RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: respiratory allergy
Accession: DOID:0060496
browse the term
Definition: An allergic disease that is located_in the respiratory tract. (DO)
Synonyms: exact_synonym: airway allergy; airway hyper responsiveness; respiratory hypersensitivities; respiratory hypersensitivity
related_synonym: allergic lung disease
primary_id: MESH:D012130
GViewer not supported for the selected species.
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CCL11
C-C motif chemokine ligand 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr16:27,792,699...27,796,437
Ensembl chr16:27,794,033...27,796,460
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CCL8
C-C motif chemokine ligand 8
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr16:27,821,149...27,823,919
Ensembl chr16:27,821,970...27,823,528
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CCR3
C-C motif chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20022477
NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135
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CLDN4
claudin 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30608172
NCBI chr28:9,242,054...9,244,972
Ensembl chr28:9,242,909...9,243,538
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CLDN5
claudin 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30608172
NCBI chr19:6,227,881...6,230,199
Ensembl chr19:6,228,965...6,229,621
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CXCL1
C-X-C motif chemokine ligand 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23056391
NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900 Ensembl chr 7:22,569,355...22,569,900
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CXCL6
C-X-C motif chemokine ligand 6
ISO
mRNA:increased expression:lung
RGD
PMID:18417511
RGD:5135242
NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207
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F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:20186875
RGD:4892588
NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005
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HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12095164
NCBI chr22:47,187,156...47,298,761
Ensembl chr22:47,295,011...47,296,471
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HSPA5
heat shock protein family A (Hsp70) member 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211530
NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
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IL10
interleukin 10
ISO
RGD
PMID:20583974
RGD:4140460
NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
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IL13
interleukin 13
susceptibility
ISO
DNA:SNP, missense mutation:promoter, exon:-1112C>T, p.R130Q (human) mRNA:increased expression:lung
RGD
PMID:18849614 PMID:19564030
RGD:4145637 RGD:8549507
NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
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IL15
interleukin 15
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18394133
NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488
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IL1A
interleukin 1 alpha
ISO
RGD
PMID:12663678
RGD:4143222
NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611
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IL1B
interleukin 1 beta
ISO
RGD
PMID:12663678
RGD:4143222
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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IL1RL1
interleukin 1 receptor like 1
ISO
associated with Fungal Lung Diseases
RGD
PMID:25746970
RGD:39938968
NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265
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IL1RN
interleukin 1 receptor antagonist
ISO
RGD
PMID:12663678
RGD:4143222
NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326
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IL27
interleukin 27
ISO
RGD
PMID:20817868
RGD:4145651
NCBI chr 5:26,348,559...26,358,028
Ensembl chr 5:26,348,848...26,356,360
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IL33
interleukin 33
treatment
ISO
RGD
PMID:25424936
RGD:40400692
NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436
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IL4
interleukin 4
ISO
associated with Pneumonia, Pneumocystis carinii CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18394133 PMID:21343358
RGD:5128506
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18394133
NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237
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LOC103233044
metallothionein-1X
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr 5:42,637,027...42,638,751
Ensembl chr 5:42,637,113...42,638,611
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LOC103242760
C-C motif chemokine 16
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr16:29,473,639...29,477,861
Ensembl chr16:29,452,308...29,458,007 Ensembl chr16:29,452,308...29,458,007 Ensembl chr16:29,452,308...29,458,007
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MBL2
mannose binding lectin 2
susceptibility
ISO
DNA:SNP:intron:1011G>A(human)
RGD
PMID:16487239
RGD:8693711
NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079
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NOS2
nitric oxide synthase 2
treatment
ISO
RGD
PMID:19800904 PMID:21983654
RGD:4891497 RGD:8549812
NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257
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NOS3
nitric oxide synthase 3
ISO
DNA:polymorphism: :c. -786C>T (human)
RGD
PMID:18086269
RGD:4892054
NCBI chr21:119,174,829...119,196,840
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PTPN6
protein tyrosine phosphatase non-receptor type 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18441283
NCBI chr11:6,977,480...6,994,525
Ensembl chr11:6,984,710...6,994,545
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SERPINE1
serpin family E member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211530
NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202
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SLC30A4
solute carrier family 30 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr26:37,692,164...37,732,102
Ensembl chr26:37,692,219...37,731,292
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SLC39A1
solute carrier family 39 member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr20:9,847,928...9,852,998
Ensembl chr20:9,847,968...9,853,413
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SLC39A14
solute carrier family 39 member 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr 8:20,446,756...20,502,585
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SLC39A4
solute carrier family 39 member 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17085522
NCBI chr 8:138,622,100...138,626,749
Ensembl chr 8:138,622,224...138,626,376
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TLR4
toll like receptor 4
susceptibility
ISO
DNA:polymorphisms,haplotype: :−2027A>G, ¿1608T>C(human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:10835634 PMID:21704886
RGD:7800728
NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18394133
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TSLP
thymic stromal lymphopoietin
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:28329851
NCBI chr23:14,419,820...14,423,331
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UPP1
uridine phosphorylase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24211530
NCBI chr21:10,686,600...10,707,181
Ensembl chr21:10,686,093...10,706,347
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VEGFA
vascular endothelial growth factor A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30608172
NCBI chr17:28,377,959...28,394,508
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CXCL8
C-X-C motif chemokine ligand 8
treatment
ISO
RGD
PMID:30059697
RGD:39939057
NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068
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CCL26
C-C motif chemokine ligand 26
treatment
ISO
RGD
PMID:25530546
RGD:11081163
NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875
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EPX
eosinophil peroxidase
ISO
protein:increased expression:urine:
RGD
PMID:11846868
RGD:13506893
NCBI chr16:35,196,433...35,208,269
Ensembl chr16:35,192,971...35,207,874
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IL25
interleukin 25
treatment
ISO
RGD
PMID:17889290
RGD:40902975
NCBI chr29:23,742,377...23,747,902
Ensembl chr29:23,744,449...23,747,176
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LOC103232241
cysteinyl leukotriene receptor 1
treatment
ISO
RGD
PMID:23933317
RGD:40903070
NCBI chr X:67,218,777...67,300,655
Ensembl chr X:67,220,048...67,221,061
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MHC-DPA1
major histocompatibility complex, class II, DP alpha 1
susceptibility
ISO
DNA:polymorphism:
RGD
PMID:28380482
RGD:13506910
NCBI chr17:39,009,361...39,017,978
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MHC-DPB1
major histocompatibility complex, class II, DP beta 1
susceptibility
ISO
DNA:polymorphism:
RGD
PMID:28380482
RGD:13506910
NCBI chr17:38,996,329...39,007,097
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TREM1
triggering receptor expressed on myeloid cells 1
exacerbates
ISO
RGD
PMID:21592044
RGD:126928124
NCBI chr17:30,873,647...30,885,292
Ensembl chr17:30,873,666...30,886,967
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CCL17
C-C motif chemokine ligand 17
ISO
associated with Cystic Fibrosis
RGD
PMID:17898016
RGD:4145612
NCBI chr 5:43,343,525...43,350,096
Ensembl chr 5:43,346,329...43,348,599
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CCR1
C-C motif chemokine receptor 1
ISO
RGD
PMID:15951834
RGD:5688155
NCBI chr22:7,634,205...7,641,380
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CCR2
C-C motif chemokine receptor 2
ISO
RGD
PMID:10946288
RGD:8661731
NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728
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CFTR
CF transmembrane conductance regulator
ISO
DNA:mutations: :
RGD
PMID:11243954
RGD:4140482
NCBI chr21:86,154,313...86,332,436
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ICAM1
intercellular adhesion molecule 1
ISO
RGD
PMID:7743671
RGD:8547590
NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263
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IL1A
interleukin 1 alpha
ISO
RGD
PMID:8699818
RGD:7794730
NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611
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MBL2
mannose binding lectin 2
susceptibility
ISO
Chronic Necrotizing Pulmonary Aspergillosis; DNA:missense mutation:exon:p.R52C (human) DNA:SNP:intron:1011G>A(human)
RGD
PMID:11474427 PMID:16487239
RGD:4889577 RGD:8693711
NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079
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TNF
tumor necrosis factor
ISO
RGD
PMID:8699818
RGD:7794730
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TNFRSF1A
TNF receptor superfamily member 1A
susceptibility
ISO
DNA:snps:5' utr, exon:g.-609G>T rs4149570, g.36A>G rs767455 (human)
RGD
PMID:20646338
RGD:5131174
NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902
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ABCB1
ATP binding cassette subfamily B member 1
severity
ISO
DNA:snp:exon:c.1236C>T (human)
RGD
PMID:24040855
RGD:8657076
NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274
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BCL2
BCL2 apoptosis regulator
ISO
mRNA, protein:increased expression:nasal mucosa (rat)
RGD
PMID:15362690
RGD:11522724
NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895
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CAT
catalase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29028686
NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
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CCL11
C-C motif chemokine ligand 11
treatment
ISO
RGD
PMID:23089405
RGD:7248414
NCBI chr16:27,792,699...27,796,437
Ensembl chr16:27,794,033...27,796,460
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CCL26
C-C motif chemokine ligand 26
ISO
protein:increased expression:oronasal secretion (human)
RGD
PMID:23883806
RGD:7364793
NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875
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CD40
CD40 molecule
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566
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CD40LG
CD40 ligand
ISO
protein:increased expression:lymphocyte
RGD
PMID:19086656
RGD:8547782
NCBI chr X:111,655,301...111,667,602
Ensembl chr X:111,655,397...111,666,639
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CLDN3
claudin 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr28:9,301,312...9,303,496
Ensembl chr28:9,302,446...9,303,108
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CLDN7
claudin 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr16:6,632,695...6,635,994
Ensembl chr16:6,630,412...6,635,327
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CTLA4
cytotoxic T-lymphocyte associated protein 4
treatment
ISO
RGD
PMID:10436391
RGD:11344920
NCBI chr10:89,637,176...89,644,436
Ensembl chr10:89,638,314...89,642,344
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FCGR3A
Fc fragment of IgG receptor IIIa
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr20:2,466,492...2,475,579
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GRIA1
glutamate ionotropic receptor AMPA type subunit 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr23:55,944,128...56,265,748
Ensembl chr23:56,101,294...56,265,849
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GRIA2
glutamate ionotropic receptor AMPA type subunit 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:34624383
NCBI chr 7:103,808,789...103,957,947
Ensembl chr 7:103,808,797...103,953,040
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HMOX1
heme oxygenase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
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HRH1
histamine receptor H1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23333628
NCBI chr22:47,187,156...47,298,761
Ensembl chr22:47,295,011...47,296,471
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IFNG
interferon gamma
treatment
ISO
associated with Asthma CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12787306 PMID:18510219 PMID:29871060
RGD:10755770 RGD:7829803
NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
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IL10
interleukin 10
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:23253209 PMID:23883806 PMID:36127783
RGD:7364793 RGD:7364818
NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
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IL13
interleukin 13
susceptibility no_association
ISO
CTD Direct Evidence: marker/mechanism DNA:SNPs:promoter, cds:-1112C>T, p.R130Q (rs1800925, rs20541) (human)
OMIM CTD RGD
PMID:12928861
RGD:8549516
NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
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IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
protein:increased expression:serum
RGD
PMID:21462799
RGD:8549521
NCBI chr X:102,589,947...102,628,853
Ensembl chr X:102,590,045...102,603,260
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IL17A
interleukin 17A
susceptibility
ISO
mRNA:increased expression:peripheral blood mononuclear cell (human) DNA:snp:promoter:c.-444A>G (human)
RGD
PMID:21535180 PMID:22507625
RGD:5147409 RGD:9068429
NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785
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IL18
interleukin 18
no_association severity
ISO
DNA:SNP:promoter:-140C>G (rs360721) (human) DNA:SNP:promoter:-137G>C (rs187238) (human)
RGD
PMID:22840759
RGD:8655914
NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
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IL1B
interleukin 1 beta
ISO
protein:increased expression:nasal mucus
RGD
PMID:7750009
RGD:7401199
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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IL2
interleukin 2
ISO
RGD
PMID:12592663
RGD:8662963
NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969
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IL4
interleukin 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:8908280 PMID:9893928 PMID:14653048 PMID:24620662 PMID:36127783
RGD:11522769 RGD:7829796 RGD:7829802 RGD:7829827
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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IL5
interleukin 5
treatment
ISO
RGD
PMID:23934070 PMID:24620662
RGD:11354976 RGD:11522769
NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
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ITGB2
integrin subunit beta 2
treatment
ISO
RGD
PMID:12046991
RGD:9698435
NCBI chr 2:88,597,554...88,644,890
Ensembl chr 2:88,597,556...88,624,025
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MRC1
mannose receptor C-type 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:36127783
NCBI chr 9:17,751,053...17,849,258
Ensembl chr 9:17,751,133...17,849,406
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MUC1
mucin 1, cell surface associated
severity
ISO
mRNA,protein:decreased expression:nasal mucosa
RGD
PMID:31425778
RGD:127345100
NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
ISO
mRNA, protein:increased expression:nasal cavity epithelium
RGD
PMID:22972875
RGD:7364746
NCBI chr 1:981,515...1,018,242
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NOD2
nucleotide binding oligomerization domain containing 2
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:23858718
RGD:8547523
NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499
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OCLN
occludin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33441633
NCBI chr 4:65,581,943...65,641,516
Ensembl chr 4:65,582,460...65,644,787
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PON1
paraoxonase 1
severity
ISO
protein:decreased activity:plasma (human)
RGD
PMID:23406590
RGD:8547583
NCBI chr21:53,713,434...53,739,658
Ensembl chr21:53,714,012...53,739,875
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PRKG1
protein kinase cGMP-dependent 1
ISO
protein:increased expression:nasal cavity epithelium
RGD
PMID:24012634
RGD:7775060
NCBI chr 9:78,858,269...80,188,163
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16979129
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
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SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA:decreased expression:nasal mucosa, lung
RGD
PMID:17882576
RGD:5144135
NCBI chr 1:11,470,091...11,474,915
Ensembl chr 1:11,470,195...11,474,149
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SCGB3A2
secretoglobin family 3A member 2
susceptibility
ISO
DNA:SNP: :rs7726552 (human)
RGD
PMID:21410962
RGD:5144225
NCBI chr23:50,327,428...50,417,518
Ensembl chr23:50,414,139...50,417,373
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SERPINE1
serpin family E member 1
ISO
mRNA:increased expression:nasal mucosa (mouse)
RGD
PMID:21339035
RGD:8547809
NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202
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TACR1
tachykinin receptor 1
ISO
mRNA:increased expression:nasal mucosa
RGD
PMID:12768696
RGD:5147835
NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596
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TGFB1
transforming growth factor beta 1
treatment
ISO
RGD
PMID:31368266
RGD:14995445
NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365
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TLR2
toll like receptor 2
severity
ISO
DNA:polymorphism:cds:p.R753Q(human) protein:increased expression:neutrophil: mRNA:decreased expression:nasal mucosa:
RGD
PMID:18219831 PMID:18381801 PMID:22402138 PMID:22555057
RGD:7800732 RGD:7800742 RGD:8552972 RGD:8552993
NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795
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TLR4
toll like receptor 4
severity susceptibility no_association treatment
ISO
DNA:polymorphism:cds:p.D299G(human) DNA:SNP: :rs1927911(human) protein:decreased expression:nasal mucosa: DNA:polymorphism: :4216G>C(human) protein:increased expression:nasal lavage,leukocyte, bone marrow:
RGD
PMID:17069098 PMID:19763595 PMID:22402138 PMID:22555057 PMID:22577387 PMID:23639307 More...
RGD:4145354 RGD:7800732 RGD:7800736 RGD:7800738 RGD:7800740 RGD:8552993
NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515
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CYP2C19
cytochrome P450 family 2 subfamily C member 19
treatment
ISO
associated with Eosinophilic Esophagitis; DNA:polymorphisms::
RGD
PMID:26416193
RGD:11352743
NCBI chr 9:87,981,300...88,025,007
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IL3
interleukin 3
susceptibility
ISO
DNA:SNP: :rs40401(human)
RGD
PMID:23953855
RGD:13506915
NCBI chr23:34,894,630...34,899,105
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CACNG6
calcium voltage-gated channel auxiliary subunit gamma 6
susceptibility
ISO
DNA:SNP,haplotype:rs192808(human)
RGD
PMID:20860846
RGD:13524562
NCBI chr 6:46,680,827...46,700,959
Ensembl chr 6:46,682,088...46,700,938
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CCR3
C-C motif chemokine receptor 3
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20022477 PMID:20485159
RGD:4145619
NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135
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CYSLTR1
cysteinyl leukotriene receptor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481 PMID:17641958 PMID:20485159
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CYSLTR2
cysteinyl leukotriene receptor 2
ISO
DNA:SNPs: :-819T>G, 2078C>T, 2534A>G (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15970796 PMID:16502481 PMID:20485159
RGD:5144000
NCBI chr 3:26,578,248...26,624,364
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FANCC
FA complementation group C
ISO
DNA:haplotype::rs4647416(human)
RGD
PMID:21670957
RGD:11045795
NCBI chr12:107,780,087...107,991,828
Ensembl chr12:107,845,135...107,991,237
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IL4
interleukin 4
susceptibility
ISO
DNA:SNPs:promoter,5'UTR,intron:multiple
RGD
PMID:20921925
RGD:11528633
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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LOC103233689
thromboxane A2 receptor
susceptibility
ISO
DNA:polymorphism: :795T>C (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15898979 PMID:16502481 PMID:20485159
RGD:11059537
NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761
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LTC4S
leukotriene C4 synthase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9393345 PMID:9466979 PMID:10970818 PMID:20485159
NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179
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MHC-DPB1
major histocompatibility complex, class II, DP beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr17:38,996,329...39,007,097
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MHC-DQA1
major histocompatibility complex, class II, DQ alpha 1
susceptibility
ISO
RGD
PMID:25975240
RGD:11074090
NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871
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MS4A2
membrane spanning 4-domains A2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16502481
NCBI chr 1:13,657,842...13,666,314
Ensembl chr 1:13,654,696...13,665,925
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POSTN
periostin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18391768
NCBI chr 3:16,060,013...16,095,867
Ensembl chr 3:16,059,965...16,095,791
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PTGDR2
prostaglandin D2 receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20485159
NCBI chr 1:12,989,750...12,994,979
Ensembl chr 1:12,992,188...12,993,378
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PTGER2
prostaglandin E receptor 2
ISO
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
ClinVar
PMID:15496426
NCBI chr24:29,395,799...29,410,723
Ensembl chr24:29,396,464...29,409,575
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PTGIR
prostaglandin I2 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:20485159
NCBI chr 6:39,977,057...39,983,592
Ensembl chr 6:39,977,864...39,980,860
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PTGS2
prostaglandin-endoperoxide synthase 2
ISO
protein:increased expression:mast cell CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9487340 PMID:16502481 PMID:20485159
RGD:5143936
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
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TAP2
transporter 2, ATP binding cassette subfamily B member
ISO
RGD
PMID:21796142
RGD:5147839
NCBI chr17:39,266,870...39,277,658
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TBX21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma, aspirin-induced, susceptibility to
ClinVar
PMID:15806396
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
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ABCB1
ATP binding cassette subfamily B member 1
ISO
protein:increased expression:blood, lymphocyte
RGD
PMID:19484671
RGD:4890020
NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274
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ABCC1
ATP binding cassette subfamily C member 1 (ABCC1 blood group)
ISO
RGD
PMID:18931056
RGD:5128825
NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567
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ABO
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
no_association
ISO
RGD
PMID:16008680 PMID:19771478
RGD:5128831 RGD:5128835
NCBI chr12:4,863,100...4,892,204
Ensembl chr12:4,863,165...4,885,849
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ACSL3
acyl-CoA synthetase long chain family member 3
ISO
DNA:hypermethylation:promoter
RGD
PMID:19221603
RGD:13831295
NCBI chr10:108,787,341...108,867,523
Ensembl chr10:108,787,061...108,869,042
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ADA
adenosine deaminase
susceptibility
ISO
DNA:polymorphisms (human)
RGD
PMID:16754522
RGD:5128848
NCBI chr 2:19,167,209...19,200,233
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ADAM33
ADAM metallopeptidase domain 33
susceptibility no_association disease_progression
ISO
DNA:SNPs (human) DNA:SNPs: :multiple (human) DNA:SNPs:introns,exon:7575G>A, 11188A>T, 12433T>C (human) DNA:polymorphism: :p.M764T (human) mRNA:increased expression:bronchus mRNA:increased expression:lung
RGD
PMID:16893396 PMID:17339047 PMID:17961406 PMID:18778489 PMID:19635592 PMID:19940503 More...
RGD:4145359 RGD:4145360 RGD:4145378 RGD:4145379 RGD:4145380 RGD:4145382
NCBI chr 2:34,352,514...34,366,694
Ensembl chr 2:34,353,505...34,366,559
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ADAM8
ADAM metallopeptidase domain 8
severity
ISO
mRNA:increased expression:respiratory tract mRNA:increased expression:bronchus
RGD
PMID:17339047 PMID:19373511 PMID:20194813
RGD:4145380 RGD:5128872 RGD:5128878
NCBI chr26:53,114,184...53,129,650
Ensembl chr26:53,114,924...53,126,900
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ADCY2
adenylate cyclase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr 4:6,989,077...7,415,282
Ensembl chr 4:6,989,169...7,414,617
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ADCYAP1R1
ADCYAP receptor type I
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21059121
NCBI chr21:27,274,039...27,333,316
Ensembl chr21:27,278,788...27,333,220
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ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
susceptibility
ISO
protein:increased expression:respiratory system fluid/secretion DNA:SNPs: :rs1154404, rs28730619 (human)
RGD
PMID:15919956 PMID:17543375 PMID:19395503 PMID:19514054
RGD:5128882 RGD:5128890 RGD:5128891 RGD:5128892
NCBI chr 7:47,190,031...47,211,670
Ensembl chr 7:47,190,294...47,211,651
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
RGD
PMID:19168697
RGD:5686821
NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391
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ADORA1
adenosine A1 receptor
ISO
protein:increased expression:bronchus DNA:SNPs: :1405C>T (human)
RGD
PMID:17959644 PMID:19019667 PMID:20400685
RGD:4145444 RGD:4890386 RGD:5129097
NCBI chr25:26,180,898...26,221,424
Ensembl chr25:26,182,446...26,220,776
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ADORA2A
adenosine A2a receptor
ISO
DNA:SNP (human) mRNA:decreased expression:aorta
RGD
PMID:16339780 PMID:17293374 PMID:18310516 PMID:19019667
RGD:4890366 RGD:4890380 RGD:4890385 RGD:4890386
NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926
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ADRB2
adrenoceptor beta 2
susceptibility
ISO
ClinVar Annotator: match by term: Beta-2-adrenoreceptor agonist, reduced response to DNA:SNP: :-1023A>G (human)
ClinVar RGD
PMID:8383511 PMID:15284533 PMID:16596417 PMID:19638684
RGD:4145081
NCBI chr23:51,445,920...51,447,942
Ensembl chr23:51,446,154...51,447,401
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AGER
advanced glycosylation end-product specific receptor
treatment onset
ISO
protein:decreased expression:lung (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21920897 PMID:23304218 PMID:33075463
RGD:6767554 RGD:7244279
NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127
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AGTR1
angiotensin II receptor type 1
ISO
RGD
PMID:17877756 PMID:19080339
RGD:5147452 RGD:5147457
NCBI chr15:41,957,826...42,002,776
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AGTR2
angiotensin II receptor type 2
ISO
mRNA, protein:increased expression:lung
RGD
PMID:19080339
RGD:5147457
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ALDH2
aldehyde dehydrogenase 2 family member
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9600491 PMID:11506308
NCBI chr11:107,019,015...107,060,784
Ensembl chr11:107,019,111...107,060,374
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ALOX15
arachidonate 15-lipoxygenase
ISO
protein:increased expression:lung
RGD
PMID:18692885 PMID:19628725
RGD:5509605 RGD:5509784
NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645
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ALOX5
arachidonate 5-lipoxygenase
severity susceptibility treatment no_association
ISO
DNA:repeat:promoter (human) DNA:polymorphism:cds:p.E254K (human) CTD Direct Evidence: marker/mechanism mRNA:increased expression:blood, leukocyte protein:increased expression:lung DNA:polymorphism:promoter (human)
RGD CTD OMIM
PMID:8879219 PMID:9642160 PMID:10369259 PMID:11035107 PMID:12911785 PMID:16364163 PMID:17394438 PMID:18204779 PMID:19033731 PMID:20128419 More...
RGD:4890407 RGD:4890408 RGD:4890410 RGD:4890413 RGD:4890415 RGD:4890422 RGD:5147462 RGD:5147465 RGD:5147467 RGD:734557
NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331
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ALOX5AP
arachidonate 5-lipoxygenase activating protein
no_association susceptibility
ISO
mRNA:increased expression:blood, leukocyte DNA:polymorphism:promoter (human) protein:increased expression:lung DNA:SNP: :rs10507391 (human) DNA:substitution, repeat:promoter:-336G>A, -169(A)19-23 (human) DNA:repeat:promoter:-169(A)21 (human) DNA:polymorphisms:intron:IVS2+12C>A, IVS2+105T>C (human) DNA:SNPs (human)
RGD
PMID:8879219 PMID:9642160 PMID:10527888 PMID:11035107 PMID:12911785 PMID:15784112 PMID:18547289 PMID:20067482 PMID:20128419 More...
RGD:4890405 RGD:4890407 RGD:4890409 RGD:4890422 RGD:5147462 RGD:5147464 RGD:5147465 RGD:5147466 RGD:5147467
NCBI chr 3:9,618,030...9,642,990
Ensembl chr 3:9,617,949...9,643,184
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AMBP
alpha-1-microglobulin/bikunin precursor
ISO
protein:increased expression:serum
RGD
PMID:14621078
RGD:6904149
NCBI chr12:25,508,516...25,526,821
Ensembl chr12:25,508,682...25,527,016
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ANG
angiogenin
severity
ISO
protein:increased expression:sputum
RGD
PMID:16478840
RGD:6892719
NCBI chr29:21,215,985...21,226,927
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ANXA1
annexin A1
ISO
RGD
PMID:22092555
RGD:7421657
NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562
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AREG
amphiregulin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15696081
NCBI chr 7:22,979,574...22,990,179
Ensembl chr 7:22,980,249...22,990,162
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ARG1
arginase 1
ISO
mRNA, protein:increased expression:lung, mononuclear cell (human) mRNA:increased expression:lung (mouse) CTD Direct Evidence: marker/mechanism DNA:SNP: :rs2781667 (human)
RGD CTD
PMID:12813022 PMID:19281908 PMID:19800904 PMID:20124949
RGD:4143187 RGD:5129205
NCBI chr13:41,971,955...41,983,372
Ensembl chr13:41,971,802...41,983,049
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ARG2
arginase 2
severity susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP: :rs3742879, rs17249437 (human) DNA:SNPs (human) mRNA:increased expression:lung (mouse)
CTD RGD
PMID:12813022 PMID:16387594 PMID:19281908 PMID:20124949
RGD:4143187 RGD:5129205 RGD:5129207
NCBI chr24:44,851,139...44,884,118
Ensembl chr24:44,851,175...44,883,853
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BCL2
BCL2 apoptosis regulator
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:18357729
NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895
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BDKRB2
bradykinin receptor B2
onset
ISO
protein:increased expression:blood, eosinophil DNA:polymorphism:exon (human)
RGD
PMID:8856156 PMID:11517947 PMID:14727005 PMID:19038786
RGD:4890454 RGD:4890456 RGD:4891028 RGD:4891042
NCBI chr24:74,084,907...74,125,604
Ensembl chr24:74,118,210...74,122,909
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BDNF
brain derived neurotrophic factor
severity susceptibility
ISO
DNA:polymorphisms: :p.V66M, -270C>T (human) protein:decreased expression:blood, eosinophil protein:increased expression:plasma DNA:polymorphisms: :p.V66M (rs6265) (human) DNA:SNP,haplotypes: :rs10767664,rs12273539,rs962369(human)
RGD
PMID:11737043 PMID:12752594 PMID:17584309 PMID:19895626 PMID:20874832 PMID:21723144 More...
RGD:4891063 RGD:4891067 RGD:4891117 RGD:4891122 RGD:4891123 RGD:8655967
NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336
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BGLAP
bone gamma-carboxyglutamate protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8429434
NCBI chr20:7,623,716...7,626,353
Ensembl chr20:7,623,883...7,624,812
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BMPR1B
bone morphogenetic protein receptor type 1B
ISO
protein:decreased expression:bronchus
RGD
PMID:18292470
RGD:5129470
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BMPR2
bone morphogenetic protein receptor type 2
ISO
protein:decreased expression:bronchus
RGD
PMID:18292470
RGD:5129470
NCBI chr10:88,103,442...88,302,578
Ensembl chr10:88,106,072...88,303,734
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C3
complement C3
severity
ISO
DNA:SNP:intron:rs11569562 (human) protein:increased expression:respiratory system fluid/secretion DNA:SNPs: :multiple (human) protein:increased expression:serum Interaction with IL4RA DNA:SNP: :4896C>T (human)
RGD
PMID:11591733 PMID:15278436 PMID:16355111 PMID:18566738 PMID:20395963 PMID:20402389 PMID:20589464 PMID:20802484 More...
RGD:5129501 RGD:5129505 RGD:5129512 RGD:5129517 RGD:5129519 RGD:5129537 RGD:5129538 RGD:5129681
NCBI chr 6:6,250,422...6,289,264
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C3AR1
complement C3a receptor 1
severity
ISO
protein:increased expression:lung, leukocyte mRNA:increased expression:lung
RGD
PMID:15278436 PMID:15940127 PMID:17544263 PMID:20045013 PMID:20802484
RGD:5129512 RGD:5129560 RGD:5129561 RGD:5129681 RGD:5129686
NCBI chr11:8,128,192...8,135,517
Ensembl chr11:8,128,620...8,130,062
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C5
complement C5
severity
ISO
mRNA:decreased expression:lung
RGD
PMID:10973279 PMID:11591795 PMID:15278436 PMID:20143644 PMID:20802484
RGD:1600651 RGD:5129512 RGD:5129681 RGD:5129706 RGD:5130158
NCBI chr12:18,525,855...18,624,048
Ensembl chr12:18,525,880...18,623,636
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C5AR1
complement C5a receptor 1
severity
ISO
protein:increased expression:lung, leukocyte protein:increased expression:respiratory tract
RGD
PMID:15940127 PMID:16511606 PMID:17544263 PMID:20802484
RGD:5129560 RGD:5129561 RGD:5129681 RGD:5130166
NCBI chr 6:40,633,540...40,651,839
Ensembl chr 6:40,633,448...40,652,845
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CARD11
caspase recruitment domain family member 11
ISO
ClinVar Annotator: match by term: Asthma
ClinVar
PMID:18323416 PMID:23027925 PMID:23129749 PMID:25352053 PMID:25741868 PMID:26861442 PMID:28492532 PMID:28824638 PMID:29472930 More...
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CARM1
coactivator associated arginine methyltransferase 1
ISO
mRNA:decreased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr 6:9,866,715...9,915,655
Ensembl chr 6:9,866,534...9,914,682
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CASP1
caspase 1
ISO
protein:increased expression:serum
RGD
PMID:12396474
RGD:5130192
NCBI chr 1:96,389,697...96,400,610
Ensembl chr 1:96,389,657...96,400,849
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CAT
catalase
severity
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphism:promoter:-21A>T (human) protein:decreased activity:respiratory system fluid/secretion protein:increased expression:erythrocyte DNA:polymorphism:promoter:-262C>T (human)
CTD RGD
PMID:16622028 PMID:18048809 PMID:19373626 PMID:19475625
RGD:5130751 RGD:5130753 RGD:5130856 RGD:5130867
NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
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CCL1
C-C motif chemokine ligand 1
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:20455898
RGD:4891420
NCBI chr16:27,868,925...27,890,143
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CCL11
C-C motif chemokine ligand 11
treatment susceptibility severity
ISO
DNA:polymorphism: :p.A23T (human)
RGD OMIM
PMID:17845580 PMID:20704746 PMID:22932891
RGD:4145387 RGD:4145457 RGD:7248416
NCBI chr16:27,792,699...27,796,437
Ensembl chr16:27,794,033...27,796,460
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CCL17
C-C motif chemokine ligand 17
ISO
mRNA:increased expression:lung protein:increased expression:respiratory system fluid/secretion
RGD
PMID:11160256 PMID:15947487 PMID:15993846 PMID:20074456 PMID:20237293
RGD:2306304 RGD:4145486 RGD:4145487 RGD:4145513 RGD:4145603
NCBI chr 5:43,343,525...43,350,096
Ensembl chr 5:43,346,329...43,348,599
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CCL19
C-C motif chemokine ligand 19
ISO
protein:increased expression:bronchus submucosa, mast cell
RGD
PMID:16959919
RGD:5130911
NCBI chr12:45,928,212...45,930,897
Ensembl chr12:45,929,071...45,930,904
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CCL2
C-C motif chemokine ligand 2
severity treatment
ISO
CTD Direct Evidence: marker/mechanism DNA:haplotype::-2518A>G (human) protein:increased expression:lung mRNA:increased expression:lung (mouse) protein:increased expression:serum
CTD RGD
PMID:12055264 PMID:17964702 PMID:19373627 PMID:20205697 PMID:23454776 PMID:25441643 More...
RGD:11528569 RGD:11528570 RGD:2307055 RGD:4145509 RGD:4891466 RGD:8551842
NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416
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CCL20
C-C motif chemokine ligand 20
ISO
associated with Allergic Rhinitis;protein:increased expression:serum protein:increased expression:respiratory system fluid/secretion
RGD
PMID:18422729 PMID:22469443
RGD:7483597 RGD:7483618
NCBI chr10:113,815,099...113,836,562
Ensembl chr10:113,832,573...113,835,736
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CCL22
C-C motif chemokine ligand 22
ISO
mRNA, protein:increased expression:respiratory system mucosa, respiratory system fluid/secretion
RGD
PMID:18684970
RGD:4145489
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CCL24
C-C motif chemokine ligand 24
susceptibility
ISO
protein:increased expression:plasma DNA:SNPs: :304C>A, 1272A>G (human) DNA:SNP: :1265A>G (human) DNA:SNPs: :179T>C, 275C>T (human) protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12761043 PMID:12952266 PMID:15207712 PMID:16304252 PMID:17060636 PMID:17548626 PMID:18712274 More...
RGD:4891483 RGD:4891484 RGD:4891485 RGD:4891495 RGD:4891496 RGD:5130930 RGD:5130932
NCBI chr28:10,067,482...10,069,992
Ensembl chr28:10,066,664...10,069,695
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CCL26
C-C motif chemokine ligand 26
treatment
ISO
protein:increased expression:plasma DNA:SNPs: :77C>T, 2497T>G (human) DNA:SNPs: :77C>T, 716A>G, 1579G>A (human)
RGD
PMID:15207712 PMID:16304252 PMID:18712274 PMID:25399816 PMID:25530546
RGD:11081163 RGD:11087575 RGD:4891483 RGD:4891495 RGD:5130930
NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875
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CCL27
C-C motif chemokine ligand 27
ISO
RGD
PMID:19541356
RGD:5130899
NCBI chr12:45,956,596...45,959,354
Ensembl chr12:45,958,642...45,959,313
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CCL28
C-C motif chemokine ligand 28
ISO
mRNA:increased expression:lung (mouse)
RGD
PMID:16290206
RGD:4892195
NCBI chr 4:42,163,094...42,194,517
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CCL5
C-C motif chemokine ligand 5
susceptibility
ISO
CTD Direct Evidence: marker/mechanism DNA:transition:5' utr:-403G>A (human) protein:increased expression:smooth muscle cell protein:increased expression:lung, secretion (mouse)
CTD RGD
PMID:8534483 PMID:18208670 PMID:20092989 PMID:20430255
RGD:2307112 RGD:4891381 RGD:4891430
NCBI chr16:29,351,214...29,361,317
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CCL7
C-C motif chemokine ligand 7
ISO
Promoter polymorphism
RGD
PMID:19965981 PMID:21388664
RGD:5130979 RGD:5130983
NCBI chr16:27,777,795...27,780,413
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CCR1
C-C motif chemokine receptor 1
severity
ISO
mRNA:increased expression:lung associated with Respiratory Syncytial Virus Infections
RGD
PMID:15593301 PMID:15654816
RGD:5688158 RGD:5688159
NCBI chr22:7,634,205...7,641,380
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CCR2
C-C motif chemokine receptor 2
susceptibility
ISO
DNA:haplotype:cds:p.V64I(human) DNA:SNP:cds:p.V64I (human) protein:increased expression:lung, dendritic cell (mouse)
RGD
PMID:17298432 PMID:19917684 PMID:23454776
RGD:4145110 RGD:8549811 RGD:8551842
NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728
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CCR3
C-C motif chemokine receptor 3
ISO
protein:increased expression:respiratory system fluid/secretion, neutrophil DNA:SNP:exon:51T>C (human)
RGD
PMID:16978084 PMID:17145927 PMID:18699933 PMID:19017998 PMID:19657453 PMID:20134116 PMID:20220260 More...
RGD:1601020 RGD:4145618 RGD:4145623 RGD:4145632 RGD:4145633 RGD:4145638 RGD:4145646
NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135
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CCR4
C-C motif chemokine receptor 4
ISO
mRNA:increased expression:lung
RGD
PMID:15993846
RGD:2306304
NCBI chr15:77,435,195...77,439,164
Ensembl chr15:77,437,265...77,438,347
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CCR5
C-C motif chemokine receptor 5
no_association
ISO
mRNA:increased expression:lung (mouse) DNA:polymorphism, frameshift mutation: :-59029G>A, p.S185_T195del (rs333) (human) DNA:frameshift mutation:cds:p.S185_T195del rs333 (human) protein:decreased expression:blood, lymphocyte (human)
RGD
PMID:15256090 PMID:16474097 PMID:18094012 PMID:20220260 PMID:23454776
RGD:4145638 RGD:4892088 RGD:4892093 RGD:4892108 RGD:8551842
NCBI chr22:7,803,794...7,818,112
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CCR6
C-C motif chemokine receptor 6
ISO
protein:increased expression:lung, dendritic cell (mouse)
RGD
PMID:19917684
RGD:8549811
NCBI chr13:94,865,480...94,894,331
Ensembl chr13:94,865,936...94,894,315
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CCR7
C-C motif chemokine receptor 7
ISO
protein:increased expression:lung, dendritic cell (mouse)
RGD
PMID:19917684
RGD:8549811
NCBI chr16:65,620,632...65,632,394
Ensembl chr16:65,620,665...65,632,984
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CCR8
C-C motif chemokine receptor 8
ISO
mRNA:increased expression:lung
RGD
PMID:15993846
RGD:2306304
NCBI chr15:83,215...87,282
Ensembl chr15:83,495...84,562
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CCR9
C-C motif chemokine receptor 9
ISO
mRNA, protein:increased expression:blood, mature NK T cell
RGD
PMID:16210593
RGD:5130925
NCBI chr22:7,354,139...7,375,280
Ensembl chr22:7,354,489...7,377,676
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CD14
CD14 molecule
no_association severity susceptibility
ISO
protein:increased expression:serum CTD Direct Evidence: marker/mechanism DNA:polymorphism:promoter:c. -159C>T (human) DNA:polymorphism:promoter:c. -260C>T (human) DNA:SNPs: : protein:increased expression:serum|DNA:polymorphism:promoter:c. -159C>T (human)
RGD CTD
PMID:15741437 PMID:15940135 PMID:16387800 PMID:17607003 PMID:18312481 PMID:19096003 More...
RGD:4144208 RGD:4144228 RGD:4144813 RGD:4144814 RGD:4144815
NCBI chr23:43,264,917...43,266,825
Ensembl chr23:43,264,336...43,266,993
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CD1D
CD1d molecule
susceptibility
ISO
associated with fasciolopsiasis
RGD
PMID:20304473
RGD:4140417
NCBI chr20:5,726,307...5,733,355
Ensembl chr20:5,727,049...5,730,061
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CD209
CD209 molecule
ISO
RGD
PMID:21471959
RGD:5131188
NCBI chr 6:7,219,576...7,235,755
Ensembl chr 6:7,228,378...7,235,208
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CD274
CD274 molecule
treatment
ISO
associated with Chlamydia pneumonia
RGD
PMID:26378990
RGD:41412180
NCBI chr12:74,038,844...74,060,662
Ensembl chr12:74,041,767...74,056,806
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CD28
CD28 molecule
ISO
RGD
PMID:21356099
RGD:5131612
NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387
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CD40
CD40 molecule
treatment
ISO
RGD
PMID:19159017 PMID:19220210 PMID:20205594 PMID:20941750
RGD:4144188 RGD:4892277 RGD:5132272 RGD:8547792
NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566
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CD40LG
CD40 ligand
severity
ISO
RGD
PMID:9502776
RGD:11352238
NCBI chr X:111,655,301...111,667,602
Ensembl chr X:111,655,397...111,666,639
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CD80
CD80 molecule
ISO
RGD
PMID:21051864 PMID:21352203 PMID:21440530
RGD:5132619 RGD:5132620 RGD:5132621
NCBI chr22:61,258,281...61,294,772
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CD86
CD86 molecule
treatment
ISO
DNA:snp:exon:p.I179V rs2681417 (human) protein:increased expression:blood, B cell (human) protein:increased expression:lung, alveolar macrophage (mouse) protein:increased expression:lung, dendritic cell (rat)
RGD
PMID:9449507 PMID:9551945 PMID:17513529 PMID:20668438 PMID:20941750 PMID:25344652 More...
RGD:11354965 RGD:4892199 RGD:4892202 RGD:4892277 RGD:4892280 RGD:4892555
NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366
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CDHR3
cadherin related family member 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr21:74,875,272...74,947,964
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CFTR
CF transmembrane conductance regulator
susceptibility
ISO
DNA:deletion: :p.F508del(human)
RGD
PMID:20298391
RGD:4140387
NCBI chr21:86,154,313...86,332,436
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CHAT
choline O-acetyltransferase
ISO
Protein:decreased expression:lung epithelium
RGD
PMID:17328924
RGD:5686690
NCBI chr 9:42,159,367...42,216,137
Ensembl chr 9:42,162,601...42,214,705
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CHI3L1
chitinase 3 like 1
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 7
OMIM ClinVar
PMID:18403759
NCBI chr25:26,160,993...26,169,005
Ensembl chr25:26,160,961...26,169,566
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CHML
CHM like Rab escort protein
ISO
RGD
PMID:18343558
RGD:5133238
NCBI chr25:78,712,003...78,714,842
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CHRM1
cholinergic receptor muscarinic 1
ISO
RGD
PMID:16931638
RGD:5133416
NCBI chr 1:10,978,464...10,991,650
Ensembl chr 1:10,989,207...10,990,589
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CHRM2
cholinergic receptor muscarinic 2
ISO
DNA:SNP: :rs6962027 (human)
RGD
PMID:19308904
RGD:5509586
NCBI chr21:105,574,879...105,730,265
Ensembl chr21:105,726,175...105,727,575
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CHRM3
cholinergic receptor muscarinic 3
severity
ISO
RGD
PMID:18348887 PMID:20394512
RGD:5133437 RGD:5133438
NCBI chr25:76,772,212...77,009,433
Ensembl chr25:77,001,477...77,003,249
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CHUK
component of inhibitor of nuclear factor kappa B kinase complex
ISO
RGD
PMID:21496385
RGD:5133703
NCBI chr 9:93,219,374...93,263,077
Ensembl chr 9:93,219,383...93,262,700
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CLCA1
chloride channel accessory 1
susceptibility
ISO
DNA:SNPs (human)
RGD
PMID:11296262 PMID:15318163 PMID:17898169
RGD:4145653 RGD:4145656 RGD:4145661
NCBI chr20:46,930,713...46,964,301
Ensembl chr20:46,927,412...46,963,737
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CLDN18
claudin 18
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27215490
NCBI chr15:52,509,568...52,533,205
Ensembl chr15:52,508,887...52,532,836
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CMA1
chymase 1
no_association susceptibility severity
ISO
DNA:polymorphism:5' utr:g.-1903G>A rs1800875 (human) DNA:duplications:3' utr:g.*254-?dupTG, dupGA (human) protein:increased expression:lung epithelium, mast cell (human)
RGD
PMID:15248847 PMID:15924217 PMID:20813890
RGD:1625396 RGD:1625397 RGD:5128804
NCBI chr24:1,471,767...1,475,062
Ensembl chr24:1,471,725...1,474,692
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CRHR2
corticotropin releasing hormone receptor 2
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:18408560
RGD:5130938
NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116
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CRP
C-reactive protein
ISO
protein:increased expression:serum
RGD
PMID:21140796
RGD:5131288
NCBI chr20:4,232,262...4,235,826
Ensembl chr20:4,232,913...4,235,377
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CSF2
colony stimulating factor 2
severity
ISO
protein:increased expression:sputum protein:increased expression:lung
RGD
PMID:9717963 PMID:19213775 PMID:20405019
RGD:10449521 RGD:5131473 RGD:5131476
NCBI chr23:34,906,987...34,911,252
Ensembl chr23:34,908,911...34,911,140
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CSF2RB
colony stimulating factor 2 receptor subunit beta
ISO
RGD
PMID:17145927
RGD:1601020
NCBI chr19:19,614,719...19,642,546
Ensembl chr19:19,624,234...19,640,617
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CSF3
colony stimulating factor 3
ISO
protein:increased expression:lung
RGD
PMID:20405019 PMID:21396376
RGD:5131473 RGD:5133731
NCBI chr16:66,162,814...66,166,192
Ensembl chr16:66,163,681...66,165,172
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CTLA4
cytotoxic T-lymphocyte associated protein 4
severity treatment no_association
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:serum DNA:polymorphisms:promoter, exon:-318C>T 49A>G (human) DNA:SNPs: :multiple (human) DNA:polymorphism:promoter:-318C>T (human) DNA:SNPs:promoter, exon:-1147C>T, -318C>T, 49A>G (human) DNA:SNP: :rs3087243 (human)
CTD RGD
PMID:11726402 PMID:12114354 PMID:12956753 PMID:15316504 PMID:15871446 PMID:16677453 PMID:16708626 PMID:16926542 PMID:17237396 PMID:17469155 PMID:18699801 PMID:19895365 PMID:28807506 More...
RGD:11344922 RGD:4891510 RGD:4891514 RGD:4891516 RGD:4891517 RGD:4891519 RGD:4891521 RGD:4891522 RGD:4891526 RGD:4891527 RGD:4891528 RGD:4891529
NCBI chr10:89,637,176...89,644,436
Ensembl chr10:89,638,314...89,642,344
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CTNNA3
catenin alpha 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19187332
NCBI chr 9:63,669,561...65,406,737
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CX3CR1
C-X3-C motif chemokine receptor 1
no_association
ISO
DNA:SNPs: :p.V249I, rs2669849 (human) DNA:polymorphisms: :p.V249I, p.T280M (human)
RGD
PMID:17082760 PMID:17505143 PMID:21037587
RGD:4891882 RGD:4891895 RGD:4891904
NCBI chr15:136,757...153,316
Ensembl chr15:150,718...151,785
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CXCL1
C-X-C motif chemokine ligand 1
severity
ISO
RGD
PMID:20371397
RGD:5134983
NCBI chr 7:22,327,041...22,329,405
Ensembl chr 7:22,569,355...22,569,900 Ensembl chr 7:22,569,355...22,569,900
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CXCL10
C-X-C motif chemokine ligand 10
ISO
protein:decreased expression:plasma
RGD
PMID:11994485 PMID:16602032 PMID:17302903
RGD:5135439 RGD:5135452 RGD:5135457
NCBI chr 7:24,526,657...24,529,193
Ensembl chr 7:24,526,680...24,529,130
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CXCL14
C-X-C motif chemokine ligand 14
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21150878
NCBI chr23:38,355,340...38,363,905
Ensembl chr23:38,355,341...38,363,680
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CXCL6
C-X-C motif chemokine ligand 6
ISO
RGD
PMID:9620668
RGD:5135265
NCBI chr 7:22,291,949...22,294,191
Ensembl chr 7:22,292,045...22,294,207
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CXCL9
C-X-C motif chemokine ligand 9
ISO
RGD
PMID:15210824
RGD:5135447
NCBI chr 7:24,507,121...24,513,830
Ensembl chr 7:24,507,130...24,513,121
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CXCR3
C-X-C motif chemokine receptor 3
severity susceptibility
ISO
protein:decreased expression:respiratory system fluid/secretion, T cell DNA:SNP:intron:IVS1+234G>A (human)
RGD
PMID:16043121 PMID:16548899 PMID:17641057 PMID:18094012
RGD:4892088 RGD:5135484 RGD:5143932 RGD:5143934
NCBI chr X:61,430,723...61,433,777
Ensembl chr X:61,430,725...61,433,386
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CYP1A1
cytochrome P450 family 1 subfamily A member 1
ISO
mRNA, protein:increased expression, decreased activity:lung
RGD
PMID:12415424
RGD:4892074
NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384
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CYP2D6
cytochrome P450 family 2 subfamily D member 6
ISO
DNA:polymorphism: :1934G>A (human)
RGD
PMID:19575027
RGD:5143944
NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
CTD Direct Evidence: marker/mechanism mRNA:decreased expression:leukocyte
CTD RGD
PMID:17081494 PMID:20514434 PMID:28807506
RGD:4892076 RGD:4892220
NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211
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CYSLTR1
cysteinyl leukotriene receptor 1
no_association severity
ISO
DNA:SNPs:promoter:-634C>T, -475A>C, -336A>G (human) DNA:SNPs:promoter, exon:multiple (human) mRNA, protein:increased expression:respiratory system mucosa DNA:SNP: :927T>C (human)
RGD
PMID:8087328 PMID:11591188 PMID:16123393 PMID:16630147 PMID:16771777 PMID:16776674 PMID:17153879 More...
RGD:4781742 RGD:4782072 RGD:4784257 RGD:4847129 RGD:4848936 RGD:4888514 RGD:4889116
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CYSLTR2
cysteinyl leukotriene receptor 2
ISO
DNA:polymorphism: :601A>G (human) DNA:polymorphism: :-1220A>C (human)
RGD
PMID:15454733 PMID:15475736
RGD:5144002 RGD:5144003
NCBI chr 3:26,578,248...26,624,364
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DCN
decorin
ISO
RGD
PMID:16387756
RGD:2311423
NCBI chr11:86,552,392...86,590,229
Ensembl chr11:86,551,072...86,586,891
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DEFB1
defensin beta 1
susceptibility
ISO
DNA:SNP: :-1816 T>C (human) DNA:SNPs:5' utr:g.-52G>A, g.-44C>G, g.-20G>A (human)
RGD
PMID:15696078 PMID:16435024
RGD:4892254 RGD:4892263
NCBI chr 8:6,643,753...6,652,209
Ensembl chr 8:6,643,556...6,651,699
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DNAH5
dynein axonemal heavy chain 5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr 4:13,401,980...13,718,900
Ensembl chr 4:13,401,092...13,652,755
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DNMT1
DNA methyltransferase 1
ISO
CTD Direct Evidence: marker/mechanism DNA,mRNA:hypermethylation,decreased expression:promoter,respiratory tract:
CTD RGD
PMID:23196709 PMID:23423710
RGD:9588646
NCBI chr 6:9,199,006...9,263,890
Ensembl chr 6:9,199,003...9,263,607
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DPP10
dipeptidyl peptidase like 10
ISO
DNA:SNPs (human) DNA:SNP:exon (human) DNA:SNP: :rs10208402 (human) protein:increased expression:bronchus
RGD
PMID:14566338 PMID:17967935 PMID:19672052 PMID:21103062
RGD:4889866 RGD:4892275 RGD:4892276 RGD:4892278
NCBI chr10:14,434,244...15,822,419
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EBI3
Epstein-Barr virus induced 3
ISO
RGD
PMID:21255010
RGD:5128488
NCBI chr 6:3,975,805...3,985,389
Ensembl chr 6:3,976,228...3,984,962
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EDN1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism DNA:transition:intron:g.4124T>C (human) Severe Persistent Allergic Asthma; protein:increased secretion:lung (human)
CTD RGD
PMID:11668616 PMID:16981460 PMID:20588001
RGD:4144869 RGD:4144895
NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198
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EDNRA
endothelin receptor type A
ISO
RGD
PMID:17448648 PMID:18632188
RGD:4892288 RGD:4892322
NCBI chr 7:93,980,983...94,043,863
Ensembl chr 7:93,985,797...94,042,296
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EDNRB
endothelin receptor type B
ISO
DNA:polymorphism (human) mRNA:increased expression:bronchus, smooth muscle cell
RGD
PMID:15245576 PMID:17470272 PMID:18632188
RGD:4892288 RGD:4892321 RGD:4892324
NCBI chr 3:56,969,493...56,993,719
Ensembl chr 3:56,969,101...56,992,731
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EGFR
epidermal growth factor receptor
severity
ISO
protein:increased expression:lung epithelium (rat) protein:increased expression:lung epithelium (mouse) protein:increased expression:bronchial epithelium (human)
RGD
PMID:12580917 PMID:19954006 PMID:21072743 PMID:21224214
RGD:5131468 RGD:5131633 RGD:5131642 RGD:5131870
NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239
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EGR1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human) mRNA:increased expression:bronchoalveolar lavage cell (human)
RGD
PMID:11254538 PMID:18507785 PMID:18774390
RGD:5130915 RGD:5131985 RGD:5131993
NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374
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ELP1
elongator acetyltransferase complex subunit 1
no_association
ISO
RGD
PMID:11281413 PMID:12774215
RGD:5129157 RGD:5129158
NCBI chr12:30,620,685...30,687,583
Ensembl chr12:30,620,278...30,687,405
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EPHX1
epoxide hydrolase 1
susceptibility
ISO
DNA:SNPs:exons:p.Y113H (rs1051740), p.H139R (rs2234922) (human)
RGD
PMID:17711870
RGD:4889407
NCBI chr25:3,924,396...3,960,264
Ensembl chr25:3,924,606...3,945,535
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EPX
eosinophil peroxidase
disease_progression severity
ISO
protein:increased activity:sputum,nasal,pharyngeal mucosa
RGD
PMID:12199967 PMID:20813885 PMID:26645423
RGD:11574908 RGD:13506891 RGD:13506892
NCBI chr16:35,196,433...35,208,269
Ensembl chr16:35,192,971...35,207,874
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ESR2
estrogen receptor 2
ISO
mRNA:decreased expression:lung (rat)
RGD
PMID:18375789
RGD:8694127
NCBI chr24:41,426,333...41,513,802
Ensembl chr24:41,447,224...41,512,486
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F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:19864598
RGD:4892589
NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005
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F7
coagulation factor VII
treatment
ISO
RGD
PMID:24523826
RGD:11040539
NCBI chr 3:91,109,864...91,122,707
Ensembl chr 3:91,110,380...91,123,327
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FCER1A
Fc fragment of IgE receptor Ia
severity
ISO
Asthma symptoms persistent despite steroids Fatal asthma subjects
RGD
PMID:20937062 PMID:21388666
RGD:5128711 RGD:5128717
NCBI chr20:4,635,316...4,640,787
Ensembl chr20:4,635,328...4,640,590
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FCGR2A
Fc fragment of IgG receptor IIa
ISO
protein:increased expression:alveolar macrophage
RGD
PMID:9117017
RGD:5147982
NCBI chr20:2,480,710...2,512,429
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FCGR3A
Fc fragment of IgG receptor IIIa
susceptibility
ISO
DNA:polymorphism:exon:p.F158V(rs396991)(human)
RGD
PMID:18199088
RGD:5508449
NCBI chr20:2,466,492...2,475,579
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FGA
fibrinogen alpha chain
treatment
ISO
RGD
PMID:24523826
RGD:11040539
NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405
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FKBP5
FKBP prolyl isomerase 5
ISO
ClinVar Annotator: match by term: Asthma
ClinVar
NCBI chr17:36,432,595...36,551,233
Ensembl chr17:36,481,024...36,552,456
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FOXP3
forkhead box P3
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:27633092 PMID:27965764 PMID:28944907 PMID:29317916
RGD:38548920 RGD:38549365
NCBI chr X:46,349,890...46,365,133
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GATA3
GATA binding protein 3
ISO
RGD
PMID:9949310 PMID:18186587
RGD:5128802 RGD:5128803
NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064
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GC
GC vitamin D binding protein
ISO
protein, mRNA:increased expression:bronchoalveolar lavage fluid:
RGD
PMID:21169467
RGD:5509920
NCBI chr 7:20,254,604...20,298,384
Ensembl chr 7:20,253,879...20,298,265
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GSDMB
gasdermin B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr16:66,253,562...66,266,391
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GSTM3
glutathione S-transferase mu 3
ISO
DNA:polymorphism
RGD
PMID:11470996 PMID:17550934
RGD:5135038 RGD:5135039
NCBI chr20:23,797,794...23,802,910
Ensembl chr20:23,799,177...23,802,921
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GSTO2
glutathione S-transferase omega 2
susceptibility
ISO
DNA:polymorphism:exon:p. N142D (human)
RGD
PMID:20374258
RGD:5490988
NCBI chr 9:97,319,695...97,348,406
Ensembl chr 9:97,325,215...97,349,422
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GSTP1
glutathione S-transferase pi 1
no_association severity susceptibility disease_progression
ISO
DNA:SNPs: :p.I105V, p.A114V (human) CTD Direct Evidence: marker/mechanism DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human) DNA:polymorphism:exon:p.I105V (rs1695) (human) DNA:SNPs:intron,exon:(rs749174), (rs1138272)(human) DNA:polymorphism:exon:p.I105V (human) DNA:SNP: :p.A114V (human)
RGD CTD
PMID:10806136 PMID:11994713 PMID:15693909 PMID:16176403 PMID:16870661 PMID:18057098 PMID:18709160 PMID:18787219 PMID:18988661 PMID:20210814 PMID:20858151 PMID:24117884 PMID:29411558 More...
RGD:4140946 RGD:4140947 RGD:4140951 RGD:4142519 RGD:4142526 RGD:5490985 RGD:5490991 RGD:5490999
NCBI chr 1:6,676,897...6,679,936
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HAVCR1
hepatitis A virus cellular receptor 1
ISO
RGD
PMID:20628202
RGD:5128851
NCBI chr23:59,422,769...59,454,183
Ensembl chr23:59,423,334...59,453,531
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HAVCR2
hepatitis A virus cellular receptor 2
ISO
RGD
PMID:17517968
RGD:5135525
NCBI chr23:59,479,794...59,501,532
Ensembl chr23:59,475,826...59,500,836
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HDAC2
histone deacetylase 2
ISO
mRNA:decreased expression:macrophage:
RGD
PMID:20538962
RGD:9590321
NCBI chr13:59,873,248...59,904,542
Ensembl chr13:59,873,767...59,905,742
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HDC
histidine decarboxylase
ISO
associated with Rhinitis;DNA:SNP: :p.E644D (rs2073440) (human)
RGD
PMID:20608921
RGD:5128884
NCBI chr26:33,051,048...33,074,872
Ensembl chr26:33,051,966...33,074,563
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HIF1A
hypoxia inducible factor 1 subunit alpha
treatment
ISO
RGD
PMID:18160846
RGD:10402541
NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288
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HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
ISO
RGD
PMID:20084838
RGD:5508450
NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686
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HMOX1
heme oxygenase 1
severity
ISO
mRNA;protein:increased expression:Leukocytes, Mononuclear CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16196283 PMID:18048809 PMID:20596599
RGD:4145403 RGD:4145408
NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
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HNMT
histamine N-methyltransferase
no_association
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to
RGD OMIM ClinVar
PMID:10752634 PMID:10803682 PMID:15693910 PMID:16205835 PMID:17651147 PMID:25741868 More...
RGD:5128885 RGD:5128887 RGD:5128888
NCBI chr10:22,188,151...22,238,665
Ensembl chr10:22,188,110...22,238,671
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HSD11B2
hydroxysteroid 11-beta dehydrogenase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:11932298
NCBI chr 5:60,017,967...60,040,959
Ensembl chr 5:60,019,434...60,025,353
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HTR2A
5-hydroxytryptamine receptor 2A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25322896
NCBI chr 3:24,820,029...24,884,472
Ensembl chr 3:24,820,035...24,883,432
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ICAM1
intercellular adhesion molecule 1
ISO
mRNA:increased expression:aorta (mouse) CTD Direct Evidence: marker/mechanism protein:increased secretion:lung (human) protein:increased expression:lung, serum (rat)
RGD CTD
PMID:17014439 PMID:20205697 PMID:20400685 PMID:20953388 PMID:25003170
RGD:4145331 RGD:4145444 RGD:4145509
NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263
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IFNG
interferon gamma
resistance treatment
ISO
protein:increased expression:sputum
RGD
PMID:12396623 PMID:19542437 PMID:20817868 PMID:20953328
RGD:10755706 RGD:4145525 RGD:4145651 RGD:5128479
NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
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IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715 PMID:21737883
RGD:6480255 RGD:6480431
NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542
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IFNL3
interferon lambda 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22295096
NCBI chr 6:33,843,140...33,845,444
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IKZF3
IKAROS family zinc finger 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25256354
NCBI chr16:66,302,107...66,399,152
Ensembl chr16:66,303,117...66,397,765
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IL10
interleukin 10
susceptibility treatment
ISO
protein:decreased expression:plasma DNA:polymorphism: :-627C>A (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12938145 PMID:20121766 PMID:20230687 PMID:20237464 PMID:20560982 PMID:20644177 PMID:21998459 PMID:29317916 More...
RGD:11046261 RGD:4140421 RGD:4140451 RGD:4140459 RGD:4140471 RGD:4143221 RGD:5131623
NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
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IL12A
interleukin 12A
ISO
RGD
PMID:17056578 PMID:17548618
RGD:4373570 RGD:4438438
NCBI chr15:30,887,048...30,896,577
Ensembl chr15:30,887,897...30,894,550
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IL12B
interleukin 12B
susceptibility severity
ISO
DNA:polymorphisms:promoter, 3'utr: ClinVar Annotator: match by term: Asthma, susceptibility to DNA:polymorphism:promoter DNA:polymorphisms:introns:
RGD ClinVar
PMID:12241719 PMID:15322986 PMID:16210052
RGD:1600043 RGD:4145428 RGD:4145438
NCBI chr23:61,714,293...61,731,835
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IL13
interleukin 13
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to protein:increased expression:serum DNA:polymorphism: :c.-1055C>T (human) DNA:polymorphism:cds:p.R130Q (human) protein:increased expression:sputum
OMIM ClinVar RGD
PMID:10699178 PMID:11588017 PMID:11678850 PMID:11709756 PMID:11758895 PMID:12847555 PMID:12928861 PMID:15356556 PMID:15483090 PMID:15711639 PMID:15879126 PMID:18258919 PMID:18328894 PMID:20198887 PMID:25741868 More...
RGD:4145593 RGD:4145639 RGD:4145777 RGD:4763153 RGD:4763761
NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
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IL13RA1
interleukin 13 receptor subunit alpha 1
no_association
ISO
DNA:polymorphism: :1050C>T (human) DNA:polymorphism: :1398A>G (human) DNA:polymorphisms:promoter, 3' utr:-281T>G, 1365A>G (human) mRNA:increased expression:bronchus
RGD
PMID:10686479 PMID:11714828 PMID:17006604 PMID:17392323 PMID:18480254 PMID:20383033 More...
RGD:4892639 RGD:4892646 RGD:4892647 RGD:4892650 RGD:4892654 RGD:4892655
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IL13RA2
interleukin 13 receptor subunit alpha 2
ISO
mRNA:increased expression:bronchus protein:increased expression:serum
RGD
PMID:17885690 PMID:20383033 PMID:21462799
RGD:4892646 RGD:4892649 RGD:8549521
NCBI chr X:102,589,947...102,628,853
Ensembl chr X:102,590,045...102,603,260
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IL15
interleukin 15
no_association
ISO
DNA:SNPs: :multiple (human)
RGD
PMID:11160248 PMID:15131572 PMID:15843549 PMID:16629787 PMID:19133918
RGD:4984421 RGD:4990462 RGD:5000757 RGD:5000758 RGD:5000760
NCBI chr 7:88,548,773...88,644,977
Ensembl chr 7:88,548,671...88,645,488
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IL16
interleukin 16
severity no_association
ISO
associated with Rhinitis;protein:increased expression:respiratory system fluid/secretion DNA:SNP:promoter:-295T>C (human) protein:increased expression:serum
RGD
PMID:10585533 PMID:12872394 PMID:15784111 PMID:16387589 PMID:16734115
RGD:5024928 RGD:5024930 RGD:5024934 RGD:5024935 RGD:5024937
NCBI chr26:2,080,985...2,208,764
Ensembl chr26:2,077,228...2,208,431
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IL17A
interleukin 17A
susceptibility
ISO
DNA:SNP:promoter:rs2275913 (human) protein:increased expression:alveolar macrophage protein:increased expression:sputum mRNA,protein:increased expression:Leukocytes, Mononuclear, lung, serum
RGD
PMID:15730730 PMID:18060619 PMID:18941201 PMID:20351038 PMID:20437253
RGD:4839043 RGD:4888527 RGD:4889114 RGD:4889139 RGD:4889152
NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785
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IL17RB
interleukin 17 receptor B
ISO
associated with Picornaviridae Infections
RGD
PMID:25273095
RGD:39128256
NCBI chr22:15,229,020...15,249,145
Ensembl chr22:15,229,053...15,248,437
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IL18
interleukin 18
susceptibility severity disease_progression
ISO
DNA:SNP:promoter:c.and -137G>C (rs187238)(human) DNA:SNPs:Promoter:c. -607C>A (rs1946518), -137G/C (rs187238) (human) protein:increased expression:serum DNA:SNP:promoter: c.-380C>G (rs5744247)(human) DNA:polymorphism: :c. -105A>C (human)
RGD
PMID:11174201 PMID:16433859 PMID:17767553 PMID:18200581 PMID:18826499 PMID:19745201 PMID:20497957 More...
RGD:4889585 RGD:4889863 RGD:4889898 RGD:4889900 RGD:4889908 RGD:4889910 RGD:4889923
NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
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IL18R1
interleukin 18 receptor 1
ISO
DNA:SNPs: :multiple (human) DNA:SNP: :rs3771166 (human)
RGD
PMID:11972614 PMID:18382474 PMID:18774397 PMID:19910030 PMID:20860503
RGD:5024942 RGD:5024945 RGD:5024946 RGD:5024947 RGD:5024948
NCBI chr14:6,026,683...6,067,808
Ensembl chr14:6,026,443...6,066,884
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IL19
interleukin 19
ISO
mRNA, protein:increased expression:lung, serum protein:increased expression:serum
RGD
PMID:15557163
RGD:5037236
NCBI chr25:22,514,199...22,523,680
Ensembl chr25:22,514,559...22,520,499
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IL1A
interleukin 1 alpha
ISO
DNA:polymorphisms: :
RGD
PMID:18763028
RGD:4142802
NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611
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IL1B
interleukin 1 beta
susceptibility
ISO
protein:decreased expression:neutrophil DNA:polymorphism: :-511C>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:9176529 PMID:18926055 PMID:19684087 PMID:19842845
RGD:4142830 RGD:4142836 RGD:4142864
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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IL1RL1
interleukin 1 receptor like 1
susceptibility severity
ISO
CTD Direct Evidence: marker/mechanism DNA:SNP: :rs1041973 (human) DNA:SNP: :rs1420101 (human) DNA:SNP: :rs10197862 (human) protein:increased expression:serum DNA:SNPs:intron:rs1420089, rs1861245,rs1946131 (human)
CTD RGD
PMID:11463601 PMID:17407196 PMID:17623648 PMID:19179489 PMID:19198610 PMID:19852851 PMID:21150878 PMID:21281963 PMID:21804549 PMID:24241537 PMID:27472835 More...
RGD:5144235 RGD:5144237 RGD:5144239 RGD:5144240 RGD:5144242 RGD:5144243 RGD:5144244 RGD:5144245
NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265
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IL1RN
interleukin 1 receptor antagonist
susceptibility severity
ISO
DNA:polymorphism:intron (human) DNA:SNPs: :rs447713, rs3087271 (human) protein:increased expression:plasma DNA, protein:repeat, decreased expression (human) CTD Direct Evidence: marker/mechanism DNA:SNP: :rs2234678 (human) DNA:SNPs: :multiple (human)
RGD CTD
PMID:9176529 PMID:10843772 PMID:11027520 PMID:15020290 PMID:16409203 PMID:16724092 PMID:17107994 PMID:18763028 PMID:18926055 More...
RGD:4142802 RGD:4142864 RGD:4143163 RGD:4143208 RGD:4143209 RGD:4143216 RGD:4143224 RGD:4143225
NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326
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IL2
interleukin 2
susceptibility
ISO
DNA:SNP:promoter:rs2069762(human)
RGD
PMID:16333313 PMID:20926789
RGD:4889118 RGD:8663473
NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969
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IL21
interleukin 21
ISO
DNA:SNP:exon:5250C>T (human)
RGD
PMID:18802358
RGD:5147396
NCBI chr 7:69,859,793...69,872,237
Ensembl chr 7:69,863,535...69,872,025
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IL22
interleukin 22
treatment severity
ISO
mRNA:increased expression:blood, mononuclear cell protein:increased expression:serum
RGD
PMID:21297073 PMID:21535180 PMID:21998459
RGD:11046261 RGD:5147403 RGD:5147409
NCBI chr11:63,881,743...63,887,695
Ensembl chr11:63,882,093...63,886,761
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IL23R
interleukin 23 receptor
ISO
RGD
PMID:19935773
RGD:5037240
NCBI chr20:65,853,379...65,946,000
Ensembl chr20:65,854,349...65,938,024
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IL25
interleukin 25
ISO
mRNA, protein:increased expression:lung
RGD
PMID:25273095
RGD:39128256
NCBI chr29:23,742,377...23,747,902
Ensembl chr29:23,744,449...23,747,176
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IL27
interleukin 27
treatment susceptibility
ISO
DNA:SNP: :g.-964A>G (human) protein:increased expression:sputum
RGD
PMID:17318299 PMID:17878337 PMID:19542437 PMID:20817868 PMID:26595888
RGD:11076728 RGD:4145651 RGD:5128479 RGD:5128485 RGD:5128491
NCBI chr 5:26,348,559...26,358,028
Ensembl chr 5:26,348,848...26,356,360
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IL27RA
interleukin 27 receptor subunit alpha
ISO
RGD
PMID:16081811
RGD:5128496
NCBI chr 6:12,679,270...12,699,254
Ensembl chr 6:12,686,838...12,701,867
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IL2RA
interleukin 2 receptor subunit alpha
ISO
RGD
PMID:17351063 PMID:20525707 PMID:21377197
RGD:2325990 RGD:5147437 RGD:5147445
NCBI chr 9:6,134,961...6,187,731
Ensembl chr 9:6,141,430...6,149,447
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IL2RB
interleukin 2 receptor subunit beta
ISO
DNA:SNP: :rs2284033 (human)
RGD
PMID:18641329 PMID:20860503
RGD:5024942 RGD:5147447
NCBI chr19:19,830,919...19,853,534
Ensembl chr19:19,828,898...19,852,988
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IL3
interleukin 3
susceptibility
ISO
DNA:polymorphism:cds:+79T>C(S27P)(human) DNA:SNP: :rs40401(human)
RGD
PMID:15372320 PMID:24684517
RGD:13506914 RGD:13506916
NCBI chr23:34,894,630...34,899,105
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IL33
interleukin 33
severity treatment
ISO
associated with fungal infectious disease CTD Direct Evidence: marker/mechanism associated with viral pneumonia;
RGD CTD
PMID:19198610 PMID:21804549 PMID:24241537 PMID:25746970 PMID:27472835 PMID:28947081 PMID:29067999 More...
RGD:39938968 RGD:39939002
NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436
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IL4
interleukin 4
treatment no_association
ISO
DNA:polymorphism (human) mRNA, protein:increase expression:leukocyte, serum protein:increased expression:respiratory system fluid/secretion CTD Direct Evidence: marker/mechanism mRNA:increased expression:lung, spleen protein:increased expression:lung DNA:SNP: :589C>T (human)
RGD CTD
PMID:18211752 PMID:18357729 PMID:20524005 PMID:21103062 PMID:21354484 PMID:21364926 PMID:21375458 PMID:24450480 PMID:24946644 More...
RGD:10402791 RGD:10402799 RGD:2317290 RGD:4889866 RGD:5128500 RGD:5128502 RGD:5128557 RGD:5128560
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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IL4R
interleukin 4 receptor
susceptibility disease_progression severity
ISO
DNA:polymorphism:cds:p. S478P (human) OMIM:600807 DNA:polymorphism:cds:p.Q576R (human) DNA:SNPs: :multiple DNA:SNPs:cds:p. I75V, Q576R (human) DNA:polymorphism:cds:p.Q551R (human) DNA:SNPs:cds:p.E375A, Q551R (human) DNA:polymorphism::-1902G/A (human) protein:increased secretion:plasma DNA:polymorphism:cds:p.I50V (human) DNA:mutation:cds:p.Q576R (mouse)
RGD MouseDO
PMID:11398072 PMID:11709756 PMID:12133990 PMID:12940513 PMID:15479272 PMID:16917945 PMID:17170387 PMID:17586032 PMID:17823973 PMID:18425216 PMID:19770271 PMID:20605987 PMID:20868478 PMID:20953944 More...
RGD:4890003 RGD:4890024 RGD:4890346 RGD:4890347 RGD:4890348 RGD:4890349 RGD:4890351 RGD:4890352 RGD:4890387 RGD:4890402 RGD:4890404 RGD:4890406 RGD:5128514 RGD:5128553
NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015
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IL5
interleukin 5
disease_progression treatment
ISO
CTD Direct Evidence: marker/mechanism protein: increased levels: sputum protein:increased expression:respiratory system fluid/secretion DNA:polymorphism:promoter:-703C>T (human) protein:increased expression:lungs, respiratory system fluid/secretion
RGD CTD
PMID:7540862 PMID:9182686 PMID:9493449 PMID:11159041 PMID:15502111 PMID:15626484 PMID:17074272 PMID:18629290 PMID:19947994 PMID:22085848 PMID:22186238 PMID:23266719 PMID:25008888 More...
RGD:11354973 RGD:4145461 RGD:4890938 RGD:4890940 RGD:4890947 RGD:4890948 RGD:4890962 RGD:4890963 RGD:5687140 RGD:5687144 RGD:5687189
NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
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IL5RA
interleukin 5 receptor subunit alpha
ISO
DNA:SNPs (human) DNA:SNP: :c.25091G>A (human)
RGD
PMID:10224351 PMID:10848907 PMID:16217591 PMID:17276963 PMID:20513521 PMID:20592918 More...
RGD:5128614 RGD:5128617 RGD:5128623 RGD:5128625 RGD:5128626 RGD:5128627
NCBI chr22:39,156,711...39,199,394
Ensembl chr22:39,158,023...39,192,861
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IL6
interleukin 6
ISO
protein:increased expression:lung CTD Direct Evidence: marker/mechanism associated with Hypersensitivity;protein:increased expression:sputum
RGD CTD
PMID:20658762 PMID:20816188 PMID:20840469 PMID:21115736 PMID:29902480
RGD:4143265 RGD:4143266 RGD:4143271 RGD:5128630
NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237
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IL6R
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17496315 PMID:21115736 PMID:29902480
RGD:5128630 RGD:5128662
NCBI chr20:9,345,723...9,418,963
Ensembl chr20:9,361,152...9,396,610
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IL9
interleukin 9
ISO
protein:increased expression:sputum, macrophage, cytoplasm protein:increased expression:respiratory system fluid/secretion
RGD
PMID:12153980 PMID:15303135 PMID:15531759 PMID:17446528 PMID:21356110
RGD:5128686 RGD:5128690 RGD:5128691 RGD:5128700 RGD:5128707
NCBI chr23:38,641,228...38,645,810
Ensembl chr23:38,641,741...38,645,276
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IL9R
interleukin 9 receptor
ISO
RGD
PMID:10629460
RGD:5128704
NCBI chr X:130,006,399...130,019,191
Ensembl chr X:130,006,899...130,020,894
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IRAK3
interleukin 1 receptor associated kinase 3
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 5
OMIM ClinVar
PMID:17503328
NCBI chr11:61,868,817...61,920,896
Ensembl chr11:61,869,173...61,920,406
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IRF1
interferon regulatory factor 1
susceptibility no_association
ISO
DNA:repeat:intron (human) DNA:polymorphisms:promoter, cds:-300G>T, 4396A>G, 6355G>A (human) protein:increased expression:respiratory tract epithelium
RGD
PMID:10225979 PMID:11069564 PMID:16961714
RGD:5128723 RGD:5128724 RGD:5128726
NCBI chr23:35,309,058...35,317,765
Ensembl chr23:35,307,772...35,316,763
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IRF3
interferon regulatory factor 3
ISO
RGD
PMID:20673978
RGD:5128793
NCBI chr 6:42,835,285...42,841,487
Ensembl chr 6:42,831,203...42,840,796
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ITGB3
integrin subunit beta 3
ISO
DNA:SNPs: :
RGD
PMID:17556058
RGD:5037230
NCBI chr16:59,372,171...59,431,434
Ensembl chr16:59,374,889...59,410,857
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ITGB6
integrin subunit beta 6
ISO
OMIM:600807
MouseDO
NCBI chr10:45,506,355...45,650,979
Ensembl chr10:45,504,987...45,595,543
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ITPR1
inositol 1,4,5-trisphosphate receptor type 1
ISO
RGD
PMID:21777465
RGD:5147661
NCBI chr22:40,574,569...40,925,857
Ensembl chr22:40,574,374...40,926,842
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KDR
kinase insert domain receptor
ISO
associated with Rhinitis,Allergic,Seasonal;protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148 PMID:20921519
RGD:5684385 RGD:8551771
NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771
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KIF3A
kinesin family member 3A
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr23:35,496,770...35,554,536
Ensembl chr23:35,514,130...35,551,472
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KRT19
keratin 19
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15478392
NCBI chr16:64,714,497...64,719,805
Ensembl chr16:64,714,970...64,719,678
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LEP
leptin
ISO
protein:increased expression:plasma
RGD
PMID:19705789
RGD:5128781
NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220
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LGALS3
galectin 3
treatment
ISO
RGD
PMID:16424226
RGD:9685213
NCBI chr24:32,311,343...32,328,335
Ensembl chr24:32,311,271...32,328,339
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LOC103221883
uncharacterized LOC103221883
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19426955 PMID:21611147
NCBI chr 4:55,148,012...56,665,684
Ensembl chr 4:55,153,563...55,390,027
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LOC103223672
low affinity immunoglobulin gamma Fc region receptor II-b
ISO
RGD
PMID:20179765
RGD:11344929
NCBI chr20:2,398,425...2,413,328
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LOC103224275
glutathione S-transferase Mu 1
resistance susceptibility
ISO
DNA:deletion: : CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11075422 PMID:16870661 PMID:17651144 PMID:18988661 PMID:21051083
RGD:4140921 RGD:4142509 RGD:5490962
NCBI chr20:23,854,969...23,861,634
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LOC103232241
cysteinyl leukotriene receptor 1
ISO
RGD
PMID:16387808 PMID:17689528
RGD:4781449 RGD:4843543
NCBI chr X:67,218,777...67,300,655
Ensembl chr X:67,220,048...67,221,061
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LOC103233057
C-C motif chemokine 22
ISO
mRNA:increased expression:lung protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10384142 PMID:15993846 PMID:18316417
RGD:2306304 RGD:4891474 RGD:4891475
NCBI chr 5:43,297,206...43,305,662
Ensembl chr 5:43,297,897...43,305,642
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LOC103233058
fractalkine
ISO
protein:increased expression:plasma
RGD
PMID:14657873
RGD:4891906
NCBI chr 5:43,310,711...43,323,533
Ensembl chr 5:43,310,753...43,323,529
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LOC103233229
cadherin-1
ISO
RGD
PMID:21540309
RGD:5132878
NCBI chr 5:58,578,244...58,679,677
Ensembl chr 5:58,578,146...58,679,541
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LOC103233451
cytochrome b-245 light chain
susceptibility
ISO
DNA:polymorphism: :-930A>G (human) DNA:SNPs: :-930A>G, 242C>T, 640A>G (human)
RGD
PMID:18716406 PMID:19459419
RGD:4311041 RGD:4772770
NCBI chr 5:74,023,134...74,030,793
Ensembl chr 5:74,023,082...74,030,750
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LOC103233689
thromboxane A2 receptor
severity susceptibility
ISO
DNA:polymorphism:cds:924T>C(human) ClinVar Annotator: match by term: Asthma
RGD ClinVar
PMID:2955539 PMID:7929844 PMID:8428006 PMID:8613548 PMID:12000493 PMID:15805995 More...
RGD:11059534 RGD:11059535
NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761
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LOC103234663
interferon lambda-1
exacerbates
ISO
associated with common cold;mRNA:decreased expression:sputum (human) associated with common cold;protein:increased expression: nasal cavity (human)
RGD
PMID:22135341 PMID:25784275
RGD:126848770 RGD:126848775
NCBI chr 6:33,901,382...33,904,356
Ensembl chr 6:33,901,801...33,903,894
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LOC103243260
corticotropin-releasing factor receptor 1
ISO
DNA:SNP: :RS242941 (human) DNA:SNPs: :rs1876828, rs242939, rs242941 (human)
RGD
PMID:16113459 PMID:19663668
RGD:5147485 RGD:5147488
NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712
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LOC103246958
caspase recruitment domain-containing protein 11
susceptibility
ISO
RGD
PMID:16751370
RGD:11100037
NCBI chr28:18,657,941...18,714,202
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LTA
lymphotoxin alpha
susceptibility no_association
ISO
DNA:polymorphism:intron DNA:polymorphisms:promoter
RGD
PMID:12530118 PMID:15969671 PMID:17536219 PMID:18947013
RGD:4143254 RGD:4143370 RGD:4143371 RGD:4143373
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LTA4H
leukotriene A4 hydrolase
ISO
mRNA:increased expression:lung, cerebral cortex (rat)
RGD
PMID:15715933
RGD:2316607
NCBI chr11:91,371,383...91,413,396
Ensembl chr11:91,371,383...91,406,542
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MBL2
mannose binding lectin 2
susceptibility
ISO
associated with Bronchiolitis;DNA:polymorphism:exon: DNA:SNP:cds:p.G54D(human)
RGD
PMID:22512728 PMID:22674410
RGD:12910828 RGD:8693709
NCBI chr 9:78,389,534...78,394,753
Ensembl chr 9:78,389,947...78,396,079
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MEFV
MEFV innate immunity regulator, pyrin
susceptibility
ISO
DNA:mutations:exons
RGD
PMID:18219832
RGD:5129186
NCBI chr 5:2,971,323...2,991,501
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MHC-DPA1
major histocompatibility complex, class II, DP alpha 1
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:21814517
RGD:13506911
NCBI chr17:39,009,361...39,017,978
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MHC-DPB1
major histocompatibility complex, class II, DP beta 1
susceptibility
ISO
DNA:polymorphisms: : DNA:haplotype CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:16792590 PMID:17956852 PMID:21217921 PMID:21814517
RGD:13506911 RGD:5143938
NCBI chr17:38,996,329...39,007,097
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MHC-DQA1
major histocompatibility complex, class II, DQ alpha 1
ISO
DNA:polymorphism (human) CTD Direct Evidence: marker/mechanism DNA:polymorphisms (human)
RGD CTD
PMID:10051703 PMID:10792356 PMID:11802952 PMID:12890388 PMID:19052351
RGD:1331670 RGD:5147617 RGD:5147799 RGD:5147831
NCBI chr17:39,422,445...39,428,777
Ensembl chr17:39,420,134...39,428,871
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MHC-DRA
major histocompatibility complex, class II, DR alpha
susceptibility
ISO
DNA:polymorphisms: :
RGD
PMID:20159242
RGD:13506913
NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261
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MIF
macrophage migration inhibitory factor
severity
ISO
DNA:repeats:promoter DNA:SNP:promoter:rs755622(human) protein:increased expression:bronchoalveolar lavage fluid
RGD
PMID:9637721 PMID:16186482 PMID:16455830 PMID:17373669 PMID:19317738
RGD:1641985 RGD:4891035 RGD:4891043 RGD:4891052 RGD:4891059
NCBI chr19:7,000,837...7,001,700
Ensembl chr19:7,000,793...7,001,757
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MMP1
matrix metallopeptidase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24469321
NCBI chr 1:94,167,507...94,177,357
Ensembl chr 1:94,167,219...94,176,767
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MMP10
matrix metallopeptidase 10
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16926187
NCBI chr 1:94,147,995...94,158,315
Ensembl chr 1:94,148,087...94,158,097
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MMP9
matrix metallopeptidase 9
ISO
mRNA, protein:increased expression:lung CTD Direct Evidence: marker/mechanism DNA:SNP: : rs2664538(human) protein:increased expression:serum
RGD CTD
PMID:11742282 PMID:15131573 PMID:16191269 PMID:19361849 PMID:19940022 PMID:20181264 PMID:21439806 More...
RGD:2325953 RGD:5129204 RGD:5129522 RGD:5129687 RGD:5130859
NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712
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MPO
myeloperoxidase
susceptibility
ISO
DNA:polymorphism: :−463G > A (human) protein:increased expression:serum
RGD
PMID:10731862 PMID:19544176
RGD:5130989 RGD:5130994
NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671
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MS4A2
membrane spanning 4-domains A2
susceptibility
ISO
DNA:SNPs: : rs556917, rs502581, rs502419 (human) Atopy and bronchial hyperresponsiveness, OMIM:147050 DNA:polymorphism:CDS:amino acid E237G DNA:SNPs:multiple:, rs573790, rs2583476, rs569108 DNA:SNP: : -109C>T (human)
RGD
PMID:8817330 PMID:19218813 PMID:19862939 PMID:21320344
RGD:1599903 RGD:5131092 RGD:5131149 RGD:5131151
NCBI chr 1:13,657,842...13,666,314
Ensembl chr 1:13,654,696...13,665,925
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MTHFR
methylenetetrahydrofolate reductase
ISO
DNA:transition:cds:g.677C>T (human)
RGD
PMID:20456312
RGD:4891145
NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950
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MUC1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:11802251
RGD:5131281
NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962
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MUC2
mucin 2, oligomeric mucus/gel-forming
ISO
associated with hypersensitivity
RGD
PMID:11062147 PMID:14594655
RGD:5131178 RGD:7349354
NCBI chr 1:893,554...926,854
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MUC5AC
mucin 5AC, oligomeric mucus/gel-forming
treatment
ISO
protein:increased expression:lung mRNA,protein:increased expression:lung mRNA, protein:increased expression:lung
RGD
PMID:14594655 PMID:17590487 PMID:17698377 PMID:21549818 PMID:21780541
RGD:2324962 RGD:5131204 RGD:7349354 RGD:7349407 RGD:7364729
NCBI chr 1:981,515...1,018,242
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MUC5B
mucin 5B, oligomeric mucus/gel-forming
ISO
protein:altered expression:sputum
RGD
PMID:11587997 PMID:11802783
RGD:5131252 RGD:7364763
NCBI chr 1:1,040,756...1,083,246
Ensembl chr 1:1,042,110...1,081,240
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MUC7
mucin 7, secreted
ISO
ClinVar Annotator: match by term: Asthma, protection against
ClinVar OMIM
PMID:11378823 PMID:16759176 PMID:28492532
NCBI chr 7:18,982,090...18,990,627
Ensembl chr 7:18,982,103...18,989,955
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MYB
MYB proto-oncogene, transcription factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chr13:38,203,923...38,242,148
Ensembl chr13:38,203,731...38,241,864
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MYD88
MYD88 innate immune signal transduction adaptor
ameliorates
ISO
RGD
PMID:26882889
RGD:11531666
NCBI chr15:1,276,804...1,281,811
Ensembl chr15:1,276,798...1,281,166
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MYLK
myosin light chain kinase
ISO
RGD
PMID:17472811
RGD:4891492
NCBI chr22:57,032,264...57,259,253
Ensembl chr22:57,065,331...57,257,464
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NAT2
N-acetyltransferase 2
susceptibility
ISO
Asthma, Aspirin-Induced; DNA:polymorphism: : DNA:polymorphisms: :
RGD
PMID:16924569 PMID:20602614
RGD:5131600 RGD:5131606
NCBI chr 8:16,451,144...16,494,961
Ensembl chr 8:16,493,749...16,494,621
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NFE2L2
NFE2 like bZIP transcription factor 2
severity
ISO
mRNA:increased expression:bronchoalveolar lavage cell, peripheral blood mononuclear cell (human)
RGD
PMID:21514635
RGD:6893376
NCBI chr10:62,789,647...62,825,651
Ensembl chr10:62,790,124...62,825,339
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NGF
nerve growth factor
severity
ISO
protein:increased expression:lung, serum protein:increased expression:blood, eosinophil
RGD
PMID:11737043 PMID:12752594 PMID:17164945 PMID:17497413
RGD:4891068 RGD:4891108 RGD:4891122 RGD:4891123
NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833
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NGFR
nerve growth factor receptor
ISO
RGD
PMID:12540484 PMID:16603479
RGD:5144070 RGD:5144072
NCBI chr16:69,894,000...69,914,209
Ensembl chr16:69,894,139...69,912,189
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NOD1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human) DNA:insertion:cds:
RGD
PMID:15718249 PMID:16918516
RGD:5131518 RGD:5131519
NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619
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NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:intron, exon/3'UTR (rs1077861, rs3135500) (human)
RGD
PMID:16008671 PMID:21051079
RGD:5131477 RGD:5508757
NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499
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NOS1
nitric oxide synthase 1
susceptibility
ISO
DNA:repeats: : DNA:repeats:intron DNA:repeats:exon
RGD
PMID:10673365 PMID:10833424 PMID:14767694 PMID:20609134
RGD:5132615 RGD:5132860 RGD:5132863 RGD:5132869
NCBI chr11:112,642,374...112,673,882
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NOS2
nitric oxide synthase 2
severity disease_progression no_association
ISO
protein:increased expression, increased activity:lung (rat) DNA:SNP:exon:p.S608L (human) CTD Direct Evidence: marker/mechanism protein:increased expression:lung, bronchoalveolar lavage fluid DNA:repeats:promoter associated with Rhinitis, Allergic, Seasonal; protein:increased expression:nasal mucosa DNA:repeats:promoter, introns (human) mRNA:increased expression:monocyte DNA:repeat:promoter
RGD CTD
PMID:16540403 PMID:16703578 PMID:17161822 PMID:17177683 PMID:17189532 PMID:18254476 PMID:18714530 PMID:19800904 PMID:20841959 PMID:20842520 PMID:21847581 More...
RGD:4891419 RGD:4891480 RGD:4891508 RGD:4891910 RGD:4891924 RGD:4891925 RGD:4891927 RGD:4891953 RGD:4891957 RGD:5509073
NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257
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NOS3
nitric oxide synthase 3
susceptibility
ISO
DNA:repeats:intron DNA:polymorphisms:promoter:c. -786C>T, -691C>T (human) DNA:snps, repeat, haplotype:promoter, introns, exons:multiple (human)
RGD
PMID:16081038 PMID:16837812 PMID:18486767
RGD:4892053 RGD:4892058 RGD:4892062
NCBI chr21:119,174,829...119,196,840
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NPSR1
neuropeptide S receptor 1
susceptibility
ISO
ClinVar Annotator: match by term: Asthma-related traits, susceptibility to, 2
OMIM ClinVar
PMID:15073379
NCBI chr21:23,558,313...23,784,475
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NPY
neuropeptide Y
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:9731035
NCBI chr21:34,068,533...34,076,205
Ensembl chr21:34,068,530...34,075,127
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NQO1
NAD(P)H quinone dehydrogenase 1
susceptibility
ISO
DNA:SNP:exon:c. 609C>T (human) DNA:SNP:exon:c.609C>T (human) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19027876 PMID:19591959 PMID:20049212
RGD:5135005 RGD:5135006
NCBI chr 5:57,676,547...57,695,434
Ensembl chr 5:57,675,981...57,716,599
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NR3C1
nuclear receptor subfamily 3 group C member 1
treatment severity susceptibility
ISO
protein:increased expression, decreased activity:leukocyte, mononuclear DNA:polymorphism:intron
RGD
PMID:15295049 PMID:18396779 PMID:18799869 PMID:20727335 PMID:21113676
RGD:4892328 RGD:4892568 RGD:4892594 RGD:4892609 RGD:7174728
NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125
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NTF3
neurotrophin 3
ISO
protein:increased expression:lung, serum
RGD
PMID:11737043 PMID:17497413
RGD:4891068 RGD:4891123
NCBI chr11:5,477,208...5,542,404
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NTF4
neurotrophin 4
ISO
protein:increased expression:lung, serum
RGD
PMID:17497413
RGD:4891068
NCBI chr 6:42,254,693...42,284,899
Ensembl chr 6:42,279,190...42,279,822
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NTRK1
neurotrophic receptor tyrosine kinase 1
ISO
mRNA:increased expression:lung:
RGD
PMID:16708804 PMID:20934630
RGD:5684766 RGD:5684772
NCBI chr20:6,987,903...7,027,381
Ensembl chr20:6,987,905...7,008,670
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ORMDL3
ORMDL sphingolipid biosynthesis regulator 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21150878 PMID:25256354
NCBI chr16:66,243,503...66,249,800
Ensembl chr16:66,243,539...66,250,167
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P2RY12
purinergic receptor P2Y12
ISO
RGD
PMID:19822647 PMID:22010907
RGD:6480532 RGD:6480533
NCBI chr15:39,315,140...39,361,614
Ensembl chr15:39,359,612...39,360,637
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PARP1
poly(ADP-ribose) polymerase 1
treatment
ISO
protein:increased activation:lung, blood, mononuclear cell CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:12594058 PMID:18261157 PMID:26205779
RGD:11073727 RGD:5683910
NCBI chr25:3,350,798...3,405,040
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PDCD1
programmed cell death 1
treatment
ISO
associated with Chlamydia pneumonia
RGD
PMID:26378990
RGD:41412180
NCBI chr10:127,877,383...127,886,234
Ensembl chr10:127,878,554...127,886,088
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PDE4B
phosphodiesterase 4B
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21912604
NCBI chr20:66,729,561...67,297,729
Ensembl chr20:66,728,664...66,771,691
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PDGFB
platelet derived growth factor subunit B
ISO
protein: increased expression
RGD
PMID:21216974
RGD:6483071
NCBI chr19:21,865,792...21,888,068
Ensembl chr19:21,863,768...21,886,395
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PGF
placental growth factor
ISO
RGD
PMID:22268141
RGD:6483605
NCBI chr24:52,160,904...52,174,493
Ensembl chr24:52,161,787...52,173,989
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PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
ISO
RGD
PMID:18754810
RGD:6482695
NCBI chr21:75,781,812...75,823,404
Ensembl chr21:75,784,648...75,825,496
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PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ISO
RGD
PMID:18188456
RGD:8693422
NCBI chr 6:8,920,860...8,935,943
Ensembl chr 6:8,920,785...8,936,033
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PLA2G4A
phospholipase A2 group IVA
ISO
RGD
PMID:15557087
RGD:1642462
NCBI chr25:42,443,480...42,590,895
Ensembl chr25:42,443,385...42,590,431
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PLA2G7
phospholipase A2 group VII
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:10733466
RGD:1581025
NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269
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PLAU
plasminogen activator, urokinase
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18519237 PMID:21912604
RGD:4892037
NCBI chr 9:57,452,904...57,459,345
Ensembl chr 9:57,452,761...57,459,286
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PPP2CA
protein phosphatase 2 catalytic subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22205926
NCBI chr23:36,999,110...37,028,916
Ensembl chr23:36,997,078...37,029,280
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PRF1
perforin 1
ISO
RGD
PMID:21426642 PMID:22250087
RGD:6482815 RGD:6482818
NCBI chr 9:60,692,544...60,698,000
Ensembl chr 9:60,692,600...60,698,465
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PRG2
proteoglycan 2, pro eosinophil major basic protein
severity disease_progression no_association
ISO
mRNA:increased expression:eosinophil: associated with viral infection;mRNA:increased expression:sputum: associated with cough;protein:increased expression:sputum:
RGD
PMID:11067904 PMID:16982448 PMID:22022864 PMID:24450586
RGD:13506941 RGD:13506942 RGD:13506943 RGD:13506944
NCBI chr 1:15,850,181...15,854,511
Ensembl chr 1:15,850,913...15,854,517
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PRMT1
protein arginine methyltransferase 1
ISO
mRNA:increased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr 6:42,854,873...42,863,113
Ensembl chr 6:42,854,918...42,863,014
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PRMT2
protein arginine methyltransferase 2
ISO
mRNA:increased expression:lung, spleen
RGD
PMID:20423833
RGD:9491823
NCBI chr 2:90,225,051...90,256,541
Ensembl chr 2:90,225,346...90,256,558
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PRMT3
protein arginine methyltransferase 3
ISO
mRNA:increased expression:lung
RGD
PMID:20423833
RGD:9491823
NCBI chr 1:44,486,165...44,621,002
Ensembl chr 1:44,485,880...44,620,936
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PRMT5
protein arginine methyltransferase 5
ISO
mRNA:increased expression:lung, spleen
RGD
PMID:20423833
RGD:9491823
NCBI chr29:23,288,458...23,297,746
Ensembl chr29:23,288,835...23,297,518
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PROC
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:26381519
RGD:11099992
NCBI chr10:2,789,227...2,799,783
Ensembl chr10:2,789,277...2,799,531
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PTEN
phosphatase and tensin homolog
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17982072
NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146
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PTGDR
prostaglandin D2 receptor
susceptibility
ISO
OMIM
NCBI chr24:29,347,796...29,359,783
Ensembl chr24:29,350,749...29,359,754
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PTGDR2
prostaglandin D2 receptor 2
ISO
Aspirin exacerbated asthma CTD Direct Evidence: therapeutic
RGD CTD
PMID:18757520 PMID:19392992 PMID:19796209 PMID:27103662
RGD:5135018 RGD:5135019 RGD:5135020
NCBI chr 1:12,989,750...12,994,979
Ensembl chr 1:12,992,188...12,993,378
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PTGER3
prostaglandin E receptor 3
treatment
ISO
RGD
PMID:23221044
RGD:10043366
NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959
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PTGS2
prostaglandin-endoperoxide synthase 2
susceptibility severity
ISO
mRNA, protein:increased expression:lung: DNA:SNP: :8473T>C (human) DNA:SNP: :rs689465 (human) mRNA:increased expression:lung
RGD
PMID:15316498 PMID:17573729 PMID:18097056 PMID:18489027 PMID:19342146 PMID:19862936 PMID:19878559 More...
RGD:5135514 RGD:5135515 RGD:5135522 RGD:5135526 RGD:5135534 RGD:5143923 RGD:5143931
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
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PYHIN1
pyrin and HIN domain family member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21804549
NCBI chr20:4,967,123...5,006,172
Ensembl chr20:4,967,224...5,006,035
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RAD50
RAD50 double strand break repair protein
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24241537
NCBI chr23:35,375,206...35,458,801
Ensembl chr23:35,375,305...35,458,622
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RHOA
ras homolog family member A
ISO
RGD
PMID:18391481
RGD:2298885
NCBI chr22:10,757,381...10,809,257
Ensembl chr22:10,757,337...10,772,704
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RUNX1
RUNX family transcription factor 1
ISO
DNA:SNPs: :multiple
RGD
PMID:21803869
RGD:6482835
NCBI chr 2:78,819,189...79,082,491
Ensembl chr 2:78,819,194...78,924,495
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RUNX3
RUNX family transcription factor 3
ISO
OMIM:600807
MouseDO
NCBI chr20:107,769,244...107,802,154
Ensembl chr20:107,736,683...107,802,307
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SCGB1A1
secretoglobin family 1A member 1
susceptibility
ISO
associated with allergic rhinitis; DNA:SNP:exon:38G>A (human) ClinVar Annotator: match by term: Asthma, susceptibility to
RGD ClinVar
PMID:9550363 PMID:9643286 PMID:12100044 PMID:21255142
RGD:5144226
NCBI chr 1:11,470,091...11,474,915
Ensembl chr 1:11,470,195...11,474,149
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SCGB3A2
secretoglobin family 3A member 2
susceptibility severity no_association
ISO
ClinVar Annotator: match by term: Asthma, susceptibility to DNA:SNP:promoter:-112G>A (human)
OMIM ClinVar RGD
PMID:11813133 PMID:18089940 PMID:18201431
RGD:5144230 RGD:5144231
NCBI chr23:50,327,428...50,417,518
Ensembl chr23:50,414,139...50,417,373
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SELL
selectin L
ISO
RGD
PMID:21437035 PMID:21515793
RGD:5685685 RGD:5685696
NCBI chr25:59,345,080...59,365,684
Ensembl chr25:59,345,069...59,366,946
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SERPINA1
serpin family A member 1
ISO
Fisher rats, shown to exhibit hyperactive airway responses at 14 days of age, had higher transcript and protein levels of Serpina1 than same age Brown Norway rats.
RGD
PMID:20118217
RGD:5131869
NCBI chr24:72,158,521...72,171,139
Ensembl chr24:72,156,784...72,163,500
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SERPINE1
serpin family E member 1
severity no_association susceptibility
ISO
protein:increased activity, increased expression:plasma, lung protein:increased expression:plasma DNA:polymorphism:promoter:rs1799768 (human)
RGD
PMID:18594148 PMID:19063817 PMID:19604112 PMID:19703828
RGD:4144831 RGD:4144832 RGD:4144833 RGD:4144836
NCBI chr28:12,047,520...12,060,662
Ensembl chr28:12,047,529...12,060,202
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SFTPB
surfactant protein B
ISO
mRNA, protein:decreased expression:lung protein:increased expression:lung protein:decreased expression:lung, Clara cell
RGD
PMID:11472974 PMID:15816355 PMID:16629790 PMID:18926058
RGD:4143289 RGD:4143398 RGD:4143462 RGD:4143465
NCBI chr14:21,487,424...21,497,491
Ensembl chr14:21,488,387...21,499,850
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SFTPC
surfactant protein C
susceptibility
ISO
protein:increased expression:lung mRNA, protein:decreased expression:lung DNA:polymorphism: :p.A53T (human)
RGD
PMID:11472974 PMID:16629790 PMID:19910179
RGD:4143462 RGD:4143465 RGD:4144063
NCBI chr 8:20,229,756...20,233,568
Ensembl chr 8:20,230,870...20,234,020
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SFTPD
surfactant protein D
ISO
associated with Bronchitis;protein:increased expression:lung mRNA, protein:increased expression:lung
RGD
PMID:11472974 PMID:16629790 PMID:16839409 PMID:18266831 PMID:18802356
RGD:4143462 RGD:4143465 RGD:4143508 RGD:4143516 RGD:4143517
NCBI chr 9:51,809,241...51,820,974
Ensembl chr 9:51,811,052...51,820,650
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SLC11A1
solute carrier family 11 member 1
ISO
RGD
PMID:12847242
RGD:5684966
NCBI chr10:104,276,553...104,288,466
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SLC18A3
solute carrier family 18 member A3
ISO
RGD
PMID:17328924
RGD:5686690
NCBI chr 9:42,216,187...42,219,665
Ensembl chr 9:42,216,568...42,218,166
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SLC22A1
solute carrier family 22 member 1
ISO
RGD
PMID:17328924
RGD:5686690
NCBI chr13:87,744,600...87,780,846
Ensembl chr13:87,745,023...87,781,073
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SLC5A7
solute carrier family 5 member 7
ISO
mRNA:decreased expression:lung
RGD
PMID:17328924
RGD:5686690
NCBI chr14:11,346,281...11,373,754
Ensembl chr14:11,347,861...11,370,297
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SLC6A4
solute carrier family 6 member 4
susceptibility
ISO
DNA:repeat:intron (human)
RGD
PMID:19806585
RGD:4889460
NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616
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SOD1
superoxide dismutase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:22867017
NCBI chr 2:60,461,219...60,472,999
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SOD2
superoxide dismutase 2
ISO
RGD
PMID:15743779
RGD:1581231
NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
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STAT4
signal transducer and activator of transcription 4
treatment
ISO
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:18211752 PMID:28807506
RGD:2317290
NCBI chr10:76,553,626...76,708,540
Ensembl chr10:76,553,606...76,674,928
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STAT6
signal transducer and activator of transcription 6
treatment
ISO
RGD
PMID:16083555 PMID:19087723
RGD:7244151 RGD:7244153
NCBI chr11:53,005,378...53,020,899
Ensembl chr11:53,006,145...53,021,203
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TAC1
tachykinin precursor 1
ISO
protein:increased expression:lung
RGD
PMID:11031342
RGD:5147836
NCBI chr21:51,339,085...51,347,561
Ensembl chr21:51,339,095...51,347,550
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TACR1
tachykinin receptor 1
ISO
mRNA:increased expression:lung mRNA,protein:increased expression:lung
RGD
PMID:8240667 PMID:16409782 PMID:17392578
RGD:2304339 RGD:5147475 RGD:5147645
NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596
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TACR2
tachykinin receptor 2
ISO
DNA:SNP:cds:p.G231E (human)
RGD
PMID:19880429 PMID:20175803
RGD:5147640 RGD:5147641
NCBI chr 9:61,902,565...61,915,402
Ensembl chr 9:61,903,477...61,914,558
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TAP1
transporter 1, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphism: :
RGD
PMID:12640628
RGD:5147845
NCBI chr17:39,252,000...39,260,195
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TBX21
T-box transcription factor 21
ISO
CTD Direct Evidence: marker/mechanism OMIM:600807
CTD MouseDO
PMID:15806396
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
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TGFB1
transforming growth factor beta 1
onset no_association
ISO
DNA:SNPs:promoter, exon:multiple (human) DNA:SNP: :-509C>T (human) DNA:polymorphism: :-509C>T (human) DNA:SNP:cds:915G>C (human) CTD Direct Evidence: marker/mechanism DNA:polymorphisms: :multiple (human) mRNA:increased expression:lung protein:increased expression:serum
RGD CTD
PMID:16365456 PMID:17673695 PMID:18366906 PMID:18711258 PMID:19046298 PMID:19096005 PMID:19136038 PMID:19138248 PMID:19222424 PMID:19317336 PMID:19533439 PMID:19620629 PMID:20485865 More...
RGD:4143443 RGD:4145113 RGD:4145132 RGD:4145139 RGD:4145142 RGD:4145143 RGD:4145144 RGD:4145280 RGD:4145295 RGD:4145297 RGD:4145299
NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365
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THBD
thrombomodulin
ISO
RGD
PMID:20709825
RGD:5684984
NCBI chr 2:52,041,950...52,045,946
Ensembl chr 2:52,043,746...52,045,626
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TIMP3
TIMP metallopeptidase inhibitor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16926187
NCBI chr19:15,621,609...15,684,118
Ensembl chr19:15,622,431...15,680,449
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TLR1
toll like receptor 1
susceptibility
ISO
DNA:SNP (human)
RGD
PMID:18547625
RGD:4889528
NCBI chr27:11,482,307...11,490,847
Ensembl chr27:11,488,294...11,490,654
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TLR10
toll like receptor 10
susceptibility
ISO
DNA:SNP (human)
RGD
PMID:18547625
RGD:4889528
NCBI chr27:11,486,273...11,515,841
Ensembl chr27:11,512,239...11,514,671
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TLR2
toll like receptor 2
susceptibility severity
ISO
DNA:SNP: :rs4696480 (human) DNA:SNP: :rs3804100 (human) DNA:polymorphism:cds:p.R753Q(human) DNA:SNP: :rs7656411 (human) DNA:SNP: :596T>C (human)
RGD
PMID:18202345 PMID:18787777 PMID:19096003 PMID:19148143 PMID:20685742 PMID:20815312 PMID:22402138 More...
RGD:2312679 RGD:4144171 RGD:4144228 RGD:4145334 RGD:4145343 RGD:4145352 RGD:7800732
NCBI chr 7:100,239,533...100,565,955
Ensembl chr 7:100,258,441...100,260,795
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TLR3
toll like receptor 3
no_association
ISO
DNA:snp:cds:p.L412F (human) Asthma, Virus-Induced; mRNA:increased expression:sputum (human)
RGD
PMID:14987294 PMID:17434873 PMID:17610940 PMID:21129050 PMID:21364926
RGD:5128500 RGD:5129226 RGD:5129475 RGD:5129478 RGD:5129493
NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232
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TLR4
toll like receptor 4
susceptibility severity no_association
ISO
DNA:SNPs:: protein:decreased expression:leukocytes, mononuclear DNA:Polymorphism:cds:p.D299G (human) DNA:polymorphisms:cds:c.896A>G, 1196C>T (human) DNA:SNPs: :rs10983755, rs1927914 (human)
RGD
PMID:15356557 PMID:16266379 PMID:19067129 PMID:19159017 PMID:19330007 PMID:20628601 PMID:20685742 More...
RGD:4144141 RGD:4144171 RGD:4144176 RGD:4144188 RGD:4144190 RGD:4144198 RGD:4144817
NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515
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TLR6
toll like receptor 6
susceptibility
ISO
DNA:SNP (human) DNA:SNP: :p.S249P (human)
RGD
PMID:15266299 PMID:18547625
RGD:4889528 RGD:4889538
NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571
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TNC
tenascin C
ISO
DNA:SNPs: :multiple (human) CTD Direct Evidence: marker/mechanism DNA:SNP:exon:p.L1677I (human) protein:increased expression:bronchus basement membrane
RGD CTD
PMID:9310019 PMID:16115819 PMID:17125141 PMID:18305139
RGD:4889565 RGD:4889569 RGD:4889572 RGD:4889589
NCBI chr12:24,457,616...24,556,194
Ensembl chr12:24,457,738...24,556,451
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TNF
tumor necrosis factor
no_association susceptibility
ISO
DNA:polymorphism:promoter: associated with obesity; DNA:polymorphism:promoter ClinVar Annotator: match by term: Asthma, susceptibility to
RGD OMIM ClinVar
PMID:8056188 PMID:9818939 PMID:10450718 PMID:11261930 PMID:11506397 PMID:11826025 PMID:11896460 PMID:12485196 PMID:12530118 PMID:12746914 PMID:12759288 PMID:14681301 PMID:14718719 PMID:16418737 PMID:16720636 PMID:16865291 PMID:16909270 PMID:18050183 PMID:18713756 PMID:19196817 PMID:19365401 PMID:22760475 PMID:22992668 More...
RGD:4143238 RGD:4143254
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TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:lung (mouse)
RGD
PMID:20484920
RGD:5131201
NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902
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TNIP1
TNFAIP3 interacting protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:24453940
NCBI chr23:53,586,243...53,643,599
Ensembl chr23:53,587,008...53,621,489
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TRPA1
transient receptor potential cation channel subfamily A member 1
severity
ISO
ovalbumin sensitization CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:19458046 PMID:31969645
RGD:127285811
NCBI chr 8:67,698,067...67,754,407
Ensembl chr 8:67,698,786...67,751,885
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TSLP
thymic stromal lymphopoietin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21804549
NCBI chr23:14,419,820...14,423,331
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UCN
urocortin
ISO
associated with Hypersensitivity;mRNA, protein:increased expression:lung
RGD
PMID:16427607
RGD:1642781
NCBI chr14:80,303,210...80,304,910
Ensembl chr14:80,304,416...80,304,790
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UTS2
urotensin 2
ISO
RGD
PMID:17045018
RGD:2306832
NCBI chr20:123,903,137...123,910,180
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VDR
vitamin D receptor
no_association
ISO
DNA:SNPs (human) DNA:SNPs: :multiple (human) DNA:SNP (human) DNA:SNP: :rs7975232 (human)
RGD
PMID:15282200 PMID:19622139 PMID:20124605 PMID:21103062
RGD:4889854 RGD:4889866 RGD:4889867 RGD:4889868
NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684
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VEGFA
vascular endothelial growth factor A
ISO
protein:increased expression:sputum CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:11907124 PMID:15201500 PMID:19178538 PMID:19263519
RGD:6892723
NCBI chr17:28,377,959...28,394,508
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VIP
vasoactive intestinal peptide
ISO
RGD
PMID:16782752 PMID:21419198
RGD:5685381 RGD:5685620
NCBI chr13:80,217,602...80,228,320
Ensembl chr13:80,218,572...80,228,278
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WDR36
WD repeat domain 36
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19198610
NCBI chr23:14,427,459...14,464,125
Ensembl chr23:14,427,487...14,466,704
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MHC-DRA
major histocompatibility complex, class II, DR alpha
susceptibility
ISO
DNA:SNPs,haplotype:introns:
RGD
PMID:22391069
RGD:13506908
NCBI chr17:39,623,324...39,628,464
Ensembl chr17:39,622,402...39,629,261
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TBX21
T-box transcription factor 21
ISO
ClinVar Annotator: match by term: Asthma and nasal polyps
ClinVar
PMID:15806396
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
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ALOX15
arachidonate 15-lipoxygenase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:17959182 PMID:21558275 PMID:25741868 PMID:30643255
NCBI chr16:4,112,795...4,121,764
Ensembl chr16:4,111,151...4,121,645
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LTC4S
leukotriene C4 synthase
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar
PMID:25741868
NCBI chr23:81,523,784...81,526,297
Ensembl chr23:81,523,775...81,526,179
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PTGER2
prostaglandin E receptor 2
susceptibility
ISO
CTD Direct Evidence: marker/mechanism
OMIM CTD
NCBI chr24:29,395,799...29,410,723
Ensembl chr24:29,396,464...29,409,575
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TBX21
T-box transcription factor 21
susceptibility
ISO
ClinVar Annotator: match by term: Asthma, nasal polyps, and aspirin intolerance
ClinVar OMIM
PMID:25741868
NCBI chr16:68,131,258...68,145,579
Ensembl chr16:68,131,536...68,144,415
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CCR5
C-C motif chemokine receptor 5
disease_progression
ISO
DNA:polymorphisms:5' utr:multiple (human)
RGD
PMID:20075058
RGD:4892065
NCBI chr22:7,803,794...7,818,112
G
CD28
CD28 molecule
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12952926
NCBI chr10:89,471,710...89,505,152
Ensembl chr10:89,471,730...89,500,387
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GCLM
glutamate-cysteine ligase modifier subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:16766924
NCBI chr20:39,339,948...39,359,980
Ensembl chr20:39,339,908...39,359,430
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HMOX1
heme oxygenase 1
ISO
protein:increased activity:sputum
RGD
PMID:19453654
RGD:4145349
NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
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IL2RA
interleukin 2 receptor subunit alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8977230
NCBI chr 9:6,134,961...6,187,731
Ensembl chr 9:6,141,430...6,149,447
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IL6
interleukin 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8428540
NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237
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MHC-DPB1
major histocompatibility complex, class II, DP beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8105536 PMID:11551429 PMID:14662898 PMID:15273960 PMID:17927685 PMID:17956852 More...
NCBI chr17:38,996,329...39,007,097
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TGFB1
transforming growth factor beta 1
severity
ISO
CTD Direct Evidence: marker/mechanism DNA:polymorphisms: :-509C>T (human)
CTD RGD
PMID:15750822 PMID:17785866
RGD:4145294
NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365
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TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:8428540 PMID:12449171 PMID:15127972 PMID:16980557
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MUC1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:15881280
RGD:5131172
NCBI chr20:8,641,701...8,646,739
Ensembl chr20:8,642,842...8,646,962
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NFKBIA
NFKB inhibitor alpha
exacerbates
ISO
associated with respiratory syncytial virus infectious disease;DNA:SNPs:protomer: (rs2233409) (human)
RGD
PMID:23487427
RGD:40902982
NCBI chr24:12,211,619...12,216,185
Ensembl chr24:12,210,281...12,214,854
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NGF
nerve growth factor
treatment
ISO
RGD
PMID:30681402
RGD:405100716
NCBI chr20:18,361,795...18,413,987
Ensembl chr20:18,413,108...18,413,833
G
CCL26
C-C motif chemokine ligand 26
severity
ISO
protein:increased expression:sputum (human)
RGD
PMID:25936567
RGD:11531115
NCBI chr28:10,036,177...10,038,962
Ensembl chr28:10,036,337...10,038,875
G
EPX
eosinophil peroxidase
treatment
ISO
RGD
PMID:28751233
RGD:13506890
NCBI chr16:35,196,433...35,208,269
Ensembl chr16:35,192,971...35,207,874
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ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:10984370
RGD:4890423
NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331
G
CCL5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (human)
RGD
PMID:19996575
RGD:4892021
NCBI chr16:29,351,214...29,361,317
G
TACR1
tachykinin receptor 1
ISO
RGD
PMID:8630576
RGD:5147837
NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596
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ACSL3
acyl-CoA synthetase long chain family member 3
ISO
RGD
PMID:23526225
RGD:13831300
NCBI chr10:108,787,341...108,867,523
Ensembl chr10:108,787,061...108,869,042
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BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:29713367
RGD:13792581
NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895
G
CD86
CD86 molecule
treatment
ISO
RGD
PMID:25344652
RGD:11354965
NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366
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FASLG
Fas ligand
treatment
ISO
RGD
PMID:29713367
RGD:13792581
NCBI chr25:56,488,572...56,496,469
Ensembl chr25:56,489,417...56,496,251
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IL23A
interleukin 23 subunit alpha
ISO
RGD
PMID:19935773 PMID:26344076
RGD:11251537 RGD:5037240
NCBI chr11:52,289,486...52,296,735
Ensembl chr11:52,295,106...52,297,244
G
CCL5
C-C motif chemokine ligand 5
ISO
protein:increased secretion:lung, secretion (mouse) mRNA:increased expression:lung:bronchoalveolar lavage cell (human)
RGD
PMID:10384061 PMID:16387809
RGD:4891434 RGD:4891436
NCBI chr16:29,351,214...29,361,317
G
CCL7
C-C motif chemokine ligand 7
ISO
RGD
PMID:20027288
RGD:5130978
NCBI chr16:27,777,795...27,780,413
G
CCR3
C-C motif chemokine receptor 3
ISO
RGD
PMID:19842835
RGD:4145620
NCBI chr22:7,648,410...7,698,523
Ensembl chr22:7,697,068...7,698,135
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CD86
CD86 molecule
ISO
associated with Paramyxoviridae Infections; protein:increased expression:lung (mouse)
RGD
PMID:19282343
RGD:4892294
NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366
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CXCL10
C-X-C motif chemokine ligand 10
ISO
mRNA:increased expression:alveolar macrophage
RGD
PMID:14991597 PMID:15725351
RGD:5135448 RGD:5135490
NCBI chr 7:24,526,657...24,529,193
Ensembl chr 7:24,526,680...24,529,130
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CXCL11
C-X-C motif chemokine ligand 11
ISO
RGD
PMID:14991597
RGD:5135448
NCBI chr 7:24,540,401...24,543,456
Ensembl chr 7:24,541,767...24,542,832
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CXCL9
C-X-C motif chemokine ligand 9
ISO
mRNA:increased expression:alveolar macrophage
RGD
PMID:14991597 PMID:15725351
RGD:5135448 RGD:5135490
NCBI chr 7:24,507,121...24,513,830
Ensembl chr 7:24,507,130...24,513,121
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CXCR3
C-X-C motif chemokine receptor 3
ISO
RGD
PMID:14991597 PMID:19842835
RGD:4145620 RGD:5135448
NCBI chr X:61,430,723...61,433,777
Ensembl chr X:61,430,725...61,433,386
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CYP2E1
cytochrome P450 family 2 subfamily E member 1
ISO
mRNA:decreased expression:leukocyte
RGD
PMID:20514434
RGD:4892076
NCBI chr26:53,390,054...53,403,309
Ensembl chr26:53,390,089...53,404,211
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IL13
interleukin 13
ISO
mRNA:increased expression:lung
RGD
PMID:9916735 PMID:20861649
RGD:4145650 RGD:5128548
NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
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IL17A
interleukin 17A
ISO
associated with Silicosis
RGD
PMID:19151189 PMID:20421647
RGD:4888525 RGD:4889106
NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785
G
IL1A
interleukin 1 alpha
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:10882225
RGD:4142832
NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611
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IL1B
interleukin 1 beta
disease_progression
ISO
protein:increased expression:serum (human)
RGD
PMID:1519663 PMID:19556641
RGD:4142842 RGD:7401229
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
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IL5
interleukin 5
ISO
protein:increased expression:lung,respiratory system fluid/secretion
RGD
PMID:19151189
RGD:4889106
NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
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NOS2
nitric oxide synthase 2
ISO
protein:increased expression:lung
RGD
PMID:11789718
RGD:4891449
NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257
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SOD2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:10673208
NCBI chr13:87,284,537...87,297,998
Ensembl chr13:87,280,686...87,297,974
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TAP1
transporter 1, ATP binding cassette subfamily B member
susceptibility
ISO
DNA:polymorphisms:cds:P. D637G, P661P (human)
RGD
PMID:18342853
RGD:5147840
NCBI chr17:39,252,000...39,260,195
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TLR6
toll like receptor 6
ISO
RGD
PMID:20070409
RGD:4889532
NCBI chr27:11,439,288...11,461,580
Ensembl chr27:11,459,181...11,461,571
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TNC
tenascin C
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:9780295
RGD:4889595
NCBI chr12:24,457,616...24,556,194
Ensembl chr12:24,457,738...24,556,451
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TNF
tumor necrosis factor
ISO
protein:increased expression:Bronchoalveolar Lavage Fluid
RGD
PMID:10882225 PMID:15653992
RGD:4142832 RGD:4143466
G
TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:alveolar macrophage (human)
RGD
PMID:15929959
RGD:5131148
NCBI chr11:6,364,544...6,378,880
Ensembl chr11:6,364,330...6,378,902
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TNFRSF1B
TNF receptor superfamily member 1B
ISO
protein:increased expression:alveolar macrophage (human)
RGD
PMID:15929959
RGD:5131148
NCBI chr20:119,590,621...119,633,562
Ensembl chr20:119,590,325...119,633,497
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VEGFA
vascular endothelial growth factor A
ISO
RGD
PMID:15764076
RGD:5684419
NCBI chr17:28,377,959...28,394,508
G
IL12B
interleukin 12B
ISO
RGD
PMID:12084045
RGD:4145430
NCBI chr23:61,714,293...61,731,835
G
TNF
tumor necrosis factor
ISO
DNA:polymorphism:promoter protein:increased secretion:macrophage
RGD
PMID:8466130 PMID:11179110
RGD:4143374 RGD:4143375
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HAVCR1
hepatitis A virus cellular receptor 1
ISO
ClinVar Annotator: match by term: IgE responsiveness, atopic
ClinVar
PMID:14534576 PMID:21339644
NCBI chr23:59,422,769...59,454,183
Ensembl chr23:59,423,334...59,453,531
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IL17A
interleukin 17A
ISO
associated with Nasal Polyps;protein:increased expression:nasal polyps (human)
RGD
PMID:24141678
RGD:9068428
NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785
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IL21R
interleukin 21 receptor
ISO
ClinVar Annotator: match by term: IgE responsiveness, atopic | ClinVar Annotator: match by term: Ige, elevated level of
ClinVar
PMID:12700598 PMID:17015683 PMID:25741868 PMID:28492532
NCBI chr 5:25,105,947...25,153,914
Ensembl chr 5:25,106,519...25,153,703
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IL4R
interleukin 4 receptor
ISO
ClinVar Annotator: match by term: IgE responsiveness, atopic
ClinVar
PMID:25741868 PMID:28492532
NCBI chr 5:25,019,638...25,069,732
Ensembl chr 5:25,046,701...25,070,015
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AGER
advanced glycosylation end-product specific receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:33075463
NCBI chr17:39,847,343...39,851,288
Ensembl chr17:39,847,759...39,851,127
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CDH17
cadherin 17
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr 8:89,101,788...89,179,353
Ensembl chr 8:89,101,744...89,179,251
G
HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr26:53,760,172...54,007,356
Ensembl chr26:53,792,593...54,007,489
G
MHC-DOA
major histocompatibility complex, class II, DO alpha
treatment
ISO
DNA:SNP: :rs3128935(human)
RGD
PMID:24709764
RGD:13506912
NCBI chr17:39,084,785...39,090,477
Ensembl chr17:39,085,080...39,090,474
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MHC-DPB1
major histocompatibility complex, class II, DP beta 1
susceptibility
ISO
DNA:SNP: : rs928976(human)
RGD
PMID:24709764
RGD:13506912
NCBI chr17:38,996,329...39,007,097
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PLA2G4A
phospholipase A2 group IVA
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27504716
NCBI chr25:42,443,480...42,590,895
Ensembl chr25:42,443,385...42,590,431
G
PRKCA
protein kinase C alpha
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:27504716
NCBI chr16:54,638,548...55,144,372
Ensembl chr16:54,642,729...54,948,256
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr25:42,733,535...42,742,463
Ensembl chr25:42,734,771...42,742,429
G
TENM3
teneurin transmembrane protein 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25918132
NCBI chr 7:127,231,840...128,792,832
Ensembl chr 7:128,598,835...128,795,211
G
TGFB1
transforming growth factor beta 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
NCBI chr 6:35,651,583...35,674,387
Ensembl chr 6:35,648,677...35,674,365
G
TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25721048
G
ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:decreased expression:serum
RGD
PMID:19725899
RGD:5686851
NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391
G
ALB
albumin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19389874
NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407
G
ALOX5AP
arachidonate 5-lipoxygenase activating protein
ISO
protein:increased expression:nasal turbinate
RGD
PMID:19364335
RGD:5147461
NCBI chr 3:9,618,030...9,642,990
Ensembl chr 3:9,617,949...9,643,184
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CAT
catalase
ISO
protein:decreased expression:plasma
RGD
PMID:20493834
RGD:5130771
NCBI chr 1:30,792,533...30,828,920
Ensembl chr 1:30,792,399...30,829,592
G
CCL2
C-C motif chemokine ligand 2
ISO
protein:increased expression:nasal turbinate, mucosa (human)
RGD
PMID:9865755
RGD:8548839
NCBI chr16:27,763,354...27,765,437
Ensembl chr16:27,763,555...27,765,416
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CCR2
C-C motif chemokine receptor 2
ISO
mRNA:increased expression:Nasal Mucosa
RGD
PMID:17982926
RGD:4145109
NCBI chr22:7,795,192...7,801,242
Ensembl chr22:7,798,646...7,799,728
G
CCR5
C-C motif chemokine receptor 5
ISO
mRNA:increased expression:nasal mucosa (human)
RGD
PMID:17982926
RGD:4145109
NCBI chr22:7,803,794...7,818,112
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CD40
CD40 molecule
ISO
RGD
PMID:20226305
RGD:5132269
NCBI chr 2:17,753,713...17,765,134
Ensembl chr 2:17,753,394...17,764,566
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CD86
CD86 molecule
ISO
protein:increased expression:nasal mucosa, dendritic cell (human)
RGD
PMID:17088138
RGD:4892343
NCBI chr22:58,741,534...58,805,417
Ensembl chr22:58,741,525...58,805,366
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EGR1
early growth response 1
ISO
DNA:snp:5' utr:g.-4071A>G rs7729723 (human)
RGD
PMID:19833116
RGD:5131984
NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374
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F2RL1
F2R like trypsin receptor 1
ISO
RGD
PMID:17727088
RGD:4892590
NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005
G
GSTP1
glutathione S-transferase pi 1
susceptibility
ISO
DNA:polymorphism:exon:p.I105V (rs1695) (human)
RGD
PMID:17181111
RGD:4142523
NCBI chr 1:6,676,897...6,679,936
G
HMOX1
heme oxygenase 1
ISO
mRNA, protein:increased expression: nasal mucosa
RGD
PMID:16540907
RGD:4145406
NCBI chr19:18,144,466...18,157,944
Ensembl chr19:18,144,545...18,157,971
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ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx (human) protein:increased expression:lung, endothelium (mouse)
RGD
PMID:19047814 PMID:19968652
RGD:4145464 RGD:4145520
NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263
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IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542
G
IL13
interleukin 13
ISO
mRNA, protein:increased expression:nasal mucosa
RGD
PMID:8520776
RGD:4782826
NCBI chr23:35,475,762...35,479,419
Ensembl chr23:35,476,490...35,478,869
G
IL17A
interleukin 17A
severity
ISO
protein:increased expression:serum
RGD
PMID:19226302
RGD:4889151
NCBI chr17:20,314,082...20,319,917
Ensembl chr17:20,315,773...20,318,785
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IL18
interleukin 18
susceptibility
ISO
DNA:SNP:promoter:c. -607A>C (rs1946518) (human)
RGD
PMID:16406079
RGD:4889924
NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
G
IL1A
interleukin 1 alpha
ISO
DNA:polymorphism:exon:c.4845G>T (human)
RGD
PMID:14533660
RGD:4142859
NCBI chr14:15,789,710...15,801,938
Ensembl chr14:15,789,013...15,796,611
G
IL1R1
interleukin 1 receptor type 1
ISO
RGD
PMID:18637763
RGD:5037238
NCBI chr14:5,781,486...5,852,872
Ensembl chr14:5,781,479...5,855,942
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IL2
interleukin 2
ISO
protein:decreased expression:serum:
RGD
PMID:17608155
RGD:8662959
NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969
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IL4
interleukin 4
treatment
ISO
protein:increased expression:serum
RGD
PMID:9237816 PMID:15329007 PMID:21171297
RGD:5128559 RGD:7829804 RGD:7829817
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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IL5
interleukin 5
ISO
protein: increased levels: sputum
RGD
PMID:22186238
RGD:5687140
NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
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LOC103233689
thromboxane A2 receptor
treatment
ISO
RGD
PMID:15247523
RGD:11059532
NCBI chr 6:3,354,358...3,365,779
Ensembl chr 6:3,355,314...3,359,761
G
MMP2
matrix metallopeptidase 2
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr 5:41,264,382...41,291,657
Ensembl chr 5:41,264,354...41,291,004
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MMP9
matrix metallopeptidase 9
ISO
protein:increased expression:nasal mucosa:
RGD
PMID:19786210
RGD:5130872
NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712
G
NOS2
nitric oxide synthase 2
ISO
protein:increased expression:nasal mucosa
RGD
PMID:14587983
RGD:4892078
NCBI chr16:21,533,011...21,576,645
Ensembl chr16:21,533,484...21,574,257
G
NOS3
nitric oxide synthase 3
ISO
DNA:snp:promoter:g.-786T>C (human)
RGD
PMID:18086269
RGD:4892054
NCBI chr21:119,174,829...119,196,840
G
NR3C1
nuclear receptor subfamily 3 group C member 1
ISO
protein:altered expression:nasal mucosa
RGD
PMID:20185258
RGD:4892593
NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125
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PPARG
peroxisome proliferator activated receptor gamma
ISO
mRNA, protein:increased expression:nasal mucosa (human)
RGD
PMID:17116814
RGD:8552811
NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
G
PLA2G7
phospholipase A2 group VII
ISO
ClinVar Annotator: match by term: Platelet-activating factor acetylhydrolase deficiency
ClinVar OMIM
PMID:8675689 PMID:9412624 PMID:10194471 PMID:10733466 PMID:16787988 PMID:25741868 PMID:28406212 More...
NCBI chr17:25,538,645...25,571,230
Ensembl chr17:25,538,438...25,574,269
G
ALOX5
arachidonate 5-lipoxygenase
ISO
RGD
PMID:16677242
RGD:5147463
NCBI chr 9:41,085,257...41,145,760
Ensembl chr 9:41,085,361...41,145,331
G
APOA4
apolipoprotein A4
resistance
ISO
protein:increased expression:blood serum (human)
RGD
PMID:20810159
RGD:5685642
NCBI chr 1:108,186,627...108,190,508
Ensembl chr 1:108,186,921...108,189,698
G
BDNF
brain derived neurotrophic factor
severity
ISO
protein:increased expression:blood, nasal cavity epithelium
RGD
PMID:18266897
RGD:5144117
NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336
G
CCL5
C-C motif chemokine ligand 5
ISO
protein:increased expression:inferior turbinate, epithelium (human)
RGD
PMID:20459697
RGD:4891379
NCBI chr16:29,351,214...29,361,317
G
CMA1
chymase 1
ISO
protein:increased expression:nasal mucosa, mast cell (human)
RGD
PMID:11549546
RGD:5128839
NCBI chr24:1,471,767...1,475,062
Ensembl chr24:1,471,725...1,474,692
G
FGA
fibrinogen alpha chain
ISO
RGD
PMID:21887273
RGD:5688767
NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405
G
GSTO1
glutathione S-transferase omega 1
ISO
protein:decreased expression;T lymphocyte:
RGD
PMID:21410266
RGD:5491008
NCBI chr 9:97,305,094...97,317,892
G
ICAM1
intercellular adhesion molecule 1
ISO
protein:increased secretion:nasopharynx, secretion (human)
RGD
PMID:20128420
RGD:4145459
NCBI chr 6:9,320,991...9,338,125
Ensembl chr 6:9,322,550...9,338,263
G
IFNGR1
interferon gamma receptor 1
ISO
DNA: SNP: Leu467Pro
RGD
PMID:12851715
RGD:6480431
NCBI chr13:36,203,038...36,224,039
Ensembl chr13:36,203,004...36,222,542
G
IL10
interleukin 10
treatment
ISO
RGD
PMID:19505388
RGD:7365025
NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836
G
IL18
interleukin 18
no_association susceptibility
ISO
DNA:SNPs:promoters:multiple DNA:SNPs:promoters, exon:multiple
RGD
PMID:12532106
RGD:8655871
NCBI chr 1:103,485,868...103,511,632
Ensembl chr 1:103,482,083...103,510,150
G
IL4
interleukin 4
ISO
protein:increased expression:serum mRNA:increased expression:nose:
RGD
PMID:7551298 PMID:9237816
RGD:7829817 RGD:8662960
NCBI chr23:35,492,158...35,501,349
Ensembl chr23:35,492,939...35,501,258
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KDR
kinase insert domain receptor
ISO
protein:increased expression:nasal cavity of mucosa:
RGD
PMID:17651148
RGD:8551771
NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771
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MMP9
matrix metallopeptidase 9
ISO
DNA:SNPs:promoter, intron, cds:-1590C>T, 2127G>T, p.R668Q (rs3918242, rs2274755, rs17577) (human)
RGD
PMID:22237587
RGD:8547819
NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712
G
NOD1
nucleotide binding oligomerization domain containing 1
susceptibility
ISO
DNA:SNP: :rs2075817 (human)
RGD
PMID:16918516
RGD:5131519
NCBI chr21:27,907,628...27,957,621
Ensembl chr21:27,926,710...27,957,619
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NOD2
nucleotide binding oligomerization domain containing 2
susceptibility
ISO
DNA:polymorphisms:5'UTR/exon, exon:rs5743266, rs2066842 (human)
RGD
PMID:16008671
RGD:5131477
NCBI chr 5:36,492,158...36,531,766
Ensembl chr 5:36,496,414...36,530,499
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PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:respiratory system epithelium
RGD
PMID:19364335
RGD:5147461
NCBI chr12:17,195,403...17,218,450
Ensembl chr12:17,192,628...17,218,315
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SCGB1A1
secretoglobin family 1A member 1
ISO
mRNA, protein:decreased expression:nasal lavage fluid
RGD
PMID:15836756
RGD:5144234
NCBI chr 1:11,470,091...11,474,915
Ensembl chr 1:11,470,195...11,474,149
G
TLR3
toll like receptor 3
ISO
protein:decreased expression:bone marrow, blood, eosinophil (human)
RGD
PMID:19752565
RGD:5129130
NCBI chr 7:131,991,068...132,014,366
Ensembl chr 7:131,991,029...132,016,232
G
TLR4
toll like receptor 4
susceptibility
ISO
DNA:polymorphisms:cds:p.D299G, T399I (human)
RGD
PMID:18517079
RGD:4144192
NCBI chr12:21,873,762...21,885,562
Ensembl chr12:21,871,773...21,885,515
G
VEGFA
vascular endothelial growth factor A
ISO
mRNA,protein:increased expression:nasal biopsies,nasal lavage fluid:
RGD
PMID:12633568
RGD:7483595
NCBI chr17:28,377,959...28,394,508
G
PNPLA6
patatin like phospholipase domain containing 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:23418070
NCBI chr 6:7,030,802...7,056,664
Ensembl chr 6:7,032,445...7,056,661
G
IFNG
interferon gamma
resistance
ISO
RGD
PMID:20817868
RGD:4145651
NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473
G
IL1B
interleukin 1 beta
ISO
protein:increased expression:lung
RGD
PMID:9927362
RGD:4143184
NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729
G
IL5
interleukin 5
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10934091
RGD:4890960
NCBI chr23:35,360,143...35,375,169
Ensembl chr23:35,360,506...35,362,178
G
MPO
myeloperoxidase
ISO
protein:increased expression:serum
RGD
PMID:10731862
RGD:5130994
NCBI chr16:35,120,194...35,130,851
Ensembl chr16:35,120,581...35,130,671
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