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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:tongue squamous cell carcinoma
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Accession:DOID:0050865 term browser browse the term
Definition:A head and neck squamous cell carcinoma that is located_in the tongue. (DO)
Synonyms:exact_synonym: SCCT
 primary_id: RDO:9000054
 xref: EFO:1000055;   NCI:C4648

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tongue squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO protein:increased activity:saliva: RGD PMID:20379753 RGD:152995262 NCBI chr 2:19,167,209...19,200,233 JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing disease_progression ISO protein:decreased expression:serum RGD PMID:23181352 RGD:8694469 NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391 		JBrowse link
G BCL2 BCL2 apoptosis regulator ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr18:16,440,560...16,643,187
Ensembl chr18:16,441,733...16,637,895 		JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 exacerbates ISO protein:increased expression:tongue (human) RGD PMID:18621506 RGD:153323319 NCBI chr 1:93,721,449...93,746,638 JBrowse link
G BRINP3 BMP/retinoic acid inducible neural specific 3 ISO mRNA:decreased expression:tongue: RGD PMID:19787213 RGD:14398487 NCBI chr25:38,950,219...39,340,920
Ensembl chr25:39,147,423...39,340,564 		JBrowse link
G CAV2 caveolin 2 ISO protein:increased expression:mucosa of tongue RGD PMID:20558341 RGD:8661771 NCBI chr21:85,197,452...85,206,521
Ensembl chr21:85,197,537...85,206,588 		JBrowse link
G CCND1 cyclin D1 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:4,909,616...4,922,272
Ensembl chr 1:4,907,353...4,922,357 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A disease_progression ISO RGD PMID:12162767 RGD:8662376 NCBI chr17:35,445,668...35,454,334
Ensembl chr17:35,445,223...35,454,342 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO mRNA:increased expression:head, neck (human) RGD PMID:31452775 RGD:150520018 NCBI chr 7:22,202,497...22,205,730
Ensembl chr 7:22,202,527...22,204,068 		JBrowse link
G EGFR epidermal growth factor receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr21:3,664,622...3,853,492
Ensembl chr21:3,666,339...3,853,239 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO RGD PMID:19691460 RGD:126781771 NCBI chr11:52,020,912...52,043,809
Ensembl chr11:52,021,058...52,044,028 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 severity ISO RGD PMID:19691460 RGD:126781771 NCBI chr10:97,099,090...98,281,697 JBrowse link
G FANCB FA complementation group B ISO RGD PMID:17409780 RGD:11049143 NCBI chr  X:13,321,304...13,352,368
Ensembl chr  X:13,321,527...13,342,478 		JBrowse link
G FANCC FA complementation group C ISO RGD PMID:17409780 RGD:11049143 NCBI chr12:107,780,087...107,991,828
Ensembl chr12:107,845,135...107,991,237 		JBrowse link
G FANCF FA complementation group F ISO mRNA:decreased expression:tongue: RGD PMID:17409780 RGD:11049143 NCBI chr 1:42,377,150...42,381,653
Ensembl chr 1:42,378,883...42,380,007 		JBrowse link
G FANCG FA complementation group G ISO RGD PMID:17409780 RGD:11049143 NCBI chr12:45,537,817...45,544,038
Ensembl chr12:45,538,303...45,543,766 		JBrowse link
G FANCI FA complementation group I ISO RGD PMID:17409780 RGD:11049143 NCBI chr29:7,788,983...7,864,505
Ensembl chr29:7,790,458...7,855,552 		JBrowse link
G FANCL FA complementation group L ISO RGD PMID:17409780 RGD:11049143 NCBI chr14:48,725,447...48,803,892
Ensembl chr14:48,725,541...48,805,356 		JBrowse link
G FANCM FA complementation group M ISO RGD PMID:17409780 RGD:11049143 NCBI chr24:22,255,750...22,327,191
Ensembl chr24:22,256,236...22,329,609 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr24:52,497,465...52,501,161
Ensembl chr24:52,497,521...52,501,514 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:38,916,039...38,924,129 JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit ISO protein:decreased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 1:8,356,263...8,365,606
Ensembl chr 1:8,356,836...8,364,918 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr14:79,201,128...79,222,363
Ensembl chr14:79,201,649...79,222,373 		JBrowse link
G FUBP1 far upstream element binding protein 1 exacerbates ISO mRNA, protein:increased expression:tongue (human) RGD PMID:32339054 RGD:151361191 NCBI chr20:55,194,681...55,233,666
Ensembl chr20:55,194,743...55,230,277 		JBrowse link
G GJA1 gap junction protein alpha 1 ISO protein:decreased expression:epithelium RGD PMID:23568744 RGD:8662380 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G HGF hepatocyte growth factor ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr21:67,118,785...67,193,506
Ensembl chr21:67,120,722...67,193,504 		JBrowse link
G IFNG interferon gamma disease_progression ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr11:63,785,493...63,791,071
Ensembl chr11:63,786,041...63,790,473 		JBrowse link
G IL10 interleukin 10 disease_progression ISO protein:increased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr25:22,590,389...22,595,877
Ensembl chr25:22,590,962...22,594,836 		JBrowse link
G IL1RL1 interleukin 1 receptor like 1 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr14:5,966,551...6,020,391
Ensembl chr14:6,005,061...6,020,265 		JBrowse link
G IL2 interleukin 2 ISO protein:decreased expression:serum: RGD PMID:17338814 RGD:8662972 NCBI chr 7:69,729,635...69,736,279
Ensembl chr 7:69,730,282...69,734,969 		JBrowse link
G IL33 interleukin 33 disease_progression ISO RGD PMID:25193287 RGD:39938972 NCBI chr12:73,235,585...73,283,665
Ensembl chr12:73,237,406...73,252,436 		JBrowse link
G JAK3 Janus kinase 3 disease_progression ISO RGD PMID:26860129 RGD:11531126 NCBI chr 6:16,301,760...16,323,343
Ensembl chr 6:16,300,525...16,322,859 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO mRNA,protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr20:74,204,481...74,207,835
Ensembl chr20:74,205,542...74,206,546 		JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:11,479,108...11,480,942
Ensembl chr 6:11,479,407...11,480,450 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 6:16,754,553...16,756,458
Ensembl chr 6:16,755,247...16,756,290 		JBrowse link
G KDR kinase insert domain receptor treatment ISO RGD PMID:19380367 RGD:8551769 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO mRNA:increased expression:tongue squamous epithelium (human) RGD PMID:28319306 RGD:150429750 NCBI chr16:11,366,610...11,485,411
Ensembl chr16:11,366,751...11,486,125 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO protein:increased expression:tongue: RGD PMID:20848408 RGD:8548612 NCBI chr21:85,370,574...85,486,405
Ensembl chr21:85,397,645...85,488,093 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO protein:increased expression:tongue (human) RGD PMID:26581505 RGD:11535375 NCBI chr 2:17,867,267...17,874,757
Ensembl chr 2:17,867,177...17,874,712 		JBrowse link
G MTUS1 microtubule associated scaffold protein 1 disease_progression ISO RGD PMID:22153618 RGD:25330347 NCBI chr 8:15,739,220...15,899,834
Ensembl chr 8:15,741,294...15,853,293 		JBrowse link
G SLC1A5 solute carrier family 1 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 6:40,139,417...40,150,312 JBrowse link
G SLC3A2 solute carrier family 3 member 2 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 1:11,011,351...11,050,494
Ensembl chr 1:11,008,120...11,050,298 		JBrowse link
G SLC7A11 solute carrier family 7 member 11 severity ISO RGD PMID:24762957 RGD:151361157 NCBI chr 7:85,149,810...85,225,061
Ensembl chr 7:85,154,068...85,225,144 		JBrowse link
G SLC7A5 solute carrier family 7 member 5 disease_progression ISO RGD PMID:24762957 RGD:151361157 NCBI chr 5:73,229,953...73,269,801
Ensembl chr 5:73,229,951...73,269,754 		JBrowse link
G SOX2 SRY-box transcription factor 2 disease_progression ISO RGD PMID:21689966 RGD:8661665 NCBI chr15:7,673,581...7,676,812
Ensembl chr15:7,674,867...7,675,826 		JBrowse link
G TP53 tumor protein p53 ISO protein:increased expression:tongue: RGD PMID:20385474 RGD:8547851 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15379
    Stomatognathic Diseases 1297
      mouth disease 978
        Mouth Neoplasms 241
          Tongue Neoplasms 68
            tongue cancer 50
              tongue squamous cell carcinoma 46
Path 2
Term Annotations click to browse term
  disease 15379
    disease of anatomical entity 15010
      nervous system disease 13117
        Neurologic Manifestations 9703
          sensory system disease 6807
            mouth disease 978
              Mouth Neoplasms 241
                oral cavity cancer 135
                  tongue cancer 50
                    tongue squamous cell carcinoma 46
paths to the root