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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:tongue squamous cell carcinoma
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Accession:DOID:0050865 term browser browse the term
Definition:A head and neck squamous cell carcinoma that is located_in the tongue. (DO)
Synonyms:exact_synonym: SCCT
 primary_id: RDO:9000054
 xref: EFO:1000055;   NCI:C4648


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tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEP protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing disease_progression IEP protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G BCL2 BCL2 apoptosis regulator IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 exacerbates IEP protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670 		JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 IEP mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr 1:190,097,658...190,477,864
Ensembl chr 1:190,097,658...190,478,404 		JBrowse link
G CAV2 caveolin 2 IEP protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541 		JBrowse link
G CCND1 cyclin D1 IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression IEP RGD PMID:12162767 RGD:8662376 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 HEP mRNA:increased expression:head, neck (human) RGD PMID:31452775 RGD:150520018 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression IEP RGD PMID:19691460 RGD:126781771 NCBI chr12:56,080,108...56,103,505
Ensembl chr12:56,076,799...56,103,505 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity IEP RGD PMID:19691460 RGD:126781771 NCBI chr 2:211,375,717...212,538,802
Ensembl chr 2:211,375,717...212,538,841 		JBrowse link
G FANCB FA complementation group B IEP RGD PMID:17409780 RGD:11049143 NCBI chr  X:14,689,524...14,873,069
Ensembl chr  X:14,690,388...14,873,255 		JBrowse link
G FANCC FA complementation group C IEP RGD PMID:17409780 RGD:11049143 NCBI chr 9:95,099,054...95,317,709
Ensembl chr 9:95,099,054...95,426,796 		JBrowse link
G FANCF FA complementation group F IEP mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823 		JBrowse link
G FANCG FA complementation group G IEP RGD PMID:17409780 RGD:11049143 NCBI chr 9:35,073,839...35,079,942
Ensembl chr 9:35,073,835...35,080,004 		JBrowse link
G FANCI FA complementation group I IEP RGD PMID:17409780 RGD:11049143 NCBI chr15:89,243,979...89,317,259
Ensembl chr15:89,243,945...89,317,261 		JBrowse link
G FANCL FA complementation group L IEP RGD PMID:17409780 RGD:11049143 NCBI chr 2:58,159,243...58,241,380
Ensembl chr 2:58,159,243...58,241,410 		JBrowse link
G FANCM FA complementation group M IEP RGD PMID:17409780 RGD:11049143 NCBI chr14:45,135,930...45,200,890
Ensembl chr14:45,135,930...45,200,890 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit IEP protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317 		JBrowse link
G FUBP1 far upstream element binding protein 1 exacerbates IEP mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr 1:77,944,055...77,979,501
Ensembl chr 1:77,944,055...77,979,110 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G HGF hepatocyte growth factor IEP protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G IFNG interferon gamma disease_progression ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 disease_progression IEP RGD PMID:25193287 RGD:39938972 NCBI chr 2:102,311,563...102,352,356
Ensembl chr 2:102,311,502...102,352,037 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL33 interleukin 33 disease_progression IEP RGD PMID:25193287 RGD:39938972 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G JAK3 Janus kinase 3 disease_progression ISO RGD PMID:26860129 RGD:11531126 NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit IEP mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 IEP mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr17:12,020,877...12,143,828
Ensembl chr17:12,020,829...12,143,830 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase IEP protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G MMP9 matrix metallopeptidase 9 IEP protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 disease_progression IEP RGD PMID:22153618 RGD:25330347 NCBI chr 8:17,643,802...17,801,521
Ensembl chr 8:17,643,795...17,801,094 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr19:46,774,883...46,788,594
Ensembl chr19:46,774,883...46,788,594 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 severity IEP RGD PMID:24762957 RGD:151361157 NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression IEP RGD PMID:24762957 RGD:151361157 NCBI chr16:87,830,023...87,869,507
Ensembl chr16:87,830,023...87,869,507 		JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression IEP RGD PMID:21689966 RGD:8661665 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 97557
    Stomatognathic Diseases 3518
      mouth disease 2671
        Mouth Neoplasms 305
          Tongue Neoplasms 74
            tongue cancer 52
              tongue squamous cell carcinoma 46
Path 2
Term Annotations click to browse term
  disease 97557
    disease of anatomical entity 91096
      nervous system disease 52952
        Neurologic Manifestations 31832
          sensory system disease 20899
            mouth disease 2671
              Mouth Neoplasms 305
                oral cavity cancer 184
                  tongue cancer 52
                    tongue squamous cell carcinoma 46
paths to the root