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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:drug allergy
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Accession:DOID:0060500 term browser browse the term
Definition:An allergic disease that is triggered by a drug. (DO)
Synonyms:exact_synonym: Drug Allergies;   Drug Hypersensitivities;   Drug Hypersensitivity
 primary_id: MESH:D004342
 xref: EFO:0009482


show annotations for term's descendants           Sort by:
drug allergy term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20216337 NCBI chr14:110,955,698...111,038,898
Ensembl chr14:110,955,633...111,037,537 		JBrowse link
G ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18727619 NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703 		JBrowse link
G ADORA1 adenosine A1 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19019667 NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365 		JBrowse link
G ADORA2A adenosine A2a receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:19019667 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G CCL11 chemokine (C-C motif) ligand 11 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14616128 NCBI chr12:40,779,906...40,782,862
Ensembl chr12:40,779,173...40,782,893 		JBrowse link
G CCL24 C-C motif chemokine ligand 24 ISO CTD Direct Evidence: marker/mechanism CTD PMID:14616128 NCBI chr 3:10,347,397...10,361,500 JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16630147 NCBI chr  X:62,380,778...62,407,736
Ensembl chr  X:62,380,780...62,456,689 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15970796 NCBI chr11:18,988,665...19,011,015
Ensembl chr11:18,987,174...19,011,015 		JBrowse link
G FASLG Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:19706026 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G FCER1A Fc epsilon receptor Ia ISO CTD Direct Evidence: marker/mechanism CTD PMID:17125826 PMID:20485159 NCBI chr 4:91,118,867...91,125,448
Ensembl chr 4:91,118,879...91,125,437 		JBrowse link
G FCER1G Fc epsilon receptor Ig ISO CTD Direct Evidence: marker/mechanism CTD PMID:18534082 PMID:18595682 NCBI chr 4:89,242,467...89,246,344
Ensembl chr 4:89,242,472...89,246,450 		JBrowse link
G GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) ISO CTD Direct Evidence: marker/mechanism CTD PMID:19706026 NCBI chr 7:74,705,499...74,708,781
Ensembl chr 7:74,705,409...74,708,790 		JBrowse link
G HNMT histamine N-methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr15:13,733,412...13,768,106
Ensembl chr15:13,732,680...13,768,199 		JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:16538175 NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,914,629 		JBrowse link
G IL10 interleukin 10 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19222424 PMID:20485159 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378 		JBrowse link
G IL13 interleukin 13 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093 		JBrowse link
G IL2 interleukin 2 ISO RGD PMID:1549655 RGD:8662975 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15867870 PMID:20485159 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G IL4R interleukin 4 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544 		JBrowse link
G LOC100737977 tumor necrosis factor receptor superfamily member 10B-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19652058 NCBI chr14:7,344,788...7,371,086 JBrowse link
G LOC100739508 glutathione S-transferase P-like susceptibility ISO associated with Acquired Immunodeficiency Syndrome;DNA:polymorphism:exon:A>G313 (rs1695) (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16297214 PMID:20485159 RGD:5490995 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G LTC4S leukotriene C4 synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16433794 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285 		JBrowse link
G MLN motilin ISO CTD Direct Evidence: marker/mechanism CTD PMID:16538176 NCBI chr 7:30,003,501...30,013,064
Ensembl chr 7:30,003,526...30,013,064 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16839402 PMID:18534082 PMID:20485159 NCBI chr 2:11,400,415...11,420,314
Ensembl chr 2:11,400,420...11,420,298 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19767079 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228 		JBrowse link
G POSTN periostin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr11:13,225,183...13,258,973
Ensembl chr11:13,224,959...13,258,978 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20587336 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17508966 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035 		JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21233199 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21449675 NCBI chr18:9,717,291...9,886,699
Ensembl chr18:9,717,294...9,886,681 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:11294926 PMID:20485159 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
aspirin-induced respiratory disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNG6 calcium voltage-gated channel auxiliary subunit gamma 6 susceptibility ISO DNA:SNP,haplotype:rs192808(human) RGD PMID:20860846 RGD:13524562 NCBI chr 6:56,123,598...56,151,145
Ensembl chr 6:56,129,834...56,151,133 		JBrowse link
G CCR2 C-C motif chemokine receptor 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:20022477 PMID:20485159 RGD:4145619 NCBI chr13:29,251,950...29,286,470
Ensembl chr13:29,285,012...29,376,343 		JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 PMID:17641958 PMID:20485159 NCBI chr  X:62,380,778...62,407,736
Ensembl chr  X:62,380,780...62,456,689 		JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 ISO CTD Direct Evidence: marker/mechanism
DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human)		 CTD
RGD		 PMID:15970796 PMID:16502481 PMID:20485159 RGD:5144000 NCBI chr11:18,988,665...19,011,015
Ensembl chr11:18,987,174...19,011,015 		JBrowse link
G FANCC FA complementation group C ISO DNA:haplotype::rs4647416(human) RGD PMID:21670957 RGD:11045795 NCBI chr10:26,796,546...27,055,271
Ensembl chr10:26,796,572...27,061,801 		JBrowse link
G IL4 interleukin 4 susceptibility ISO DNA:SNPs:promoter,5'UTR,intron:multiple RGD PMID:20921925 RGD:11528633 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G LTC4S leukotriene C4 synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159 NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285 		JBrowse link
G MS4A2 membrane spanning 4-domains A2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 NCBI chr 2:11,400,415...11,420,314
Ensembl chr 2:11,400,420...11,420,298 		JBrowse link
G POSTN periostin ISO CTD Direct Evidence: marker/mechanism CTD PMID:18391768 NCBI chr11:13,225,183...13,258,973
Ensembl chr11:13,224,959...13,258,978 		JBrowse link
G PTGDR2 prostaglandin D2 receptor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr 2:10,891,280...10,897,194
Ensembl chr 2:10,892,011...10,903,017 		JBrowse link
G PTGER2 prostaglandin E receptor 2 ISO ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to ClinVar PMID:15496426 NCBI chr 1:181,993,961...182,009,959
Ensembl chr 1:181,994,560...182,009,953 		JBrowse link
G PTGIR prostaglandin I2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:20485159 NCBI chr 6:52,522,639...52,527,338
Ensembl chr 6:52,522,638...52,527,345 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO protein:increased expression:mast cell
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:9487340 PMID:16502481 PMID:20485159 RGD:5143936 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G TAP2 transporter 2, ATP binding cassette subfamily B member ISO RGD PMID:21796142 RGD:5147839 NCBI chr 7:25,045,085...25,056,915
Ensembl chr 7:25,045,685...25,056,300 		JBrowse link
G TBX21 T-box transcription factor 21 ISO ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to ClinVar PMID:15806396 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
G TBXA2R thromboxane A2 receptor susceptibility ISO DNA:polymorphism: :795T>C (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:15898979 PMID:16502481 PMID:20485159 RGD:11059537 NCBI chr 2:75,068,413...75,081,305
Ensembl chr 2:75,068,698...75,087,731 		JBrowse link
asthma, nasal polyps, and aspirin intolerance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX15 arachidonate 15-lipoxygenase ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar PMID:17959182 PMID:21558275 PMID:30643255 NCBI chr12:52,287,174...52,295,873
Ensembl chr12:52,287,160...52,295,871 		JBrowse link
G PTGER2 prostaglandin E receptor 2 susceptibility ISO CTD Direct Evidence: marker/mechanism OMIM
CTD		 NCBI chr 1:181,993,961...182,009,959
Ensembl chr 1:181,994,560...182,009,953 		JBrowse link
G TBX21 T-box transcription factor 21 susceptibility ISO ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance ClinVar
OMIM		 PMID:25741868 NCBI chr12:23,996,415...24,009,353
Ensembl chr12:23,996,415...24,009,355 		JBrowse link
Drug Eruptions term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,016...90,907,094 		JBrowse link
G APOA1 apolipoprotein A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21055120 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G APOC2 apolipoprotein C2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21055120 NCBI chr 6:51,404,219...51,406,302 JBrowse link
G APOC3 apolipoprotein C3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21055120 NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533 		JBrowse link
G BDNF brain derived neurotrophic factor ISO mRNA:increased expression:lymph node, ear: RGD PMID:19904815 RGD:8657071 NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,624,048...32,679,765 		JBrowse link
G C4A complement C4A (Rodgers blood group) ISO CTD Direct Evidence: marker/mechanism CTD PMID:21055120 NCBI chr 7:24,068,019...24,083,060
Ensembl chr 7:24,068,019...24,083,061 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19351467 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP2C49 cytochrome P450 2C49 susceptibility
treatment		 ISO DNA:SNP: :Rs4244285(human)
associated with tuberculosis; DNA.polymorphism, haplotype:cds:p.W212X (human)		 RGD PMID:20941486 PMID:23551241 RGD:11352742 RGD:124713543 NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19351467 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817 		JBrowse link
G FCER1A Fc epsilon receptor Ia ISO CTD Direct Evidence: marker/mechanism CTD PMID:16502481 NCBI chr 4:91,118,867...91,125,448
Ensembl chr 4:91,118,879...91,125,437 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:31150805 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IL17A interleukin 17A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31150805 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153 		JBrowse link
G IL18 interleukin 18 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18204966 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL2 interleukin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31150805 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G IL4 interleukin 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19351467 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365 		JBrowse link
G KNG1 kininogen 1 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:1371395 PMID:3034372 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958 		JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:18204966 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:14723717 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:31150805 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G TAC1 tachykinin precursor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:1371395 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:31150805 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TTR transthyretin ISO CTD Direct Evidence: marker/mechanism CTD PMID:21055120 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,326...115,503,977 		JBrowse link
Drug Hypersensitivity Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1QA complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,204 		JBrowse link
G C1QB complement C1q B chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 6:80,601,680...80,606,076
Ensembl chr 6:80,601,665...80,607,471 		JBrowse link
G C1QC complement C1q C chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452 		JBrowse link
G CRP C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G HSPA1L heat shock protein family A (Hsp70) member 1 like ISO DNA:polymorphism, haplotype: :p.M493T (human) RGD PMID:15024131 RGD:8662461 NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,914,629 		JBrowse link
G IL1RN interleukin 1 receptor antagonist ISO DNA:SNP:intron:rs2234663 (human) RGD PMID:23461376 RGD:11051970
G LBP lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G LOC110258578 interleukin-1 beta-like ISO DNA:SNP:promoter:-511C>T (rs 16944) (human) RGD PMID:23461376 RGD:11051970
G LRG1 leucine rich alpha-2-glycoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 2:74,300,598...74,303,117
Ensembl chr 2:74,300,619...74,314,315 		JBrowse link
G ORM1 orosomucoid 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 1:254,939,154...254,943,065 JBrowse link
G VWF von Willebrand factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,452 		JBrowse link
erythema nodosum term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,212...72,472,228 		JBrowse link
G CFB complement factor B ISO associated with Leprosy RGD PMID:2783924 RGD:7421527 NCBI chr 7:24,034,077...24,040,523
Ensembl chr 7:24,033,740...24,041,179 		JBrowse link
G LTA lymphotoxin alpha ISO associated with Sarcoidosis;DNA:polymorphism:intron RGD PMID:19225544 RGD:8548773 NCBI chr 7:23,696,387...23,698,280
Ensembl chr 7:23,696,040...23,698,299 		JBrowse link
G TNF tumor necrosis factor susceptibility ISO associated with Inflammatory Bowel Diseases;DNA:polymorphisms: :-1031T>C(human) RGD PMID:12198697 RGD:7364926 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G VDR vitamin D receptor susceptibility ISO associated with Behcet Syndrome;DNA:polymorphism: : rs7975232(human) RGD PMID:24880677 RGD:13217417 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
Hand-Foot Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDR kinase insert domain receptor treatment ISO DNA:polymorphism:cds:p.H472Q(human) RGD PMID:20630084 RGD:8552374 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
Nakajo Syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSMB8 proteasome 20S subunit beta 8 ISO ClinVar Annotator: match by term: Nodular erythema digital changes ClinVar PMID:20159315 PMID:20534754 PMID:21129723 PMID:21953331 PMID:25741868 More... NCBI chr 7:25,058,456...25,061,666
Ensembl chr 7:25,058,465...25,062,245 		JBrowse link
Poor Metabolism of Thiopurines, 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPMT thiopurine S-methyltransferase ISO ClinVar Annotator: match by term: THIOPURINES, POOR METABOLISM OF, 1 OMIM
ClinVar		 PMID:8561894 PMID:9931345 PMID:25741868 NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012 		JBrowse link
Poor Metabolism of Thiopurines, 2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUDT15 nudix hydrolase 15 ISO ClinVar Annotator: match by term: Thiopurines, poor metabolism of, 2 OMIM
ClinVar		 PMID:22992668 PMID:25108385 PMID:25624441 PMID:25741868 PMID:26033531 More... NCBI chr11:19,572,963...19,584,565
Ensembl chr11:19,572,644...19,584,528 		JBrowse link
Serum Sickness term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin ISO CTD Direct Evidence: marker/mechanism CTD PMID:350256 PMID:9380243 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
Stevens-Johnson syndrome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin ISO CTD Direct Evidence: therapeutic CTD PMID:12239465 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G APCS amyloid P component, serum ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 4:90,900,585...90,901,854
Ensembl chr 4:90,898,689...90,901,874 		JBrowse link
G C1QA complement C1q A chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 6:80,586,259...80,589,213
Ensembl chr 6:80,586,280...80,589,204 		JBrowse link
G C1QC complement C1q C chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 6:80,592,591...80,597,464
Ensembl chr 6:80,592,473...80,597,452 		JBrowse link
G CAV1 caveolin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G CELF2 CUGBP Elav-like family member 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr10:60,504,925...60,867,631
Ensembl chr10:60,506,504...61,084,960 		JBrowse link
G CFP complement factor properdin ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr  X:42,145,754...42,152,879
Ensembl chr  X:42,143,697...42,152,868 		JBrowse link
G CLU clusterin ISO mRNA:decreased expression:conjunctiva RGD PMID:12036968 RGD:8699507 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G COPS5 COP9 signalosome subunit 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 4:67,740,528...67,758,153
Ensembl chr 4:67,739,251...67,758,150 		JBrowse link
G CRP C-reactive protein, pentraxin-related ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218 		JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:11321886 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753 		JBrowse link
G CTNNB1 catenin beta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G CUL1 cullin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 9:109,454,523...109,559,114
Ensembl chr 9:109,454,534...109,557,649 		JBrowse link
G CUL4A cullin 4A ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr11:78,557,030...78,588,964
Ensembl chr11:78,557,013...78,589,193 		JBrowse link
G DERL1 derlin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 4:16,310,407...16,341,405
Ensembl chr 4:16,310,314...16,341,433 		JBrowse link
G ELMO1 engulfment and cell motility 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr18:36,755,026...37,336,095
Ensembl chr18:36,786,378...37,347,283 		JBrowse link
G EP300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G FBXO6 F-box protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 6:71,755,335...71,774,264
Ensembl chr 6:71,768,498...71,774,243 		JBrowse link
G IFNG interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G LBP lipopolysaccharide binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr17:41,398,935...41,429,467
Ensembl chr17:41,393,818...41,429,551 		JBrowse link
G LRG1 leucine rich alpha-2-glycoprotein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 2:74,300,598...74,303,117
Ensembl chr 2:74,300,619...74,314,315 		JBrowse link
G MIF macrophage migration inhibitory factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9372356 NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068 		JBrowse link
G MIR18A microRNA mir-18a ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr11:60,734,791...60,734,882
Ensembl chr11:60,734,791...60,734,882 		JBrowse link
G NEDD4 NEDD4 E3 ubiquitin protein ligase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 1:115,941,945...116,069,884
Ensembl chr 1:115,941,940...116,070,305 		JBrowse link
G NFKBIZ NFKB inhibitor zeta ISO MouseDO NCBI chr13:157,261,419...157,273,119
Ensembl chr13:157,261,419...157,272,688 		JBrowse link
G NOS2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:10620138 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NUCB1 nucleobindin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 6:54,186,610...54,209,457
Ensembl chr 6:54,180,038...54,209,930 		JBrowse link
G ORM1 orosomucoid 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 1:254,939,154...254,943,065 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PML PML nuclear body scaffold ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 7:59,405,044...59,450,155
Ensembl chr 7:59,405,053...59,450,105 		JBrowse link
G PROS1 protein S ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr13:165,915,298...165,999,118
Ensembl chr13:165,911,366...165,999,811 		JBrowse link
G PSMC5 proteasome 26S subunit, ATPase 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr12:15,101,946...15,106,326
Ensembl chr12:15,101,859...15,106,213 		JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21966456 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,955...142,161,286 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr17:51,153,151...51,200,515
Ensembl chr17:51,153,154...51,200,300 		JBrowse link
G RB1 RB transcriptional corepressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690 		JBrowse link
G RBX1 ring-box 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 5:7,500,492...7,515,388
Ensembl chr 5:7,500,490...7,515,370 		JBrowse link
G SLA-3 MHC class I antigen 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19629158 NCBI chr 7:22,938,211...22,942,735 JBrowse link
G TNF tumor necrosis factor ISO protein:increased expression:blister: RGD PMID:9852250 RGD:7401184 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G VCP valosin containing protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:25811541 NCBI chr 1:235,854,532...235,869,712
Ensembl chr 1:235,851,206...235,869,634 		JBrowse link
G VWF von Willebrand factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:34142820 NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,452 		JBrowse link
thiopurine S-methyltransferase deficiency term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPMT thiopurine S-methyltransferase ISO ClinVar Annotator: match by term: Thiopurine methyltransferase deficiency ClinVar PMID:1960624 PMID:7862671 PMID:8561894 PMID:8644731 PMID:9177237 More... NCBI chr 7:13,821,656...13,846,107
Ensembl chr 7:13,820,866...13,846,012 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 17415
    Chemically-Induced Disorders 1237
      Drug-Related Side Effects and Adverse Reactions 606
        drug allergy 107
          D-mannitol allergy 0
          Drug Eruptions + 70
          abacavir allergy 0
          alcuronium bromide allergy 0
          amodiaquine allergy 0
          aspirin allergy 0
          aspirin-induced respiratory disease + 17
          beta-lactam allergy + 0
          carbamazepine allergy 0
          carbapenem allergy 0
          cephalosporin allergy + 0
          chlorhexidine allergy 0
          co-trimoxazole allergy 0
          corticosteroid allergy 0
          cyclophosphamide allergy 0
          diclofenac allergy 0
          disodium cromoglycate allergy 0
          gallamine allergy 0
          isoniazide allergy 0
          ketoprofen photoallergic dermatitis 0
          lidocaine allergy 0
          melphalan allergy 0
          mepivacaine allergy 0
          neomycin sulfate allergic contact dermatitis 0
          oxirane allergy 0
          patent blue V allergy 0
          phenobarbital allergy 0
          phenytoin allergy 0
          phthalyl group allergy 0
          quinidine allergy 0
          ranitidine allergy 0
          rocuronium allergy 0
          sodium aurothiomalate allergy 0
          succinylcholine allergy 0
          sulfamethoxazole allergy 0
          sulfasalazine allergy 0
          sulfonamide allergy 0
          suprofen allergy 0
          thiopental allergy 0
          thiopurine S-methyltransferase deficiency + 2
          trimethoprim allergy 0
          tubocurarine allergy 0
Path 2
Term Annotations click to browse term
  disease 17415
    disease of anatomical entity 14875
      Immune & Inflammatory Diseases 4951
        immune system disease 4288
          allergic disease 576
            drug allergy 107
              D-mannitol allergy 0
              Drug Eruptions + 70
              abacavir allergy 0
              alcuronium bromide allergy 0
              amodiaquine allergy 0
              aspirin allergy 0
              aspirin-induced respiratory disease + 17
              beta-lactam allergy + 0
              carbamazepine allergy 0
              carbapenem allergy 0
              cephalosporin allergy + 0
              chlorhexidine allergy 0
              co-trimoxazole allergy 0
              corticosteroid allergy 0
              cyclophosphamide allergy 0
              diclofenac allergy 0
              disodium cromoglycate allergy 0
              gallamine allergy 0
              isoniazide allergy 0
              ketoprofen photoallergic dermatitis 0
              lidocaine allergy 0
              melphalan allergy 0
              mepivacaine allergy 0
              neomycin sulfate allergic contact dermatitis 0
              oxirane allergy 0
              patent blue V allergy 0
              phenobarbital allergy 0
              phenytoin allergy 0
              phthalyl group allergy 0
              quinidine allergy 0
              ranitidine allergy 0
              rocuronium allergy 0
              sodium aurothiomalate allergy 0
              succinylcholine allergy 0
              sulfamethoxazole allergy 0
              sulfasalazine allergy 0
              sulfonamide allergy 0
              suprofen allergy 0
              thiopental allergy 0
              thiopurine S-methyltransferase deficiency + 2
              trimethoprim allergy 0
              tubocurarine allergy 0
paths to the root