RGD DISEASE ONTOLOGY - ANNOTATIONS |
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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
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Term: | respiratory allergy |
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Accession: | DOID:0060496
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browse the term
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Definition: | An allergic disease that is located_in the respiratory tract. (DO) |
Synonyms: | exact_synonym: | airway allergy; airway hyper responsiveness; respiratory hypersensitivities; respiratory hypersensitivity |
| related_synonym: | allergic lung disease |
| primary_id: | MESH:D012130 |
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CCL11 |
C-C motif chemokine ligand 11 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334
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CCL15 |
C-C motif chemokine ligand 15 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr17:35,997,582...36,001,553
Ensembl chr17:35,996,440...36,001,553
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CCL23 |
C-C motif chemokine ligand 23 |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr17:36,013,058...36,017,972
Ensembl chr17:36,013,056...36,017,972
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CCL8 |
C-C motif chemokine ligand 8 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr17:34,319,435...34,321,402
Ensembl chr17:34,319,435...34,321,402
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CCR3 |
C-C motif chemokine receptor 3 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20022477 |
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NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706
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CLDN4 |
claudin 4 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30608172 |
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NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,690
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CLDN5 |
claudin 5 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30608172 |
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NCBI chr22:19,523,024...19,525,337
Ensembl chr22:19,523,024...19,527,545
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CXCL1 |
C-X-C motif chemokine ligand 1 |
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EXP |
CTD Direct Evidence: therapeutic |
CTD |
PMID:23056391 |
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NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
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CXCL5 |
C-X-C motif chemokine ligand 5 |
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ISO |
mRNA:increased expression:lung |
RGD |
PMID:18417511 |
RGD:5135242 |
NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677
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CXCL6 |
C-X-C motif chemokine ligand 6 |
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ISO |
mRNA:increased expression:lung |
RGD |
PMID:18417511 |
RGD:5135242 |
NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
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F2RL1 |
F2R like trypsin receptor 1 |
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IDA |
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RGD |
PMID:20186875 |
RGD:4892588 |
NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
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HRH1 |
histamine receptor H1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12095164 |
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NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
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HSPA5 |
heat shock protein family A (Hsp70) member 5 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24211530 |
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NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
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IL10 |
interleukin 10 |
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ISO |
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RGD |
PMID:20583974 |
RGD:4140460 |
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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IL13 |
interleukin 13 |
susceptibility |
ISO IAGP |
mRNA:increased expression:lung DNA:SNP, missense mutation:promoter, exon:-1112C>T, p.R130Q (human) |
RGD |
PMID:19564030 PMID:18849614 |
RGD:4145637, RGD:8549507 |
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL15 |
interleukin 15 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18394133 |
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NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987
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IL1A |
interleukin 1 alpha |
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ISO |
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RGD |
PMID:12663678 |
RGD:4143222 |
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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IL1B |
interleukin 1 beta |
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ISO |
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RGD |
PMID:12663678 |
RGD:4143222 |
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1RL1 |
interleukin 1 receptor like 1 |
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ISO |
associated with Fungal Lung Diseases |
RGD |
PMID:25746970 |
RGD:39938968 |
NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037
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IL1RN |
interleukin 1 receptor antagonist |
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ISO |
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RGD |
PMID:12663678 |
RGD:4143222 |
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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IL27 |
interleukin 27 |
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ISO |
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RGD |
PMID:20817868 |
RGD:4145651 |
NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051
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IL33 |
interleukin 33 |
treatment |
ISO |
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RGD |
PMID:25424936 |
RGD:40400692 |
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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IL4 |
interleukin 4 |
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ISO EXP |
associated with Pneumonia, Pneumocystis carinii CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:18394133 PMID:21343358 |
RGD:5128506 |
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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IL6 |
interleukin 6 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18394133 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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MBL2 |
mannose binding lectin 2 |
susceptibility |
IAGP |
DNA:SNP:intron:1011G>A(human) |
RGD |
PMID:16487239 |
RGD:8693711 |
NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
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MT1X |
metallothionein 1X |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
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MT2A |
metallothionein 2A |
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ISO |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
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NOS2 |
nitric oxide synthase 2 |
treatment |
ISO |
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RGD |
PMID:19800904 PMID:21983654 |
RGD:4891497, RGD:8549812 |
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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NOS3 |
nitric oxide synthase 3 |
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IAGP |
DNA:polymorphism: :c. -786C>T (human) |
RGD |
PMID:18086269 |
RGD:4892054 |
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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PTPN6 |
protein tyrosine phosphatase non-receptor type 6 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18441283 |
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NCBI chr12:6,946,577...6,961,316
Ensembl chr12:6,946,468...6,961,316
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SERPINE1 |
serpin family E member 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24211530 |
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NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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SLC30A4 |
solute carrier family 30 member 4 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr15:45,479,606...45,522,755
Ensembl chr15:45,479,606...45,522,755
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SLC39A1 |
solute carrier family 39 member 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr 1:153,959,110...153,968,184
Ensembl chr 1:153,959,099...153,968,184
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SLC39A14 |
solute carrier family 39 member 14 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr 8:22,367,278...22,434,129
Ensembl chr 8:22,367,278...22,434,129
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SLC39A4 |
solute carrier family 39 member 4 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:17085522 |
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NCBI chr 8:144,412,414...144,416,844
Ensembl chr 8:144,409,742...144,416,844
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TLR4 |
toll like receptor 4 |
susceptibility |
IAGP EXP |
DNA:polymorphisms,haplotype: :−2027A>G, ¿1608T>C(human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:10835634 PMID:21704886 |
RGD:7800728 |
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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TNF |
tumor necrosis factor |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18394133 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TSLP |
thymic stromal lymphopoietin |
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EXP |
CTD Direct Evidence: therapeutic |
CTD |
PMID:28329851 |
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NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
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UPP1 |
uridine phosphorylase 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24211530 |
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NCBI chr 7:48,088,704...48,108,736
Ensembl chr 7:48,088,628...48,108,736
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VEGFA |
vascular endothelial growth factor A |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:30608172 |
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NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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CXCL8 |
C-X-C motif chemokine ligand 8 |
treatment |
IEP |
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RGD |
PMID:30059697 |
RGD:39939057 |
NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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CCL26 |
C-C motif chemokine ligand 26 |
treatment |
ISO |
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RGD |
PMID:25530546 |
RGD:11081163 |
NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896
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CYSLTR1 |
cysteinyl leukotriene receptor 1 |
treatment |
ISO |
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RGD |
PMID:23933317 |
RGD:40903070 |
NCBI chr X:78,271,468...78,327,611
Ensembl chr X:78,271,468...78,327,691
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EPX |
eosinophil peroxidase |
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IEP |
protein:increased expression:urine: |
RGD |
PMID:11846868 |
RGD:13506893 |
NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174
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HLA-B |
major histocompatibility complex, class I, B |
susceptibility |
IAGP |
DNA:polymorphism: |
RGD |
PMID:28380482 |
RGD:13506910 |
NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
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HLA-C |
major histocompatibility complex, class I, C |
susceptibility |
IAGP |
DNA:polymorphism: |
RGD |
PMID:28380482 |
RGD:13506910 |
NCBI chr 6:31,268,749...31,272,092
Ensembl chr 6:31,268,749...31,272,130
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HLA-DPA1 |
major histocompatibility complex, class II, DP alpha 1 |
susceptibility |
IAGP |
DNA:polymorphism: |
RGD |
PMID:28380482 |
RGD:13506910 |
NCBI chr 6:33,064,569...33,080,748
Ensembl chr 6:33,064,569...33,080,775
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HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
susceptibility |
IAGP |
DNA:polymorphism: |
RGD |
PMID:28380482 |
RGD:13506910 |
NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
susceptibility |
IAGP |
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RGD |
PMID:22397267 |
RGD:13506905 |
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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IL25 |
interleukin 25 |
treatment |
ISO |
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RGD |
PMID:17889290 |
RGD:40902975 |
NCBI chr14:23,372,809...23,376,403
Ensembl chr14:23,372,809...23,376,403
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TREM1 |
triggering receptor expressed on myeloid cells 1 |
exacerbates |
ISO |
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RGD |
PMID:21592044 PMID:21592044 |
RGD:126928124, RGD:126928124 |
NCBI chr 6:41,267,385...41,286,682
Ensembl chr 6:41,267,100...41,286,682
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CCL17 |
C-C motif chemokine ligand 17 |
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IEP |
associated with Cystic Fibrosis |
RGD |
PMID:17898016 |
RGD:4145612 |
NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063
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CCR1 |
C-C motif chemokine receptor 1 |
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ISO |
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RGD |
PMID:15951834 |
RGD:5688155 |
NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313
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CCR2 |
C-C motif chemokine receptor 2 |
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ISO |
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RGD |
PMID:10946288 |
RGD:8661731 |
NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
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CFTR |
CF transmembrane conductance regulator |
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IAGP |
DNA:mutations: : |
RGD |
PMID:11243954 |
RGD:4140482 |
NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
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HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
susceptibility |
IAGP |
associated with cystic fibrosis; DNA:polymorphisms: :DQB1*06:02, DQB1*02:01(human) |
RGD |
PMID:23278646 |
RGD:36049760 |
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
susceptibility |
IAGP |
associated with cystic fibrosis; DNA:polymorphisms: : |
RGD |
PMID:23278646 |
RGD:36049760 |
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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ICAM1 |
intercellular adhesion molecule 1 |
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ISO |
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RGD |
PMID:7743671 |
RGD:8547590 |
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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IL1A |
interleukin 1 alpha |
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ISO |
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RGD |
PMID:8699818 |
RGD:7794730 |
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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MBL2 |
mannose binding lectin 2 |
susceptibility |
IAGP |
Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human) DNA:SNP:intron:1011G>A(human) |
RGD |
PMID:11474427 PMID:16487239 |
RGD:4889577, RGD:8693711 |
NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
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TLR9 |
toll like receptor 9 |
susceptibility |
ISO IAGP |
DNA:SNP:promoter:g.-1237T>C (rs5743836) (human) |
RGD |
PMID:18936185 PMID:18275280 |
RGD:5130858, RGD:5130863 |
NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645
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TNF |
tumor necrosis factor |
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ISO |
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RGD |
PMID:8699818 |
RGD:7794730 |
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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TNFRSF1A |
TNF receptor superfamily member 1A |
susceptibility |
IAGP |
DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human) |
RGD |
PMID:20646338 |
RGD:5131174 |
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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ABCB1 |
ATP binding cassette subfamily B member 1 |
severity |
IAGP |
DNA:snp:exon:c.1236C>T (human) |
RGD |
PMID:24040855 |
RGD:8657076 |
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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ACE |
angiotensin I converting enzyme |
no_association |
IAGP |
DNA:deletion:intron:IVS16+1464-1751del (human) |
RGD |
PMID:15112973 |
RGD:8142345 |
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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BCL2 |
BCL2 apoptosis regulator |
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ISO |
mRNA, protein:increased expression:nasal mucosa (rat) |
RGD |
PMID:15362690 |
RGD:11522724 |
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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CAT |
catalase |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:29028686 |
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NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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CCL11 |
C-C motif chemokine ligand 11 |
treatment |
ISO |
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RGD |
PMID:23089405 |
RGD:7248414 |
NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334
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CCL26 |
C-C motif chemokine ligand 26 |
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IEP |
protein:increased expression:oronasal secretion (human) |
RGD |
PMID:23883806 |
RGD:7364793 |
NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896
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CD40 |
CD40 molecule |
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IEP |
protein:increased expression:lymphocyte |
RGD |
PMID:19086656 |
RGD:8547782 |
NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
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CD40LG |
CD40 ligand |
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IEP |
protein:increased expression:lymphocyte |
RGD |
PMID:19086656 |
RGD:8547782 |
NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390
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CLDN3 |
claudin 3 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr 7:73,768,997...73,770,270
Ensembl chr 7:73,768,997...73,770,270
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CLDN7 |
claudin 7 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr17:7,259,903...7,263,213
Ensembl chr17:7,259,903...7,263,983
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CTLA4 |
cytotoxic T-lymphocyte associated protein 4 |
treatment |
ISO |
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RGD |
PMID:10436391 |
RGD:11344920 |
NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
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F2 |
coagulation factor II, thrombin |
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IEP |
protein:increased expression:nasal mucus |
RGD |
PMID:21711961 |
RGD:5147783 |
NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
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G |
FCGR3A |
Fc gamma receptor IIIa |
susceptibility |
IAGP |
DNA:polymorphism:exon:p.F158V(rs396991)(human) |
RGD |
PMID:18199088 |
RGD:5508449 |
NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968
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G |
GRIA1 |
glutamate ionotropic receptor AMPA type subunit 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34624383 |
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NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869
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G |
GRIA2 |
glutamate ionotropic receptor AMPA type subunit 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:34624383 |
|
NCBI chr 4:157,220,120...157,366,075
Ensembl chr 4:157,204,182...157,387,146
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G |
HLA-G |
major histocompatibility complex, class I, G |
|
IEP |
|
RGD |
PMID:20487636 |
RGD:5144132 |
NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125
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G |
HMOX1 |
heme oxygenase 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36127783 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HRH1 |
histamine receptor H1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23333628 |
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NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557
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G |
IFNG |
interferon gamma |
treatment |
IEP EXP ISO |
associated with Asthma CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:29871060 PMID:12787306 PMID:18510219 |
RGD:7829803, RGD:10755770 |
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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G |
IL10 |
interleukin 10 |
treatment |
IEP EXP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:36127783 PMID:23883806 PMID:23253209 |
RGD:7364793, RGD:7364818 |
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL13 |
interleukin 13 |
susceptibility no_association |
IAGP EXP |
DNA:SNP:promoter:-1512A>C (rs1881457) (human) CTD Direct Evidence: marker/mechanism DNA:polymorphism:exon:c. 2044G>A (human) DNA:missense mutation:cds:p.R130Q (rs20541) (human) DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human) |
CTD OMIM RGD |
PMID:23996716 PMID:17091279 PMID:22852128 PMID:12928861 |
RGD:8549501, RGD:4152796, RGD:8549518, RGD:8549516 |
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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G |
IL13RA2 |
interleukin 13 receptor subunit alpha 2 |
|
IEP |
protein:increased expression:serum |
RGD |
PMID:21462799 |
RGD:8549521 |
NCBI chr X:115,003,982...115,017,616
Ensembl chr X:115,003,975...115,019,977
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G |
IL17A |
interleukin 17A |
susceptibility |
IAGP IEP |
DNA:snp:promoter:c.-444A>G (human) mRNA:increased expression:peripheral blood mononuclear cell (human) |
RGD |
PMID:22507625 PMID:21535180 |
RGD:9068429, RGD:5147409 |
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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G |
IL18 |
interleukin 18 |
severity no_association |
IAGP |
DNA:SNP:promoter:-137G>C (rs187238) (human) DNA:SNP:promoter:-140C>G (rs360721) (human) |
RGD |
PMID:22840759 PMID:22840759 |
RGD:8655914, RGD:8655914 |
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
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G |
IL1B |
interleukin 1 beta |
|
IEP |
protein:increased expression:nasal mucus |
RGD |
PMID:7750009 |
RGD:7401199 |
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL2 |
interleukin 2 |
|
ISO |
|
RGD |
PMID:12592663 |
RGD:8662963 |
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL4 |
interleukin 4 |
treatment |
IEP EXP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:36127783 PMID:9893928 PMID:24620662 PMID:8908280 PMID:14653048 |
RGD:7829796, RGD:11522769, RGD:7829827, RGD:7829802 |
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL5 |
interleukin 5 |
treatment |
ISO |
|
RGD |
PMID:23934070 PMID:24620662 |
RGD:11354976, RGD:11522769 |
NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
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G |
ITGB2 |
integrin subunit beta 2 |
treatment |
ISO |
|
RGD |
PMID:12046991 |
RGD:9698435 |
NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989
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G |
MRC1 |
mannose receptor C-type 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:36127783 |
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NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
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G |
MUC1 |
mucin 1, cell surface associated |
severity |
IEP ISO |
mRNA,protein:decreased expression:nasal mucosa |
RGD |
PMID:31425778 PMID:31425778 PMID:31425778 |
RGD:127345100, RGD:127345100, RGD:127345100 |
NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
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G |
MUC5AC |
mucin 5AC, oligomeric mucus/gel-forming |
|
ISO |
mRNA, protein:increased expression:nasal cavity epithelium |
RGD |
PMID:22972875 |
RGD:7364746 |
NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
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G |
NOD2 |
nucleotide binding oligomerization domain containing 2 |
|
IEP |
mRNA:increased expression:nasal mucosa (human) |
RGD |
PMID:23858718 |
RGD:8547523 |
NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077
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G |
OCLN |
occludin |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33441633 |
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NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104
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G |
PON1 |
paraoxonase 1 |
severity |
IEP |
protein:decreased activity:plasma (human) |
RGD |
PMID:23406590 |
RGD:8547583 |
NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
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G |
PRKG1 |
protein kinase cGMP-dependent 1 |
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ISO |
protein:increased expression:nasal cavity epithelium |
RGD |
PMID:24012634 |
RGD:7775060 |
NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16979129 |
|
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
SCGB1A1 |
secretoglobin family 1A member 1 |
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ISO |
mRNA:decreased expression:nasal mucosa, lung |
RGD |
PMID:17882576 |
RGD:5144135 |
NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195
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G |
SCGB3A2 |
secretoglobin family 3A member 2 |
susceptibility |
IAGP |
DNA:SNP: :rs7726552 (human) |
RGD |
PMID:21410962 |
RGD:5144225 |
NCBI chr 5:147,878,711...147,882,191
Ensembl chr 5:147,870,682...147,882,191
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G |
SERPINE1 |
serpin family E member 1 |
|
ISO |
mRNA:increased expression:nasal mucosa (mouse) |
RGD |
PMID:21339035 |
RGD:8547809 |
NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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G |
TACR1 |
tachykinin receptor 1 |
|
ISO |
mRNA:increased expression:nasal mucosa |
RGD |
PMID:12768696 |
RGD:5147835 |
NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
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G |
TGFB1 |
transforming growth factor beta 1 |
treatment |
ISO |
|
RGD |
PMID:31368266 |
RGD:14995445 |
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TLR2 |
toll like receptor 2 |
severity |
IAGP IEP ISO |
DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil: mRNA:decreased expression:nasal mucosa: |
RGD |
PMID:22402138 PMID:22555057 PMID:18381801 PMID:18219831 |
RGD:7800732, RGD:8552993, RGD:8552972, RGD:7800742 |
NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
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G |
TLR4 |
toll like receptor 4 |
severity treatment susceptibility no_association |
IAGP IEP IDA |
DNA:polymorphism:cds:p.D299G(human) protein:increased expression:nasal lavage,leukocyte, bone marrow: protein:decreased expression:nasal mucosa: DNA:SNP: :rs1927911(human) DNA:polymorphism: :4216G>C(human) |
RGD |
PMID:22402138 PMID:22555057 PMID:22577387 PMID:17069098 PMID:23639307 PMID:19763595 More...
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RGD:7800732, RGD:8552993, RGD:7800740, RGD:7800738, RGD:7800736, RGD:4145354 |
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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G |
TLR9 |
toll like receptor 9 |
|
IEP |
protein:decreased expression:nasal mucosa: |
RGD |
PMID:22577387 |
RGD:7800740 |
NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645
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G |
CYP2C19 |
cytochrome P450 family 2 subfamily C member 19 |
treatment |
IAGP |
associated with Eosinophilic Esophagitis; DNA:polymorphisms:: |
RGD |
PMID:26416193 |
RGD:11352743 |
NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
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G |
IL3 |
interleukin 3 |
susceptibility |
IAGP |
DNA:SNP: :rs40401(human) |
RGD |
PMID:23953855 |
RGD:13506915 |
NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
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G |
CACNG6 |
calcium voltage-gated channel auxiliary subunit gamma 6 |
susceptibility |
IAGP |
DNA:SNP,haplotype:rs192808(human) |
RGD |
PMID:20860846 |
RGD:13524562 |
NCBI chr19:53,991,149...54,012,666
Ensembl chr19:53,991,637...54,012,666
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G |
CCR3 |
C-C motif chemokine receptor 3 |
|
IEP EXP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:20485159 PMID:20022477 |
RGD:4145619 |
NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706
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G |
CYSLTR1 |
cysteinyl leukotriene receptor 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16502481 PMID:17641958 PMID:20485159 |
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NCBI chr X:78,271,468...78,327,611
Ensembl chr X:78,271,468...78,327,691
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G |
CYSLTR2 |
cysteinyl leukotriene receptor 2 |
|
IAGP EXP |
DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16502481 PMID:20485159 PMID:15970796 |
RGD:5144000 |
NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226
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G |
FANCC |
FA complementation group C |
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IAGP |
DNA:haplotype::rs4647416(human) |
RGD |
PMID:21670957 |
RGD:11045795 |
NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796
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G |
HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16502481 |
|
NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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G |
HLA-DQA1 |
major histocompatibility complex, class II, DQ alpha 1 |
susceptibility |
IAGP |
|
RGD |
PMID:25975240 |
RGD:11074090 |
NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062
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G |
HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
susceptibility |
IAGP |
|
RGD |
PMID:25975240 |
RGD:11074090 |
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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G |
HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
susceptibility |
IAGP |
|
RGD |
PMID:25975240 |
RGD:11074090 |
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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G |
HLA-DRB3 |
major histocompatibility complex, class II, DR beta 3 |
susceptibility |
IAGP |
|
RGD |
PMID:25975240 |
RGD:11074090 |
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G |
HLA-DRB4 |
major histocompatibility complex, class II, DR beta 4 |
susceptibility |
IAGP |
|
RGD |
PMID:25975240 |
RGD:11074090 |
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G |
IL4 |
interleukin 4 |
susceptibility |
IAGP |
DNA:SNPs:promoter,5'UTR,intron:multiple |
RGD |
PMID:20921925 |
RGD:11528633 |
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
LOC109286563 |
TBX21 promoter region |
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IAGP |
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to |
ClinVar |
PMID:15806396 |
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NCBI chr17:47,731,244...47,733,594
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G |
LTC4S |
leukotriene C4 synthase |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159 |
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NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647
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G |
MS4A2 |
membrane spanning 4-domains A2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16502481 |
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NCBI chr11:60,088,259...60,098,467
Ensembl chr11:60,088,261...60,098,467
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G |
POSTN |
periostin |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18391768 |
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NCBI chr13:37,562,585...37,598,768
Ensembl chr13:37,562,583...37,598,844
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G |
PTGDR2 |
prostaglandin D2 receptor 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20485159 |
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NCBI chr11:60,850,933...60,855,950
Ensembl chr11:60,850,933...60,855,950
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G |
PTGER2 |
prostaglandin E receptor 2 |
|
IAGP EXP |
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to CTD Direct Evidence: marker/mechanism |
ClinVar CTD |
PMID:15496426 PMID:16502481 |
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NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,329,822
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G |
PTGIR |
prostaglandin I2 receptor |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:20485159 |
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NCBI chr19:46,610,687...46,625,089
Ensembl chr19:46,618,550...46,625,089
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
|
IEP EXP |
protein:increased expression:mast cell CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16502481 PMID:20485159 PMID:9487340 |
RGD:5143936 |
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
TAP2 |
transporter 2, ATP binding cassette subfamily B member |
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IAGP |
|
RGD |
PMID:21796142 |
RGD:5147839 |
NCBI chr 6:32,821,831...32,838,739
Ensembl chr 6:32,821,833...32,838,739
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G |
TBX21 |
T-box transcription factor 21 |
|
IAGP EXP |
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to CTD Direct Evidence: marker/mechanism |
ClinVar CTD |
PMID:15806396 PMID:16502481 |
|
NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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G |
TBXA2R |
thromboxane A2 receptor |
susceptibility |
IAGP EXP |
DNA:polymorphism: :795T>C (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16502481 PMID:20485159 PMID:15898979 |
RGD:11059537 |
NCBI chr19:3,594,507...3,606,875
Ensembl chr19:3,594,507...3,606,875
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
|
IEP |
protein:increased expression:blood, lymphocyte |
RGD |
PMID:19484671 |
RGD:4890020 |
NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 (ABCC1 blood group) |
|
ISO |
|
RGD |
PMID:18931056 |
RGD:5128825 |
NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
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G |
ABO |
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
no_association |
IAGP |
|
RGD |
PMID:19771478 PMID:16008680 |
RGD:5128835, RGD:5128831 |
NCBI chr 9:133,250,401...133,275,201
Ensembl chr 9:133,233,278...133,276,024
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G |
ACE |
angiotensin I converting enzyme |
susceptibility |
IAGP |
DNA:polymorphism (human) |
RGD |
PMID:19484664 PMID:19383228 |
RGD:4140913, RGD:4140919 |
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
ACSL3 |
acyl-CoA synthetase long chain family member 3 |
|
IDA |
DNA:hypermethylation:promoter |
RGD |
PMID:19221603 |
RGD:13831295 |
NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
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G |
ADA |
adenosine deaminase |
susceptibility |
IAGP |
DNA:polymorphisms (human) |
RGD |
PMID:16754522 |
RGD:5128848 |
NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
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G |
ADAM33 |
ADAM metallopeptidase domain 33 |
no_association disease_progression susceptibility |
ISO IAGP IEA IEP |
mRNA:increased expression:lung DNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human) mRNA:increased expression:bronchus DNA:polymorphism: :p.M764T (human) DNA:SNPs: :multiple (human) DNA:SNPs (human) |
RGD GAD |
PMID:19635592 PMID:16893396 PMID:15118671 PMID:17339047 PMID:17961406 PMID:18778489 PMID:19940503 More...
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RGD:4145360, RGD:4145382, RGD:1331525, RGD:4145380, RGD:4145379, RGD:4145378, RGD:4145359 |
NCBI chr20:3,667,975...3,682,010
Ensembl chr20:3,667,965...3,682,246
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G |
ADAM8 |
ADAM metallopeptidase domain 8 |
severity |
ISO IEP |
mRNA:increased expression:respiratory tract mRNA:increased expression:bronchus |
RGD |
PMID:19373511 PMID:17339047 PMID:20194813 |
RGD:5128878, RGD:4145380, RGD:5128872 |
NCBI chr10:133,262,423...133,276,868
Ensembl chr10:133,262,420...133,276,868
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G |
ADCY2 |
adenylate cyclase 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21912604 |
|
NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081
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G |
ADCYAP1R1 |
ADCYAP receptor type I |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21059121 |
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NCBI chr 7:31,052,308...31,111,474
Ensembl chr 7:31,052,308...31,111,474
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G |
ADH5 |
alcohol dehydrogenase 5 (class III), chi polypeptide |
susceptibility |
ISO IAGP IEP |
DNA:SNPs: :rs1154404, rs28730619 (human) protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:15919956 PMID:17543375 PMID:19395503 PMID:19514054 |
RGD:5128892, RGD:5128882, RGD:5128891, RGD:5128890 |
NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
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ISO |
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RGD |
PMID:19168697 |
RGD:5686821 |
NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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G |
ADORA1 |
adenosine A1 receptor |
|
IAGP ISO IEP |
DNA:SNPs: :1405C>T (human) protein:increased expression:bronchus |
RGD |
PMID:19019667 PMID:20400685 PMID:17959644 |
RGD:4890386, RGD:4145444, RGD:5129097 |
NCBI chr 1:203,127,726...203,167,405
Ensembl chr 1:203,090,654...203,167,405
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G |
ADORA2A |
adenosine A2a receptor |
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ISO IAGP |
mRNA:decreased expression:aorta DNA:SNP (human) |
RGD |
PMID:17293374 PMID:18310516 PMID:19019667 PMID:16339780 |
RGD:4890380, RGD:4890366, RGD:4890386, RGD:4890385 |
NCBI chr22:24,423,597...24,442,357
Ensembl chr22:24,417,879...24,442,357
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G |
ADRB2 |
adrenoceptor beta 2 |
susceptibility |
IAGP IEA ISO IDA |
DNA:polymorphism: :p.R16G (human) ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to DNA:SNP: :-1023A>G (human) DNA:SNPs: :p.R16G, p.Q27E (human) DNA:SNPs:promoter:multiple (human) DNA:SNP: :p.Q27E (human) |
ClinVar RGD |
PMID:8383511 PMID:15284533 PMID:16596417 PMID:19800676 PMID:19029431 PMID:15118671 PMID:19638684 PMID:18785519 PMID:19423772 PMID:20443840 PMID:20004781 PMID:18569231 PMID:1655856 More...
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RGD:4145061, RGD:4145092, RGD:1331525, RGD:4145081, RGD:4145094, RGD:4145107, RGD:4145108, RGD:4145105, RGD:4145096, RGD:5129113 |
NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623
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G |
AGER |
advanced glycosylation end-product specific receptor |
treatment onset |
IEP EXP ISO |
CTD Direct Evidence: marker/mechanism protein:decreased expression:lung (rat) |
CTD RGD |
PMID:23304218 PMID:33075463 PMID:21920897 PMID:23304218 |
RGD:7244279, RGD:6767554, RGD:7244279 |
NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
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G |
AGTR1 |
angiotensin II receptor type 1 |
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ISO |
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RGD |
PMID:17877756 PMID:19080339 |
RGD:5147452, RGD:5147457 |
NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
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G |
AGTR2 |
angiotensin II receptor type 2 |
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ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:19080339 |
RGD:5147457 |
NCBI chr X:116,170,744...116,174,974
Ensembl chr X:116,170,744...116,174,974
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G |
ALDH2 |
aldehyde dehydrogenase 2 family member |
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IEA EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9600491 PMID:11506308 PMID:15118671 |
RGD:1331525 |
NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
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G |
ALOX15 |
arachidonate 15-lipoxygenase |
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ISO |
protein:increased expression:lung |
RGD |
PMID:19628725 PMID:18692885 |
RGD:5509605, RGD:5509784 |
NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
no_association susceptibility treatment severity |
IAGP EXP IEP ISO IMP |
DNA:polymorphism:promoter (human) CTD Direct Evidence: marker/mechanism mRNA:increased expression:blood, leukocyte protein:increased expression:lung DNA:repeat:promoter (human) DNA:polymorphism:cds:p.E254K (human) |
OMIM CTD RGD |
PMID:20128419 PMID:9642160 PMID:12911785 PMID:8879219 PMID:19033731 PMID:11035107 PMID:10369259 PMID:17394438 PMID:16364163 PMID:18204779 More...
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RGD:4890407, RGD:5147467, RGD:5147465, RGD:5147462, RGD:4890408, RGD:4890422, RGD:734557, RGD:4890413, RGD:4890415, RGD:4890410 |
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
ALOX5AP |
arachidonate 5-lipoxygenase activating protein |
no_association susceptibility |
IAGP IEP ISO |
DNA:polymorphism:promoter (human) mRNA:increased expression:blood, leukocyte DNA:repeat:promoter:-169(A)21 (human) DNA:substitution, repeat:promoter:-336G>A, -169(A)19-23 (human) DNA:polymorphisms:intron:IVS2+12C>A, IVS2+105T>C (human) protein:increased expression:lung DNA:SNPs (human) DNA:SNP: :rs10507391 (human) |
RGD |
PMID:20128419 PMID:9642160 PMID:10527888 PMID:12911785 PMID:15784112 PMID:8879219 PMID:11035107 PMID:18547289 PMID:20067482 More...
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RGD:4890407, RGD:5147467, RGD:5147466, RGD:5147465, RGD:5147464, RGD:5147462, RGD:4890422, RGD:4890409, RGD:4890405 |
NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426
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G |
AMBP |
alpha-1-microglobulin/bikunin precursor |
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IEP |
protein:increased expression:serum |
RGD |
PMID:14621078 |
RGD:6904149 |
NCBI chr 9:114,060,127...114,078,300
Ensembl chr 9:114,060,127...114,078,328
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G |
ANG |
angiogenin |
severity |
IEP |
protein:increased expression:sputum |
RGD |
PMID:16478840 |
RGD:6892719 |
NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971
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G |
ANXA1 |
annexin A1 |
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ISO |
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RGD |
PMID:22092555 |
RGD:7421657 |
NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,629
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G |
AREG |
amphiregulin |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15696081 |
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NCBI chr 4:74,445,136...74,455,005
Ensembl chr 4:74,445,136...74,455,005
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G |
ARG1 |
arginase 1 |
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IAGP EXP ISO IEP |
DNA:SNP: :rs2781667 (human) CTD Direct Evidence: marker/mechanism mRNA:increased expression:lung (mouse) mRNA, protein:increased expression:lung, mononuclear cell (human) |
CTD RGD |
PMID:19281908 PMID:19800904 PMID:20124949 PMID:12813022 PMID:12813022 |
RGD:5129205, RGD:4143187, RGD:4143187 |
NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
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G |
ARG2 |
arginase 2 |
severity susceptibility |
IAGP EXP ISO |
DNA:SNP: :rs3742879, rs17249437 (human) CTD Direct Evidence: marker/mechanism mRNA:increased expression:lung (mouse) DNA:SNPs (human) |
CTD RGD |
PMID:19281908 PMID:20124949 PMID:12813022 PMID:16387594 |
RGD:5129205, RGD:4143187, RGD:5129207 |
NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708
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G |
BCL2 |
BCL2 apoptosis regulator |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:18357729 |
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NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
BDKRB2 |
bradykinin receptor B2 |
onset |
IAGP IEP IMP ISO |
DNA:polymorphism:exon (human) protein:increased expression:blood, eosinophil |
RGD |
PMID:11517947 PMID:19038786 PMID:8856156 PMID:14727005 |
RGD:4890456, RGD:4891028, RGD:4891042, RGD:4890454 |
NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166
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G |
BDNF |
brain derived neurotrophic factor |
susceptibility severity |
IDA IAGP IEP |
DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human) DNA:polymorphisms: :p.V66M, -270C>T (human) DNA:polymorphisms: :p.V66M (rs6265) (human) protein:increased expression:plasma protein:decreased expression:blood, eosinophil |
RGD |
PMID:11737043 PMID:21723144 PMID:17584309 PMID:19895626 PMID:20874832 PMID:12752594 More...
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RGD:4891123, RGD:8655967, RGD:4891067, RGD:4891117, RGD:4891063, RGD:4891122 |
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
BGLAP |
bone gamma-carboxyglutamate protein |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8429434 |
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NCBI chr 1:156,242,184...156,243,317
Ensembl chr 1:156,242,184...156,243,317
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G |
BMPR1B |
bone morphogenetic protein receptor type 1B |
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IEP |
protein:decreased expression:bronchus |
RGD |
PMID:18292470 |
RGD:5129470 |
NCBI chr 4:94,757,955...95,158,450
Ensembl chr 4:94,757,955...95,158,448
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G |
BMPR2 |
bone morphogenetic protein receptor type 2 |
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IEP |
protein:decreased expression:bronchus |
RGD |
PMID:18292470 |
RGD:5129470 |
NCBI chr 2:202,376,327...202,567,749
Ensembl chr 2:202,376,327...202,567,751
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G |
C3 |
complement C3 |
severity |
ISO IEP IAGP |
protein:increased expression:respiratory system fluid/secretion protein:increased expression:serum Interaction with IL4RA DNA:SNP:intron:rs11569562 (human) DNA:SNPs: :multiple (human) DNA:SNP: :4896C>T (human) |
RGD |
PMID:20802484 PMID:20589464 PMID:20402389 PMID:20395963 PMID:18566738 PMID:16355111 PMID:15278436 PMID:11591733 More...
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RGD:5129681, RGD:5129519, RGD:5129537, RGD:5129538, RGD:5129501, RGD:5129505, RGD:5129512, RGD:5129517 |
NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562
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G |
C3AR1 |
complement C3a receptor 1 |
severity |
ISO IAGP IEP |
mRNA:increased expression:lung protein:increased expression:lung, leukocyte |
RGD |
PMID:20045013 PMID:15278436 PMID:20802484 PMID:17544263 PMID:17544263 PMID:15940127 More...
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RGD:5129686, RGD:5129512, RGD:5129681, RGD:5129560, RGD:5129560, RGD:5129561 |
NCBI chr12:8,056,844...8,066,359
Ensembl chr12:8,056,844...8,066,359
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G |
C5 |
complement C5 |
severity |
IAGP ISO IEP |
mRNA:decreased expression:lung |
RGD |
PMID:15278436 PMID:20802484 PMID:20143644 PMID:11591795 PMID:10973279 |
RGD:5129512, RGD:5129681, RGD:5129706, RGD:1600651, RGD:5130158 |
NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,932,987...121,075,195
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G |
C5AR1 |
complement C5a receptor 1 |
severity |
ISO IEP |
protein:increased expression:respiratory tract protein:increased expression:lung, leukocyte |
RGD |
PMID:20802484 PMID:15940127 PMID:16511606 PMID:17544263 |
RGD:5129681, RGD:5129561, RGD:5130166, RGD:5129560 |
NCBI chr19:47,307,477...47,322,066
Ensembl chr19:47,290,023...47,322,066
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G |
CARD11 |
caspase recruitment domain family member 11 |
susceptibility |
ISO IAGP |
ClinVar Annotator: match by term: Asthma |
ClinVar RGD |
PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 PMID:26861442 PMID:28492532 PMID:28824638 PMID:29472930 PMID:16751370 More...
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RGD:11100037 |
NCBI chr 7:2,906,142...3,043,867
Ensembl chr 7:2,906,142...3,044,228
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G |
CARD11-AS1 |
CARD11 antisense RNA 1 |
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IAGP |
ClinVar Annotator: match by term: Asthma |
ClinVar |
PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 PMID:26861442 PMID:28492532 PMID:28824638 PMID:29472930 More...
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NCBI chr 7:2,944,035...2,947,087
Ensembl chr 7:2,944,027...2,947,091
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G |
CARM1 |
coactivator associated arginine methyltransferase 1 |
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ISO |
mRNA:decreased expression:lung |
RGD |
PMID:20423833 |
RGD:9491823 |
NCBI chr19:10,871,553...10,923,075
Ensembl chr19:10,871,553...10,923,075
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G |
CASP1 |
caspase 1 |
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IEP |
protein:increased expression:serum |
RGD |
PMID:12396474 |
RGD:5130192 |
NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250
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G |
CAT |
catalase |
severity |
IEP EXP IDA IAGP |
protein:increased expression:erythrocyte CTD Direct Evidence: marker/mechanism protein:decreased activity:respiratory system fluid/secretion DNA:polymorphism:promoter:-262C>T (human) DNA:polymorphism:promoter:-21A>T (human) |
CTD RGD |
PMID:18048809 PMID:19475625 PMID:16622028 PMID:18048809 PMID:19373626 |
RGD:5130751, RGD:5130867, RGD:5130856, RGD:5130753 |
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCL1 |
C-C motif chemokine ligand 1 |
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IEP |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:20455898 |
RGD:4891420 |
NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233
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G |
CCL11 |
C-C motif chemokine ligand 11 |
treatment susceptibility severity |
ISO IAGP EXP IEP |
CTD Direct Evidence: marker/mechanism protein:increased expression:plasma DNA:polymorphism: :p.A23T (human) mRNA:increased expression:lung |
OMIM CTD RGD |
PMID:17060636 PMID:22932891 PMID:16304252 PMID:17074272 PMID:9034156 PMID:17845580 PMID:18250471 PMID:20704746 More...
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RGD:4891485, RGD:7248416, RGD:5130930, RGD:4145461, RGD:4145451, RGD:4145457, RGD:4145392, RGD:4145387 |
NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334
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G |
CCL17 |
C-C motif chemokine ligand 17 |
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ISO IEP |
mRNA:increased expression:lung protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:15993846 PMID:20074456 PMID:15947487 PMID:20237293 PMID:11160256 |
RGD:2306304, RGD:4145487, RGD:4145513, RGD:4145486, RGD:4145603 |
NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063
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G |
CCL19 |
C-C motif chemokine ligand 19 |
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IEP |
protein:increased expression:bronchus submucosa, mast cell |
RGD |
PMID:16959919 |
RGD:5130911 |
NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
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G |
CCL2 |
C-C motif chemokine ligand 2 |
treatment severity |
IEP EXP ISO IAGP |
CTD Direct Evidence: marker/mechanism mRNA:increased expression:lung (mouse) DNA:haplotype::-2518A>G (human) protein:increased expression:lung protein:increased expression:serum |
CTD RGD |
PMID:19373627 PMID:20205697 PMID:12055264 PMID:25441643 PMID:23454776 PMID:17964702 PMID:19373627 More...
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RGD:4145509, RGD:11528570, RGD:11528569, RGD:8551842, RGD:2307055, RGD:4891466 |
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCL20 |
C-C motif chemokine ligand 20 |
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IEP |
protein:increased expression:respiratory system fluid/secretion associated with Allergic Rhinitis;protein:increased expression:serum |
RGD |
PMID:18422729 PMID:22469443 |
RGD:7483597, RGD:7483618 |
NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
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G |
CCL22 |
C-C motif chemokine ligand 22 |
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ISO IEP |
protein:increased expression:respiratory system fluid/secretion mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion mRNA:increased expression:lung |
RGD |
PMID:18316417 PMID:10384142 PMID:18684970 PMID:15993846 |
RGD:4891474, RGD:4891475, RGD:4145489, RGD:2306304 |
NCBI chr16:57,357,909...57,366,189
Ensembl chr16:57,358,783...57,366,189
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G |
CCL24 |
C-C motif chemokine ligand 24 |
susceptibility |
IAGP IEP ISO IMP |
DNA:SNP: :1265A>G (human) protein:increased expression:plasma DNA:SNPs: :179T>C, 275C>T (human) DNA:SNPs: :304C>A, 1272A>G (human) protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:12761043 PMID:16304252 PMID:15207712 PMID:18712274 PMID:17060636 PMID:17548626 PMID:12952266 More...
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RGD:5130932, RGD:5130930, RGD:4891495, RGD:4891483, RGD:4891485, RGD:4891484, RGD:4891496 |
NCBI chr 7:75,810,825...75,823,372
Ensembl chr 7:75,810,825...75,823,356
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G |
CCL26 |
C-C motif chemokine ligand 26 |
treatment |
IAGP ISO IEP |
DNA:SNPs: :77C>T, 716A>G, 1579G>A (human) protein:increased expression:plasma DNA:SNPs: :77C>T, 2497T>G (human) |
RGD |
PMID:18712274 PMID:25399816 PMID:25530546 PMID:16304252 PMID:15207712 |
RGD:4891483, RGD:11087575, RGD:11081163, RGD:5130930, RGD:4891495 |
NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896
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G |
CCL27 |
C-C motif chemokine ligand 27 |
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IEP |
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RGD |
PMID:19541356 |
RGD:5130899 |
NCBI chr 9:34,661,890...34,662,657
Ensembl chr 9:34,661,880...34,664,048
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G |
CCL28 |
C-C motif chemokine ligand 28 |
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ISO |
mRNA:increased expression:lung (mouse) |
RGD |
PMID:16290206 |
RGD:4892195 |
NCBI chr 5:43,356,975...43,412,391
Ensembl chr 5:43,376,645...43,412,391
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G |
CCL4 |
C-C motif chemokine ligand 4 |
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IEP |
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RGD |
PMID:18774390 |
RGD:5130915 |
NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621
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G |
CCL5 |
C-C motif chemokine ligand 5 |
susceptibility |
ISO EXP IAGP |
protein:increased expression:lung, secretion (mouse) CTD Direct Evidence: marker/mechanism protein:increased expression:smooth muscle cell DNA:transition:5' utr:-403G>A (human) |
CTD RGD |
PMID:8534483 PMID:20092989 PMID:18208670 PMID:20430255 |
RGD:4891430, RGD:2307112, RGD:4891381 |
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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G |
CCL7 |
C-C motif chemokine ligand 7 |
|
ISO IEP |
Promoter polymorphism |
RGD |
PMID:19965981 PMID:21388664 |
RGD:5130979, RGD:5130983 |
NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
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G |
CCR1 |
C-C motif chemokine receptor 1 |
severity |
ISO |
mRNA:increased expression:lung associated with Respiratory Syncytial Virus Infections |
RGD |
PMID:15654816 PMID:15593301 |
RGD:5688158, RGD:5688159 |
NCBI chr 3:46,201,711...46,208,313
Ensembl chr 3:46,201,711...46,208,313
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G |
CCR2 |
C-C motif chemokine receptor 2 |
susceptibility |
IAGP ISO |
DNA:SNP:cds:p.V64I (human) DNA:haplotype:cds:p.V64I(human) protein:increased expression:lung, dendritic cell (mouse) |
RGD |
PMID:17298432 PMID:23454776 PMID:19917684 |
RGD:4145110, RGD:8551842, RGD:8549811 |
NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
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G |
CCR3 |
C-C motif chemokine receptor 3 |
|
ISO IEP IAGP |
protein:increased expression:respiratory system fluid/secretion, neutrophil DNA:SNP:exon:51T>C (human) |
RGD |
PMID:16978084 PMID:19017998 PMID:20220260 PMID:19657453 PMID:20134116 PMID:18699933 PMID:17145927 More...
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RGD:4145646, RGD:4145632, RGD:4145638, RGD:4145623, RGD:4145618, RGD:4145633, RGD:1601020 |
NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706
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G |
CCR4 |
C-C motif chemokine receptor 4 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:15993846 |
RGD:2306304 |
NCBI chr 3:32,951,644...32,956,349
Ensembl chr 3:32,951,644...32,957,120
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|
G |
CCR5 |
C-C motif chemokine receptor 5 |
no_association |
IEP IAGP ISO |
protein:decreased expression:blood, lymphocyte (human) DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human) DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) mRNA:increased expression:lung (mouse) |
RGD |
PMID:15256090 PMID:23454776 PMID:16474097 PMID:20220260 PMID:18094012 |
RGD:4892108, RGD:8551842, RGD:4892093, RGD:4145638, RGD:4892088 |
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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|
G |
CCR6 |
C-C motif chemokine receptor 6 |
|
ISO |
protein:increased expression:lung, dendritic cell (mouse) |
RGD |
PMID:19917684 |
RGD:8549811 |
NCBI chr 6:167,111,795...167,139,141
Ensembl chr 6:167,111,807...167,139,141
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|
G |
CCR7 |
C-C motif chemokine receptor 7 |
|
ISO |
protein:increased expression:lung, dendritic cell (mouse) |
RGD |
PMID:19917684 |
RGD:8549811 |
NCBI chr17:40,553,769...40,565,472
Ensembl chr17:40,551,081...40,565,472
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|
G |
CCR8 |
C-C motif chemokine receptor 8 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:15993846 |
RGD:2306304 |
NCBI chr 3:39,329,709...39,333,680
Ensembl chr 3:39,329,709...39,333,680
|
|
G |
CCR9 |
C-C motif chemokine receptor 9 |
|
IEP |
mRNA, protein:increased expression:blood, mature NK T cell |
RGD |
PMID:16210593 |
RGD:5130925 |
NCBI chr 3:45,886,064...45,903,174
Ensembl chr 3:45,884,425...45,903,174
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|
G |
CD14 |
CD14 molecule |
no_association severity susceptibility |
IAGP EXP IEP |
DNA:polymorphism:promoter:c. -159C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNPs: : protein:increased expression:serum protein:increased expression:serum|DNA:polymorphism:promoter:c. -159C>T (human) DNA:polymorphism:promoter:c. -260C>T (human) |
CTD RGD |
PMID:17607003 PMID:15741437 PMID:19096003 PMID:16387800 PMID:16387800 PMID:18312481 PMID:15940135 More...
|
RGD:4144815, RGD:4144228, RGD:4144813, RGD:4144813, RGD:4144208, RGD:4144814 |
NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,700
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|
G |
CD1D |
CD1d molecule |
susceptibility |
ISO |
associated with fasciolopsiasis |
RGD |
PMID:20304473 |
RGD:4140417 |
NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427
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|
G |
CD209 |
CD209 molecule |
|
IEP |
|
RGD |
PMID:21471959 |
RGD:5131188 |
NCBI chr19:7,739,993...7,747,534
Ensembl chr19:7,739,993...7,747,564
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|
G |
CD274 |
CD274 molecule |
treatment |
ISO |
associated with Chlamydia pneumonia |
RGD |
PMID:26378990 |
RGD:41412180 |
NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566
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|
G |
CD28 |
CD28 molecule |
|
IEP |
|
RGD |
PMID:21356099 |
RGD:5131612 |
NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,517...203,739,756
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|
G |
CD40 |
CD40 molecule |
treatment |
IEP ISO IAGP |
|
RGD |
PMID:19220210 PMID:20205594 PMID:20941750 PMID:19159017 |
RGD:5132272, RGD:8547792, RGD:4892277, RGD:4144188 |
NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
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G |
CD40LG |
CD40 ligand |
severity |
ISO |
|
RGD |
PMID:9502776 |
RGD:11352238 |
NCBI chr X:136,648,158...136,660,390
Ensembl chr X:136,648,158...136,660,390
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|
G |
CD80 |
CD80 molecule |
|
ISO |
|
RGD |
PMID:21352203 PMID:21051864 PMID:21440530 |
RGD:5132620, RGD:5132621, RGD:5132619 |
NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614
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|
G |
CD86 |
CD86 molecule |
treatment |
ISO IEP IAGP |
protein:increased expression:lung, alveolar macrophage (mouse) protein:increased expression:blood, B cell (human) protein:increased expression:lung, dendritic cell (rat) DNA:snp:exon:p.I179V rs2681417 (human) |
RGD |
PMID:20941750 PMID:25344652 PMID:9449507 PMID:20668438 PMID:9551945 PMID:17513529 More...
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RGD:4892277, RGD:11354965, RGD:4892555, RGD:4892199, RGD:4892202, RGD:4892280 |
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CDH1 |
cadherin 1 |
|
IAGP |
|
RGD |
PMID:21540309 |
RGD:5132878 |
NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537
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|
G |
CDHR3 |
cadherin related family member 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24241537 |
|
NCBI chr 7:105,963,264...106,036,432
Ensembl chr 7:105,876,796...106,036,432
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G |
CFTR |
CF transmembrane conductance regulator |
susceptibility |
IAGP |
DNA:deletion: :p.F508del(human) |
RGD |
PMID:20298391 |
RGD:4140387 |
NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
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|
G |
CHAT |
choline O-acetyltransferase |
|
ISO |
Protein:decreased expression:lung epithelium |
RGD |
PMID:17328924 |
RGD:5686690 |
NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
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G |
CHI3L1 |
chitinase 3 like 1 |
susceptibility |
IMP IAGP IEP |
human gene in mouse model ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 7 DNA:snp:5' utr:g.-131C>G rs4950928 (human) protein:increased secretion:serum (human) |
OMIM ClinVar RGD |
PMID:18403759 PMID:19414556 PMID:19568425 PMID:18003958 |
RGD:4892663, RGD:4892630, RGD:4892632 |
NCBI chr 1:203,178,931...203,186,704
Ensembl chr 1:203,178,931...203,186,704
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G |
CHIA |
chitinase acidic |
no_association |
IAGP ISO IEP |
DNA:snps:5' utr, cds:multiple (human) DNA:snps:multiple (human) mRNA:increased expression:lung, epithelial cell (human) mRNA:increased expression:lung (mouse) |
RGD |
PMID:16179638 PMID:20226308 PMID:19548841 PMID:15192232 PMID:14734765 |
RGD:4996473, RGD:5024922, RGD:5024921, RGD:4985150, RGD:4990463 |
NCBI chr 1:111,290,851...111,320,563
Ensembl chr 1:111,290,851...111,320,566
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|
G |
CHML |
CHM like Rab escort protein |
|
IAGP |
|
RGD |
PMID:18343558 |
RGD:5133238 |
NCBI chr 1:241,628,851...241,640,369
Ensembl chr 1:241,628,851...241,640,369
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G |
CHRM1 |
cholinergic receptor muscarinic 1 |
|
IAGP |
|
RGD |
PMID:16931638 |
RGD:5133416 |
NCBI chr11:62,908,679...62,921,878
Ensembl chr11:62,908,679...62,921,807
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G |
CHRM2 |
cholinergic receptor muscarinic 2 |
|
IAGP |
DNA:SNP: :rs6962027 (human) |
RGD |
PMID:19308904 |
RGD:5509586 |
NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
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|
G |
CHRM3 |
cholinergic receptor muscarinic 3 |
severity |
IEP ISO |
|
RGD |
PMID:20394512 PMID:18348887 |
RGD:5133437, RGD:5133438 |
NCBI chr 1:239,386,568...239,915,450
Ensembl chr 1:239,386,565...239,915,452
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G |
CHUK |
component of inhibitor of nuclear factor kappa B kinase complex |
|
ISO |
|
RGD |
PMID:21496385 |
RGD:5133703 |
NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596
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G |
CLCA1 |
chloride channel accessory 1 |
susceptibility |
IDA ISO IAGP |
DNA:SNPs (human) |
RGD |
PMID:17898169 PMID:11296262 PMID:15318163 |
RGD:4145653, RGD:4145661, RGD:4145656 |
NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259
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G |
CLDN18 |
claudin 18 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27215490 |
|
NCBI chr 3:137,998,816...138,033,649
Ensembl chr 3:137,998,735...138,033,655
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|
G |
CMA1 |
chymase 1 |
severity no_association susceptibility |
IEP IAGP |
protein:increased expression:lung epithelium, mast cell (human) DNA:polymorphism:5' utr:g.-1903G>A rs1800875 (human) DNA:duplications:3' utr:g.*254-?dupTG, dupGA (human) |
RGD |
PMID:20813890 PMID:15248847 PMID:15924217 |
RGD:5128804, RGD:1625397, RGD:1625396 |
NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265
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|
G |
CRHR1 |
corticotropin releasing hormone receptor 1 |
|
IAGP |
DNA:SNP: :RS242941 (human) DNA:SNPs: :rs1876828, rs242939, rs242941 (human) |
RGD |
PMID:19663668 PMID:16113459 |
RGD:5147485, RGD:5147488 |
NCBI chr17:45,784,320...45,835,828
Ensembl chr17:45,784,277...45,835,828
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|
G |
CRHR2 |
corticotropin releasing hormone receptor 2 |
|
IAGP |
DNA:SNPs: :multiple (human) |
RGD |
PMID:18408560 |
RGD:5130938 |
NCBI chr 7:30,651,942...30,700,103
Ensembl chr 7:30,651,942...30,700,129
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|
G |
CRP |
C-reactive protein |
|
IEP |
protein:increased expression:serum |
RGD |
PMID:21140796 |
RGD:5131288 |
NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589
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|
G |
CSF2 |
colony stimulating factor 2 |
severity |
ISO IEP |
protein:increased expression:lung protein:increased expression:sputum |
RGD |
PMID:20405019 PMID:9717963 PMID:19213775 |
RGD:5131473, RGD:10449521, RGD:5131476 |
NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
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G |
CSF2RB |
colony stimulating factor 2 receptor subunit beta |
|
ISO |
|
RGD |
PMID:17145927 |
RGD:1601020 |
NCBI chr22:36,913,628...36,940,439
Ensembl chr22:36,913,628...36,940,439
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G |
CSF3 |
colony stimulating factor 3 |
|
IDA ISO |
protein:increased expression:lung |
RGD |
PMID:21396376 PMID:20405019 |
RGD:5133731, RGD:5131473 |
NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813
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|
G |
CTLA4 |
cytotoxic T-lymphocyte associated protein 4 |
severity treatment no_association |
IEP EXP ISO IDA IAGP |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism DNA:SNP: :rs3087243 (human) DNA:polymorphism:promoter:-318C>T (human) DNA:SNPs:promoter, exon:-1147C>T, -318C>T, 49A>G (human) DNA:SNPs: :multiple (human) DNA:polymorphisms:promoter, exon:-318C>T 49A>G (human) |
CTD RGD |
PMID:28807506 PMID:15871446 PMID:11726402 PMID:17237396 PMID:16677453 PMID:18699801 PMID:19895365 PMID:12114354 PMID:12956753 PMID:16926542 PMID:16708626 PMID:15316504 PMID:17469155 More...
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RGD:4891529, RGD:11344922, RGD:4891514, RGD:4891517, RGD:4891510, RGD:4891526, RGD:4891522, RGD:4891521, RGD:4891528, RGD:4891516, RGD:4891519, RGD:4891527 |
NCBI chr 2:203,867,771...203,873,965
Ensembl chr 2:203,853,888...203,873,965
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G |
CTNNA3 |
catenin alpha 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19187332 |
|
NCBI chr10:65,912,523...67,763,594
Ensembl chr10:65,912,457...67,763,637
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|
G |
CX3CL1 |
C-X3-C motif chemokine ligand 1 |
|
IEP |
protein:increased expression:plasma |
RGD |
PMID:14657873 |
RGD:4891906 |
NCBI chr16:57,372,490...57,385,044
Ensembl chr16:57,372,477...57,385,044
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|
G |
CX3CR1 |
C-X3-C motif chemokine receptor 1 |
no_association |
ISO IAGP |
DNA:polymorphisms: :p.V249I, p.T280M (human) DNA:SNPs: :p.V249I, rs2669849 (human) |
RGD |
PMID:21037587 PMID:17505143 PMID:17082760 |
RGD:4891882, RGD:4891904, RGD:4891895 |
NCBI chr 3:39,263,494...39,292,966
Ensembl chr 3:39,263,495...39,281,735
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|
G |
CXCL1 |
C-X-C motif chemokine ligand 1 |
severity |
IEP |
|
RGD |
PMID:20371397 |
RGD:5134983 |
NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
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|
G |
CXCL10 |
C-X-C motif chemokine ligand 10 |
|
IEP ISO |
protein:decreased expression:plasma |
RGD |
PMID:17302903 PMID:16602032 PMID:11994485 |
RGD:5135439, RGD:5135457, RGD:5135452 |
NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
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G |
CXCL14 |
C-X-C motif chemokine ligand 14 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21150878 |
|
NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
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|
G |
CXCL2 |
C-X-C motif chemokine ligand 2 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:20045013 |
RGD:5129686 |
NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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|
G |
CXCL5 |
C-X-C motif chemokine ligand 5 |
|
IEP ISO |
mRNA:increased expression:bronchus epithelium |
RGD |
PMID:17234659 PMID:9620668 |
RGD:5135243, RGD:5135265 |
NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677
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G |
CXCL6 |
C-X-C motif chemokine ligand 6 |
|
ISO |
|
RGD |
PMID:9620668 |
RGD:5135265 |
NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
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|
G |
CXCL9 |
C-X-C motif chemokine ligand 9 |
|
ISO |
|
RGD |
PMID:15210824 |
RGD:5135447 |
NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
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|
G |
CXCR3 |
C-X-C motif chemokine receptor 3 |
susceptibility severity |
ISO IAGP IEP |
DNA:SNP:intron:IVS1+234G>A (human) protein:decreased expression:respiratory system fluid/secretion, T cell |
RGD |
PMID:18094012 PMID:16043121 PMID:16548899 PMID:17641057 |
RGD:4892088, RGD:5143934, RGD:5143932, RGD:5135484 |
NCBI chr X:71,615,919...71,618,511
Ensembl chr X:71,615,916...71,618,511
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G |
CYBA |
cytochrome b-245 alpha chain |
susceptibility |
IAGP |
DNA:SNPs: :-930A>G, 242C>T, 640A>G (human) DNA:polymorphism: :-930A>G (human) |
RGD |
PMID:18716406 PMID:19459419 |
RGD:4772770, RGD:4311041 |
NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083
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|
G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
|
ISO |
mRNA, protein:increased expression, decreased activity:lung |
RGD |
PMID:12415424 |
RGD:4892074 |
NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
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|
G |
CYP2D6 |
cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) |
|
IAGP |
DNA:polymorphism: :1934G>A (human) |
RGD |
PMID:19575027 |
RGD:5143944 |
NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
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|
G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
|
IEP EXP ISO |
mRNA:decreased expression:leukocyte CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28807506 PMID:20514434 PMID:17081494 |
RGD:4892076, RGD:4892220 |
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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|
G |
CYSLTR1 |
cysteinyl leukotriene receptor 1 |
no_association severity |
IAGP IMP ISO IEP |
DNA:SNPs:promoter, exon:multiple (human) DNA:SNPs:promoter:-634C>T, -475A>C, -336A>G (human) DNA:SNP: :927T>C (human) mRNA, protein:increased expression:respiratory system mucosa |
RGD |
PMID:16771777 PMID:16630147 PMID:17153879 PMID:16776674 PMID:11591188 PMID:8087328 PMID:16387808 PMID:17689528 PMID:16123393 More...
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RGD:4889116, RGD:4784257, RGD:4781742, RGD:4782072, RGD:4848936, RGD:4888514, RGD:4843543, RGD:4781449, RGD:4847129 |
NCBI chr X:78,271,468...78,327,611
Ensembl chr X:78,271,468...78,327,691
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G |
CYSLTR2 |
cysteinyl leukotriene receptor 2 |
|
IAGP |
DNA:polymorphism: :601A>G (human) DNA:polymorphism: :-1220A>C (human) |
RGD |
PMID:15475736 PMID:15454733 |
RGD:5144002, RGD:5144003 |
NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226
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G |
DCN |
decorin |
|
ISO |
|
RGD |
PMID:16387756 |
RGD:2311423 |
NCBI chr12:91,140,484...91,182,817
Ensembl chr12:91,140,484...91,183,217
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|
G |
DEFB1 |
defensin beta 1 |
susceptibility |
IAGP |
DNA:SNP: :-1816 T>C (human) DNA:SNPs:5' utr:g.-52G>A, g.-44C>G, g.-20G>A (human) |
RGD |
PMID:15696078 PMID:16435024 |
RGD:4892263, RGD:4892254 |
NCBI chr 8:6,870,592...6,877,936
Ensembl chr 8:6,870,592...6,877,936
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G |
DNAH5 |
dynein axonemal heavy chain 5 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21912604 |
|
NCBI chr 5:13,690,328...14,011,818
Ensembl chr 5:13,690,328...14,011,818
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G |
DNMT1 |
DNA methyltransferase 1 |
|
ISO EXP |
DNA,mRNA:hypermethylation,decreased expression:promoter,respiratory tract: CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:23423710 PMID:23196709 |
RGD:9588646 |
NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286
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G |
DPP10 |
dipeptidyl peptidase like 10 |
|
IAGP IEA ISO |
DNA:SNPs (human) DNA:SNP: :rs10208402 (human) protein:increased expression:bronchus DNA:SNP:exon (human) |
RGD GAD |
PMID:21103062 PMID:19672052 PMID:15118671 PMID:17967935 PMID:14566338 |
RGD:4889866, RGD:4892275, RGD:1331525, RGD:4892278, RGD:4892276 |
NCBI chr 2:114,442,641...115,845,780
Ensembl chr 2:114,442,299...115,845,780
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G |
EBI3 |
Epstein-Barr virus induced 3 |
|
ISO |
|
RGD |
PMID:21255010 |
RGD:5128488 |
NCBI chr19:4,229,523...4,237,528
Ensembl chr19:4,229,523...4,237,528
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G |
EDN1 |
endothelin 1 |
|
IEP EXP IAGP |
Severe Persistent Allergic Asthma; protein:increased secretion:lung (human) CTD Direct Evidence: marker/mechanism DNA:transition:intron:g.4124T>C (human) |
CTD RGD |
PMID:16981460 PMID:20588001 PMID:11668616 |
RGD:4144895, RGD:4144869 |
NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194
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G |
EDNRA |
endothelin receptor type A |
|
ISO |
|
RGD |
PMID:17448648 PMID:18632188 |
RGD:4892322, RGD:4892288 |
NCBI chr 4:147,481,097...147,544,954
Ensembl chr 4:147,480,917...147,544,954
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G |
EDNRB |
endothelin receptor type B |
|
IAGP ISO |
DNA:polymorphism (human) mRNA:increased expression:bronchus, smooth muscle cell |
RGD |
PMID:17470272 PMID:15245576 PMID:18632188 |
RGD:4892321, RGD:4892324, RGD:4892288 |
NCBI chr13:77,895,487...77,975,527
Ensembl chr13:77,895,481...77,975,529
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G |
EGFR |
epidermal growth factor receptor |
severity |
IEP ISO |
protein:increased expression:bronchial epithelium (human) protein:increased expression:lung epithelium (rat) protein:increased expression:lung epithelium (mouse) |
RGD |
PMID:12580917 PMID:21224214 PMID:19954006 PMID:21072743 |
RGD:5131468, RGD:5131633, RGD:5131870, RGD:5131642 |
NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
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G |
EGR1 |
early growth response 1 |
|
IEP IAGP ISO |
mRNA:increased expression:bronchoalveolar lavage cell (human) DNA:snp:5' utr:g.-4071A>G rs7729723 (human) |
RGD |
PMID:18774390 PMID:18507785 PMID:11254538 |
RGD:5130915, RGD:5131993, RGD:5131985 |
NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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|
G |
ELP1 |
elongator acetyltransferase complex subunit 1 |
no_association |
IAGP |
|
RGD |
PMID:12774215 PMID:11281413 |
RGD:5129158, RGD:5129157 |
NCBI chr 9:108,867,517...108,934,124
Ensembl chr 9:108,866,898...108,934,328
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G |
EPHX1 |
epoxide hydrolase 1 |
susceptibility |
IAGP |
DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human) |
RGD |
PMID:17711870 |
RGD:4889407 |
NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563
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G |
EPX |
eosinophil peroxidase |
severity disease_progression |
IEP |
protein:increased activity:sputum,nasal,pharyngeal mucosa |
RGD |
PMID:26645423 PMID:12199967 PMID:20813885 |
RGD:11574908, RGD:13506892, RGD:13506891 |
NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174
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G |
ESR2 |
estrogen receptor 2 |
|
ISO |
mRNA:decreased expression:lung (rat) |
RGD |
PMID:18375789 |
RGD:8694127 |
NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
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G |
F2 |
coagulation factor II, thrombin |
|
IEP |
protein:increased expression:plasma associated with Rhinosinusitis, associated with Nasal Polyps;protein:increased expression:nasal mucus |
RGD |
PMID:21658190 PMID:21711961 |
RGD:5147753, RGD:5147783 |
NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
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G |
F2RL1 |
F2R like trypsin receptor 1 |
|
IDA |
|
RGD |
PMID:19864598 |
RGD:4892589 |
NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
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G |
F7 |
coagulation factor VII |
treatment |
ISO |
|
RGD |
PMID:24523826 |
RGD:11040539 |
NCBI chr13:113,105,788...113,120,685
Ensembl chr13:113,105,788...113,120,685
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G |
FAS |
Fas cell surface death receptor |
|
ISO |
mRNA:increased expression:eosinophil |
RGD |
PMID:16337971 |
RGD:1600350 |
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FCER1A |
Fc epsilon receptor Ia |
severity |
IEP |
Fatal asthma subjects Asthma symptoms persistent despite steroids |
RGD |
PMID:20937062 PMID:21388666 |
RGD:5128717, RGD:5128711 |
NCBI chr 1:159,283,575...159,308,202
Ensembl chr 1:159,289,714...159,308,224
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G |
FCGR2A |
Fc gamma receptor IIa |
|
IEP |
protein:increased expression:alveolar macrophage |
RGD |
PMID:9117017 |
RGD:5147982 |
NCBI chr 1:161,505,457...161,524,048
Ensembl chr 1:161,505,430...161,524,013
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G |
FCGR2B |
Fc gamma receptor IIb |
|
ISO |
|
RGD |
PMID:20179765 |
RGD:11344929 |
NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654
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G |
FCGR3A |
Fc gamma receptor IIIa |
susceptibility |
IAGP |
DNA:polymorphism:exon:p.F158V(rs396991)(human) |
RGD |
PMID:18199088 |
RGD:5508449 |
NCBI chr 1:161,541,759...161,550,737
Ensembl chr 1:161,541,759...161,550,968
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G |
FGA |
fibrinogen alpha chain |
treatment |
ISO |
|
RGD |
PMID:24523826 |
RGD:11040539 |
NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742
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G |
FKBP5 |
FKBP prolyl isomerase 5 |
|
IAGP |
ClinVar Annotator: match by term: Asthma |
ClinVar |
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NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
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G |
FOXP3 |
forkhead box P3 |
treatment |
EXP ISO |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:27965764 PMID:29317916 PMID:28944907 PMID:27633092 |
RGD:38549365, RGD:38548920 |
NCBI chr X:49,250,438...49,264,710
Ensembl chr X:49,250,438...49,264,800
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G |
GATA3 |
GATA binding protein 3 |
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ISO IEP |
|
RGD |
PMID:18186587 PMID:9949310 |
RGD:5128803, RGD:5128802 |
NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198
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G |
GC |
GC vitamin D binding protein |
|
ISO IEP |
protein, mRNA:increased expression:bronchoalveolar lavage fluid: |
RGD |
PMID:21169467 PMID:21169467 |
RGD:5509920, RGD:5509920 |
NCBI chr 4:71,741,693...71,805,520
Ensembl chr 4:71,741,696...71,804,041
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G |
GSDMB |
gasdermin B |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24241537 |
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NCBI chr17:39,904,595...39,918,635
Ensembl chr17:39,904,595...39,919,854
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G |
GSTA1 |
glutathione S-transferase alpha 1 |
susceptibility |
IAGP |
DNA:polymorphism:promoter: -69C>T (human) |
RGD |
PMID:20374258 |
RGD:5490988 |
NCBI chr 6:52,791,371...52,803,816
Ensembl chr 6:52,791,371...52,803,860
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G |
GSTM1 |
glutathione S-transferase mu 1 |
resistance susceptibility |
IAGP EXP |
DNA:deletion: : CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16870661 PMID:18988661 PMID:17651144 PMID:21051083 PMID:11075422 |
RGD:4142509, RGD:5490962, RGD:4140921 |
NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
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G |
GSTM3 |
glutathione S-transferase mu 3 |
|
IAGP IEP |
DNA:polymorphism |
RGD |
PMID:11470996 PMID:17550934 |
RGD:5135039, RGD:5135038 |
NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
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G |
GSTO2 |
glutathione S-transferase omega 2 |
susceptibility |
IAGP |
DNA:polymorphism:exon:p. N142D (human) |
RGD |
PMID:20374258 |
RGD:5490988 |
NCBI chr10:104,269,184...104,304,950
Ensembl chr10:104,268,873...104,304,950
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G |
GSTP1 |
glutathione S-transferase pi 1 |
no_association susceptibility disease_progression severity |
IAGP EXP ISO |
DNA:SNPs: :p.I105V, p.A114V (human) CTD Direct Evidence: marker/mechanism DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human) DNA:SNPs:intron,exon:(rs749174), (rs1138272)(human) DNA:polymorphism:exon:p.I105V (human) DNA:SNP: :p.A114V (human) DNA:polymorphism:exon:p.I105V (rs1695) (human) |
CTD RGD |
PMID:11994713 PMID:16870661 PMID:18988661 PMID:24117884 PMID:29411558 PMID:16176403 PMID:15693909 PMID:20210814 PMID:20858151 PMID:18057098 PMID:18709160 PMID:18787219 PMID:10806136 More...
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RGD:4142519, RGD:5490999, RGD:5490991, RGD:5490985, RGD:4140951, RGD:4140947, RGD:4140946, RGD:4142526 |
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
GSTT1 |
glutathione S-transferase theta 1 |
susceptibility |
IAGP |
DNA:deletion: : |
RGD |
PMID:15300848 PMID:21051083 PMID:11075422 |
RGD:4142539, RGD:5490962, RGD:4140921 |
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G |
HAVCR1 |
hepatitis A virus cellular receptor 1 |
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IEP |
|
RGD |
PMID:20628202 |
RGD:5128851 |
NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
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G |
HAVCR2 |
hepatitis A virus cellular receptor 2 |
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ISO |
|
RGD |
PMID:17517968 |
RGD:5135525 |
NCBI chr 5:157,085,832...157,109,044
Ensembl chr 5:157,085,422...157,142,869
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G |
HDAC2 |
histone deacetylase 2 |
|
IEP |
mRNA:decreased expression:macrophage: |
RGD |
PMID:20538962 |
RGD:9590321 |
NCBI chr 6:113,933,028...113,971,148
Ensembl chr 6:113,933,028...114,011,308
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G |
HDC |
histidine decarboxylase |
|
IAGP |
associated with Rhinitis;DNA:SNP: :p.E644D (rs2073440) (human) |
RGD |
PMID:20608921 |
RGD:5128884 |
NCBI chr15:50,241,947...50,265,726
Ensembl chr15:50,241,947...50,265,965
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G |
HIF1A |
hypoxia inducible factor 1 subunit alpha |
treatment |
ISO |
|
RGD |
PMID:18160846 |
RGD:10402541 |
NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G |
HLA-B |
major histocompatibility complex, class I, B |
susceptibility |
IAGP |
DNA:polymorphism: |
RGD |
PMID:28380482 |
RGD:13506910 |
NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
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|
G |
HLA-DPA1 |
major histocompatibility complex, class II, DP alpha 1 |
susceptibility |
IAGP |
DNA:polymorphism: : |
RGD |
PMID:21814517 |
RGD:13506911 |
NCBI chr 6:33,064,569...33,080,748
Ensembl chr 6:33,064,569...33,080,775
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G |
HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
susceptibility |
IAGP EXP |
DNA:haplotype DNA:polymorphisms: : CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:16792590 PMID:17956852 PMID:21217921 PMID:21814517 |
RGD:5143938, RGD:13506911 |
NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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G |
HLA-DQA1 |
major histocompatibility complex, class II, DQ alpha 1 |
|
IAGP EXP |
DNA:polymorphisms (human) CTD Direct Evidence: marker/mechanism DNA:polymorphism (human) |
CTD RGD |
PMID:10792356 PMID:12890388 PMID:10051703 PMID:11802952 PMID:19052351 |
RGD:5147799, RGD:1331670, RGD:5147831, RGD:5147617 |
NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062
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G |
HLA-DQA2 |
major histocompatibility complex, class II, DQ alpha 2 |
susceptibility |
IAGP |
DNA:polymorphism: :rs3916765(human) |
RGD |
PMID:20159242 |
RGD:13506913 |
NCBI chr 6:32,741,391...32,747,198
Ensembl chr 6:32,741,391...32,747,198
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G |
HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
susceptibility disease_progression no_association |
IAGP EXP |
Alternaria sensitive asthma DNA:polymorphisms: : CTD Direct Evidence: marker/mechanism DNA:polymorphisms (human) |
CTD RGD |
PMID:10792356 PMID:20298583 PMID:20159242 PMID:20214848 PMID:23331206 PMID:11802952 PMID:12890388 PMID:19052351 More...
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RGD:4144113, RGD:13506913, RGD:4144181, RGD:13506906, RGD:5147831, RGD:5147799, RGD:5147617 |
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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G |
HLA-DRA |
major histocompatibility complex, class II, DR alpha |
susceptibility |
IAGP |
DNA:polymorphisms: : |
RGD |
PMID:20159242 |
RGD:13506913 |
NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
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G |
HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
susceptibility no_association severity |
IAGP EXP |
DNA:polymorphisms: : CTD Direct Evidence: marker/mechanism DNA:polymorphism (human) |
CTD RGD |
PMID:16792590 PMID:20214848 PMID:20159242 PMID:23331206 PMID:10051703 PMID:19439981 PMID:20486920 PMID:19528258 More...
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RGD:4144181, RGD:13506913, RGD:13506906, RGD:1331670, RGD:5147663, RGD:5147607, RGD:4144196 |
NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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G |
HLA-DRB3 |
major histocompatibility complex, class II, DR beta 3 |
susceptibility |
IAGP |
|
RGD |
PMID:22397267 |
RGD:13506905 |
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G |
HLA-G |
major histocompatibility complex, class I, G |
susceptibility |
IAGP EXP |
CTD Direct Evidence: marker/mechanism |
CTD OMIM RGD |
PMID:15611928 |
RGD:5144118 |
NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125
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G |
HMGCR |
3-hydroxy-3-methylglutaryl-CoA reductase |
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IMP |
|
RGD |
PMID:20084838 |
RGD:5508450 |
NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001
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G |
HMOX1 |
heme oxygenase 1 |
severity |
IEP EXP ISO |
mRNA;protein:increased expression:Leukocytes, Mononuclear CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:18048809 PMID:16196283 PMID:20596599 |
RGD:4145408, RGD:4145403 |
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
HNMT |
histamine N-methyltransferase |
no_association |
IAGP EXP |
ClinVar Annotator: match by term: Asthma, susceptibility to CTD Direct Evidence: marker/mechanism |
OMIM ClinVar CTD RGD |
PMID:10752634 PMID:10803682 PMID:16205835 PMID:17651147 PMID:25741868 PMID:17651147 PMID:10803682 PMID:21040557 PMID:15693910 PMID:16205835 More...
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RGD:5128885, RGD:5128881, RGD:5128883, RGD:5128888, RGD:5128887 |
NCBI chr 2:137,964,473...138,016,364
Ensembl chr 2:137,964,020...138,016,364
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G |
HP |
haptoglobin |
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IEP |
|
RGD |
PMID:21471098 PMID:21169467 |
RGD:5144151, RGD:5509920 |
NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055
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G |
HSD11B2 |
hydroxysteroid 11-beta dehydrogenase 2 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:11932298 |
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NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553
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G |
HTR2A |
5-hydroxytryptamine receptor 2A |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25322896 |
|
NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076
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G |
ICAM1 |
intercellular adhesion molecule 1 |
|
ISO EXP IEP |
mRNA:increased expression:aorta (mouse) CTD Direct Evidence: marker/mechanism protein:increased secretion:lung (human) protein:increased expression:lung, serum (rat) |
CTD RGD |
PMID:17014439 PMID:25003170 PMID:20400685 PMID:20205697 PMID:20953388 |
RGD:4145444, RGD:4145509, RGD:4145331 |
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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G |
IFNG |
interferon gamma |
treatment resistance |
IEP ISO IEA |
protein:increased expression:sputum |
RGD GAD |
PMID:20817868 PMID:12396623 PMID:15118671 PMID:20953328 PMID:19542437 |
RGD:4145651, RGD:10755706, RGD:1331525, RGD:4145525, RGD:5128479 |
NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
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G |
IFNGR1 |
interferon gamma receptor 1 |
|
ISO IAGP |
DNA: SNP: Leu467Pro |
RGD |
PMID:21737883 PMID:12851715 |
RGD:6480255, RGD:6480431 |
NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449
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G |
IFNL1 |
interferon lambda 1 |
exacerbates |
IEP |
associated with common cold;mRNA:decreased expression:sputum (human) associated with common cold;protein:increased expression: nasal cavity (human) |
RGD |
PMID:25784275 PMID:22135341 |
RGD:126848770, RGD:126848775 |
NCBI chr19:39,296,407...39,298,673
Ensembl chr19:39,296,407...39,298,673
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G |
IFNL3 |
interferon lambda 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22295096 |
|
NCBI chr19:39,243,455...39,245,250
Ensembl chr19:39,243,455...39,245,250
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G |
IKZF3 |
IKAROS family zinc finger 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25256354 |
|
NCBI chr17:39,757,715...39,864,312
Ensembl chr17:39,757,715...39,864,312
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G |
IL10 |
interleukin 10 |
treatment susceptibility |
ISO EXP IAGP IEP |
CTD Direct Evidence: marker/mechanism DNA:polymorphism: :-627C>A (human) protein:decreased expression:plasma |
CTD RGD |
PMID:29317916 PMID:20560982 PMID:21998459 PMID:12938145 PMID:20237464 PMID:20230687 PMID:20644177 PMID:20121766 More...
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RGD:5131623, RGD:11046261, RGD:4143221, RGD:4140471, RGD:4140421, RGD:4140459, RGD:4140451 |
NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL12A |
interleukin 12A |
|
ISO |
|
RGD |
PMID:17056578 PMID:17548618 |
RGD:4438438, RGD:4373570 |
NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019
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G |
IL12B |
interleukin 12B |
severity susceptibility |
IAGP |
DNA:polymorphisms:introns: ClinVar Annotator: match by term: Asthma, susceptibility to DNA:polymorphism:promoter DNA:polymorphisms:promoter, 3'utr: |
ClinVar RGD |
PMID:15322986 PMID:15322986 PMID:12241719 PMID:16210052 |
RGD:1600043, RGD:4145428, RGD:4145438 |
NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
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G |
IL13 |
interleukin 13 |
susceptibility severity no_association |
IAGP EXP IEP ISO |
DNA:polymorphism:promoter:c. -1055C>T (human) ClinVar Annotator: match by term: Asthma, susceptibility to CTD Direct Evidence: marker/mechanism associated with Dermatitis, Atopic;DNA, protein:SNP, increased expression:promoter, serum:-1112C>T (human) DNA:polymorphism: :-1512A>C, -1112C>T, 2044G>A (human) protein:increased expression:serum DNA:polymorphism:3'utr:c.4738G>A (human) DNA:polymorphism: :c. 2044G>A (human) mRNA, protein:increased expression:esophagus, Bronchoalveolar Lavage Fluid DNA:polymorphisms:promoters,exon4: rs1881457, rs1800925, rs20541 (human) DNA:polymorphism: :p. R110Q (human) DNA:polymorphism: :c. 1923C>T (human) DNA:SNP: :c. -646A>G (human) DNA:polymorphisms: :rs20541, rs1295685(human) DNA:polymorphism: :c.-1055C>T (human) DNA:polymorphism:cds:p.R130Q (human) protein:increased expression:sputum |
ClinVar OMIM CTD RGD |
PMID:10699178 PMID:11588017 PMID:11709756 PMID:12847555 PMID:12928861 PMID:15356556 PMID:15483090 PMID:15711639 PMID:15879126 PMID:22867017 PMID:25741868 PMID:16024972 PMID:23317483 PMID:17006604 PMID:11758895 PMID:12604708 PMID:11588017 PMID:18341619 PMID:20819635 PMID:16393274 PMID:18222984 PMID:18258919 PMID:19796199 PMID:12091879 PMID:15315330 PMID:19575932 PMID:17303794 PMID:20484924 PMID:20198887 PMID:11678850 PMID:18328894 PMID:16120094 More...
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RGD:4220633, RGD:8549509, RGD:4892639, RGD:4763153, RGD:2301686, RGD:4765128, RGD:4145776, RGD:4145453, RGD:4145508, RGD:2307110, RGD:4145639, RGD:4145601, RGD:4145664, RGD:4321828, RGD:4145775, RGD:4146241, RGD:4145534, RGD:4145593, RGD:4763761, RGD:4145777, RGD:4206706 |
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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IL13RA1 |
interleukin 13 receptor subunit alpha 1 |
no_association |
ISO IAGP |
DNA:polymorphisms:promoter, 3' utr:-281T>G, 1365A>G (human) mRNA:increased expression:bronchus DNA:polymorphism: :1398A>G (human) DNA:polymorphism: :1050C>T (human) |
RGD |
PMID:11714828 PMID:18480254 PMID:17392323 PMID:20383033 PMID:17006604 PMID:10686479 More...
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RGD:4892654, RGD:4892647, RGD:4892650, RGD:4892646, RGD:4892639, RGD:4892655 |
NCBI chr X:118,727,606...118,805,228
Ensembl chr X:118,727,133...118,794,535
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G |
IL13RA2 |
interleukin 13 receptor subunit alpha 2 |
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ISO IEP |
mRNA:increased expression:bronchus protein:increased expression:serum |
RGD |
PMID:20383033 PMID:21462799 PMID:17885690 |
RGD:4892646, RGD:8549521, RGD:4892649 |
NCBI chr X:115,003,982...115,017,616
Ensembl chr X:115,003,975...115,019,977
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G |
IL15 |
interleukin 15 |
no_association |
IAGP ISO |
DNA:SNPs: :multiple (human) |
RGD |
PMID:19133918 PMID:16629787 PMID:11160248 PMID:15843549 PMID:15131572 |
RGD:5000760, RGD:4984421, RGD:4990462, RGD:5000757, RGD:5000758 |
NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987
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G |
IL16 |
interleukin 16 |
no_association severity |
IAGP IEP ISO |
DNA:SNP:promoter:-295T>C (human) associated with Rhinitis;protein:increased expression:respiratory system fluid/secretion protein:increased expression:serum |
RGD |
PMID:15784111 PMID:16734115 PMID:12872394 PMID:10585533 PMID:16387589 |
RGD:5024935, RGD:5024928, RGD:5024930, RGD:5024937, RGD:5024934 |
NCBI chr15:81,182,712...81,314,058
Ensembl chr15:81,159,575...81,314,058
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IL17A |
interleukin 17A |
susceptibility |
IEP ISO IAGP |
protein:increased expression:sputum DNA:SNP:promoter:rs2275913 (human) protein:increased expression:alveolar macrophage mRNA,protein:increased expression:Leukocytes, Mononuclear, lung, serum |
RGD |
PMID:15730730 PMID:20351038 PMID:20437253 PMID:18941201 PMID:18060619 |
RGD:4889114, RGD:4888527, RGD:4889139, RGD:4889152, RGD:4839043 |
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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G |
IL17RB |
interleukin 17 receptor B |
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ISO |
associated with Picornaviridae Infections |
RGD |
PMID:25273095 |
RGD:39128256 |
NCBI chr 3:53,846,568...53,865,794
Ensembl chr 3:53,846,568...53,865,794
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G |
IL18 |
interleukin 18 |
severity susceptibility disease_progression |
IAGP ISO IMP IEP |
DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human) DNA:SNP:promoter:c.and -137G>C (rs187238)(human) DNA:polymorphism: :c. -105A>C (human) DNA:SNP:promoter: c.-380C>G (rs5744247)(human) protein:increased expression:serum |
RGD |
PMID:17767553 PMID:18826499 PMID:20497957 PMID:20497957 PMID:16433859 PMID:18200581 PMID:19745201 PMID:11174201 More...
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RGD:4889585, RGD:4889908, RGD:4889898, RGD:4889898, RGD:4889923, RGD:4889910, RGD:4889900, RGD:4889863 |
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
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G |
IL18R1 |
interleukin 18 receptor 1 |
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IAGP ISO |
DNA:SNPs: :multiple (human) DNA:SNP: :rs3771166 (human) |
RGD |
PMID:18774397 PMID:19910030 PMID:20860503 PMID:11972614 PMID:18382474 |
RGD:5024946, RGD:5024945, RGD:5024942, RGD:5024948, RGD:5024947 |
NCBI chr 2:102,355,796...102,398,776
Ensembl chr 2:102,311,529...102,398,777
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G |
IL19 |
interleukin 19 |
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IEP |
protein:increased expression:serum |
RGD |
PMID:15557163 |
RGD:5037236 |
NCBI chr 1:206,770,773...206,842,981
Ensembl chr 1:206,770,764...206,842,981
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G |
IL1A |
interleukin 1 alpha |
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IAGP |
DNA:polymorphisms: : |
RGD |
PMID:18763028 |
RGD:4142802 |
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1B |
interleukin 1 beta |
susceptibility |
IAGP EXP ISO IEP |
DNA:polymorphism: :-511C>T (human) CTD Direct Evidence: marker/mechanism protein:decreased expression:neutrophil |
CTD RGD |
PMID:9176529 PMID:18926055 PMID:19684087 PMID:19842845 |
RGD:4142864, RGD:4142836, RGD:4142830 |
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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IL1RL1 |
interleukin 1 receptor like 1 |
susceptibility severity |
ISO EXP IAGP IEP |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism DNA:SNP: :rs1420101 (human) DNA:SNPs:intron:rs1420089, rs1861245,rs1946131 (human) DNA:SNP: :rs10197862 (human) DNA:SNP: :rs1041973 (human) |
CTD RGD |
PMID:19198610 PMID:21150878 PMID:21804549 PMID:24241537 PMID:27472835 PMID:17623648 PMID:17407196 PMID:19179489 PMID:19198610 PMID:19852851 PMID:21150878 PMID:21281963 PMID:11463601 More...
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RGD:5144235, RGD:5144245, RGD:5144244, RGD:5144243, RGD:5144242, RGD:5144240, RGD:5144239, RGD:5144237 |
NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037
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IL1RN |
interleukin 1 receptor antagonist |
severity susceptibility |
IEP EXP IAGP IMP |
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism DNA:polymorphism:intron (human) DNA:SNP: :rs2234678 (human) DNA:SNPs: :rs447713, rs3087271 (human) DNA:SNPs: :multiple (human) DNA, protein:repeat, decreased expression (human) |
CTD RGD |
PMID:9176529 PMID:10843772 PMID:18926055 PMID:17107994 PMID:16409203 PMID:16724092 PMID:15020290 PMID:18763028 PMID:11027520 More...
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RGD:4143225, RGD:4142864, RGD:4143208, RGD:4143163, RGD:4143209, RGD:4143216, RGD:4142802, RGD:4143224 |
NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016
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G |
IL2 |
interleukin 2 |
susceptibility |
IEP IAGP |
DNA:SNP:promoter:rs2069762(human) |
RGD |
PMID:20926789 PMID:16333313 |
RGD:4889118, RGD:8663473 |
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL21 |
interleukin 21 |
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IAGP |
DNA:SNP:exon:5250C>T (human) |
RGD |
PMID:18802358 |
RGD:5147396 |
NCBI chr 4:122,610,108...122,621,066
Ensembl chr 4:122,610,108...122,621,066
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G |
IL22 |
interleukin 22 |
treatment severity |
ISO IEP |
mRNA:increased expression:blood, mononuclear cell protein:increased expression:serum |
RGD |
PMID:21789181 PMID:21998459 PMID:21535180 PMID:21297073 |
RGD:5147401, RGD:11046261, RGD:5147409, RGD:5147403 |
NCBI chr12:68,248,242...68,253,604
Ensembl chr12:68,248,242...68,253,604
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G |
IL23R |
interleukin 23 receptor |
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ISO |
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RGD |
PMID:19935773 |
RGD:5037240 |
NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979
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G |
IL25 |
interleukin 25 |
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ISO |
mRNA, protein:increased expression:lung |
RGD |
PMID:25273095 |
RGD:39128256 |
NCBI chr14:23,372,809...23,376,403
Ensembl chr14:23,372,809...23,376,403
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G |
IL27 |
interleukin 27 |
susceptibility treatment |
IAGP ISO IEP |
DNA:SNP: :g.-964A>G (human) protein:increased expression:sputum |
RGD |
PMID:17318299 PMID:26595888 PMID:17878337 PMID:20817868 PMID:19542437 |
RGD:5128485, RGD:11076728, RGD:5128491, RGD:4145651, RGD:5128479 |
NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051
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IL27RA |
interleukin 27 receptor subunit alpha |
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ISO |
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RGD |
PMID:16081811 |
RGD:5128496 |
NCBI chr19:14,031,762...14,053,218
Ensembl chr19:14,031,762...14,053,218
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G |
IL2RA |
interleukin 2 receptor subunit alpha |
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ISO |
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RGD |
PMID:21377197 PMID:20525707 |
RGD:5147437, RGD:5147445 |
NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
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G |
IL2RB |
interleukin 2 receptor subunit beta |
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IAGP ISO |
DNA:SNP: :rs2284033 (human) |
RGD |
PMID:20860503 PMID:18641329 |
RGD:5024942, RGD:5147447 |
NCBI chr22:37,125,838...37,175,118
Ensembl chr22:37,118,666...37,175,118
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G |
IL3 |
interleukin 3 |
susceptibility |
IAGP |
DNA:SNP: :rs40401(human) DNA:polymorphism:cds:+79T>C(S27P)(human) |
RGD |
PMID:24684517 PMID:15372320 |
RGD:13506914, RGD:13506916 |
NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204
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G |
IL32 |
interleukin 32 |
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IEP |
protein:increased expression:blood serum (human) |
RGD |
PMID:22336080 |
RGD:150340749 |
NCBI chr16:3,065,403...3,069,530
Ensembl chr16:3,065,297...3,082,192
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G |
IL33 |
interleukin 33 |
treatment severity |
EXP ISO IEP |
CTD Direct Evidence: marker/mechanism associated with viral pneumonia; associated with fungal infectious disease |
CTD RGD |
PMID:19198610 PMID:21804549 PMID:24241537 PMID:27472835 PMID:29067999 PMID:28947081 PMID:25746970 More...
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RGD:39939002, RGD:39938968 |
NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
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G |
IL4 |
interleukin 4 |
treatment no_association |
IAGP EXP ISO IEP |
DNA:polymorphism (human) CTD Direct Evidence: marker/mechanism mRNA, protein:increase expression:leukocyte, serum protein:increased expression:lung DNA:SNP: :589C>T (human) mRNA:increased expression:lung, spleen protein:increased expression:respiratory system fluid/secretion |
CTD RGD |
PMID:18357729 PMID:21103062 PMID:24946644 PMID:24450480 PMID:18211752 PMID:20524005 PMID:21364926 PMID:21354484 PMID:21375458 More...
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RGD:4889866, RGD:10402799, RGD:10402791, RGD:2317290, RGD:5128560, RGD:5128500, RGD:5128502, RGD:5128557 |
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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IL4R |
interleukin 4 receptor |
susceptibility severity disease_progression |
ISO ISS IAGP IDA IEP |
DNA:mutation:cds:p.Q576R (mouse) OMIM:600807 DNA:polymorphism:promoter:c.-3223C>T (human) DNA:SNPs:cds:p. I75V, Q576R (human) DNA:polymorphism:cds:p.I50V (human) DNA:polymorphism:cds:p.Q551R (human) DNA:polymorphism::-1902G/A (human) DNA:SNPs: :multiple protein:increased secretion:plasma DNA:polymorphism:cds:p.Q576R (human) DNA:polymorphism:cds:p. S478P (human) DNA:SNPs:cds:p.E375A, Q551R (human) |
MouseDO RGD |
PMID:19770271 PMID:15479272 PMID:12133990 PMID:18425216 PMID:17586032 PMID:11398072 PMID:20868478 PMID:17823973 PMID:15479272 PMID:12940513 PMID:20953944 PMID:11709756 PMID:20605987 PMID:16917945 PMID:17170387 More...
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RGD:4890003, RGD:4890351, RGD:4890404, RGD:4890346, RGD:4890348, RGD:4890406, RGD:4890387, RGD:4890347, RGD:4890351, RGD:4890402, RGD:5128514, RGD:4890024, RGD:5128553, RGD:4890352, RGD:4890349 |
NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
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IL5 |
interleukin 5 |
treatment disease_progression |
ISO EXP IEP IAGP IDA |
CTD Direct Evidence: marker/mechanism protein:increased expression:lungs, respiratory system fluid/secretion protein: increased levels: sputum protein:increased expression:respiratory system fluid/secretion DNA:polymorphism:promoter:-703C>T (human) |
CTD RGD |
PMID:7540862 PMID:23266719 PMID:19947994 PMID:25008888 PMID:11159041 PMID:22085848 PMID:22186238 PMID:9493449 PMID:15626484 PMID:9182686 PMID:17074272 PMID:18629290 PMID:15502111 More...
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RGD:4890938, RGD:11354973, RGD:5687189, RGD:5687144, RGD:5687140, RGD:4890962, RGD:4890947, RGD:4890963, RGD:4145461, RGD:4890940, RGD:4890948 |
NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
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IL5RA |
interleukin 5 receptor subunit alpha |
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IAGP ISO IEP IMP |
DNA:SNPs (human) DNA:SNP: :c.25091G>A (human) |
RGD |
PMID:16217591 PMID:17276963 PMID:20592918 PMID:10224351 PMID:20513521 PMID:10848907 More...
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RGD:5128626, RGD:5128617, RGD:5128614, RGD:5128623, RGD:5128625, RGD:5128627 |
NCBI chr 3:3,066,324...3,110,374
Ensembl chr 3:3,066,324...3,126,613
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IL6 |
interleukin 6 |
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IEP EXP ISO |
associated with Hypersensitivity;protein:increased expression:sputum CTD Direct Evidence: marker/mechanism protein:increased expression:lung |
CTD RGD |
PMID:29902480 PMID:20816188 PMID:20840469 PMID:20658762 PMID:21115736 |
RGD:4143266, RGD:4143265, RGD:4143271, RGD:5128630 |
NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
IL6R |
interleukin 6 receptor |
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ISO EXP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:29902480 PMID:17496315 PMID:21115736 |
RGD:5128662, RGD:5128630 |
NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450
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G |
IL9 |
interleukin 9 |
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ISO IMP IEP |
protein:increased expression:respiratory system fluid/secretion protein:increased expression:sputum, macrophage, cytoplasm |
RGD |
PMID:12153980 PMID:21356110 PMID:15531759 PMID:17446528 PMID:15303135 |
RGD:5128700, RGD:5128707, RGD:5128690, RGD:5128686, RGD:5128691 |
NCBI chr 5:135,892,246...135,895,841
Ensembl chr 5:135,892,246...135,895,841
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IL9R |
interleukin 9 receptor |
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IEP |
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RGD |
PMID:10629460 |
RGD:5128704 |
NCBI chr X:155,997,696...156,013,020 NCBI chr Y:57,184,072...57,197,869
Ensembl chr X:155,997,696...156,013,017 Ensembl chr Y:155,997,696...156,013,017
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G |
IRAK3 |
interleukin 1 receptor associated kinase 3 |
susceptibility |
IAGP |
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 5 |
OMIM ClinVar |
PMID:17503328 |
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NCBI chr12:66,189,214...66,254,622
Ensembl chr12:66,189,195...66,254,622
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G |
IRF1 |
interferon regulatory factor 1 |
no_association susceptibility |
IAGP IEP |
DNA:polymorphisms:promoter, cds:-300G>T, 4396A>G, 6355G>A (human) protein:increased expression:respiratory tract epithelium DNA:repeat:intron (human) |
RGD |
PMID:11069564 PMID:10225979 PMID:16961714 |
RGD:5128726, RGD:5128723, RGD:5128724 |
NCBI chr 5:132,481,609...132,490,773
Ensembl chr 5:132,440,440...132,508,719
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G |
IRF3 |
interferon regulatory factor 3 |
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ISO |
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RGD |
PMID:20673978 |
RGD:5128793 |
NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875
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G |
ITGB3 |
integrin subunit beta 3 |
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IAGP |
DNA:SNPs: : |
RGD |
PMID:17556058 |
RGD:5037230 |
NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743
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G |
ITGB6 |
integrin subunit beta 6 |
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ISS |
OMIM:600807 |
MouseDO |
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NCBI chr 2:160,099,671...160,200,272
Ensembl chr 2:160,099,667...160,271,888
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G |
ITPR1 |
inositol 1,4,5-trisphosphate receptor type 1 |
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ISO |
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RGD |
PMID:21777465 |
RGD:5147661 |
NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506
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KDR |
kinase insert domain receptor |
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ISO IEP |
associated with Rhinitis,Allergic,Seasonal;protein:increased expression:nasal cavity of mucosa: |
RGD |
PMID:20921519 PMID:17651148 |
RGD:5684385, RGD:8551771 |
NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595
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G |
KIF3A |
kinesin family member 3A |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21912604 |
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NCBI chr 5:132,688,812...132,737,546
Ensembl chr 5:132,692,628...132,737,638
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G |
KRT19 |
keratin 19 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:15478392 |
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NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308
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G |
LEP |
leptin |
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IEP |
protein:increased expression:plasma |
RGD |
PMID:19705789 |
RGD:5128781 |
NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629
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G |
LGALS3 |
galectin 3 |
treatment |
IMP |
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RGD |
PMID:16424226 |
RGD:9685213 |
NCBI chr14:55,129,252...55,145,430
Ensembl chr14:55,124,110...55,145,423
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G |
LOC129994952 |
ATAC-STARR-seq lymphoblastoid silent region 16492 |
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IAGP |
ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to |
ClinVar |
PMID:16596417 |
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NCBI chr 5:148,826,740...148,826,879
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G |
LTA |
lymphotoxin alpha |
susceptibility no_association |
IAGP |
DNA:polymorphisms:promoter DNA:polymorphism:intron |
RGD |
PMID:15969671 PMID:18947013 PMID:12530118 PMID:17536219 |
RGD:4143373, RGD:4143370, RGD:4143254, RGD:4143371 |
NCBI chr 6:31,560,610...31,574,324
Ensembl chr 6:31,572,054...31,574,324
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G |
LTA4H |
leukotriene A4 hydrolase |
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ISO |
mRNA:increased expression:lung, cerebral cortex (rat) |
RGD |
PMID:15715933 |
RGD:2316607 |
NCBI chr12:96,000,753...96,043,520
Ensembl chr12:96,000,753...96,043,520
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G |
MBL2 |
mannose binding lectin 2 |
susceptibility |
IAGP |
associated with Bronchiolitis;DNA:polymorphism:exon: DNA:SNP:cds:p.G54D(human) |
RGD |
PMID:22512728 PMID:22674410 |
RGD:8693709, RGD:12910828 |
NCBI chr10:52,765,380...52,772,784
Ensembl chr10:52,765,380...52,772,784
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G |
MEFV |
MEFV innate immunity regulator, pyrin |
susceptibility |
IAGP |
DNA:mutations:exons |
RGD |
PMID:18219832 |
RGD:5129186 |
NCBI chr16:3,242,027...3,256,633
Ensembl chr16:3,242,027...3,256,633
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|
G |
MIF |
macrophage migration inhibitory factor |
severity |
IAGP ISO IEP |
DNA:SNP:promoter:rs755622(human) protein:increased expression:bronchoalveolar lavage fluid DNA:repeats:promoter |
RGD |
PMID:19317738 PMID:17373669 PMID:9637721 PMID:16455830 PMID:16186482 |
RGD:4891059, RGD:4891035, RGD:4891043, RGD:1641985, RGD:4891052 |
NCBI chr22:23,894,383...23,895,223
Ensembl chr22:23,894,383...23,895,227
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G |
MMP1 |
matrix metallopeptidase 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24469321 |
|
NCBI chr11:102,789,919...102,798,160
Ensembl chr11:102,789,401...102,798,160
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G |
MMP10 |
matrix metallopeptidase 10 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16926187 |
|
NCBI chr11:102,770,502...102,780,628
Ensembl chr11:102,770,502...102,780,628
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G |
MMP9 |
matrix metallopeptidase 9 |
|
IEP EXP IMP IAGP ISO |
protein:increased expression:serum CTD Direct Evidence: marker/mechanism DNA:SNP: : rs2664538(human) mRNA, protein:increased expression:lung |
CTD RGD |
PMID:11742282 PMID:15131573 PMID:21439806 PMID:19940022 PMID:20181264 PMID:16191269 PMID:19361849 More...
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RGD:5129204, RGD:5129522, RGD:5130859, RGD:2325953, RGD:5129687 |
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
MPO |
myeloperoxidase |
susceptibility |
IEP IAGP |
protein:increased expression:serum DNA:polymorphism: :−463G > A (human) |
RGD |
PMID:10731862 PMID:19544176 |
RGD:5130994, RGD:5130989 |
NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
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G |
MS4A2 |
membrane spanning 4-domains A2 |
susceptibility |
IAGP |
DNA:SNPs:multiple:, rs573790, rs2583476, rs569108 DNA:SNPs: : rs556917, rs502581, rs502419 (human) Atopy and bronchial hyperresponsiveness, OMIM:147050 DNA:polymorphism:CDS:amino acid E237G DNA:SNP: : -109C>T (human) |
RGD |
PMID:19218813 PMID:21320344 PMID:8817330 PMID:19862939 |
RGD:5131151, RGD:5131149, RGD:1599903, RGD:5131092 |
NCBI chr11:60,088,259...60,098,467
Ensembl chr11:60,088,261...60,098,467
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G |
MTHFR |
methylenetetrahydrofolate reductase |
|
IAGP |
DNA:transition:cds:g.677C>T (human) |
RGD |
PMID:20456312 |
RGD:4891145 |
NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455
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G |
MUC1 |
mucin 1, cell surface associated |
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IEP |
protein:increased expression:serum |
RGD |
PMID:11802251 |
RGD:5131281 |
NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
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G |
MUC2 |
mucin 2, oligomeric mucus/gel-forming |
|
IAGP ISO |
associated with hypersensitivity |
RGD |
PMID:11062147 PMID:14594655 |
RGD:5131178, RGD:7349354 |
NCBI chr11:1,074,874...1,110,508
Ensembl chr11:1,074,875...1,110,511
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G |
MUC5AC |
mucin 5AC, oligomeric mucus/gel-forming |
treatment |
IEP ISO |
protein:increased expression:lung mRNA, protein:increased expression:lung mRNA,protein:increased expression:lung |
RGD |
PMID:17698377 PMID:21549818 PMID:21780541 PMID:14594655 PMID:17590487 |
RGD:5131204, RGD:7364729, RGD:7349407, RGD:7349354, RGD:2324962 |
NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
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G |
MUC5B |
mucin 5B, oligomeric mucus/gel-forming |
|
IEP ISO |
protein:altered expression:sputum |
RGD |
PMID:11802783 PMID:11587997 |
RGD:5131252, RGD:7364763 |
NCBI chr11:1,223,066...1,262,172
Ensembl chr11:1,223,066...1,262,172
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G |
MUC7 |
mucin 7, secreted |
|
IAGP EXP |
ClinVar Annotator: match by term: Asthma, protection against CTD Direct Evidence: marker/mechanism |
ClinVar CTD OMIM |
PMID:11378823 PMID:16759176 PMID:28492532 |
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NCBI chr 4:70,430,492...70,482,997
Ensembl chr 4:70,430,492...70,482,997
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G |
MYB |
MYB proto-oncogene, transcription factor |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19198610 |
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NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
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G |
MYD88 |
MYD88 innate immune signal transduction adaptor |
ameliorates |
ISO |
|
RGD |
PMID:26882889 |
RGD:11531666 |
NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024
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G |
MYLK |
myosin light chain kinase |
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IAGP |
|
RGD |
PMID:17472811 |
RGD:4891492 |
NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332
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G |
NAT2 |
N-acetyltransferase 2 |
susceptibility |
IAGP |
Asthma, Aspirin-Induced; DNA:polymorphism: : DNA:polymorphisms: : |
RGD |
PMID:20602614 PMID:16924569 |
RGD:5131600, RGD:5131606 |
NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218
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G |
NFE2L2 |
NFE2 like bZIP transcription factor 2 |
severity |
IEP |
mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human) |
RGD |
PMID:21514635 |
RGD:6893376 |
NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
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G |
NGF |
nerve growth factor |
severity |
IDA IEP ISO |
protein:increased expression:lung, serum protein:increased expression:blood, eosinophil |
RGD |
PMID:11737043 PMID:17164945 PMID:17497413 PMID:12752594 |
RGD:4891123, RGD:4891108, RGD:4891068, RGD:4891122 |
NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
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G |
NGFR |
nerve growth factor receptor |
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ISO |
|
RGD |
PMID:16603479 PMID:12540484 |
RGD:5144070, RGD:5144072 |
NCBI chr17:49,495,293...49,515,008
Ensembl chr17:49,495,293...49,515,008
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G |
NOD1 |
nucleotide binding oligomerization domain containing 1 |
susceptibility |
IAGP |
DNA:SNP: :rs2075817 (human) DNA:insertion:cds: |
RGD |
PMID:16918516 PMID:15718249 |
RGD:5131519, RGD:5131518 |
NCBI chr 7:30,424,527...30,478,784
Ensembl chr 7:30,424,527...30,478,784
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G |
NOD2 |
nucleotide binding oligomerization domain containing 2 |
susceptibility |
IAGP ISO |
DNA:polymorphisms:intron, exon/3'UTR (rs1077861, rs3135500) (human) |
RGD |
PMID:16008671 PMID:21051079 |
RGD:5131477, RGD:5508757 |
NCBI chr16:50,693,606...50,733,075
Ensembl chr16:50,693,588...50,733,077
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G |
NOS1 |
nitric oxide synthase 1 |
susceptibility |
IAGP |
DNA:repeats: : DNA:repeats:intron DNA:repeats:exon |
RGD |
PMID:10673365 PMID:20609134 PMID:14767694 PMID:10833424 |
RGD:5132869, RGD:5132863, RGD:5132615, RGD:5132860 |
NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
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G |
NOS2 |
nitric oxide synthase 2 |
disease_progression no_association severity |
ISO EXP IEP IAGP |
protein:increased expression:lung, bronchoalveolar lavage fluid CTD Direct Evidence: marker/mechanism protein:increased expression, increased activity:lung (rat) associated with Rhinitis, Allergic, Seasonal; protein:increased expression:nasal mucosa DNA:repeat:promoter DNA:repeats:promoter mRNA:increased expression:monocyte DNA:repeats:promoter, introns (human) DNA:SNP:exon:p.S608L (human) |
CTD RGD |
PMID:19800904 PMID:17161822 PMID:21847581 PMID:18254476 PMID:16703578 PMID:18714530 PMID:20842520 PMID:16540403 PMID:17189532 PMID:17177683 PMID:20841959 More...
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RGD:4891927, RGD:5509073, RGD:4891910, RGD:4891953, RGD:4891508, RGD:4891419, RGD:4891957, RGD:4891924, RGD:4891925, RGD:4891480 |
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOS3 |
nitric oxide synthase 3 |
susceptibility |
IAGP |
DNA:repeats:intron DNA:polymorphisms:promoter:c. -786C>T, -691C>T (human) DNA:snps, repeat, haplotype:promoter, introns, exons:multiple (human) |
RGD |
PMID:16081038 PMID:16837812 PMID:18486767 |
RGD:4892062, RGD:4892058, RGD:4892053 |
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
NPSR1 |
neuropeptide S receptor 1 |
susceptibility |
IAGP EXP |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2 |
OMIM CTD ClinVar RGD |
PMID:15073379 PMID:15710598 PMID:15764725 PMID:16926187 PMID:17702965 PMID:15073379 PMID:18285428 More...
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RGD:4891923, RGD:4891921, RGD:4891922 |
NCBI chr 7:34,658,218...34,878,332
Ensembl chr 7:34,658,218...34,878,332
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G |
NPSR1-AS1 |
NPSR1 antisense RNA 1 |
|
IAGP |
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2 |
ClinVar |
PMID:15073379 |
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NCBI chr 7:34,346,512...34,834,331
Ensembl chr 7:34,287,269...34,871,582
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G |
NPY |
neuropeptide Y |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:9731035 |
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NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862
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G |
NQO1 |
NAD(P)H quinone dehydrogenase 1 |
susceptibility |
IDA EXP IAGP |
DNA:SNP:exon:c. 609C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNP:exon:c.609C>T (human) |
CTD RGD |
PMID:20049212 PMID:19027876 PMID:19591959 |
RGD:5135006, RGD:5135005 |
NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
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G |
NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
treatment severity susceptibility |
IEP ISO IDA IAGP |
protein:increased expression, decreased activity:leukocyte, mononuclear DNA:polymorphism:intron |
RGD |
PMID:18396779 PMID:20727335 PMID:18799869 PMID:15295049 PMID:21113676 |
RGD:4892328, RGD:7174728, RGD:4892594, RGD:4892609, RGD:4892568 |
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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G |
NTF3 |
neurotrophin 3 |
|
IDA ISO |
protein:increased expression:lung, serum |
RGD |
PMID:11737043 PMID:17497413 |
RGD:4891123, RGD:4891068 |
NCBI chr12:5,430,332...5,495,299
Ensembl chr12:5,432,108...5,521,536
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G |
NTF4 |
neurotrophin 4 |
|
ISO |
protein:increased expression:lung, serum |
RGD |
PMID:17497413 |
RGD:4891068 |
NCBI chr19:49,058,284...49,065,035
Ensembl chr19:49,061,066...49,065,076
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G |
NTRK1 |
neurotrophic receptor tyrosine kinase 1 |
|
ISO |
mRNA:increased expression:lung: |
RGD |
PMID:20934630 PMID:16708804 |
RGD:5684766, RGD:5684772 |
NCBI chr 1:156,815,750...156,881,850
Ensembl chr 1:156,815,636...156,881,850
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G |
ORMDL3 |
ORMDL sphingolipid biosynthesis regulator 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21150878 PMID:25256354 |
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NCBI chr17:39,921,041...39,927,601
Ensembl chr17:39,921,041...39,927,601
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G |
P2RY12 |
purinergic receptor P2Y12 |
|
IAGP ISO |
|
RGD |
PMID:22010907 PMID:19822647 |
RGD:6480532, RGD:6480533 |
NCBI chr 3:151,336,843...151,384,753
Ensembl chr 3:151,336,843...151,384,753
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G |
PARP1 |
poly(ADP-ribose) polymerase 1 |
treatment |
ISO EXP IDA |
CTD Direct Evidence: marker/mechanism protein:increased activation:lung, blood, mononuclear cell |
CTD RGD |
PMID:18261157 PMID:12594058 PMID:26205779 PMID:26205779 |
RGD:5683910, RGD:11073727, RGD:11073727 |
NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
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G |
PDCD1 |
programmed cell death 1 |
treatment |
ISO |
associated with Chlamydia pneumonia |
RGD |
PMID:26378990 |
RGD:41412180 |
NCBI chr 2:241,849,884...241,858,894
Ensembl chr 2:241,849,884...241,858,894
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G |
PDE4B |
phosphodiesterase 4B |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21912604 |
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NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579
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G |
PDE4D |
phosphodiesterase 4D |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19426955 PMID:21611147 |
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NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120
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G |
PDGFB |
platelet derived growth factor subunit B |
|
ISO |
protein: increased expression |
RGD |
PMID:21216974 PMID:21216974 |
RGD:6483071, RGD:6483071 |
NCBI chr22:39,223,359...39,244,982
Ensembl chr22:39,223,359...39,244,982
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G |
PGF |
placental growth factor |
|
IDA |
|
RGD |
PMID:22268141 |
RGD:6483605 |
NCBI chr14:74,941,830...74,955,764
Ensembl chr14:74,941,834...74,955,626
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G |
PIK3CG |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma |
|
ISO |
|
RGD |
PMID:18754810 |
RGD:6482695 |
NCBI chr 7:106,865,282...106,908,980
Ensembl chr 7:106,865,278...106,908,980
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G |
PIN1 |
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 |
|
ISO |
|
RGD |
PMID:18188456 |
RGD:8693422 |
NCBI chr19:9,835,318...9,849,689
Ensembl chr19:9,835,257...9,849,689
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G |
PLA2G4A |
phospholipase A2 group IVA |
|
ISO |
|
RGD |
PMID:15557087 |
RGD:1642462 |
NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
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G |
PLA2G7 |
phospholipase A2 group VII |
|
IAGP EXP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:10733466 PMID:10733466 |
RGD:1581025 |
NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693
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G |
PLAU |
plasminogen activator, urokinase |
|
IEP EXP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:21912604 PMID:18519237 |
RGD:4892037 |
NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496
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G |
PPP2CA |
protein phosphatase 2 catalytic subunit alpha |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22205926 |
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NCBI chr 5:134,194,332...134,226,073
Ensembl chr 5:134,193,978...134,226,073
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G |
PRF1 |
perforin 1 |
|
ISO |
|
RGD |
PMID:22250087 PMID:21426642 |
RGD:6482815, RGD:6482818 |
NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759
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G |
PRG2 |
proteoglycan 2, pro eosinophil major basic protein |
severity disease_progression no_association |
IEP ISO |
mRNA:increased expression:eosinophil: associated with cough;protein:increased expression:sputum: associated with viral infection;mRNA:increased expression:sputum: |
RGD |
PMID:16982448 PMID:22022864 PMID:24450586 PMID:11067904 |
RGD:13506941, RGD:13506944, RGD:13506943, RGD:13506942 |
NCBI chr11:57,386,780...57,390,650
Ensembl chr11:57,386,780...57,390,650
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G |
PRMT1 |
protein arginine methyltransferase 1 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:20423833 |
RGD:9491823 |
NCBI chr19:49,676,153...49,688,447
Ensembl chr19:49,675,786...49,689,029
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G |
PRMT2 |
protein arginine methyltransferase 2 |
|
ISO |
mRNA:increased expression:lung, spleen |
RGD |
PMID:20423833 |
RGD:9491823 |
NCBI chr21:46,635,674...46,665,124
Ensembl chr21:46,635,595...46,665,685
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G |
PRMT3 |
protein arginine methyltransferase 3 |
|
ISO |
mRNA:increased expression:lung |
RGD |
PMID:20423833 |
RGD:9491823 |
NCBI chr11:20,387,716...20,509,338
Ensembl chr11:20,387,558...20,509,338
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G |
PRMT5 |
protein arginine methyltransferase 5 |
|
ISO |
mRNA:increased expression:lung, spleen |
RGD |
PMID:20423833 |
RGD:9491823 |
NCBI chr14:22,920,529...22,929,376
Ensembl chr14:22,920,525...22,929,408
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G |
PROC |
protein C, inactivator of coagulation factors Va and VIIIa |
treatment |
IDA |
|
RGD |
PMID:26381519 |
RGD:11099992 |
NCBI chr 2:127,418,427...127,429,242
Ensembl chr 2:127,418,427...127,429,242
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G |
PTEN |
phosphatase and tensin homolog |
|
EXP |
CTD Direct Evidence: therapeutic |
CTD |
PMID:17982072 |
|
NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930
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G |
PTGDR |
prostaglandin D2 receptor |
susceptibility |
IAGP |
|
OMIM |
|
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NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724
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G |
PTGDR2 |
prostaglandin D2 receptor 2 |
|
IAGP EXP ISO |
CTD Direct Evidence: therapeutic Aspirin exacerbated asthma |
CTD RGD |
PMID:27103662 PMID:19392992 PMID:19796209 PMID:18757520 |
RGD:5135019, RGD:5135020, RGD:5135018 |
NCBI chr11:60,850,933...60,855,950
Ensembl chr11:60,850,933...60,855,950
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G |
PTGER3 |
prostaglandin E receptor 3 |
treatment |
ISO |
|
RGD |
PMID:23221044 |
RGD:10043366 |
NCBI chr 1:70,852,358...71,047,816
Ensembl chr 1:70,852,353...71,047,816
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
susceptibility severity |
ISO IAGP IMP |
mRNA:increased expression:lung DNA:SNP: :8473T>C (human) mRNA, protein:increased expression:lung: DNA:SNP: :rs689465 (human) |
RGD |
PMID:19878559 PMID:15316498 PMID:17573729 PMID:18097056 PMID:18489027 PMID:19342146 PMID:19862936 More...
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RGD:5135514, RGD:5143931, RGD:5143923, RGD:5135534, RGD:5135526, RGD:5135522, RGD:5135515 |
NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
PYHIN1 |
pyrin and HIN domain family member 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21804549 |
|
NCBI chr 1:158,931,552...158,990,870
Ensembl chr 1:158,930,796...158,977,059
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G |
RAD50 |
RAD50 double strand break repair protein |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24241537 |
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NCBI chr 5:132,556,977...132,646,349
Ensembl chr 5:132,556,019...132,646,349
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G |
RHOA |
ras homolog family member A |
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ISO |
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RGD |
PMID:18391481 |
RGD:2298885 |
NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998
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G |
RNASE3 |
ribonuclease A family member 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8874658 PMID:12153692 PMID:12587966 |
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NCBI chr14:20,891,385...20,892,348
Ensembl chr14:20,891,385...20,892,348
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G |
RUNX1 |
RUNX family transcription factor 1 |
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IAGP |
DNA:SNPs: :multiple |
RGD |
PMID:21803869 |
RGD:6482835 |
NCBI chr21:35,372,507...35,580,764
Ensembl chr21:34,787,801...36,004,667
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G |
RUNX3 |
RUNX family transcription factor 3 |
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ISS |
OMIM:600807 |
MouseDO |
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NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121
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G |
SCGB1A1 |
secretoglobin family 1A member 1 |
susceptibility |
ISO IAGP IEP |
mRNA,protein:decreased expression:bronchial alveolar lavage fluid, lung: ClinVar Annotator: match by term: Asthma, susceptibility to associated with allergic rhinitis; DNA:SNP:exon:38G>A (human) protein:decreased expression:serum |
ClinVar RGD |
PMID:9550363 PMID:9643286 PMID:12100044 PMID:12921604 PMID:21255142 PMID:15467329 More...
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RGD:5144052, RGD:5144226, RGD:5144148 |
NCBI chr11:62,419,033...62,423,195
Ensembl chr11:62,405,103...62,423,195
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G |
SCGB3A2 |
secretoglobin family 3A member 2 |
susceptibility severity no_association |
IAGP EXP ISO IEP |
DNA:SNP:promoter:-112G>A (human) CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Asthma, susceptibility to mRNA,protein:decreased expression:;lung protein:increased expression:sputum |
CTD OMIM ClinVar RGD |
PMID:11813133 PMID:11813133 PMID:15531759 PMID:16456148 PMID:17218572 PMID:18089940 PMID:18201431 More...
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RGD:5144229, RGD:5128690, RGD:5144233, RGD:5144232, RGD:5144231, RGD:5144230 |
NCBI chr 5:147,878,711...147,882,191
Ensembl chr 5:147,870,682...147,882,191
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G |
SELL |
selectin L |
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ISO |
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RGD |
PMID:21437035 PMID:21515793 |
RGD:5685685, RGD:5685696 |
NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702
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G |
SERPINA1 |
serpin family A member 1 |
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ISO |
Fisher rats, shown to exhibit hyperactive airway responses at 14 days of age, had higher transcript and protein levels of Serpina1 than same age Brown Norway rats. |
RGD |
PMID:20118217 |
RGD:5131869 |
NCBI chr14:94,376,747...94,390,635
Ensembl chr14:94,376,747...94,390,693
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G |
SERPINE1 |
serpin family E member 1 |
severity no_association susceptibility |
IEP ISO IAGP |
protein:increased expression:plasma protein:increased activity, increased expression:plasma, lung DNA:polymorphism:promoter:rs1799768 (human) |
RGD |
PMID:19703828 PMID:18594148 PMID:19604112 PMID:19063817 |
RGD:4144831, RGD:4144836, RGD:4144833, RGD:4144832 |
NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
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G |
SFTPA1 |
surfactant protein A1 |
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ISO IEP |
protein:decreased expression:lung, Clara cell, pneumocyte mRNA, protein:increased expression:lung |
RGD |
PMID:15816355 PMID:16629790 PMID:18926058 PMID:18802356 |
RGD:4143398, RGD:4143462, RGD:4143289, RGD:4143516 |
NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
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G |
SFTPB |
surfactant protein B |
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IEP ISO |
protein:increased expression:lung mRNA, protein:decreased expression:lung protein:decreased expression:lung, Clara cell |
RGD |
PMID:16629790 PMID:11472974 PMID:15816355 PMID:18926058 |
RGD:4143462, RGD:4143465, RGD:4143398, RGD:4143289 |
NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
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G |
SFTPC |
surfactant protein C |
susceptibility |
IAGP IEP ISO |
DNA:polymorphism: :p.A53T (human) protein:increased expression:lung mRNA, protein:decreased expression:lung |
RGD |
PMID:19910179 PMID:16629790 PMID:11472974 |
RGD:4144063, RGD:4143462, RGD:4143465 |
NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
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G |
SFTPD |
surfactant protein D |
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IEP ISO IDA |
associated with Bronchitis;protein:increased expression:lung mRNA, protein:increased expression:lung |
RGD |
PMID:18266831 PMID:11472974 PMID:16839409 PMID:16629790 PMID:18802356 |
RGD:4143517, RGD:4143465, RGD:4143508, RGD:4143462, RGD:4143516 |
NCBI chr10:79,937,740...79,982,383
Ensembl chr10:79,937,467...79,982,614
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G |
SLC11A1 |
solute carrier family 11 member 1 |
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ISO |
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RGD |
PMID:12847242 |
RGD:5684966 |
NCBI chr 2:218,382,273...218,396,894
Ensembl chr 2:218,382,029...218,396,894
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G |
SLC18A3 |
solute carrier family 18 member A3 |
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ISO |
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RGD |
PMID:17328924 |
RGD:5686690 |
NCBI chr10:49,610,310...49,612,720
Ensembl chr10:49,610,310...49,612,720
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G |
SLC22A1 |
solute carrier family 22 member 1 |
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ISO |
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RGD |
PMID:17328924 |
RGD:5686690 |
NCBI chr 6:160,121,815...160,158,718
Ensembl chr 6:160,121,815...160,158,718
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G |
SLC5A7 |
solute carrier family 5 member 7 |
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ISO |
mRNA:decreased expression:lung |
RGD |
PMID:17328924 |
RGD:5686690 |
NCBI chr 2:107,986,524...108,013,994
Ensembl chr 2:107,986,523...108,013,994
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G |
SLC6A4 |
solute carrier family 6 member 4 |
susceptibility |
IAGP |
DNA:repeat:intron (human) |
RGD |
PMID:19806585 |
RGD:4889460 |
NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002
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G |
SOD1 |
superoxide dismutase 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:22867017 |
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NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
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G |
SOD2 |
superoxide dismutase 2 |
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IDA |
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RGD |
PMID:15743779 |
RGD:1581231 |
NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
SPRR2B |
small proline rich protein 2B |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21912604 |
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NCBI chr 1:153,070,226...153,087,799
Ensembl chr 1:153,070,226...153,071,611
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G |
STAT4 |
signal transducer and activator of transcription 4 |
treatment |
ISO EXP |
CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:28807506 PMID:18211752 |
RGD:2317290 |
NCBI chr 2:191,029,576...191,151,596
Ensembl chr 2:191,029,576...191,178,435
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G |
STAT6 |
signal transducer and activator of transcription 6 |
treatment |
ISO |
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RGD |
PMID:19087723 PMID:16083555 |
RGD:7244151, RGD:7244153 |
NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139
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G |
TAC1 |
tachykinin precursor 1 |
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IEP |
protein:increased expression:lung |
RGD |
PMID:11031342 |
RGD:5147836 |
NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472
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G |
TACR1 |
tachykinin receptor 1 |
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ISO IEP |
protein:increased expression:lung mRNA:increased expression:lung mRNA,protein:increased expression:lung |
RGD |
PMID:17392578 PMID:8240667 PMID:16409782 |
RGD:2304339, RGD:5147645, RGD:5147475 |
NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
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G |
TACR2 |
tachykinin receptor 2 |
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IAGP IMP |
DNA:SNP:cds:p.G231E (human) |
RGD |
PMID:20175803 PMID:19880429 |
RGD:5147640, RGD:5147641 |
NCBI chr10:69,403,903...69,416,918
Ensembl chr10:69,403,903...69,416,918
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G |
TAP1 |
transporter 1, ATP binding cassette subfamily B member |
susceptibility |
IAGP |
DNA:polymorphism: : |
RGD |
PMID:12640628 |
RGD:5147845 |
NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816
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G |
TBX21 |
T-box transcription factor 21 |
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EXP ISS |
CTD Direct Evidence: marker/mechanism OMIM:600807 |
CTD MouseDO |
PMID:15806396 |
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NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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G |
TBXA2R |
thromboxane A2 receptor |
susceptibility severity |
IEA IAGP |
ClinVar Annotator: match by term: Asthma DNA:polymorphism:cds:924T>C(human) |
ClinVar RGD |
PMID:2955539 PMID:7929844 PMID:8428006 PMID:8613548 PMID:15118671 PMID:12000493 PMID:15805995 More...
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RGD:1331525, RGD:11059535, RGD:11059534 |
NCBI chr19:3,594,507...3,606,875
Ensembl chr19:3,594,507...3,606,875
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G |
TGFB1 |
transforming growth factor beta 1 |
onset no_association |
IAGP EXP ISO IEP |
DNA:SNP: :-509C>T (human) CTD Direct Evidence: marker/mechanism DNA:SNP:cds:915G>C (human) protein:increased expression:serum mRNA:increased expression:lung DNA:SNPs:promoter, exon:multiple (human) DNA:polymorphism: :-509C>T (human) DNA:polymorphisms: :multiple (human) |
CTD RGD |
PMID:16365456 PMID:19138248 PMID:17673695 PMID:18366906 PMID:19620629 PMID:19046298 PMID:19317336 PMID:20485865 PMID:19096005 PMID:18711258 PMID:19136038 PMID:19222424 PMID:19533439 More...
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RGD:4145295, RGD:4145280, RGD:4145132, RGD:4145142, RGD:4145139, RGD:4145113, RGD:4145143, RGD:4143443, RGD:4145144, RGD:4145299, RGD:4145297 |
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
THBD |
thrombomodulin |
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IDA |
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RGD |
PMID:20709825 |
RGD:5684984 |
NCBI chr20:23,045,633...23,049,672
Ensembl chr20:23,045,633...23,049,672
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G |
TIMP3 |
TIMP metallopeptidase inhibitor 3 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16926187 |
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NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041
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G |
TLR1 |
toll like receptor 1 |
susceptibility |
IAGP |
DNA:SNP (human) |
RGD |
PMID:18547625 |
RGD:4889528 |
NCBI chr 4:38,787,569...38,805,644
Ensembl chr 4:38,787,555...38,856,817
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G |
TLR10 |
toll like receptor 10 |
susceptibility |
IAGP |
DNA:SNP (human) |
RGD |
PMID:18547625 |
RGD:4889528 |
NCBI chr 4:38,772,238...38,782,990
Ensembl chr 4:38,772,238...38,782,990
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G |
TLR2 |
toll like receptor 2 |
severity susceptibility |
IAGP ISO |
DNA:SNP: :rs3804100 (human) DNA:polymorphism:cds:p.R753Q(human) DNA:SNP: :rs4696480 (human) DNA:SNP: :rs7656411 (human) DNA:SNP: :596T>C (human) |
RGD |
PMID:19148143 PMID:22402138 PMID:18202345 PMID:20685742 PMID:20815312 PMID:18787777 PMID:19096003 More...
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RGD:2312679, RGD:7800732, RGD:4145343, RGD:4144171, RGD:4145352, RGD:4145334, RGD:4144228 |
NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
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G |
TLR3 |
toll like receptor 3 |
no_association |
IEP IAGP ISO |
Asthma, Virus-Induced; mRNA:increased expression:sputum (human) DNA:snp:cds:p.L412F (human) |
RGD |
PMID:21129050 PMID:14987294 PMID:17610940 PMID:21364926 PMID:17434873 |
RGD:5129226, RGD:5129493, RGD:5129475, RGD:5128500, RGD:5129478 |
NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073
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G |
TLR4 |
toll like receptor 4 |
susceptibility no_association severity |
IAGP ISO IEP |
DNA:Polymorphism:cds:p.D299G (human) protein:decreased expression:leukocytes, mononuclear DNA:SNPs: :rs10983755, rs1927914 (human) DNA:SNPs:: DNA:polymorphisms:cds:c.896A>G, 1196C>T (human) |
RGD |
PMID:15356557 PMID:20628601 PMID:19067129 PMID:19330007 PMID:19159017 PMID:20685742 PMID:16266379 More...
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RGD:4144817, RGD:4144176, RGD:4144190, RGD:4144141, RGD:4144188, RGD:4144171, RGD:4144198 |
NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
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G |
TLR6 |
toll like receptor 6 |
susceptibility |
IAGP |
DNA:SNP: :p.S249P (human) DNA:SNP (human) |
RGD |
PMID:15266299 PMID:18547625 |
RGD:4889538, RGD:4889528 |
NCBI chr 4:38,822,897...38,868,390
Ensembl chr 4:38,822,897...38,856,817
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G |
TLR9 |
toll like receptor 9 |
susceptibility severity no_association |
IAGP ISO IEP |
DNA:SNP:promoter:g.-1237T>C (rs5743836) (human) protein:increased expression:peripheral blood mononuclear cell (human) DNA:SNP:promoter:g.-1237T>C rs5743836 (human) |
RGD |
PMID:18312481 PMID:20016192 PMID:20072849 PMID:21324137 |
RGD:4144208, RGD:5129104, RGD:4889523, RGD:5130712 |
NCBI chr 3:52,221,080...52,225,645
Ensembl chr 3:52,221,080...52,225,645
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G |
TNC |
tenascin C |
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ISO EXP IAGP IEP |
CTD Direct Evidence: marker/mechanism DNA:SNPs: :multiple (human) DNA:SNP:exon:p.L1677I (human) protein:increased expression:bronchus basement membrane |
CTD RGD |
PMID:16115819 PMID:17125141 PMID:18305139 PMID:16115819 PMID:9310019 |
RGD:4889565, RGD:4889589, RGD:4889569, RGD:4889572 |
NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207
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G |
TNF |
tumor necrosis factor |
susceptibility no_association |
IAGP EXP ISO IEP |
associated with obesity; DNA:polymorphism:promoter ClinVar Annotator: match by term: Asthma, susceptibility to CTD Direct Evidence: marker/mechanism DNA:polymorphism:promoter: c. -308A>G (human) DNA:polymorphisms:: rs1799964, rs1799724 (human) DNA:polymorphisms: : associated with nasal polys; protein:increased expression:nose DNA:polymorphism:promoter:c.-863C > A (human) |
OMIM ClinVar CTD RGD |
PMID:8056188 PMID:9818939 PMID:10450718 PMID:11261930 PMID:11506397 PMID:11826025 PMID:11896460 PMID:12356572 PMID:12485196 PMID:12746914 PMID:12759288 PMID:14681301 PMID:14718719 PMID:16418737 PMID:16456144 PMID:16720636 PMID:16865291 PMID:16909270 PMID:17450233 PMID:18050183 PMID:18713756 PMID:19365401 PMID:20049212 PMID:22760475 PMID:22992668 PMID:19196817 PMID:18711258 PMID:12530118 PMID:18811622 PMID:16393274 PMID:18763028 PMID:20465535 PMID:16728705 More...
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RGD:4143238, RGD:4143443, RGD:4143254, RGD:4143240, RGD:4145508, RGD:4142802, RGD:4143369, RGD:4143372 |
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFRSF1A |
TNF receptor superfamily member 1A |
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ISO |
protein:increased expression:lung (mouse) |
RGD |
PMID:20484920 |
RGD:5131201 |
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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G |
TNIP1 |
TNFAIP3 interacting protein 1 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:24453940 |
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NCBI chr 5:151,029,943...151,087,685
Ensembl chr 5:151,029,945...151,093,577
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G |
TRPA1 |
transient receptor potential cation channel subfamily A member 1 |
severity |
EXP ISO |
CTD Direct Evidence: marker/mechanism ovalbumin sensitization |
CTD RGD |
PMID:19458046 PMID:31969645 |
RGD:127285811 |
NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584
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G |
TSLP |
thymic stromal lymphopoietin |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:21804549 |
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NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026
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G |
UCN |
urocortin |
|
ISO |
associated with Hypersensitivity;mRNA, protein:increased expression:lung |
RGD |
PMID:16427607 |
RGD:1642781 |
NCBI chr 2:27,307,400...27,308,445
Ensembl chr 2:27,307,400...27,308,445
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G |
UTS2 |
urotensin 2 |
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IEP |
|
RGD |
PMID:17045018 |
RGD:2306832 |
NCBI chr 1:7,847,612...7,913,249
Ensembl chr 1:7,843,083...7,853,512
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G |
VDR |
vitamin D receptor |
no_association |
IAGP |
DNA:SNPs (human) DNA:SNP (human) DNA:SNPs: :multiple (human) DNA:SNP: :rs7975232 (human) |
RGD |
PMID:20124605 PMID:21103062 PMID:15282200 PMID:19622139 |
RGD:4889867, RGD:4889866, RGD:4889854, RGD:4889868 |
NCBI chr12:47,841,537...47,904,994
Ensembl chr12:47,841,537...47,943,048
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G |
VEGFA |
vascular endothelial growth factor A |
|
IEP EXP |
protein:increased expression:sputum CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:11907124 PMID:15201500 PMID:19263519 PMID:19178538 |
RGD:6892723 |
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
VIP |
vasoactive intestinal peptide |
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ISO |
|
RGD |
PMID:21419198 PMID:16782752 |
RGD:5685381, RGD:5685620 |
NCBI chr 6:152,750,797...152,759,760
Ensembl chr 6:152,750,797...152,759,765
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G |
WDR36 |
WD repeat domain 36 |
|
EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19198610 |
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NCBI chr 5:111,092,348...111,130,502
Ensembl chr 5:111,092,321...111,130,502
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G |
HLA-DRA |
major histocompatibility complex, class II, DR alpha |
susceptibility |
IAGP |
DNA:SNPs,haplotype:introns: |
RGD |
PMID:22391069 |
RGD:13506908 |
NCBI chr 6:32,439,887...32,445,046
Ensembl chr 6:32,439,878...32,445,046
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G |
LOC109286563 |
TBX21 promoter region |
|
IAGP |
ClinVar Annotator: match by term: Asthma and nasal polyps |
ClinVar |
PMID:15806396 |
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NCBI chr17:47,731,244...47,733,594
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G |
TBX21 |
T-box transcription factor 21 |
|
IAGP |
ClinVar Annotator: match by term: Asthma and nasal polyps |
ClinVar |
PMID:15806396 |
|
NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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G |
ALOX15 |
arachidonate 15-lipoxygenase |
|
IAGP |
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance |
ClinVar |
PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255 |
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NCBI chr17:4,630,919...4,641,678
Ensembl chr17:4,630,919...4,642,294
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G |
LOC109286563 |
TBX21 promoter region |
|
IAGP |
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance |
ClinVar |
PMID:25741868 |
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NCBI chr17:47,731,244...47,733,594
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G |
LOC130061064 |
ATAC-STARR-seq lymphoblastoid silent region 8640 |
|
IAGP |
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance |
ClinVar |
PMID:25741868 |
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NCBI chr17:47,733,625...47,733,794
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G |
LTC4S |
leukotriene C4 synthase |
|
IAGP |
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance |
ClinVar |
PMID:25741868 |
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NCBI chr 5:179,793,986...179,796,647
Ensembl chr 5:179,793,980...179,796,647
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PTGER2 |
prostaglandin E receptor 2 |
susceptibility |
IAGP EXP |
CTD Direct Evidence: marker/mechanism |
OMIM CTD |
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NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,329,822
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G |
TBX21 |
T-box transcription factor 21 |
susceptibility |
EXP IAGP |
CTD Direct Evidence: marker/mechanism ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance |
CTD OMIM ClinVar |
PMID:25741868 |
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NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
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G |
ACE |
angiotensin I converting enzyme |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:10194187 |
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NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
BTNL2 |
butyrophilin like 2 |
susceptibility |
IAGP EXP |
DNA:SNP: :rs3117099(human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:17927685 PMID:17927685 |
RGD:9685029 |
NCBI chr 6:32,393,339...32,407,181
Ensembl chr 6:32,393,339...32,407,181
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G |
CCR5 |
C-C motif chemokine receptor 5 |
disease_progression |
IAGP |
DNA:polymorphisms:5' utr:multiple (human) |
RGD |
PMID:20075058 |
RGD:4892065 |
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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G |
CD28 |
CD28 molecule |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:12952926 |
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NCBI chr 2:203,706,482...203,738,912
Ensembl chr 2:203,706,517...203,739,756
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G |
GCLM |
glutamate-cysteine ligase modifier subunit |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16766924 |
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NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456
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G |
HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8105536 PMID:11551429 PMID:14662898 PMID:15273960 PMID:17927685 PMID:17956852 More...
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NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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G |
HLA-DPB2 |
major histocompatibility complex, class II, DP beta 2 (pseudogene) |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16272364 |
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NCBI chr 6:33,112,516...33,129,113
Ensembl chr 6:33,112,516...33,129,084
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G |
HLA-DRB1 |
major histocompatibility complex, class II, DR beta 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:16272364 PMID:17927685 |
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NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848
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G |
HMOX1 |
heme oxygenase 1 |
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IEP |
protein:increased activity:sputum |
RGD |
PMID:19453654 |
RGD:4145349 |
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
IL2RA |
interleukin 2 receptor subunit alpha |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8977230 |
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NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
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G |
IL6 |
interleukin 6 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8428540 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
TGFB1 |
transforming growth factor beta 1 |
severity |
IAGP EXP |
DNA:polymorphisms: :-509C>T (human) CTD Direct Evidence: marker/mechanism |
CTD RGD |
PMID:15750822 PMID:17785866 PMID:17785866 |
RGD:4145294 |
NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TNF |
tumor necrosis factor |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:8428540 PMID:12449171 PMID:15127972 PMID:16980557 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
MUC1 |
mucin 1, cell surface associated |
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IEP |
protein:increased expression:serum |
RGD |
PMID:15881280 |
RGD:5131172 |
NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
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G |
NFKBIA |
NFKB inhibitor alpha |
exacerbates |
IAGP |
associated with respiratory syncytial virus infectious disease;DNA:SNPs:protomer: (rs2233409) (human) |
RGD |
PMID:23487427 |
RGD:40902982 |
NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NGF |
nerve growth factor |
treatment |
ISO |
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RGD |
PMID:30681402 |
RGD:405100716 |
NCBI chr 1:115,285,917...115,338,249
Ensembl chr 1:115,285,904...115,338,770
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G |
CCL26 |
C-C motif chemokine ligand 26 |
severity |
IEP |
protein:increased expression:sputum (human) |
RGD |
PMID:25936567 |
RGD:11531115 |
NCBI chr 7:75,769,524...75,791,597
Ensembl chr 7:75,769,533...75,789,896
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G |
EPX |
eosinophil peroxidase |
treatment |
IDA |
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RGD |
PMID:28751233 |
RGD:13506890 |
NCBI chr17:58,192,726...58,205,174
Ensembl chr17:58,192,726...58,205,174
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
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IMP |
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RGD |
PMID:10984370 |
RGD:4890423 |
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
CCL5 |
C-C motif chemokine ligand 5 |
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IEP |
protein:increased secretion:lung, secretion (human) |
RGD |
PMID:19996575 |
RGD:4892021 |
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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G |
TACR1 |
tachykinin receptor 1 |
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IMP |
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RGD |
PMID:8630576 |
RGD:5147837 |
NCBI chr 2:75,046,463...75,199,520
Ensembl chr 2:75,046,463...75,199,520
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G |
ACSL3 |
acyl-CoA synthetase long chain family member 3 |
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ISO |
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RGD |
PMID:23526225 |
RGD:13831300 |
NCBI chr 2:222,861,036...222,944,639
Ensembl chr 2:222,860,942...222,944,639
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G |
BCL2 |
BCL2 apoptosis regulator |
treatment |
ISO |
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RGD |
PMID:29713367 |
RGD:13792581 |
NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
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G |
CD86 |
CD86 molecule |
treatment |
ISO |
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RGD |
PMID:25344652 |
RGD:11354965 |
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
FAS |
Fas cell surface death receptor |
treatment |
ISO |
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RGD |
PMID:29713367 |
RGD:13792581 |
NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
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G |
FASLG |
Fas ligand |
treatment |
ISO |
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RGD |
PMID:29713367 |
RGD:13792581 |
NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
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G |
IL23A |
interleukin 23 subunit alpha |
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ISO |
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RGD |
PMID:19935773 PMID:26344076 |
RGD:5037240, RGD:11251537 |
NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410
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G |
ACE |
angiotensin I converting enzyme |
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IEP |
protein:increased expression:plasma |
RGD |
PMID:19218674 |
RGD:4140920 |
NCBI chr17:63,477,061...63,498,373
Ensembl chr17:63,477,061...63,498,380
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G |
CCL5 |
C-C motif chemokine ligand 5 |
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ISO IEP |
protein:increased secretion:lung, secretion (mouse) mRNA:increased expression:lung:bronchoalveolar lavage cell (human) |
RGD |
PMID:16387809 PMID:10384061 |
RGD:4891434, RGD:4891436 |
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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G |
CCL7 |
C-C motif chemokine ligand 7 |
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ISO |
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RGD |
PMID:20027288 |
RGD:5130978 |
NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
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G |
CCR3 |
C-C motif chemokine receptor 3 |
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IEP |
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RGD |
PMID:19842835 |
RGD:4145620 |
NCBI chr 3:46,210,696...46,266,706
Ensembl chr 3:46,130,890...46,266,706
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G |
CD86 |
CD86 molecule |
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ISO |
associated with Paramyxoviridae Infections; protein:increased expression:lung (mouse) |
RGD |
PMID:19282343 |
RGD:4892294 |
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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G |
CXCL10 |
C-X-C motif chemokine ligand 10 |
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ISO IEP |
mRNA:increased expression:alveolar macrophage |
RGD |
PMID:14991597 PMID:15725351 |
RGD:5135448, RGD:5135490 |
NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497
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G |
CXCL11 |
C-X-C motif chemokine ligand 11 |
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ISO |
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RGD |
PMID:14991597 |
RGD:5135448 |
NCBI chr 4:76,033,682...76,036,070
Ensembl chr 4:76,033,682...76,041,415
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G |
CXCL9 |
C-X-C motif chemokine ligand 9 |
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ISO IEP |
mRNA:increased expression:alveolar macrophage |
RGD |
PMID:14991597 PMID:15725351 |
RGD:5135448, RGD:5135490 |
NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509
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G |
CXCR3 |
C-X-C motif chemokine receptor 3 |
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ISO IEP |
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RGD |
PMID:14991597 PMID:19842835 |
RGD:5135448, RGD:4145620 |
NCBI chr X:71,615,919...71,618,511
Ensembl chr X:71,615,916...71,618,511
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G |
CYP2E1 |
cytochrome P450 family 2 subfamily E member 1 |
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IEP |
mRNA:decreased expression:leukocyte |
RGD |
PMID:20514434 |
RGD:4892076 |
NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
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G |
IL13 |
interleukin 13 |
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ISO |
mRNA:increased expression:lung |
RGD |
PMID:9916735 PMID:20861649 |
RGD:4145650, RGD:5128548 |
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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G |
IL17A |
interleukin 17A |
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ISO |
associated with Silicosis |
RGD |
PMID:20421647 PMID:19151189 |
RGD:4888525, RGD:4889106 |
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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G |
IL17RA |
interleukin 17 receptor A |
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ISO |
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RGD |
PMID:19414809 |
RGD:5144217 |
NCBI chr22:17,085,000...17,115,693
Ensembl chr22:17,084,954...17,115,693
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G |
IL1A |
interleukin 1 alpha |
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ISO |
protein:increased expression:Bronchoalveolar Lavage Fluid |
RGD |
PMID:10882225 |
RGD:4142832 |
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1B |
interleukin 1 beta |
disease_progression |
IEP ISO |
protein:increased expression:serum (human) |
RGD |
PMID:19556641 PMID:1519663 |
RGD:4142842, RGD:7401229 |
NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL5 |
interleukin 5 |
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ISO |
protein:increased expression:lung,respiratory system fluid/secretion |
RGD |
PMID:19151189 |
RGD:4889106 |
NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
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G |
NOS2 |
nitric oxide synthase 2 |
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IEP |
protein:increased expression:lung |
RGD |
PMID:11789718 |
RGD:4891449 |
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
SFTPA1 |
surfactant protein A1 |
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IEP |
protein:decreased expression:lung |
RGD |
PMID:10543276 |
RGD:4143437 |
NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
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G |
SOD2 |
superoxide dismutase 2 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:10673208 |
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NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
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G |
TAP1 |
transporter 1, ATP binding cassette subfamily B member |
susceptibility |
IAGP |
DNA:polymorphisms:cds:P. D637G, P661P (human) |
RGD |
PMID:18342853 |
RGD:5147840 |
NCBI chr 6:32,845,209...32,853,704
Ensembl chr 6:32,845,209...32,853,816
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G |
TLR6 |
toll like receptor 6 |
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ISO |
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RGD |
PMID:20070409 |
RGD:4889532 |
NCBI chr 4:38,822,897...38,868,390
Ensembl chr 4:38,822,897...38,856,817
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G |
TNC |
tenascin C |
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IEP |
protein:increased expression:respiratory system fluid/secretion |
RGD |
PMID:9780295 |
RGD:4889595 |
NCBI chr 9:115,019,575...115,118,157
Ensembl chr 9:115,019,575...115,118,207
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G |
TNF |
tumor necrosis factor |
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IDA ISO |
protein:increased expression:Bronchoalveolar Lavage Fluid |
RGD |
PMID:15653992 PMID:10882225 |
RGD:4143466, RGD:4142832 |
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
TNFRSF1A |
TNF receptor superfamily member 1A |
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IEP |
protein:increased expression:alveolar macrophage (human) |
RGD |
PMID:15929959 |
RGD:5131148 |
NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
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G |
TNFRSF1B |
TNF receptor superfamily member 1B |
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IEP |
protein:increased expression:alveolar macrophage (human) |
RGD |
PMID:15929959 |
RGD:5131148 |
NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228
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G |
VEGFA |
vascular endothelial growth factor A |
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IEP |
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RGD |
PMID:15764076 |
RGD:5684419 |
NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
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G |
IL12B |
interleukin 12B |
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ISO |
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RGD |
PMID:12084045 |
RGD:4145430 |
NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863
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G |
TNF |
tumor necrosis factor |
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IDA IEP IAGP |
protein:increased activity:serum protein:increased secretion:macrophage DNA:polymorphism:promoter |
RGD |
PMID:11179110 PMID:8466130 PMID:11179110 |
RGD:4143374, RGD:4143375, RGD:4143374 |
NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
HAVCR1 |
hepatitis A virus cellular receptor 1 |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic |
ClinVar |
PMID:14534576 PMID:21339644 |
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NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396
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G |
IL17A |
interleukin 17A |
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IEP |
associated with Nasal Polyps;protein:increased expression:nasal polyps (human) |
RGD |
PMID:24141678 |
RGD:9068428 |
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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G |
IL21R |
interleukin 21 receptor |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic ClinVar Annotator: match by term: Ige, elevated level of |
ClinVar |
PMID:12700598 PMID:17015683 PMID:25741868 PMID:28492532 |
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NCBI chr16:27,402,174...27,452,042
Ensembl chr16:27,402,174...27,452,042
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G |
IL21R-AS1 |
IL21R antisense RNA 1 |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr16:27,447,669...27,453,393
Ensembl chr16:27,447,669...27,453,393
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G |
IL4R |
interleukin 4 receptor |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778
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G |
LOC130058712 |
ATAC-STARR-seq lymphoblastoid active region 10626 |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr16:27,448,646...27,448,705
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G |
LOC130058713 |
ATAC-STARR-seq lymphoblastoid active region 10627 |
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IAGP |
ClinVar Annotator: match by term: IgE responsiveness, atopic |
ClinVar |
PMID:25741868 PMID:28492532 |
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NCBI chr16:27,449,006...27,449,245
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G |
AGER |
advanced glycosylation end-product specific receptor |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:33075463 |
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NCBI chr 6:32,180,969...32,184,253
Ensembl chr 6:32,180,968...32,184,322
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G |
CDH17 |
cadherin 17 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25918132 |
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NCBI chr 8:94,127,162...94,217,278
Ensembl chr 8:94,127,162...94,217,303
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G |
HERC2 |
HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25918132 |
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NCBI chr15:28,111,040...28,322,179
Ensembl chr15:28,111,040...28,322,179
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G |
HLA-B |
major histocompatibility complex, class I, B |
susceptibility |
IAGP |
DNA:SNP: :rs1811197(human) |
RGD |
PMID:24709764 |
RGD:13506912 |
NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067
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G |
HLA-DOA |
major histocompatibility complex, class II, DO alpha |
treatment |
IAGP |
DNA:SNP: :rs3128935(human) |
RGD |
PMID:24709764 |
RGD:13506912 |
NCBI chr 6:33,004,182...33,009,591
Ensembl chr 6:33,004,182...33,009,591
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G |
HLA-DPB1 |
major histocompatibility complex, class II, DP beta 1 |
susceptibility |
IAGP |
DNA:SNP: : rs928976(human) |
RGD |
PMID:24709764 |
RGD:13506912 |
NCBI chr 6:33,075,990...33,089,696
Ensembl chr 6:33,075,936...33,089,696
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G |
HLA-E |
major histocompatibility complex, class I, E |
susceptibility |
IAGP |
DNA:SNP: :rs1573294(human) |
RGD |
PMID:24709764 |
RGD:13506912 |
NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194
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G |
PLA2G4A |
phospholipase A2 group IVA |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27504716 |
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NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981
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G |
PRKCA |
protein kinase C alpha |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27504716 |
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NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
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G |
PRKD1 |
protein kinase D1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:27504716 |
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NCBI chr14:29,576,479...29,927,847
Ensembl chr14:29,576,479...30,191,898
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25721048 |
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NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25721048 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
TENM3 |
teneurin transmembrane protein 3 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25918132 |
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NCBI chr 4:181,447,613...182,803,024
Ensembl chr 4:182,143,987...182,803,024
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G |
TGFB1 |
transforming growth factor beta 1 |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25721048 |
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NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
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G |
TNF |
tumor necrosis factor |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:25721048 |
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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G |
ADIPOQ |
adiponectin, C1Q and collagen domain containing |
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IEP |
protein:decreased expression:serum |
RGD |
PMID:19725899 |
RGD:5686851 |
NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
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ALB |
albumin |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:19389874 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
ALOX5AP |
arachidonate 5-lipoxygenase activating protein |
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IEP |
protein:increased expression:nasal turbinate |
RGD |
PMID:19364335 |
RGD:5147461 |
NCBI chr13:30,713,485...30,764,426
Ensembl chr13:30,713,478...30,764,426
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CAT |
catalase |
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IEP |
protein:decreased expression:plasma |
RGD |
PMID:20493834 |
RGD:5130771 |
NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
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G |
CCL2 |
C-C motif chemokine ligand 2 |
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IEP |
protein:increased expression:nasal turbinate, mucosa (human) |
RGD |
PMID:9865755 |
RGD:8548839 |
NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCR2 |
C-C motif chemokine receptor 2 |
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IEP |
mRNA:increased expression:Nasal Mucosa |
RGD |
PMID:17982926 |
RGD:4145109 |
NCBI chr 3:46,354,111...46,360,940
Ensembl chr 3:46,353,864...46,360,940
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G |
CCR5 |
C-C motif chemokine receptor 5 |
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IEP |
mRNA:increased expression:nasal mucosa (human) |
RGD |
PMID:17982926 |
RGD:4145109 |
NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,946...46,376,206
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G |
CD40 |
CD40 molecule |
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ISO |
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RGD |
PMID:20226305 |
RGD:5132269 |
NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863
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CD86 |
CD86 molecule |
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IEP |
protein:increased expression:nasal mucosa, dendritic cell (human) |
RGD |
PMID:17088138 |
RGD:4892343 |
NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
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CHIA |
chitinase acidic |
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IEP |
mRNA, protein:increased expression:turbinate, mucosa (human) |
RGD |
PMID:20422678 |
RGD:5037226 |
NCBI chr 1:111,290,851...111,320,563
Ensembl chr 1:111,290,851...111,320,566
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G |
EGR1 |
early growth response 1 |
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IAGP |
DNA:snp:5' utr:g.-4071A>G rs7729723 (human) |
RGD |
PMID:19833116 |
RGD:5131984 |
NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
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G |
F2RL1 |
F2R like trypsin receptor 1 |
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IEP |
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RGD |
PMID:17727088 |
RGD:4892590 |
NCBI chr 5:76,819,030...76,835,315
Ensembl chr 5:76,818,933...76,835,315
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G |
GSTP1 |
glutathione S-transferase pi 1 |
susceptibility |
IAGP |
DNA:polymorphism:exon:p.I105V (rs1695) (human) |
RGD |
PMID:17181111 |
RGD:4142523 |
NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G |
HMOX1 |
heme oxygenase 1 |
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IEP |
mRNA, protein:increased expression: nasal mucosa |
RGD |
PMID:16540907 |
RGD:4145406 |
NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
ICAM1 |
intercellular adhesion molecule 1 |
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ISO IEP |
protein:increased expression:lung, endothelium (mouse) protein:increased secretion:nasopharynx (human) |
RGD |
PMID:19968652 PMID:19047814 |
RGD:4145464, RGD:4145520 |
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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G |
IFNGR1 |
interferon gamma receptor 1 |
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IAGP |
DNA: SNP: Leu467Pro |
RGD |
PMID:12851715 |
RGD:6480431 |
NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449
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G |
IL13 |
interleukin 13 |
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IEP |
mRNA, protein:increased expression:nasal mucosa |
RGD |
PMID:8520776 |
RGD:4782826 |
NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
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G |
IL17A |
interleukin 17A |
severity |
IEP |
protein:increased expression:serum |
RGD |
PMID:19226302 |
RGD:4889151 |
NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
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G |
IL18 |
interleukin 18 |
susceptibility |
IAGP |
DNA:SNP:promoter:c. -607A>C (rs1946518) (human) |
RGD |
PMID:16406079 |
RGD:4889924 |
NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,251...112,164,096
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G |
IL1A |
interleukin 1 alpha |
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IAGP |
DNA:polymorphism:exon:c.4845G>T (human) |
RGD |
PMID:14533660 |
RGD:4142859 |
NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493
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G |
IL1R1 |
interleukin 1 receptor type 1 |
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IDA |
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RGD |
PMID:18637763 |
RGD:5037238 |
NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874
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G |
IL2 |
interleukin 2 |
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IEP |
protein:decreased expression:serum: |
RGD |
PMID:17608155 |
RGD:8662959 |
NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
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G |
IL4 |
interleukin 4 |
treatment |
IEP |
protein:increased expression:serum |
RGD |
PMID:21171297 PMID:9237816 PMID:15329007 |
RGD:5128559, RGD:7829817, RGD:7829804 |
NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL5 |
interleukin 5 |
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IEP |
protein: increased levels: sputum |
RGD |
PMID:22186238 |
RGD:5687140 |
NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838
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G |
MMP2 |
matrix metallopeptidase 2 |
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IEP |
protein:increased expression:nasal mucosa: |
RGD |
PMID:19786210 |
RGD:5130872 |
NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
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G |
MMP9 |
matrix metallopeptidase 9 |
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IEP |
protein:increased expression:nasal mucosa: |
RGD |
PMID:19786210 |
RGD:5130872 |
NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
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G |
NOS2 |
nitric oxide synthase 2 |
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ISO |
protein:increased expression:nasal mucosa |
RGD |
PMID:14587983 |
RGD:4892078 |
NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
NOS3 |
nitric oxide synthase 3 |
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IAGP |
DNA:snp:promoter:g.-786T>C (human) |
RGD |
PMID:18086269 |
RGD:4892054 |
NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588
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G |
NR3C1 |
nuclear receptor subfamily 3 group C member 1 |
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IEP |
protein:altered expression:nasal mucosa |
RGD |
PMID:20185258 |
RGD:4892593 |
NCBI chr 5:143,277,931...143,435,512
Ensembl chr 5:143,277,931...143,435,512
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G |
PPARG |
peroxisome proliferator activated receptor gamma |
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IEP |
mRNA, protein:increased expression:nasal mucosa (human) |
RGD |
PMID:17116814 |
RGD:8552811 |
NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
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IEP |
protein:increased expression:respiratory system epithelium |
RGD |
PMID:19364335 |
RGD:5147461 |
NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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G |
TBXA2R |
thromboxane A2 receptor |
treatment |
IMP |
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RGD |
PMID:15247523 |
RGD:11059532 |
NCBI chr19:3,594,507...3,606,875
Ensembl chr19:3,594,507...3,606,875
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G |
PLA2G7 |
phospholipase A2 group VII |
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IAGP EXP |
ClinVar Annotator: match by term: Platelet-activating factor acetylhydrolase deficiency CTD Direct Evidence: marker/mechanism |
ClinVar OMIM CTD |
PMID:8675689 PMID:9412624 PMID:10194471 PMID:10733466 PMID:16787988 PMID:25741868 PMID:28406212 More...
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NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693
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G |
HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
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IAGP |
DNA:polymorphisms, haplotypes:cds:HLA-DQB1*0301, HLA-DQB1*0302 (human) |
RGD |
PMID:15577839 |
RGD:5147654 |
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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G |
ALOX5 |
arachidonate 5-lipoxygenase |
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IEP |
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RGD |
PMID:16677242 |
RGD:5147463 |
NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119
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G |
APOA4 |
apolipoprotein A4 |
resistance |
IEP |
protein:increased expression:blood serum (human) |
RGD |
PMID:20810159 |
RGD:5685642 |
NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304
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G |
BDNF |
brain derived neurotrophic factor |
severity |
IEP |
protein:increased expression:blood, nasal cavity epithelium |
RGD |
PMID:18266897 |
RGD:5144117 |
NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
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G |
CCL5 |
C-C motif chemokine ligand 5 |
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IEP |
protein:increased expression:inferior turbinate, epithelium (human) |
RGD |
PMID:20459697 |
RGD:4891379 |
NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
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G |
CMA1 |
chymase 1 |
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IEP |
protein:increased expression:nasal mucosa, mast cell (human) |
RGD |
PMID:11549546 |
RGD:5128839 |
NCBI chr14:24,505,353...24,508,265
Ensembl chr14:24,505,353...24,508,265
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G |
CST1 |
cystatin SN |
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EXP |
CTD Direct Evidence: marker/mechanism |
CTD |
PMID:23950865 |
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NCBI chr20:23,747,562...23,750,935
Ensembl chr20:23,747,562...23,751,268
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G |
FGA |
fibrinogen alpha chain |
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IDA |
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RGD |
PMID:21887273 |
RGD:5688767 |
NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,126...154,590,742
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G |
GSTO1 |
glutathione S-transferase omega 1 |
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IEP |
protein:decreased expression;T lymphocyte: |
RGD |
PMID:21410266 |
RGD:5491008 |
NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
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G |
HLA-DQB1 |
major histocompatibility complex, class II, DQ beta 1 |
susceptibility |
IAGP |
DNA:polymorphism:cds:HLA-DQB1*05 (human) DNA:polymorphisms, haplotype:cds:HLA-DQB1*0301, HLA-DQB1*0501 (human) |
RGD |
PMID:22032123 PMID:9641569 |
RGD:7421561, RGD:7421576 |
NCBI chr 6:32,659,467...32,666,657
Ensembl chr 6:32,659,467...32,668,383
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G |
ICAM1 |
intercellular adhesion molecule 1 |
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IEP |
protein:increased secretion:nasopharynx, secretion (human) |
RGD |
PMID:20128420 |
RGD:4145459 |
NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
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G |
IFNGR1 |
interferon gamma receptor 1 |
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