human)
CTD Direct Evidence: marker/mechanism
DNA:mutation: :p.V617F (human)
DNA:SNP: :rs10974944 (human)		 CTD
RGD		 PMID:20434300 PMID:23845539 PMID:17059429 PMID:23845539 RGD:10449376, RGD:10449391, RGD:10449376 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Kdr kinase insert domain protein receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:26600200 NCBI chr 5:76,093,487...76,139,880
Ensembl chr 5:76,093,487...76,139,118 		JBrowse link
G Klhl22 kelch-like 22 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,577,485...17,611,246
Ensembl chr16:17,577,482...17,611,246 		JBrowse link
G Med15 mediator complex subunit 15 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,469,072...17,540,811
Ensembl chr16:17,469,072...17,550,755 		JBrowse link
G Mmp14 matrix metallopeptidase 14 (membrane-inserted) IDA RGD PMID:16171603 RGD:1582570 NCBI chr14:54,669,055...54,679,913
Ensembl chr14:54,669,069...54,682,821 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:20515599 PMID:16171603 RGD:2325775, RGD:1582570 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp3 matrix metallopeptidase 3 ISO RGD PMID:20515599 RGD:2325775 NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO
IDA		 mRNA:increased expression:femoral vein (rat) RGD PMID:20515599 PMID:16920980 RGD:2325775, RGD:1582648 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase no_association
susceptibility		 ISO DNA:transition:cds:g.677C>T (human)
CTD Direct Evidence: marker/mechanism
DNA:transition: :677C>T (human)
associated with Lupus Erythematosus, Systemic; DNA:transition, transversion:cds:g.677C>T rs1801133, g.1298A>C rs1801131 (human)		 CTD
RGD		 PMID:19123085 PMID:10929044 PMID:12442281 PMID:10792297 PMID:22707612 RGD:1580590, RGD:10449394, RGD:6893655, RGD:6893602 NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell susceptibility ISO associated with orthopedic surgery;DNA:SNP::rs1799983(human) RGD PMID:23922896 RGD:11533639 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 susceptibility ISO DNA:missense mutation:cds:p.L125V (human) RGD PMID:25846278 RGD:11541089 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Pf4 platelet factor 4 ISO associated with Wounds and Injuries;mRNA:increased expression:blood RGD PMID:32347511 RGD:329901817 NCBI chr 5:90,920,362...90,921,242
Ensembl chr 5:90,920,294...90,921,242 		JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,098,215...17,224,178
Ensembl chr16:17,098,215...17,224,178 		JBrowse link
G Pigm phosphatidylinositol glycan anchor biosynthesis, class M ISO CTD Direct Evidence: marker/mechanism CTD PMID:16767100 NCBI chr 1:172,204,098...172,211,666
Ensembl chr 1:172,204,113...172,211,666 		JBrowse link
G Plat plasminogen activator, tissue ISO CTD Direct Evidence: therapeutic
ClinVar Annotator: match by term: Deep venous thrombosis		 CTD
ClinVar		 PMID:11144008 PMID:15557913 PMID:19415734 PMID:25741868 PMID:31064749 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO CTD Direct Evidence: therapeutic CTD PMID:3161212 PMID:3488869 PMID:6359570 PMID:15557913 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plg plasminogen ISO CTD Direct Evidence: therapeutic
ClinVar Annotator: match by term: Deep vein thrombosis | ClinVar Annotator: match by term: Deep venous thrombosis		 CTD
ClinVar		 PMID:7215189 PMID:10233898 PMID:12850227 PMID:12876630 PMID:15269832 More... NCBI chr17:12,597,496...12,638,271
Ensembl chr17:12,597,495...12,638,272 		JBrowse link
G Ppbp pro-platelet basic protein ameliorates ISO
IMP		 associated with Wounds and Injuries;mRNA:increased expression:blood RGD PMID:32347511 PMID:23550035 RGD:329901817, RGD:401794958 NCBI chr 5:90,916,377...90,917,922
Ensembl chr 5:90,916,377...90,917,922 		JBrowse link
G Proc protein C ISO
IMP		 DNA:missense mutation:cds:p.Q184H (human)
ClinVar Annotator: match by term: Deep vein thrombosis | ClinVar Annotator: match by term: Deep venous thrombosis
CTD Direct Evidence: marker/mechanism
DNA:missense mutation: :c.565C>T (rs146922325) (human)
DNA:missense mutations: :p.D297H, p.V420L (human)
DNA:silent mutation, missense mutation:cds:g.66C>T, p.R147W (human)		 ClinVar
CTD
RGD		 PMID:1868249 PMID:7482420 PMID:8128429 PMID:8499565 PMID:8845458 More... RGD:1578515, RGD:11100014, RGD:11099990, RGD:11099989, RGD:11035247, RGD:1578391 NCBI chr18:32,256,179...32,272,623
Ensembl chr18:32,256,179...32,272,623 		JBrowse link
G Pros1 protein S (alpha) ISO DNA:missense mutation:cds:p.G295V (human)
ClinVar Annotator: match by term: Deep vein thrombosis		 ClinVar
RGD		 PMID:7803790 PMID:12351389 PMID:20880255 PMID:22261441 PMID:25741868 More... RGD:9743896 NCBI chr16:62,674,670...62,749,709
Ensembl chr16:62,674,670...62,749,709 		JBrowse link
G Ranbp1 RAN binding protein 1 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,057,843...18,066,558
Ensembl chr16:18,057,648...18,066,596 		JBrowse link
G Rtn4r reticulon 4 receptor ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,945,506...17,970,272
Ensembl chr16:17,945,506...17,970,272 		JBrowse link
G Scarf2 scavenger receptor class F, member 2 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,615,146...17,626,158
Ensembl chr16:17,615,146...17,626,157 		JBrowse link
G Septin5 septin 5 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,440,561...18,448,688
Ensembl chr16:18,439,252...18,448,704 		JBrowse link
G Serpina10 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Venous thrombosis, susceptibility to		 CTD
ClinVar		 PMID:15461625 PMID:25741868 NCBI chr12:103,582,934...103,597,681
Ensembl chr12:103,581,045...103,597,703 		JBrowse link
G Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 susceptibility ISO protein:increased expression:plasma (human) RGD PMID:12139754 RGD:1580299 NCBI chr12:104,065,572...104,072,397
Ensembl chr12:104,067,372...104,072,396 		JBrowse link
G Serpinc1 serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 IMP
ISO		 ClinVar Annotator: match by term: Deep venous thrombosis
CTD Direct Evidence: marker/mechanism
DNA:missense mutations: :multiple		 ClinVar
CTD
RGD		 PMID:55783 PMID:1483705 PMID:1555650 PMID:1977621 PMID:2336381 More... RGD:11035247, RGD:11035248 NCBI chr 1:160,806,153...160,830,113
Ensembl chr 1:160,806,155...160,833,433 		JBrowse link
G Serpind1 serine (or cysteine) peptidase inhibitor, clade D, member 1 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:17,149,235...17,161,438
Ensembl chr16:17,149,235...17,161,439 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 ISO DNA:deletion:promoter:g.-676_-674delG (human)
mRNA:increased expression:femoral vein (rat)		 RGD PMID:14653439 PMID:26535698 PMID:9535178 RGD:1580132, RGD:11060966, RGD:8547875 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Tango2 transport and golgi organization 2 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,118,689...18,165,962
Ensembl chr16:18,118,689...18,165,967 		JBrowse link
G Tbx1 T-box 1 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,399,729...18,409,412
Ensembl chr16:18,399,729...18,409,421 		JBrowse link
G Tbxa2r thromboxane A2 receptor treatment ISO RGD PMID:7848332 RGD:11059887 NCBI chr10:81,164,102...81,171,008
Ensembl chr10:81,164,565...81,171,006 		JBrowse link
G Tfpi tissue factor pathway inhibitor ISO
IMP		 protein:increased expression:plasma:
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:18480984 PMID:18600090 PMID:17973652 PMID:12560220 RGD:11060130, RGD:11060257, RGD:11060137 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119 		JBrowse link
G Trmt2a TRM2 tRNA methyltransferase 2A ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,066,747...18,072,636
Ensembl chr16:18,066,543...18,072,636 		JBrowse link
G Txnrd2 thioredoxin reductase 2 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ISO protein:increased expression:thrombus, vein RGD PMID:23199547 RGD:7207783 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Zdhhc8 zinc finger, DHHC domain containing 8 ISO ClinVar Annotator: match by term: Deep venous thrombosis ClinVar PMID:25741868 PMID:31064749 NCBI chr16:18,038,612...18,056,471
Ensembl chr16:18,038,617...18,053,000 		JBrowse link
venous tributary occlusion of retina term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2 integrin alpha 2 no_association ISO DNA:snp:cds:g.807C>T (human) RGD PMID:16157382 RGD:1582301 NCBI chr13:114,969,617...115,068,588
Ensembl chr13:114,969,617...115,068,636 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 ISO protein:decreased expression:vitreous humor (human) RGD PMID:20714746 RGD:8554903 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      cardiovascular system disease 4698
        vascular disease 3257
          thrombosis 148
            Arterial Thrombosis 11
            Dysfibrinogenemia Causing Recurrent Thrombosis 0
            Venous Thrombosis + 91
            coronary thrombosis 3
            heparin cofactor II deficiency 2
            intracranial thrombosis + 20
            livedoid vasculitis 0
Path 2
Term Annotations click to browse term
  disease 16268
    disease of anatomical entity 15860
      cardiovascular system disease 4698
        vascular disease 3257
          Embolism and Thrombosis 172
            thrombosis 148
              Arterial Thrombosis 11
              Dysfibrinogenemia Causing Recurrent Thrombosis 0
              Venous Thrombosis + 91
              coronary thrombosis 3
              heparin cofactor II deficiency 2
              intracranial thrombosis + 20
              livedoid vasculitis 0
paths to the root